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Showing 1 to 12 of 34 entries
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Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia.

Frontiers in oncology

Pfeiffer MM, Burow H, Schleicher S, Handgretinger R, Lang P.
PMID: 23641363
Front Oncol. 2013 Apr 29;3:99. doi: 10.3389/fonc.2013.00099. eCollection 2013.

Epigenetic drugs like histone deacetylase inhibitors (HDACi) and DNA-methyltransferase inhibitors (DNMTi) have been shown to be effective against a variety of tumor entities. Among different molecular anticancer activities of epigenetic active substances, up-regulation of natural killer (NK) cell ligands...

High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma.

The British journal of dermatology

Westphal D, Garzarolli M, Sergon M, Horak P, Hutter B, Becker JC, Wiegel M, Maczey E, Blum S, Grosche-Schlee S, Rütten A, Ugurel S, Stenzinger A, Glimm H, Aust D, Baretton G, Beissert S, Fröhling S, Redler S, Surowy H, Meier F.
PMID: 34185311
Br J Dermatol. 2021 Jun 29; doi: 10.1111/bjd.20604. Epub 2021 Jun 29.

BACKGROUND: Eccrine porocarcinoma (EPC) is a rare skin cancer arising from the eccrine sweat glands. Due to the lack of effective therapies, metastasis is associated with a high mortality rate.OBJECTIVES: To investigate the drivers of EPC progression.METHODS: We carried...

Profound inhibition of CD73-dependent formation of anti-inflammatory adenosine in B cells of SLE patients.

EBioMedicine

Hesse J, Siekierka-Harreis M, Steckel B, Alter C, Schallehn M, Honke N, Schnieringer ML, Wippich M, Braband R, Schneider M, Surowy H, Wieczorek D, Schrader J, Pongratz G.
PMID: 34666225
EBioMedicine. 2021 Nov;73:103616. doi: 10.1016/j.ebiom.2021.103616. Epub 2021 Oct 16.

BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that leads to a breakdown of tolerance to self-antigens resulting in inflammation and organ damage. The anti-inflammatory activity of CD73-derived adenosine is well documented, however, its role in SLE...

Reverse total shoulder arthroplasty (RTSA) versus open reduction and internal fixation (ORIF) for displaced three-part or four-part proximal humeral fractures: a systematic review and meta-analysis.

EFORT open reviews

Suroto H, De Vega B, Deapsari F, Prajasari T, Wibowo PA, Samijo SK.
PMID: 34760293
EFORT Open Rev. 2021 Oct 19;6(10):941-955. doi: 10.1302/2058-5241.6.210049. eCollection 2021 Oct.

Despite rapid medical technology development, various challenges exist in three- and four-part proximal humeral fracture (PHF) management. This condition has led to a notably increased use of the reverse total shoulder arthroplasty (RTSA); however, open reduction and internal fixation...

A Framework for Supervision for Mindfulness-Based Teachers: a Space for Embodied Mutual Inquiry.

Mindfulness

Evans A, Crane R, Cooper L, Mardula J, Wilks J, Surawy C, Kenny M, Kuyken W.
PMID: 26000064
Mindfulness (N Y). 2015;6(3):572-581. doi: 10.1007/s12671-014-0292-4.

Over recent decades, there has been an exponential growth in mindfulness-based interventions (MBIs). To disseminate MBIs with fidelity, care needs to be taken with the training and supervision of MBI teachers. A wealth of literature exists describing the process...

Early and late apoptosis protein expression (Bcl-2, BAX and p53) in traumatic brachial plexus injury.

Journal of musculoskeletal & neuronal interactions

Suroto H, Asriel A, De Vega B, Samijo SK.
PMID: 34854392
J Musculoskelet Neuronal Interact. 2021 Dec 01;21(4):528-532.

OBJECTIVES: This research aims to analyze the expression of pro-apoptotic proteins (Bax, p53) and anti-apoptotic protein (Bcl-2) in the nerve roots of the brachial plexus following traumatic brachial plexus injury (TBPI) in the early and late stage.METHODS: A total...

Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies.

