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Showing 1 to 12 of 44 entries
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Novel insights and therapeutic interventions for pediatric osteosarcoma

Stem career interventions

Tamamyan G.
GSID: nukyZrFLdA0J
L Kager, G Tamamyan, S Bielack - Future Oncology, 2017 - Future Medicine

High-grade osteosarcomas are the most common primary malignant tumors of bone. With complete surgical resection and multi-agent chemotherapy up to 70% of patients with high-grade osteosarcomas and localized extremity tumors can become long-term survivors. The prognosis, however, is poor...

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Kager, L., Tamamyan, G., & Bielack, S. (2017). Novel insights and therapeutic interventions for pediatric osteosarcoma. Future Oncology, 13(4), 357-368.
Kager, Leo, Gevorg Tamamyan, and Stefan Bielack. "Novel insights and therapeutic interventions for pediatric osteosarcoma." Future Oncology 13.4 (2017): 357-368.
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Twinning and structure of Eu(0.6)Sr(0.4)MnO3.

Acta crystallographica. Section C, Crystal structure communications

Tamazyan R, Rotiroti N, van Smaalen S, Mukovskii Y, Arsenov A.
PMID: 16397319
Acta Crystallogr C. 2006 Jan;62:i3-5. doi: 10.1107/S0108270105036644. Epub 2005 Dec 16.

The crystal structure of europium strontium manganese trioxide, Eu(0.6)Sr(0.4)MnO3, has been refined using a multiply twinned single crystal containing six twin components. The MnO6 octahedra show Jahn-Teller distortions with nearly fourfold symmetry, but the octahedral tilting scheme reduces the...

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Tamazyan R, Rotiroti N, van Smaalen S, et al. Twinning and structure of Eu(0.6)Sr(0.4)MnO3. Acta Crystallogr C. 2005;62:i3-5doi: 10.1107/S0108270105036644.
Tamazyan, R., Rotiroti, N., van Smaalen, S., Mukovskii, Y., & Arsenov, A. (2006). Twinning and structure of Eu(0.6)Sr(0.4)MnO3. Acta crystallographica. Section C, Crystal structure communications, 62i3-5. https://doi.org/10.1107/S0108270105036644
Tamazyan, Rafael, et al. "Twinning and structure of Eu(0.6)Sr(0.4)MnO3." Acta crystallographica. Section C, Crystal structure communications vol. 62 (2006): i3-5. doi: https://doi.org/10.1107/S0108270105036644
Tamazyan R, Rotiroti N, van Smaalen S, Mukovskii Y, Arsenov A. Twinning and structure of Eu(0.6)Sr(0.4)MnO3. Acta Crystallogr C. 2006 Jan;62:i3-5. doi: 10.1107/S0108270105036644. Epub 2005 Dec 16. PMID: 16397319.
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1-Benzyl-2-(1H-indol-3-yl)-5-oxo-pyrrolidine-2-carbonitrile.

Acta crystallographica. Section E, Structure reports online

Tamazyan R, Armen A, Ashot M, Sahak G, Schinazi R.
PMID: 21201400
Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 04;64:o368. doi: 10.1107/S1600536807067670.

In the title compound, C(20)H(17)N(3)O, a potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse-transcriptase inhibitor, the pyrrolidine ring has an envelope conformation. In the crystal structure, adjacent mol-ecules are connected into infinite chains via an N-H⋯O hydrogen bond.

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Tamazyan R, Armen A, Ashot M, et al. 1-Benzyl-2-(1H-indol-3-yl)-5-oxo-pyrrolidine-2-carbonitrile. Acta Crystallogr Sect E Struct Rep Online. 2008;64:o368doi: 10.1107/S1600536807067670.
Tamazyan, R., Armen, A., Ashot, M., Sahak, G., & Schinazi, R. (2008). 1-Benzyl-2-(1H-indol-3-yl)-5-oxo-pyrrolidine-2-carbonitrile. Acta crystallographica. Section E, Structure reports online, 64o368. https://doi.org/10.1107/S1600536807067670
Tamazyan, Rafael, et al. "1-Benzyl-2-(1H-indol-3-yl)-5-oxo-pyrrolidine-2-carbonitrile." Acta crystallographica. Section E, Structure reports online vol. 64 (2008): o368. doi: https://doi.org/10.1107/S1600536807067670
Tamazyan R, Armen A, Ashot M, Sahak G, Schinazi R. 1-Benzyl-2-(1H-indol-3-yl)-5-oxo-pyrrolidine-2-carbonitrile. Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 04;64:o368. doi: 10.1107/S1600536807067670. PMID: 21201400; PMCID: PMC2960201.
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1-Benzyl-6-phenyl-imino-5-(pyrrol-2-yl-idene)hexa-hydro-pyrimidine-2,4-dione.

