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Showing 1 to 7 of 7 entries
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A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.

Nature communications

MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie NM, Todd RT, Stogios PJ, Sanchez H, O'Meara TR, Tompkins TA, Savchenko A, Selmecki A, Veri AO, Andes DR, Fidel PL, Robbins N, Nodwell J, Whitesell L, Cowen LE.
PMID: 34686660
Nat Commun. 2021 Oct 22;12(1):6151. doi: 10.1038/s41467-021-26390-w.

The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in microbiome composition to invade its human host, causing pathologies ranging from vaginal candidiasis to fungal sepsis. Bacteria of the genus Lactobacillus are colonizers of human mucosa...

Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health.

NPJ schizophrenia

Stogios N, Gdanski A, Gerretsen P, Chintoh AF, Graff-Guerrero A, Rajji TK, Remington G, Hahn MK, Agarwal SM.
PMID: 33903594
NPJ Schizophr. 2021 Apr 26;7(1):22. doi: 10.1038/s41537-021-00151-6.

Schizophrenia (SCZ) is a psychiatric disorder characterized by a wide range of positive, negative and cognitive symptoms, along with an increased risk of metabolic syndrome and cardiovascular disease that contribute to a 15-20-year reduced life expectancy. Autonomic dysfunction, in...

A novel acetyl xylan esterase enabling complete deacetylation of substituted xylans.

Biotechnology for biofuels

Razeq FM, Jurak E, Stogios PJ, Yan R, Tenkanen M, Kabel MA, Wang W, Master ER.
PMID: 29588659
Biotechnol Biofuels. 2018 Mar 22;11:74. doi: 10.1186/s13068-018-1074-3. eCollection 2018.

BACKGROUND: Acetylated 4-RESULTS: An unclassified carbohydrate esterase (FjoAcXE) was identified as a protein of unknown function from a polysaccharide utilization locus (PUL) otherwise comprising carbohydrate-active enzyme families known to target xylan. FjoAcXE was shown to efficiently release acetyl groups...

A novel C-terminal degron identified in bacterial aldehyde decarbonylases using directed evolution.

Biotechnology for biofuels

Liu Y, Chen J, Khusnutdinova AN, Correia K, Diep P, Batyrova KA, Nemr K, Flick R, Stogios P, Yakunin AF, Mahadevan R.
PMID: 32612677
Biotechnol Biofuels. 2020 Jun 29;13:114. doi: 10.1186/s13068-020-01753-5. eCollection 2020.

BACKGROUND: Aldehyde decarbonylases (ADs), which convert acyl aldehydes into alkanes, supply promising solution for producing alkanes from renewable feedstock. However the instability of ADs impedes their further application. Therefore, the current study aimed to investigate the degradation mechanism of...

Metabolic adverse effects of off-label use of second-generation antipsychotics in the adult population: a systematic review and meta-analysis.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Stogios N, Smith E, Bowden S, Tran V, Asgariroozbehani R, McIntyre WB, Remington G, Siskind D, Agarwal SM, Hahn MK.
PMID: 34446830
Neuropsychopharmacology. 2021 Aug 26; doi: 10.1038/s41386-021-01163-7. Epub 2021 Aug 26.

Prescription rates of second-generation antipsychotics (SGAs) are rapidly increasing for non-indicated (i.e., off-label) usage. SGAs used for approved indications are associated with significant metabolic adverse effects, including weight gain. The objective of this systematic review and meta-analysis is to...

Three mutations repurpose a plant karrikin receptor to a strigolactone receptor.

Proceedings of the National Academy of Sciences of the United States of America

Arellano-Saab A, Bunsick M, Al Galib H, Zhao W, Schuetz S, Bradley JM, Xu Z, Adityani C, Subha A, McKay H, de Saint Germain A, Boyer FD, McErlean CSP, Toh S, McCourt P, Stogios PJ, Lumba S.
PMID: 34301902
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30). doi: 10.1073/pnas.2103175118.

Uncovering the basis of small-molecule hormone receptors' evolution is paramount to a complete understanding of how protein structure drives function. In plants, hormone receptors for strigolactones are well suited to evolutionary inquiries because closely related homologs have different ligand...

Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies.

Cell reports methods

Esmail S, Knauer MJ, Abdoh H, Voss C, Chin-Yee B, Stogios P, Seitova A, Hutchinson A, Yusifov F, Skarina T, Evdokimova E, Ackloo S, Lowes L, Hedley BD, Bhayana V, Chin-Yee I, Li SS.
PMID: 34235498
Cell Rep Methods. 2021 Jun 21;1(2):100011. doi: 10.1016/j.crmeth.2021.100011. Epub 2021 May 12.

We have developed a rapid, accurate, and cost-effective serologic test for SARS-CoV-2 virus, which caused the COVID-19 pandemic, on the basis of antibody-dependent agglutination of antigen-coated latex particles. When validated using plasma samples that are positive or negative for...

Showing 1 to 7 of 7 entries