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Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation.

Heredity

Schlötterer C, Kofler R, Versace E, Tobler R, Franssen SU.
PMID: 26758350
Heredity (Edinb). 2016 Feb;116(2):248. doi: 10.1038/hdy.2015.85.

No abstract available.

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Schlötterer C, Kofler R, Versace E, et al. Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation. Heredity (Edinb). 2016;116(2):248doi: 10.1038/hdy.2015.85.
Schlötterer, C., Kofler, R., Versace, E., Tobler, R., & Franssen, S. U. (2016). Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation. Heredity, 116(2), 248. https://doi.org/10.1038/hdy.2015.85
Schlötterer, C, et al. "Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation." Heredity vol. 116,2 (2016): 248. doi: https://doi.org/10.1038/hdy.2015.85
Schlötterer C, Kofler R, Versace E, Tobler R, Franssen SU. Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation. Heredity (Edinb). 2016 Feb;116(2):248. doi: 10.1038/hdy.2015.85. PMID: 26758350; PMCID: PMC4806886.
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[The effect of Colchicine on the differentiation and the frequency of transdetermination in leg imaginal disks ofDrosophila melanogaster].

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen

Tobler H.
PMID: 28304687
Wilhelm Roux Arch Entwickl Mech Org. 1970 Sep;165(3):217-225. doi: 10.1007/BF01380785.

1. Treatment of male foreleg disks of late 3rd instar larvae ofDrosophila melanogaster with Colchicinein vitro (Conc. 0.005-1 mg/ml) and implantation into larval hosts of the same age results in the formation of a characteristic pattern of damage, whereby...

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Tobler H. Veränderung der Differenzierungsleistung und der Transdeterminationsfrequenz durch Colchicin in Beinimaginalscheiben vonDrosophila melanogaster. [The effect of Colchicine on the differentiation and the frequency of transdetermination in leg imaginal disks ofDrosophila melanogaster]. Wilhelm Roux Arch Entwickl Mech Org. 1970;165(3):217-225doi: 10.1007/BF01380785.
Tobler, H. (1970). Veränderung der Differenzierungsleistung und der Transdeterminationsfrequenz durch Colchicin in Beinimaginalscheiben vonDrosophila melanogaster. [The effect of Colchicine on the differentiation and the frequency of transdetermination in leg imaginal disks ofDrosophila melanogaster]. Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen, 165(3), 217-225. https://doi.org/10.1007/BF01380785
Tobler, Heinz. "Veränderung der Differenzierungsleistung und der Transdeterminationsfrequenz durch Colchicin in Beinimaginalscheiben vonDrosophila melanogaster." [The effect of Colchicine on the differentiation and the frequency of transdetermination in leg imaginal disks ofDrosophila melanogaster]. Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen vol. 165,3 (1970): 217-225. doi: https://doi.org/10.1007/BF01380785
Tobler H. Veränderung der Differenzierungsleistung und der Transdeterminationsfrequenz durch Colchicin in Beinimaginalscheiben vonDrosophila melanogaster. [The effect of Colchicine on the differentiation and the frequency of transdetermination in leg imaginal disks ofDrosophila melanogaster]. Wilhelm Roux Arch Entwickl Mech Org. 1970 Sep;165(3):217-225. doi: 10.1007/BF01380785. German. PMID: 28304687.
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Decision-making in Multiple Sclerosis: The Role of Aversion to Ambiguity for Therapeutic Inertia among Neurologists (DIScUTIR MS).

Frontiers in neurology

Saposnik G, Sempere AP, Prefasi D, Selchen D, Ruff CC, Maurino J, Tobler PN.
PMID: 28298899
Front Neurol. 2017 Mar 01;8:65. doi: 10.3389/fneur.2017.00065. eCollection 2017.

OBJECTIVES: Limited information is available on physician-related factors influencing therapeutic inertia (TI) in multiple sclerosis (MS). Our aim was to evaluate whether physicians' risk preferences are associated with TI in MS care, by applying concepts from behavioral economics.DESIGN: In...