Acta crystallographica. Section E, Structure reports online

Tamazyan R, Ayvazyan A, Martirosyan V, Avagyan K, Martirosyan A.
PMID: 21201507
Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 23;64:o483. doi: 10.1107/S1600536808001384.

In the title compound, C(21)H(20)N(4)O(2), a potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor, the pyrrolidine ring adopts an envelope conformation, while the hydrogenated pyrimidine ring adopts a weakly expressed twist conformation. The mol-ecules are connected...

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Tamazyan R, Ayvazyan A, Martirosyan V, et al. 1-Benzyl-6-phenyl-imino-5-(pyrrol-2-yl-idene)hexa-hydro-pyrimidine-2,4-dione. Acta Crystallogr Sect E Struct Rep Online. 2008;64:o483doi: 10.1107/S1600536808001384.
Tamazyan, R., Ayvazyan, A., Martirosyan, V., Avagyan, K., & Martirosyan, A. (2008). 1-Benzyl-6-phenyl-imino-5-(pyrrol-2-yl-idene)hexa-hydro-pyrimidine-2,4-dione. Acta crystallographica. Section E, Structure reports online, 64o483. https://doi.org/10.1107/S1600536808001384
Tamazyan, Rafael, et al. "1-Benzyl-6-phenyl-imino-5-(pyrrol-2-yl-idene)hexa-hydro-pyrimidine-2,4-dione." Acta crystallographica. Section E, Structure reports online vol. 64 (2008): o483. doi: https://doi.org/10.1107/S1600536808001384
Tamazyan R, Ayvazyan A, Martirosyan V, Avagyan K, Martirosyan A. 1-Benzyl-6-phenyl-imino-5-(pyrrol-2-yl-idene)hexa-hydro-pyrimidine-2,4-dione. Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 23;64:o483. doi: 10.1107/S1600536808001384. PMID: 21201507; PMCID: PMC2960353.
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Dopamine D.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Barret O, Zhang L, Alagille D, Constantinescu CC, Sandiego C, Papin C, Sullivan JM, Morley T, Carroll VM, Seibyl J, Chen J, Lee C, Villalobos A, Gray D, McCarthy TJ, Tamagnan G.
PMID: 33579806
J Nucl Med. 2021 Sep 01;62(9):1307-1313. doi: 10.2967/jnumed.120.256008. Epub 2021 Feb 12.

Non-catechol-based high-affinity selective dopamine D

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Barret O, Zhang L, Alagille D, et al. Dopamine D. J Nucl Med. 2021;62(9):1307-1313doi: 10.2967/jnumed.120.256008.
Barret, O., Zhang, L., Alagille, D., Constantinescu, C. C., Sandiego, C., Papin, C., Sullivan, J. M., Morley, T., Carroll, V. M., Seibyl, J., Chen, J., Lee, C., Villalobos, A., Gray, D., McCarthy, T. J., & Tamagnan, G. (2021). Dopamine D. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(9), 1307-1313. https://doi.org/10.2967/jnumed.120.256008
Barret, Olivier, et al. "Dopamine D." Journal of nuclear medicine : official publication, Society of Nuclear Medicine vol. 62,9 (2021): 1307-1313. doi: https://doi.org/10.2967/jnumed.120.256008
Barret O, Zhang L, Alagille D, Constantinescu CC, Sandiego C, Papin C, Sullivan JM, Morley T, Carroll VM, Seibyl J, Chen J, Lee C, Villalobos A, Gray D, McCarthy TJ, Tamagnan G. Dopamine D. J Nucl Med. 2021 Sep 01;62(9):1307-1313. doi: 10.2967/jnumed.120.256008. Epub 2021 Feb 12. PMID: 33579806.
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Design, Synthesis, and Evaluation of [.

Journal of medicinal chemistry

Matsuda S, Hattori Y, Matsumiya K, McQuade P, Yamashita T, Aida J, Sandiego CM, Gouasmat A, Carroll VM, Barret O, Tamagnan G, Koike T, Kimura H.
PMID: 34423983
J Med Chem. 2021 Sep 09;64(17):12680-12690. doi: 10.1021/acs.jmedchem.1c00653. Epub 2021 Aug 23.

