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Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis.

Frontiers in aging neuroscience

Telianidis J, Hung YH, Materia S, Fontaine SL.
PMID: 23986700
Front Aging Neurosci. 2013 Aug 23;5:44. doi: 10.3389/fnagi.2013.00044. eCollection 2013.

Over the past two decades there have been significant advances in our understanding of copper homeostasis and the pathological consequences of copper dysregulation. Cumulative evidence is revealing a complex regulatory network of proteins and pathways that maintain copper homeostasis....

Targeting Smyd3 by next-generation antisense oligonucleotides suppresses liver tumor growth.

iScience

Kontaki H, Koukaki M, Vasilarou M, Giakountis A, Deligianni E, Luo X, Kim Y, Talianidis I.
PMID: 34113819
iScience. 2021 Apr 24;24(5):102473. doi: 10.1016/j.isci.2021.102473. eCollection 2021 May 21.

The oncogenic function of suppressor of variegation, enhancer of zeste and MYeloid-Nervy-DEAF1-domain family methyltransferase Smyd3 has been implicated in various malignancies, including hepatocellular carcinoma (HCC). Here, we show that targeting Smyd3 by next-generation antisense oligonucleotides (Smyd3-ASO) is an efficient...

Hepatic cancer stem cells may arise from adult ductal progenitors.

Molecular & cellular oncology

Nikolaou KC, Talianidis I.
PMID: 27308536
Mol Cell Oncol. 2015 Mar 19;3(1):e1021946. doi: 10.1080/23723556.2015.1021946. eCollection 2016.

Cancer stem cells (CSCs) are defined as cells within tumors that can self-renew and differentiate into heterogeneous lineages of cancerous cells. The origin of CSCs is not well understood. Recent evidence suggests that CSCs in hepatocellular carcinoma could be...

Showing 1 to 3 of 3 entries