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Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.

ACS medicinal chemistry letters

Skerlj RT, Bastos CM, Booker ML, Kramer ML, Barker RH, Celatka CA, O'Shea TJ, Munoz B, Sidhu AB, Cortese JF, Wittlin S, Papastogiannidis P, Angulo-Barturen I, Jimenez-Diaz MB, Sybertz E.
PMID: 24900364
ACS Med Chem Lett. 2011 Jul 11;2(9):708-13. doi: 10.1021/ml200143c. eCollection 2011 Sep 08.

Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum is unable to salvage pyrimidines and must rely on...

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Skerlj RT, Bastos CM, Booker ML, et al. Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria. ACS Med Chem Lett. 2011;2(9):708-13doi: 10.1021/ml200143c.
Skerlj, R. T., Bastos, C. M., Booker, M. L., Kramer, M. L., Barker, R. H., Celatka, C. A., O'Shea, T. J., Munoz, B., Sidhu, A. B., Cortese, J. F., Wittlin, S., Papastogiannidis, P., Angulo-Barturen, I., Jimenez-Diaz, M. B., & Sybertz, E. (2011). Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria. ACS medicinal chemistry letters, 2(9), 708-13. https://doi.org/10.1021/ml200143c
Skerlj, Renato T, et al. "Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria." ACS medicinal chemistry letters vol. 2,9 (2011): 708-13. doi: https://doi.org/10.1021/ml200143c
Skerlj RT, Bastos CM, Booker ML, Kramer ML, Barker RH, Celatka CA, O'Shea TJ, Munoz B, Sidhu AB, Cortese JF, Wittlin S, Papastogiannidis P, Angulo-Barturen I, Jimenez-Diaz MB, Sybertz E. Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13. doi: 10.1021/ml200143c. eCollection 2011 Sep 08. PMID: 24900364; PMCID: PMC4018051.
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Simulating spray series of pesticides in agricultural practice reveals evidence for accumulation of environmental risk in soil.

The Science of the total environment

Sybertz A, Ottermanns R, Schäffer A, Scholz-Starke B, Daniels B, Frische T, Bär S, Ullrich C, Roß-Nickoll M.
PMID: 31911253
Sci Total Environ. 2020 Mar 25;710:135004. doi: 10.1016/j.scitotenv.2019.135004. Epub 2019 Dec 19.

No abstract available.

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Sybertz A, Ottermanns R, Schäffer A, et al. Simulating spray series of pesticides in agricultural practice reveals evidence for accumulation of environmental risk in soil. Sci Total Environ. 2019;710:135004doi: 10.1016/j.scitotenv.2019.135004.
Sybertz, A., Ottermanns, R., Schäffer, A., Scholz-Starke, B., Daniels, B., Frische, T., Bär, S., Ullrich, C., & Roß-Nickoll, M. (2020). Simulating spray series of pesticides in agricultural practice reveals evidence for accumulation of environmental risk in soil. The Science of the total environment, 710135004. https://doi.org/10.1016/j.scitotenv.2019.135004
Sybertz, Alexandra, et al. "Simulating spray series of pesticides in agricultural practice reveals evidence for accumulation of environmental risk in soil." The Science of the total environment vol. 710 (2020): 135004. doi: https://doi.org/10.1016/j.scitotenv.2019.135004
Sybertz A, Ottermanns R, Schäffer A, Scholz-Starke B, Daniels B, Frische T, Bär S, Ullrich C, Roß-Nickoll M. Simulating spray series of pesticides in agricultural practice reveals evidence for accumulation of environmental risk in soil. Sci Total Environ. 2020 Mar 25;710:135004. doi: 10.1016/j.scitotenv.2019.135004. Epub 2019 Dec 19. PMID: 31911253.
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MITAS: A model for assessing the time-dependent risk of sequential applications of pesticides for soil organisms by consideration of exposure, degradation and mixture toxicity.

MethodsX

Sybertz A, Roß-Nickoll M, Schäffer A, Scholz-Starke B, Daniels B, Ottermanns R.
PMID: 31908986
MethodsX. 2019 Dec 16;7:62-73. doi: 10.1016/j.mex.2019.12.004. eCollection 2020.

In agricultural landscapes it is common practice to apply pesticides as a spray series. Within a vegetation period multiple applications result in a mixture of different pesticides in the soil and other environmental compartments. •A model named MITAS (MIxture...

Cite
Sybertz A, Roß-Nickoll M, Schäffer A, et al. MITAS: A model for assessing the time-dependent risk of sequential applications of pesticides for soil organisms by consideration of exposure, degradation and mixture toxicity. MethodsX. 2019;7:62-73doi: 10.1016/j.mex.2019.12.004.
Sybertz, A., Roß-Nickoll, M., Schäffer, A., Scholz-Starke, B., Daniels, B., & Ottermanns, R. (2020). MITAS: A model for assessing the time-dependent risk of sequential applications of pesticides for soil organisms by consideration of exposure, degradation and mixture toxicity. MethodsX, 762-73. https://doi.org/10.1016/j.mex.2019.12.004
Sybertz, Alexandra, et al. "MITAS: A model for assessing the time-dependent risk of sequential applications of pesticides for soil organisms by consideration of exposure, degradation and mixture toxicity." MethodsX vol. 7 (2020): 62-73. doi: https://doi.org/10.1016/j.mex.2019.12.004
Sybertz A, Roß-Nickoll M, Schäffer A, Scholz-Starke B, Daniels B, Ottermanns R. MITAS: A model for assessing the time-dependent risk of sequential applications of pesticides for soil organisms by consideration of exposure, degradation and mixture toxicity. MethodsX. 2019 Dec 16;7:62-73. doi: 10.1016/j.mex.2019.12.004. eCollection 2020. PMID: 31908986; PMCID: PMC6938805.
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