Histone methylation is associated with the pathophysiology of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) catalyzes histone demethylation in a flavin adenine dinucleotide (FAD)-dependent manner. Thus, inhibiting LSD1 enzyme activity could offer a novel way to treat neurodevelopmental disorders. Assessing...

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Matsuda S, Hattori Y, Matsumiya K, et al. Design, Synthesis, and Evaluation of [. J Med Chem. 2021;64(17):12680-12690doi: 10.1021/acs.jmedchem.1c00653.
Matsuda, S., Hattori, Y., Matsumiya, K., McQuade, P., Yamashita, T., Aida, J., Sandiego, C. M., Gouasmat, A., Carroll, V. M., Barret, O., Tamagnan, G., Koike, T., & Kimura, H. (2021). Design, Synthesis, and Evaluation of [. Journal of medicinal chemistry, 64(17), 12680-12690. https://doi.org/10.1021/acs.jmedchem.1c00653
Matsuda, Satoru, et al. "Design, Synthesis, and Evaluation of [." Journal of medicinal chemistry vol. 64,17 (2021): 12680-12690. doi: https://doi.org/10.1021/acs.jmedchem.1c00653
Matsuda S, Hattori Y, Matsumiya K, McQuade P, Yamashita T, Aida J, Sandiego CM, Gouasmat A, Carroll VM, Barret O, Tamagnan G, Koike T, Kimura H. Design, Synthesis, and Evaluation of [. J Med Chem. 2021 Sep 09;64(17):12680-12690. doi: 10.1021/acs.jmedchem.1c00653. Epub 2021 Aug 23. PMID: 34423983.
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Structural Transition States Explored With Minimalist Coarse Grained Models: Applications to Calmodulin.

Frontiers in molecular biosciences

Delfino F, Porozov Y, Stepanov E, Tamazian G, Tozzini V.
PMID: 31750313
Front Mol Biosci. 2019 Oct 15;6:104. doi: 10.3389/fmolb.2019.00104. eCollection 2019.

Transitions between different conformational states are ubiquitous in proteins, being involved in signaling, catalysis, and other fundamental activities in cells. However, modeling those processes is extremely difficult, due to the need of efficiently exploring a vast conformational space in...

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Delfino F, Porozov Y, Stepanov E, et al. Structural Transition States Explored With Minimalist Coarse Grained Models: Applications to Calmodulin. Front Mol Biosci. 2019;6:104doi: 10.3389/fmolb.2019.00104.
Delfino, F., Porozov, Y., Stepanov, E., Tamazian, G., & Tozzini, V. (2019). Structural Transition States Explored With Minimalist Coarse Grained Models: Applications to Calmodulin. Frontiers in molecular biosciences, 6104. https://doi.org/10.3389/fmolb.2019.00104
Delfino, Francesco, et al. "Structural Transition States Explored With Minimalist Coarse Grained Models: Applications to Calmodulin." Frontiers in molecular biosciences vol. 6 (2019): 104. doi: https://doi.org/10.3389/fmolb.2019.00104
Delfino F, Porozov Y, Stepanov E, Tamazian G, Tozzini V. Structural Transition States Explored With Minimalist Coarse Grained Models: Applications to Calmodulin. Front Mol Biosci. 2019 Oct 15;6:104. doi: 10.3389/fmolb.2019.00104. eCollection 2019. PMID: 31750313; PMCID: PMC6843051.
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1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide.

Acta crystallographica. Section C, Crystal structure communications

Tamazyan R, Karapetyan H, Martirosyan A, Hovhannesyan V, Gasparyan S.
PMID: 12094054
Acta Crystallogr C. 2002 Jul;58:o386-8. doi: 10.1107/s0108270102008636. Epub 2002 Jun 12.

The structures of two potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTI), namely 1-(2-chlorobenzoyl)-2-phenylpyrrolidine-2-carboxamide, C(18)H(17)ClN(2)O(2), and 1-(2-furoyl)-2-phenylpyrrolidine-2-carboxamide, C(16)H(16)N(2)O(3), have been investigated by X-ray diffraction and the butterfly-like conformation established in each case. The pyrrolidine ring...

