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Showing 1 to 12 of 16 entries
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Molecular targets for existing and novel immunosuppressive drugs.

Expert reviews in molecular medicine

Stepkowski SM.
PMID: 14585137
Expert Rev Mol Med. 2000 Jun 21;2(4):1-23. doi: 10.1017/S1462399400001769.

Anti-neoplastic cytostatic antiproliferative agents, such as methotrexate, 6-mercaptopurine and cyclophosphamide, were originally used as immunosuppressive drugs. Although these agents induced only modest anti-rejection activity, they caused serious non-specific bone marrow suppression, impairing host resistance and increasing the incidence of...

Both Alpha- and Beta-Rhizobia Occupy the Root Nodules of .

Frontiers in microbiology

Beukes CW, Boshoff FS, Phalane FL, Hassen AI, le Roux MM, Stȩpkowski T, Venter SN, Steenkamp ET.
PMID: 31214140
Front Microbiol. 2019 Jun 04;10:1195. doi: 10.3389/fmicb.2019.01195. eCollection 2019.

No abstract available.

Bradyrhizobium altum sp. nov., Bradyrhizobium oropedii sp. nov. and Bradyrhizobium acaciae sp. nov. from South Africa show locally restricted and pantropical nodA phylogeographic patterns.

Molecular phylogenetics and evolution

Avontuur JR, Palmer M, Beukes CW, Chan WY, Tasiya T, van Zyl E, Coetzee MPA, Stepkowski T, Venter SN, Steenkamp ET.
PMID: 34757168
Mol Phylogenet Evol. 2021 Oct 29;167:107338. doi: 10.1016/j.ympev.2021.107338. Epub 2021 Oct 29.

Africa is known for its rich legume diversity with a significant number of endemic species originating in South Africa. Many of these legumes associate with rhizobial symbionts of the genus Bradyrhizobium, of which most represent new species. Yet, none...

Phylogeny and Phylogeography of Rhizobial Symbionts Nodulating Legumes of the Tribe Genisteae.

Genes

Stępkowski T, Banasiewicz J, Granada CE, Andrews M, Passaglia LMP.
PMID: 29538303
Genes (Basel). 2018 Mar 14;9(3). doi: 10.3390/genes9030163.

The legume tribe Genisteae comprises 618, predominantly temperate species, showing an amphi-Atlantic distribution that was caused by several long-distance dispersal events. Seven out of the 16 authenticated rhizobial genera can nodulate particular Genisteae species.

Horizontal Transfer of Symbiosis Genes within and Between Rhizobial Genera: Occurrence and Importance.

Genes

Andrews M, De Meyer S, James EK, Stępkowski T, Hodge S, Simon MF, Young JPW.
PMID: 29954096
Genes (Basel). 2018 Jun 27;9(7). doi: 10.3390/genes9070321.

Rhizobial symbiosis genes are often carried on symbiotic islands or plasmids that can be transferred (horizontal transfer) between different bacterial species. Symbiosis genes involved in horizontal transfer have different phylogenies with respect to the core genome of their ‘host’....

Bradyrhizobium altum sp. nov., Bradyrhizobium oropedii sp. nov. and Bradyrhizobium acaciae sp. nov. from South Africa show locally restricted and pantropical nodA phylogeographic patterns.

Molecular phylogenetics and evolution

Avontuur JR, Palmer M, Beukes CW, Chan WY, Tasiya T, van Zyl E, Coetzee MPA, Stepkowski T, Venter SN, Steenkamp ET.
PMID: 34757168
Mol Phylogenet Evol. 2021 Oct 29;167:107338. doi: 10.1016/j.ympev.2021.107338. Epub 2021 Oct 29.

Africa is known for its rich legume diversity with a significant number of endemic species originating in South Africa. Many of these legumes associate with rhizobial symbionts of the genus Bradyrhizobium, of which most represent new species. Yet, none...

Inflammatory Biomarkers in Postural Orthostatic Tachycardia Syndrome with Elevated G-Protein-Coupled Receptor Autoantibodies.

Journal of clinical medicine

Gunning WT, Stepkowski SM, Kramer PM, Karabin BL, Grubb BP.
PMID: 33562074
J Clin Med. 2021 Feb 06;10(4). doi: 10.3390/jcm10040623.

A growing body of evidence suggests that postural orthostatic tachycardia syndrome (POTS) may be an autoimmune disorder. We have reported in a previous manuscript that 89% of POTS patients (

Bradyrhizobium altum sp. nov., Bradyrhizobium oropedii sp. nov. and Bradyrhizobium acaciae sp. nov. from South Africa show locally restricted and pantropical nodA phylogeographic patterns.

Molecular phylogenetics and evolution

Avontuur JR, Palmer M, Beukes CW, Chan WY, Tasiya T, van Zyl E, Coetzee MPA, Stepkowski T, Venter SN, Steenkamp ET.
PMID: 34757168
Mol Phylogenet Evol. 2022 Feb;167:107338. doi: 10.1016/j.ympev.2021.107338. Epub 2021 Oct 29.

Africa is known for its rich legume diversity with a significant number of endemic species originating in South Africa. Many of these legumes associate with rhizobial symbionts of the genus Bradyrhizobium, of which most represent new species. Yet, none...

The Impact of Ag Nanoparticles and CdTe Quantum Dots on Expression and Function of Receptors Involved in Amyloid-β Uptake by BV-2 Microglial Cells.

Materials (Basel, Switzerland)

Sikorska K, Grądzka I, Wasyk I, Brzóska K, Stępkowski TM, Czerwińska M, Kruszewski MK.
PMID: 32698417
Materials (Basel). 2020 Jul 20;13(14). doi: 10.3390/ma13143227.

Microglial cells clear the brain of pathogens and harmful debris, including amyloid-β (Aβ) deposits that are formed during Alzheimer's disease (AD). We studied the expression of Msr1, Ager and Cd36 receptors involved in Aβ uptake and expression of Cd33...

Unique advantage of Janus kinase 3 as a target for selective and nontoxic immunosuppression.

Expert review of clinical immunology

Stepkowski SM, Kirken RA.
PMID: 20476981
Expert Rev Clin Immunol. 2005 Sep;1(3):307-10. doi: 10.1586/1744666X.1.3.307.

No abstract available.

Proposed regulation of gene expression by glucose in rodent heart.

Gene regulation and systems biology

Young ME, Yan J, Razeghi P, Cooksey RC, Guthrie PH, Stepkowski SM, McClain DA, Tian R, Taegtmeyer H.
PMID: 19936093
Gene Regul Syst Bio. 2007 Nov 05;1:251-62. doi: 10.4137/grsb.s222.

BACKGROUND: During pressure overload-induced hypertrophy, unloading-induced atrophy, and diabetes mellitus, the heart induces 'fetal' genes (e.g. myosin heavy chain beta; mhc beta).HYPOTHESIS: We propose that altered glucose homeostasis within the cardiomyocyte acts as a central mechanism for the regulation...

Radial artery occlusion after percutaneous coronary interventions - an underestimated issue.

Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

Sławin J, Kubler P, Szczepański A, Piątek J, Stępkowski M, Reczuch K.
PMID: 24570753
Postepy Kardiol Interwencyjnej. 2013;9(4):353-61. doi: 10.5114/pwki.2013.38865. Epub 2013 Nov 18.

The femoral approach is the most common arterial access for percutaneous coronary artery interventions. Despite the convenience and simplicity of this approach, it is burdened with a high risk of arterial puncture bleeding, which worsens the prognosis of the...

Showing 1 to 12 of 16 entries