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Protocol for a randomised, double-blind, placebo-controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: time course of nasal, cutaneous and immunological outcomes.

Clinical and translational allergy

Steveling EH, Lao-Araya M, Koulias C, Scadding G, Eifan A, James LK, Dumitru A, Penagos M, Calderón M, Andersen PS, Shamji M, Durham SR.
PMID: 26682038
Clin Transl Allergy. 2015 Dec 17;5:43. doi: 10.1186/s13601-015-0087-2. eCollection 2015.

BACKGROUND: Seasonal Allergic Rhinitis is characterised by inflammation of the nasal mucosa upon exposure to common aeroallergens, affecting up to 20-25 % of the population. For those patients whose symptoms are not controlled by standard medical treatment, allergen specific...

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Steveling EH, Lao-Araya M, Koulias C, et al. Protocol for a randomised, double-blind, placebo-controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: time course of nasal, cutaneous and immunological outcomes. Clin Transl Allergy. 2015;5:43doi: 10.1186/s13601-015-0087-2.
Steveling, E. H., Lao-Araya, M., Koulias, C., Scadding, G., Eifan, A., James, L. K., Dumitru, A., Penagos, M., Calderón, M., Andersen, P. S., Shamji, M., & Durham, S. R. (2015). Protocol for a randomised, double-blind, placebo-controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: time course of nasal, cutaneous and immunological outcomes. Clinical and translational allergy, 543. https://doi.org/10.1186/s13601-015-0087-2
Steveling, Esther Helen, et al. "Protocol for a randomised, double-blind, placebo-controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: time course of nasal, cutaneous and immunological outcomes." Clinical and translational allergy vol. 5 (2015): 43. doi: https://doi.org/10.1186/s13601-015-0087-2
Steveling EH, Lao-Araya M, Koulias C, Scadding G, Eifan A, James LK, Dumitru A, Penagos M, Calderón M, Andersen PS, Shamji M, Durham SR. Protocol for a randomised, double-blind, placebo-controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: time course of nasal, cutaneous and immunological outcomes. Clin Transl Allergy. 2015 Dec 17;5:43. doi: 10.1186/s13601-015-0087-2. eCollection 2015. PMID: 26682038; PMCID: PMC4682243.
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Identification of Predictors for Weight Reduction in Children and Adolescents with Overweight and Obesity (IDA-Insel Survey).

Healthcare (Basel, Switzerland)

Schiel R, Kaps A, Stein G, Steveling A.
PMID: 27417593
Healthcare (Basel). 2016 Jan 07;4(1). doi: 10.3390/healthcare4010005.

INTRODUCTION: Worldwide, overweight and obesity are known as posing serious health risks. Successful methods of prevention and therapy for overweight and obesity have remained elusive. It was the aim of the present trial to identify parameters and determinants to...

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Schiel R, Kaps A, Stein G, et al. Identification of Predictors for Weight Reduction in Children and Adolescents with Overweight and Obesity (IDA-Insel Survey). Healthcare (Basel). 2016;4(1)doi: 10.3390/healthcare4010005.
Schiel, R., Kaps, A., Stein, G., & Steveling, A. (2016). Identification of Predictors for Weight Reduction in Children and Adolescents with Overweight and Obesity (IDA-Insel Survey). Healthcare (Basel, Switzerland), 4(1), . https://doi.org/10.3390/healthcare4010005
Schiel, Ralf, et al. "Identification of Predictors for Weight Reduction in Children and Adolescents with Overweight and Obesity (IDA-Insel Survey)." Healthcare (Basel, Switzerland) vol. 4,1 (2016). doi: https://doi.org/10.3390/healthcare4010005
Schiel R, Kaps A, Stein G, Steveling A. Identification of Predictors for Weight Reduction in Children and Adolescents with Overweight and Obesity (IDA-Insel Survey). Healthcare (Basel). 2016 Jan 07;4(1). doi: 10.3390/healthcare4010005. PMID: 27417593; PMCID: PMC4934539.
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Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity.

Obesity facts

Storck LJ, Meffert PJ, Rausch J, Gärtner S, Aghdassi AA, Kühn JP, Kraft M, Pietzner M, Lerch MM, Steveling A.
PMID: 33601371
Obes Facts. 2021 Feb 18;1-11. doi: 10.1159/000511453. Epub 2021 Feb 18.