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Tamazyan R, Karapetyan H, Martirosyan A, et al. 1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide. Acta Crystallogr C. 2002;58:o386-8doi: 10.1107/s0108270102008636.
Tamazyan, R., Karapetyan, H., Martirosyan, A., Hovhannesyan, V., & Gasparyan, S. (2002). 1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide. Acta crystallographica. Section C, Crystal structure communications, 58o386-8. https://doi.org/10.1107/s0108270102008636
Tamazyan, Rafael, et al. "1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide." Acta crystallographica. Section C, Crystal structure communications vol. 58 (2002): o386-8. doi: https://doi.org/10.1107/s0108270102008636
Tamazyan R, Karapetyan H, Martirosyan A, Hovhannesyan V, Gasparyan S. 1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide. Acta Crystallogr C. 2002 Jul;58:o386-8. doi: 10.1107/s0108270102008636. Epub 2002 Jun 12. PMID: 12094054.
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1-Substituted derivatives of 2-aryl-5-oxopyrrolidine-2-carboxylic acid.

Acta crystallographica. Section C, Crystal structure communications

Karapetyan H, Tamazyan R, Martirosyan A, Hovhannesyan V, Gasparyan S.
PMID: 12094058
Acta Crystallogr C. 2002 Jul;58:o399-401. doi: 10.1107/s0108270102009241. Epub 2002 Jun 20.

The structures of two potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTI), namely 1-benzyl-5-oxo-2-phenylpyrrolidine-2-carboxamide, C(18)H(18)N(2)O(2), (III), and 2-(4-isopropoxyphenyl)-5-oxo-1-(4-tolyl)pyrrolidine-2-carbonitrile, C(21)H(22)N(2)O(2), (IV), have been investigated by X-ray diffraction, confirming the butterfly-like conformation of both compounds. The pyrrolidine...

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Karapetyan H, Tamazyan R, Martirosyan A, et al. 1-Substituted derivatives of 2-aryl-5-oxopyrrolidine-2-carboxylic acid. Acta Crystallogr C. 2002;58:o399-401doi: 10.1107/s0108270102009241.
Karapetyan, H., Tamazyan, R., Martirosyan, A., Hovhannesyan, V., & Gasparyan, S. (2002). 1-Substituted derivatives of 2-aryl-5-oxopyrrolidine-2-carboxylic acid. Acta crystallographica. Section C, Crystal structure communications, 58o399-401. https://doi.org/10.1107/s0108270102009241
Karapetyan, Harutyun, et al. "1-Substituted derivatives of 2-aryl-5-oxopyrrolidine-2-carboxylic acid." Acta crystallographica. Section C, Crystal structure communications vol. 58 (2002): o399-401. doi: https://doi.org/10.1107/s0108270102009241
Karapetyan H, Tamazyan R, Martirosyan A, Hovhannesyan V, Gasparyan S. 1-Substituted derivatives of 2-aryl-5-oxopyrrolidine-2-carboxylic acid. Acta Crystallogr C. 2002 Jul;58:o399-401. doi: 10.1107/s0108270102009241. Epub 2002 Jun 20. PMID: 12094058.
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The clinical impact of time to response in de novo accelerated-phase chronic myeloid leukemia.

American journal of hematology

Ohanian M, Kantarjian HM, Shoukier M, Dellasala S, Musaelyan A, Nogueras Gonzalez GM, Jabbour E, Abruzzo L, Verstovsek S, Borthakur G, Ravandi F, Garcia-Manero G, Tamamyan G, Champlin R, Pierce S, Ferrajoli A, Kadia T, Cortes JE.
PMID: 32557828
Am J Hematol. 2020 Jun 17; doi: 10.1002/ajh.25907. Epub 2020 Jun 17.

We aimed to describe the impact of time to response on the outcomes of 75 patients with accelerated-phase chronic myeloid leukemia (CML-AP) at diagnosis. Patients had at least 1 feature of AP: blasts ≥15% (n = 2), basophils ≥20%...

