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Showing 1 to 12 of 1320 entries
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Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis.

Oncoimmunology

Hurchla MA, Weilbaecher KN.
PMID: 23243611
Oncoimmunology. 2012 Nov 01;1(8):1411-1413. doi: 10.4161/onci.21060.

Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious...

Absence of change in the gray matter volume of patients with ulcerative colitis in remission: a voxel based morphometry study.

BioPsychoSocial medicine

Agostini A, Campieri M, Bertani A, Scarcelli A, Ballotta D, Calabrese C, Rizzello F, Gionchetti P, Nichelli P, Benuzzi F.
PMID: 25614759
Biopsychosoc Med. 2015 Jan 07;9(1):1. doi: 10.1186/s13030-014-0028-7. eCollection 2015.

BACKGROUND: Recent neuroimaging studies have investigated the brain involvement in patients with Crohn's disease (CD) and Ulcerative Colitis (UC). Functional studies found abnormalities in cognitive and emotional functions in CD and UC, while a voxel based morphometry (VBM) study...

Self-assisted optothermal trapping of gold nanorods under two-photon excitation.

Methods and applications in fluorescence

Chen H, Gratton E, Digman MA.
PMID: 28355163
Methods Appl Fluoresc. 2016 Sep 06;4(3):035003. doi: 10.1088/2050-6120/4/3/035003.

We report a self-assisted optothermal trapping and patterning of gold nanorods (GNRs) on glass surfaces with a femtosecond laser. We show that GNRs are not only the trapping targets, but also can enhance the optothermal trapping of other particles....

Evaluation of novel school-based interventions for adolescent sleep problems: does parental involvement and bright light improve outcomes?.

Sleep health

Bonnar D, Gradisar M, Moseley L, Coughlin AM, Cain N, Short MA.
PMID: 29073417
Sleep Health. 2015 Mar;1(1):66-74. doi: 10.1016/j.sleh.2014.11.002. Epub 2014 Dec 09.

OBJECTIVES: The current study aimed to evaluate school-based motivational sleep education programs (SEPs) with adjunct bright light therapy (BLT) and/or parental involvement (PI).DESIGN: Randomized controlled trial.SETTING: Six high schools, matched on socio-economic status (SES).PARTICIPANTS: A total of 193 adolescents...

Global Health Governance: The Major Players in the Field and Their Challenges.

American journal of public health

Williams MA, Wyner SN.
PMID: 29116833
Am J Public Health. 2017 Dec;107(12):1848-1850. doi: 10.2105/AJPH.2017.304148.

No abstract available.

Adjuvant hypofractionated intensity modulated radiation therapy after resection of regional lymph node metastases in patients with cutaneous malignant melanoma of the head and neck.

Practical radiation oncology

Hallemeier CL, Garces YI, Neben-Wittich MA, Olivier KR, Shon W, García JJ, Brown PD, Foote RL.
PMID: 24674323
Pract Radiat Oncol. 2013 Apr-Jun;3(2):e71-7. doi: 10.1016/j.prro.2012.06.003. Epub 2012 Jul 10.

PURPOSE: To evaluate outcomes in patients with malignant melanoma of the head and neck with resected regional lymph node (LN) metastases treated with adjuvant hypofractionated intensity modulated radiation therapy (IMRT).METHODS AND MATERIALS: A retrospective review was performed of 46...

Vitamin D Deficiency Treatment Patterns in Academic Urban Medical Center.

The American journal of pharmacy benefits

Chandler PD, Giovannucci EL, Williams MA, LeBoff MS, Bates DW, Hicks LS.
PMID: 25328637
Am J Pharm Benefits. 2014;6(1):e1-e8.

OBJECTIVE: Assess racial/ethnic and sex differences in treatment of vitamin D deficiency with high dose ergocalciferol ('vitamin D2') or other forms of vitamin D in a northeastern U.S. ambulatory clinic of an academic urban medical center.STUDY DESIGN: Cross-sectional observational...

Factors associated with high resource utilization in pediatric skin and soft tissue infection hospitalizations.

Hospital pediatrics

Lopez MA, Cruz AT, Kowalkowski MA, Raphael JL.
PMID: 24377057
Hosp Pediatr. 2013 Oct;3(4). doi: 10.1542/hpeds.2013-0013.

OBJECTIVE: To describe factors associated with prolonged lengths of stay (LOS) and increased charges for pediatric skin and soft tissue infection (SSTI) hospitalizations.METHODS: This study was a cross-sectional analysis of pediatric SSTI hospital discharges in 2009 within the Healthcare...

Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.

Cellular and molecular gastroenterology and hepatology

Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE.
PMID: 26618189
Cell Mol Gastroenterol Hepatol. 2015 Nov 01;1(6):695-709. doi: 10.1016/j.jcmgh.2015.08.002.

BACKGROUND & AIMS: Pancreatic acinar cells have an expanded apical endosomal system, the physiological and pathophysiological significance of which is still emerging. Phosphatidylinositol-3,5-bisphosphate (PI(3,5)PMETHODS: Inhibition of EE to LE trafficking was achieved using pharmacological inhibitors of PIKfyve, expression of...

Charge Separation Mechanisms in Ordered Films of Self-Assembled Donor-Acceptor Dyad Ribbons.

ACS applied materials & interfaces

Logsdon JL, Hartnett PE, Nelson JN, Harris MA, Marks TJ, Wasielewski MR.
PMID: 28430417
ACS Appl Mater Interfaces. 2017 Oct 04;9(39):33493-33503. doi: 10.1021/acsami.7b02585. Epub 2017 Apr 21.

Orthogonal attachment of polar and nonpolar side-chains to a zinc porphyrin-perylenediimide dyad (ZnP-PDI, 1a) is shown to result in self-assembly of ordered supramolecular ribbons in which the ZnP and PDI molecules form segregated π-stacked columns. Following photoexcitation of the...

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport.

ACS medicinal chemistry letters

Dockendorff C, Faloon PW, Yu M, Youngsaye W, Penman M, Nieland TJ, Nag PP, Lewis TA, Pu J, Bennion M, Negri J, Paterson C, Lam G, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M.
PMID: 26478787
ACS Med Chem Lett. 2015 Feb 02;6(4):375-380. doi: 10.1021/ml500154q. eCollection 2015 Apr 09.

A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repository (NIH MLSMR)...

Recruitment of adolescents for a smoking study: use of traditional strategies and social media.

Translational behavioral medicine

Rait MA, Prochaska JJ, Rubinstein ML.
PMID: 26327930
Transl Behav Med. 2015 Sep;5(3):254-9. doi: 10.1007/s13142-015-0312-5.

Engaging and retaining adolescents in research studies is challenging. Social media offers utility for expanding the sphere of research recruitment. This study examined and compared traditional and Facebook-based recruitment strategies on reach, enrollment, cost, and retention. Substance users aged...

Showing 1 to 12 of 1320 entries