INTRODUCTION: Patients who are overweight or obese have an increased risk of developing type 2 diabetes mellitus (T2DM). Weight loss can have a positive effect on glycemic control.OBJECTIVE: We aimed to investigate glycemic control in patients with T2DM and...

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Storck LJ, Meffert PJ, Rausch J, et al. Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity. Obes Facts. 2021;1-11doi: 10.1159/000511453.
Storck, L. J., Meffert, P. J., Rausch, J., Gärtner, S., Aghdassi, A. A., Kühn, J. P., Kraft, M., Pietzner, M., Lerch, M. M., & Steveling, A. (2021). Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity. Obesity facts, 1-11. https://doi.org/10.1159/000511453
Storck, Lena J, et al. "Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity." Obesity facts vol. (2021): 1-11. doi: https://doi.org/10.1159/000511453
Storck LJ, Meffert PJ, Rausch J, Gärtner S, Aghdassi AA, Kühn JP, Kraft M, Pietzner M, Lerch MM, Steveling A. Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity. Obes Facts. 2021 Feb 18;1-11. doi: 10.1159/000511453. Epub 2021 Feb 18. PMID: 33601371; PMCID: PMC7983589.
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Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania.

Diabetes, metabolic syndrome and obesity : targets and therapy

Kowall B, Stang A, Erbel R, Moebus S, Petersmann A, Steveling A, Jöckel KH, Völzke H.
PMID: 32606858
Diabetes Metab Syndr Obes. 2020 Jun 16;13:1989-2000. doi: 10.2147/DMSO.S242553. eCollection 2020.

AIMS/HYPOTHESIS: There is controversy on whether an obesity paradox exists in type 2 diabetes, ie, that mortality is lowest in overweight or obesity. We examined the role of potential biases in the obesity paradox.METHODS: From two regional population-based German...

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Kowall B, Stang A, Erbel R, et al. Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania. Diabetes Metab Syndr Obes. 2020;13:1989-2000doi: 10.2147/DMSO.S242553.
Kowall, B., Stang, A., Erbel, R., Moebus, S., Petersmann, A., Steveling, A., Jöckel, K. H., & Völzke, H. (2020). Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania. Diabetes, metabolic syndrome and obesity : targets and therapy, 131989-2000. https://doi.org/10.2147/DMSO.S242553
Kowall, Bernd, et al. "Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 13 (2020): 1989-2000. doi: https://doi.org/10.2147/DMSO.S242553
Kowall B, Stang A, Erbel R, Moebus S, Petersmann A, Steveling A, Jöckel KH, Völzke H. Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania. Diabetes Metab Syndr Obes. 2020 Jun 16;13:1989-2000. doi: 10.2147/DMSO.S242553. eCollection 2020. PMID: 32606858; PMCID: PMC7305936.
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Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects.

Brain : a journal of neurology

Niestroj LM, Perez-Palma E, Howrigan DP, Zhou Y, Cheng F, Saarentaus E, Nürnberg P, Stevelink R, Daly MJ, Palotie A, Lal D.
PMID: 32568404
Brain. 2020 Jul 01;143(7):2106-2118. doi: 10.1093/brain/awaa171.

Cytogenic testing is routinely applied in most neurological centres for severe paediatric epilepsies. However, which characteristics of copy number variants (CNVs) confer most epilepsy risk and which epilepsy subtypes carry the most CNV burden, have not been explored on...

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Niestroj LM, Perez-Palma E, Howrigan DP, et al. Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects. Brain. 2020;143(7):2106-2118doi: 10.1093/brain/awaa171.
Niestroj, L. M., Perez-Palma, E., Howrigan, D. P., Zhou, Y., Cheng, F., Saarentaus, E., Nürnberg, P., Stevelink, R., Daly, M. J., Palotie, A., Lal, D. (2020). Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects. Brain : a journal of neurology, 143(7), 2106-2118. https://doi.org/10.1093/brain/awaa171
Niestroj, Lisa-Marie, et al. "Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects." Brain : a journal of neurology vol. 143,7 (2020): 2106-2118. doi: https://doi.org/10.1093/brain/awaa171
Niestroj LM, Perez-Palma E, Howrigan DP, Zhou Y, Cheng F, Saarentaus E, Nürnberg P, Stevelink R, Daly MJ, Palotie A, Lal D. Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects. Brain. 2020 Jul 01;143(7):2106-2118. doi: 10.1093/brain/awaa171. PMID: 32568404; PMCID: PMC7364765.
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Gastric Balloon Implantation as Part of Morbid Adiposity Therapy Changes the Structure of the Stomach Wall.