Cancer gene therapy

Denisova E, Westphal D, Surowy HM, Meier F, Hutter B, Reifenberger J, Rütten A, Schulz A, Sergon M, Ziemer M, Brors B, Betz RC, Redler S.
PMID: 34045664
Cancer Gene Ther. 2021 May 27; doi: 10.1038/s41417-021-00347-z. Epub 2021 May 27.

Malignant sweat gland tumours are rare, with the most common form being Eccrine porocarcinoma (EP). To investigate the mutational landscape of EP, we performed whole-exome sequencing (WES) on 14 formalin-fixed paraffin-embedded samples of matched primary EP and healthy surrounding...

Adenoma and colorectal cancer risks in Lynch syndrome, Lynch-like syndrome and familial colorectal cancer type X.

International journal of cancer

Bucksch K, Zachariae S, Ahadova A, Aretz S, Büttner R, Görgens H, Holinski-Feder E, Hüneburg R, Kloor M, von Knebel Doeberitz M, Ladigan-Badura S, Moeslein G, Morak M, Nattermann J, Nguyen HP, Perne C, Redler S, Schmetz A, Steinke-Lange V, Surowy H, Vangala DB, Weitz J, Loeffler M, Engel C.
PMID: 34469588
Int J Cancer. 2022 Jan 01;150(1):56-66. doi: 10.1002/ijc.33790. Epub 2021 Sep 14.

Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are different entities of familial cancer predisposition leading to an increased risk of colorectal cancer (CRC). The aim of this prospective study was to characterise and...

Traumatic Brachial Plexus Injury in Indonesia: An Experience from a Developing Country.

Journal of reconstructive microsurgery

Suroto H, Antoni I, Siyo A, Steendam TC, Prajasari T, Mulyono HB, De Vega B.
PMID: 34470060
J Reconstr Microsurg. 2021 Sep 01; doi: 10.1055/s-0041-1735507. Epub 2021 Sep 01.

BACKGROUND:  Brachial plexus injuries (BPI) cause severe physical disability and major psycho-socioeconomic burden. Although various countries have reported BPI incidence, the data from Indonesia as the fourth most populated country in the world remains unknown. We aim to assess...

Posterior cruciate ligament research output in asian countries from 2009 - 2019: A systematic review.

Annals of medicine and surgery (2012)

Rhatomy S, Utomo DN, Suroto H, Mahyudin F.
PMID: 32994987
Ann Med Surg (Lond). 2020 Sep 12;59:76-80. doi: 10.1016/j.amsu.2020.09.006. eCollection 2020 Nov.

PURPOSE: This study aimed to determine the number of posterior cruciate ligament (PCL) publications performed in Asian countries and to identify factors associated with research output in this region.MATERIALS AND METHODS: Searches of existing academic journal articles were performed...

Apoptosis of proximal stump postganglionic brachial plexus injury, before and after six months post-trauma.

Annals of medicine and surgery (2012)

Adyaksa G, Suroto H.
PMID: 33664944
Ann Med Surg (Lond). 2021 Feb 17;63:102156. doi: 10.1016/j.amsu.2021.02.002. eCollection 2021 Mar.

BACKGROUND: The success of the micro-surgery procedure for the treatment of postganglionic brachial plexus injury was influenced by several factors, including the surgical timing and also the viability of the proximal stump. This study evaluates the evidence of apoptosis...

Lengthening of Massive Intercalary Cortical Allograft After Successful Graft Incorporation in Skeletally Immature Bone with Critical-Sized Defect: A Case Report with 6-year Follow-up.

Indian journal of orthopaedics

Mahyudin F, Hernugrahanto KD, Andrianus J, Widhiyanto L, Edward M, Suroto H.
PMID: 33569115
Indian J Orthop. 2020 Mar 24;55(1):203-207. doi: 10.1007/s43465-020-00087-6. eCollection 2021 Feb.

Bone allograft serves as an alternative to overcome the limitation of autograft. Some concerns, such as graft rejection, infection, and low union rate, arise from the use of bone allograft since the graft is a non-living and foreign material....

Showing 1 to 12 of 34 entries