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Ohanian M, Kantarjian HM, Shoukier M, et al. The clinical impact of time to response in de novo accelerated-phase chronic myeloid leukemia. Am J Hematol. 2020;doi: 10.1002/ajh.25907.
Ohanian, M., Kantarjian, H. M., Shoukier, M., Dellasala, S., Musaelyan, A., Nogueras Gonzalez, G. M., Jabbour, E., Abruzzo, L., Verstovsek, S., Borthakur, G., Ravandi, F., Garcia-Manero, G., Tamamyan, G., Champlin, R., Pierce, S., Ferrajoli, A., Kadia, T., & Cortes, J. E. (2020). The clinical impact of time to response in de novo accelerated-phase chronic myeloid leukemia. American journal of hematology, . https://doi.org/10.1002/ajh.25907
Ohanian, Maro, et al. "The clinical impact of time to response in de novo accelerated-phase chronic myeloid leukemia." American journal of hematology vol. (2020). doi: https://doi.org/10.1002/ajh.25907
Ohanian M, Kantarjian HM, Shoukier M, Dellasala S, Musaelyan A, Nogueras Gonzalez GM, Jabbour E, Abruzzo L, Verstovsek S, Borthakur G, Ravandi F, Garcia-Manero G, Tamamyan G, Champlin R, Pierce S, Ferrajoli A, Kadia T, Cortes JE. The clinical impact of time to response in de novo accelerated-phase chronic myeloid leukemia. Am J Hematol. 2020 Jun 17; doi: 10.1002/ajh.25907. Epub 2020 Jun 17. PMID: 32557828.
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Quantitative description of the tilt of distorted octahedra in ABX3 structures.

Acta crystallographica. Section B, Structural science

Tamazyan R, van Smaalen S.
PMID: 17374928
Acta Crystallogr B. 2007 Apr;63:190-200. doi: 10.1107/S010876810605244X. Epub 2007 Mar 16.

A description of the tilt of octahedra in ABX(3) perovskite-related structures is proposed that can be used to extract the unique values for the tilt parameters varphi, theta and delta of ABX(3) structures with regular and distorted octahedra up...

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Tamazyan R, van Smaalen S. Quantitative description of the tilt of distorted octahedra in ABX3 structures. Acta Crystallogr B. 2007;63:190-200doi: 10.1107/S010876810605244X.
Tamazyan, R., & van Smaalen, S. (2007). Quantitative description of the tilt of distorted octahedra in ABX3 structures. Acta crystallographica. Section B, Structural science, 63190-200. https://doi.org/10.1107/S010876810605244X
Tamazyan, Rafael, and van Smaalen, Sander. "Quantitative description of the tilt of distorted octahedra in ABX3 structures." Acta crystallographica. Section B, Structural science vol. 63 (2007): 190-200. doi: https://doi.org/10.1107/S010876810605244X
Tamazyan R, van Smaalen S. Quantitative description of the tilt of distorted octahedra in ABX3 structures. Acta Crystallogr B. 2007 Apr;63:190-200. doi: 10.1107/S010876810605244X. Epub 2007 Mar 16. PMID: 17374928.
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Monoclinic La1-xBaxMnO3 (x=0.185) at 160 K.

Acta crystallographica. Section C, Crystal structure communications

Rotiroti N, Tamazyan R, van Smaalen S, Mukovskii Y.
PMID: 16143754
Acta Crystallogr C. 2005 Sep;61:i83-5. doi: 10.1107/S0108270105017518. Epub 2005 Aug 10.

Single-crystal X-ray diffraction has shown that lanthanum barium manganese trioxide, La0.815Ba0.185MnO3, is monoclinic (I2/c) below a first-order phase transition at 187.1 (3) K. This result differs from the Pbnm symmetry usually assigned to colossal magnetoresistance oxides, A1-xA'xMnO3 with x...

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Rotiroti N, Tamazyan R, van Smaalen S, et al. Monoclinic La1-xBaxMnO3 (x=0.185) at 160 K. Acta Crystallogr C. 2005;61:i83-5doi: 10.1107/S0108270105017518.
Rotiroti, N., Tamazyan, R., van Smaalen, S., & Mukovskii, Y. (2005). Monoclinic La1-xBaxMnO3 (x=0.185) at 160 K. Acta crystallographica. Section C, Crystal structure communications, 61i83-5. https://doi.org/10.1107/S0108270105017518
Rotiroti, Nicola, et al. "Monoclinic La1-xBaxMnO3 (x=0.185) at 160 K." Acta crystallographica. Section C, Crystal structure communications vol. 61 (2005): i83-5. doi: https://doi.org/10.1107/S0108270105017518
Rotiroti N, Tamazyan R, van Smaalen S, Mukovskii Y. Monoclinic La1-xBaxMnO3 (x=0.185) at 160 K. Acta Crystallogr C. 2005 Sep;61:i83-5. doi: 10.1107/S0108270105017518. Epub 2005 Aug 10. PMID: 16143754.
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Showing 1 to 12 of 44 entries