Visceral medicine

Patrzyk M, Sonke J, Glitsch A, Kessler R, Steveling A, Lünse S, Partecke LI, Heidecke CD, Kessler W.
PMID: 34722725
Visc Med. 2021 Oct;37(5):418-425. doi: 10.1159/000514264. Epub 2021 Feb 17.

PURPOSE: The implantation of a gastric balloon (also known as intragastric balloon) is an established and reversible endoscopic procedure for adiposity therapy. Structural changes of the stomach wall are expected to occur with gastric balloon implantation; however, until now...

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Patrzyk M, Sonke J, Glitsch A, et al. Gastric Balloon Implantation as Part of Morbid Adiposity Therapy Changes the Structure of the Stomach Wall. Visc Med. 2021;37(5):418-425doi: 10.1159/000514264.
Patrzyk, M., Sonke, J., Glitsch, A., Kessler, R., Steveling, A., Lünse, S., Partecke, L. I., Heidecke, C. D., & Kessler, W. (2021). Gastric Balloon Implantation as Part of Morbid Adiposity Therapy Changes the Structure of the Stomach Wall. Visceral medicine, 37(5), 418-425. https://doi.org/10.1159/000514264
Patrzyk, Maciej, et al. "Gastric Balloon Implantation as Part of Morbid Adiposity Therapy Changes the Structure of the Stomach Wall." Visceral medicine vol. 37,5 (2021): 418-425. doi: https://doi.org/10.1159/000514264
Patrzyk M, Sonke J, Glitsch A, Kessler R, Steveling A, Lünse S, Partecke LI, Heidecke CD, Kessler W. Gastric Balloon Implantation as Part of Morbid Adiposity Therapy Changes the Structure of the Stomach Wall. Visc Med. 2021 Oct;37(5):418-425. doi: 10.1159/000514264. Epub 2021 Feb 17. PMID: 34722725; PMCID: PMC8543320.
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Using common genetic variants to find drugs for common epilepsies.

Brain communications

Mirza N, Stevelink R, Taweel B, Koeleman BPC, Marson AG.
PMID: 34988442
Brain Commun. 2021 Dec 04;3(4):fcab287. doi: 10.1093/braincomms/fcab287. eCollection 2021.

Better drugs are needed for common epilepsies. Drug repurposing offers the potential of significant savings in the time and cost of developing new treatments. In order to select the best candidate drug(s) to repurpose for a disease, it is...

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Mirza N, Stevelink R, Taweel B, et al. Using common genetic variants to find drugs for common epilepsies. Brain Commun. 2021;3(4):fcab287doi: 10.1093/braincomms/fcab287.
Mirza, N., Stevelink, R., Taweel, B., Koeleman, B. P. C., Marson, A. G. (2021). Using common genetic variants to find drugs for common epilepsies. Brain communications, 3(4), fcab287. https://doi.org/10.1093/braincomms/fcab287
Mirza, Nasir, et al. "Using common genetic variants to find drugs for common epilepsies." Brain communications vol. 3,4 (2021): fcab287. doi: https://doi.org/10.1093/braincomms/fcab287
Mirza N, Stevelink R, Taweel B, Koeleman BPC, Marson AG. Using common genetic variants to find drugs for common epilepsies. Brain Commun. 2021 Dec 04;3(4):fcab287. doi: 10.1093/braincomms/fcab287. eCollection 2021. PMID: 34988442; PMCID: PMC8710935.
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Excess Body Weight and Pancreatic Disease.

Visceral medicine

Wiese ML, Aghdassi AA, Lerch MM, Steveling A.
PMID: 34540944
Visc Med. 2021 Aug;37(4):281-286. doi: 10.1159/000517147. Epub 2021 Jul 09.

BACKGROUND: Excess body weight (EBW) is a risk factor for various acute and chronic conditions. Conversely, the "obesity paradox" suggests a protective effect of higher body weight on some disease outcomes. This article discusses the role of EBW along...

