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Showing 1 to 12 of 134 entries
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Anti-Nuclear Cytoplasmic Antibody-Associated Vasculitis: A Probable Adverse Effect of Sofosbuvir Treatment in Chronic Hepatitis C Patients.

Hospital pharmacy

Ahmad YK, Tawfeek S, Sharaf-Eldin M, Elbatea HE, Kobtan A, El-Kalla F, Badawi R, Abd-Elsalam S.
PMID: 28515509
Hosp Pharm. 2017 Apr;52(4):294-301. doi: 10.1310/hpj5204-294.

No abstract available.

Anaplastic lymphoma kinase (ALK) gene alteration in signet ring cell carcinoma of the gastrointestinal tract.

Therapeutic advances in medical oncology

Alese OB, El-Rayes BF, Sica G, Zhang G, Alexis D, La Rosa FG, Varella-Garcia M, Chen Z, Rossi MR, Adsay NV, Khuri FR, Owonikoko TK.
PMID: 25755678
Ther Adv Med Oncol. 2015 Mar;7(2):56-62. doi: 10.1177/1758834014567117.

OBJECTIVES: ALK-EML4 translocation is an established driver aberration in non-small cell lung cancer (NSCLC), with reported predilection for cases with signet ring histology. We assessed the presence of anaplastic lymphoma kinase (ALK) gene rearrangements in signet ring cancers arising...

Outcome of concurrent occult hemothorax and pneumothorax in trauma patients who required assisted ventilation.

Emergency medicine international

Mahmood I, Tawfeek Z, El-Menyar A, Zarour A, Afifi I, Kumar S, Peralta R, Latifi R, Al-Thani H.
PMID: 25785199
Emerg Med Int. 2015;2015:859130. doi: 10.1155/2015/859130. Epub 2015 Feb 16.

Background. The management and outcomes of occult hemopneumothorax in blunt trauma patients who required mechanical ventilation are not well studied. We aimed to study patients with occult hemopneumothorax on mechanical ventilation who could be carefully managed without tube thoracostomy....

Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Tawfeek HM.
PMID: 24227959
Saudi Pharm J. 2013 Oct;21(4):387-97. doi: 10.1016/j.jsps.2012.11.006.

The aim of this study was to synthesize and evaluate novel biodegradable polyesters namely; poly(ethylene glycol)-Poly(glycerol adipate-co-ω-pentadecalactone), PEG-PGA-co-PDL-PEG, and poly(ethylene glycol methyl ether)-Poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL-PEGme as an alternative sustained release carrier for lung delivery compared with non-PEG containing polymer...

Late gestational testosterone exposure causes glucose deregulation and elevated cardiac VCAM-1 and DPP-4 activity in rats.

Archives of physiology and biochemistry

Usman TO, Olatunji LA.
PMID: 31387411
Arch Physiol Biochem. 2021 Oct;127(5):445-452. doi: 10.1080/13813455.2019.1650068. Epub 2019 Aug 07.

CONTEXT: Increased vascular cell adhesion molecule-1 (VCAM-1) has been reported to be a critical link between obesity and atherosclerotic cardiovascular diseases while dipeptidyl peptidase-4 (DPP-4) has been implicated in the development of disrupted glucose regulation and inflammation.OBJECTIVE: This study...

Lack of LTβR Increases Susceptibility of IPEC-J2 Cells to Porcine Epidemic Diarrhea Virus.

Cells

Altawaty T, Liu L, Zhang H, Tao C, Hou S, Li K, Wang Y.
PMID: 30469426
Cells. 2018 Nov 21;7(11). doi: 10.3390/cells7110222.

The essential requirement of the lymphotoxin beta receptor (LTβR) in the development and maintenance of peripheral lymphoid organs is well recognized. Evidence shows that LTβR is involved in various cellular processes; however, whether it plays a role in maintaining...

Association between exercise-induced asthma and parental socio-economic status among school-aged adolescents in a semiurban community in Nigeria.

Journal of exercise rehabilitation

Adewumi AA, Adedoyin RA, Awotidebe TO, Erhabor GE, Awopeju OF, Ativie RN, Oke KI.
PMID: 28702440
J Exerc Rehabil. 2017 Jun 30;13(3):292-299. doi: 10.12965/jer.1734908.454. eCollection 2017 Jun.

This study investigated the prevalence and association between exercise-induced asthma (EIA) and parental socio-economic status (PSES) among school-aged adolescents in a semiurban community in Nigeria. Three hundred and eighty-five adolescents (185 male and 200 female adolescents) whose ages ranged...

Risk factors for the development of flank hernias and bulges following surgical flank approaches to the kidney in adults.

Arab journal of urology

Osman T, Emam A, Farouk A, ElSaeed K, Tawfeek AM, AbuHalima A.
PMID: 30534447
Arab J Urol. 2018 Jul 04;16(4):453-459. doi: 10.1016/j.aju.2018.06.001. eCollection 2018 Dec.

OBJECTIVES: To evaluate the incidence and risk factors for the development of flank incisional hernias or bulges following surgical flank approaches to the kidney.PATIENTS AND METHODS: In all, 100 consecutive adult patients who underwent variable renal surgeries via flank...

Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy.

Frontiers in oncology

Nazha B, Inal C, Owonikoko TK.
PMID: 32733795
Front Oncol. 2020 Jul 07;10:1000. doi: 10.3389/fonc.2020.01000. eCollection 2020.

Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in normal tissues, making most subtypes unsuitable as targets for cancer therapy. However, the disialoganglioside GD2 subtype has limited expression in normal tissues but is overexpressed across a wide range of...

Inhibition of TGF-β signaling attenuates disuse-induced trabecular bone loss after spinal cord injury in male mice.

Endocrinology

Sahbani K, Cardozo CP, Bauman WA, Tawfeek HA.
PMID: 34791098
Endocrinology. 2021 Nov 13; doi: 10.1210/endocr/bqab230. Epub 2021 Nov 13.

Bone loss is one of the most common complications of immobilization after spinal cord injury (SCI). Whether TGF-β signaling plays a role in SCI-induced disuse bone loss has not been determined. Thus, 16-week-old male mice underwent sham or spinal...

Erratum: GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth.

Oncotarget

Koo J, Wang X, Owonikoko TK, Ramalingam SS, Khuri FR, Sun SY.
PMID: 33613851
Oncotarget. 2021 Feb 02;12(3):251-252. doi: 10.18632/oncotarget.27752. eCollection 2021 Feb 02.

[This corrects the article DOI: 10.18632/oncotarget.3291.].

Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G.

Clinical lung cancer

Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR.
PMID: 33583720
Clin Lung Cancer. 2021 May;22(3):187-194.e1. doi: 10.1016/j.cllc.2021.01.001. Epub 2021 Jan 10.

PURPOSE: This signal finding study (S1400G) was designed to evaluate the efficacy of talazoparib in advanced stage squamous cell lung cancer harboring homologous recombination repair deficiency.PATIENTS AND METHODS: The full eligible population (FEP) had tumors with a deleterious mutation...

Showing 1 to 12 of 134 entries