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Wiese ML, Aghdassi AA, Lerch MM, et al. Excess Body Weight and Pancreatic Disease. Visc Med. 2021;37(4):281-286doi: 10.1159/000517147.
Wiese, M. L., Aghdassi, A. A., Lerch, M. M., & Steveling, A. (2021). Excess Body Weight and Pancreatic Disease. Visceral medicine, 37(4), 281-286. https://doi.org/10.1159/000517147
Wiese, Mats L, et al. "Excess Body Weight and Pancreatic Disease." Visceral medicine vol. 37,4 (2021): 281-286. doi: https://doi.org/10.1159/000517147
Wiese ML, Aghdassi AA, Lerch MM, Steveling A. Excess Body Weight and Pancreatic Disease. Visc Med. 2021 Aug;37(4):281-286. doi: 10.1159/000517147. Epub 2021 Jul 09. PMID: 34540944; PMCID: PMC8406348.
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NHS CHECK: protocol for a cohort study investigating the psychosocial impact of the COVID-19 pandemic on healthcare workers.

BMJ open

Lamb D, Greenberg N, Hotopf M, Raine R, Razavi R, Bhundia R, Scott H, Carr E, Gafoor R, Bakolis I, Hegarty S, Souliou E, Rafferty AM, Rhead R, Weston D, Gnangapragasam S, Marlow S, Wessely S, Stevelink S.
PMID: 34193505
BMJ Open. 2021 Jun 30;11(6):e051687. doi: 10.1136/bmjopen-2021-051687.

INTRODUCTION: The COVID-19 pandemic has had profound effects on the working lives of healthcare workers (HCWs), but the extent to which their well-being and mental health have been affected remains unclear. This longitudinal cohort study aims to recruit a...

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Lamb D, Greenberg N, Hotopf M, et al. NHS CHECK: protocol for a cohort study investigating the psychosocial impact of the COVID-19 pandemic on healthcare workers. BMJ Open. 2021;11(6):e051687doi: 10.1136/bmjopen-2021-051687.
Lamb, D., Greenberg, N., Hotopf, M., Raine, R., Razavi, R., Bhundia, R., Scott, H., Carr, E., Gafoor, R., Bakolis, I., Hegarty, S., Souliou, E., Rafferty, A. M., Rhead, R., Weston, D., Gnangapragasam, S., Marlow, S., Wessely, S., & Stevelink, S. (2021). NHS CHECK: protocol for a cohort study investigating the psychosocial impact of the COVID-19 pandemic on healthcare workers. BMJ open, 11(6), e051687. https://doi.org/10.1136/bmjopen-2021-051687
Lamb, Danielle, et al. "NHS CHECK: protocol for a cohort study investigating the psychosocial impact of the COVID-19 pandemic on healthcare workers." BMJ open vol. 11,6 (2021): e051687. doi: https://doi.org/10.1136/bmjopen-2021-051687
Lamb D, Greenberg N, Hotopf M, Raine R, Razavi R, Bhundia R, Scott H, Carr E, Gafoor R, Bakolis I, Hegarty S, Souliou E, Rafferty AM, Rhead R, Weston D, Gnangapragasam S, Marlow S, Wessely S, Stevelink S. NHS CHECK: protocol for a cohort study investigating the psychosocial impact of the COVID-19 pandemic on healthcare workers. BMJ Open. 2021 Jun 30;11(6):e051687. doi: 10.1136/bmjopen-2021-051687. PMID: 34193505; PMCID: PMC8249177.
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Nutrition in Pancreatic Cancer: A Review.

Gastrointestinal tumors

Gärtner S, Krüger J, Aghdassi AA, Steveling A, Simon P, Lerch MM, Mayerle J.
PMID: 27403414
Gastrointest Tumors. 2016 May;2(4):195-202. doi: 10.1159/000442873. Epub 2016 Jan 08.

BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related mortality in both genders. More than 80% of patients suffer from significant weight loss at diagnosis and over time develop severe cachexia. Early nutritional support is therefore essential.SUMMARY: This...

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Gärtner S, Krüger J, Aghdassi AA, et al. Nutrition in Pancreatic Cancer: A Review. Gastrointest Tumors. 2016;2(4):195-202doi: 10.1159/000442873.
Gärtner, S., Krüger, J., Aghdassi, A. A., Steveling, A., Simon, P., Lerch, M. M., & Mayerle, J. (2016). Nutrition in Pancreatic Cancer: A Review. Gastrointestinal tumors, 2(4), 195-202. https://doi.org/10.1159/000442873
Gärtner, Simone, et al. "Nutrition in Pancreatic Cancer: A Review." Gastrointestinal tumors vol. 2,4 (2016): 195-202. doi: https://doi.org/10.1159/000442873
Gärtner S, Krüger J, Aghdassi AA, Steveling A, Simon P, Lerch MM, Mayerle J. Nutrition in Pancreatic Cancer: A Review. Gastrointest Tumors. 2016 May;2(4):195-202. doi: 10.1159/000442873. Epub 2016 Jan 08. PMID: 27403414; PMCID: PMC4924449.
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On the construction of nonequatorial minimal hyperspheres in S(1) with stable cones in R.

Proceedings of the National Academy of Sciences of the United States of America

Hsiang WY, Sterling I.
PMID: 16578781
Proc Natl Acad Sci U S A. 1984 Dec;81(24):8035-6. doi: 10.1073/pnas.81.24.8035.

Within the framework of equivariant differential geometry, we outline the construction of some imbedded minimal hyperspheres of S(n)(1) and show that many of them have a stable cone in R(n+1). The statement of these and related results are given.

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Hsiang WY, Sterling I. On the construction of nonequatorial minimal hyperspheres in S(1) with stable cones in R. Proc Natl Acad Sci U S A. 1984;81(24):8035-6doi: 10.1073/pnas.81.24.8035.
Hsiang, W. Y., & Sterling, I. (1984). On the construction of nonequatorial minimal hyperspheres in S(1) with stable cones in R. Proceedings of the National Academy of Sciences of the United States of America, 81(24), 8035-6. https://doi.org/10.1073/pnas.81.24.8035
Hsiang, W Y, and Sterling, I. "On the construction of nonequatorial minimal hyperspheres in S(1) with stable cones in R." Proceedings of the National Academy of Sciences of the United States of America vol. 81,24 (1984): 8035-6. doi: https://doi.org/10.1073/pnas.81.24.8035
Hsiang WY, Sterling I. On the construction of nonequatorial minimal hyperspheres in S(1) with stable cones in R. Proc Natl Acad Sci U S A. 1984 Dec;81(24):8035-6. doi: 10.1073/pnas.81.24.8035. PMID: 16578781; PMCID: PMC392289.
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Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark.

Nutrition & metabolism

Hannemann A, Thuesen BH, Friedrich N, Völzke H, Steveling A, Ittermann T, Hegenscheid K, Nauck M, Linneberg A, Wallaschofski H.
PMID: 26085837
Nutr Metab (Lond). 2015 Jun 10;12:24. doi: 10.1186/s12986-015-0019-0. eCollection 2015.

BACKGROUND: Body mass index (BMI) and serum 25-hydroxy vitamin D3 (25OHD) concentrations are inversely related. As BMI contains only limited information regarding body fat distribution, we aimed to analyze the cross-sectional associations of abdominal visceral or subcutaneous adipose tissue,...

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Hannemann A, Thuesen BH, Friedrich N, et al. Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark. Nutr Metab (Lond). 2015;12:24doi: 10.1186/s12986-015-0019-0.
Hannemann, A., Thuesen, B. H., Friedrich, N., Völzke, H., Steveling, A., Ittermann, T., Hegenscheid, K., Nauck, M., Linneberg, A., & Wallaschofski, H. (2015). Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark. Nutrition & metabolism, 1224. https://doi.org/10.1186/s12986-015-0019-0
Hannemann, A, et al. "Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark." Nutrition & metabolism vol. 12 (2015): 24. doi: https://doi.org/10.1186/s12986-015-0019-0
Hannemann A, Thuesen BH, Friedrich N, Völzke H, Steveling A, Ittermann T, Hegenscheid K, Nauck M, Linneberg A, Wallaschofski H. Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark. Nutr Metab (Lond). 2015 Jun 10;12:24. doi: 10.1186/s12986-015-0019-0. eCollection 2015. PMID: 26085837; PMCID: PMC4470034.
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