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Saposnik G, Sempere AP, Prefasi D, et al. Decision-making in Multiple Sclerosis: The Role of Aversion to Ambiguity for Therapeutic Inertia among Neurologists (DIScUTIR MS). Front Neurol. 2017;8:65doi: 10.3389/fneur.2017.00065.
Saposnik, G., Sempere, A. P., Prefasi, D., Selchen, D., Ruff, C. C., Maurino, J., & Tobler, P. N. (2017). Decision-making in Multiple Sclerosis: The Role of Aversion to Ambiguity for Therapeutic Inertia among Neurologists (DIScUTIR MS). Frontiers in neurology, 865. https://doi.org/10.3389/fneur.2017.00065
Saposnik, Gustavo, et al. "Decision-making in Multiple Sclerosis: The Role of Aversion to Ambiguity for Therapeutic Inertia among Neurologists (DIScUTIR MS)." Frontiers in neurology vol. 8 (2017): 65. doi: https://doi.org/10.3389/fneur.2017.00065
Saposnik G, Sempere AP, Prefasi D, Selchen D, Ruff CC, Maurino J, Tobler PN. Decision-making in Multiple Sclerosis: The Role of Aversion to Ambiguity for Therapeutic Inertia among Neurologists (DIScUTIR MS). Front Neurol. 2017 Mar 01;8:65. doi: 10.3389/fneur.2017.00065. eCollection 2017. PMID: 28298899; PMCID: PMC5331032.
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Chemical characterization of bohrium (element 107).

Nature

Eichler R, Bruchle W, Dressler R, Dullmann CE, Eichler B, Gaggeler HW, Gregorich KE, Hoffman DC, Hubener S, Jost DT, Kirbach UW, Laue CA, Lavanchy VM, Nitsche H, Patin JB, Piguet D, Schadel M, Shaughnessy DA, Strellis DA, Taut S, Tobler L, Tsyganov YS, Turler A, Vahle A, Wilk PA, Yakushev AB.
PMID: 10993071
Nature. 2000 Sep 07;407(6800):63-5. doi: 10.1038/35024044.

The arrangement of the chemical elements in the periodic table highlights resemblances in chemical properties, which reflect the elements' electronic structure. For the heaviest elements, however, deviations in the periodicity of chemical properties are expected: electrons in orbitals with...

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Eichler R, Bruchle W, Dressler R, et al. Chemical characterization of bohrium (element 107). Nature. 2000;407(6800):63-5doi: 10.1038/35024044.
Eichler, R., Bruchle, W., Dressler, R., Dullmann, C. E., Eichler, B., Gaggeler, H. W., Gregorich, K. E., Hoffman, D. C., Hubener, S., Jost, D. T., Kirbach, U. W., Laue, C. A., Lavanchy, V. M., Nitsche, H., Patin, J. B., Piguet, D., Schadel, M., Shaughnessy, D. A., Strellis, D. A., Taut, S., Tobler, L., Tsyganov, Y. S., Turler, A., Vahle, A., Wilk, P. A., & Yakushev, A. B. (2000). Chemical characterization of bohrium (element 107). Nature, 407(6800), 63-5. https://doi.org/10.1038/35024044
Eichler, et al. "Chemical characterization of bohrium (element 107)." Nature vol. 407,6800 (2000): 63-5. doi: https://doi.org/10.1038/35024044
Eichler R, Bruchle W, Dressler R, Dullmann CE, Eichler B, Gaggeler HW, Gregorich KE, Hoffman DC, Hubener S, Jost DT, Kirbach UW, Laue CA, Lavanchy VM, Nitsche H, Patin JB, Piguet D, Schadel M, Shaughnessy DA, Strellis DA, Taut S, Tobler L, Tsyganov YS, Turler A, Vahle A, Wilk PA, Yakushev AB. Chemical characterization of bohrium (element 107). Nature. 2000 Sep 07;407(6800):63-5. doi: 10.1038/35024044. PMID: 10993071.
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On-column deracemization of an atropisomeric biphenyl by quinine-based stationary phase and determination of rotational energy barrier by enantioselective stopped-flow HPLC and CEC.

Chirality

Tobler E, Lämmerhofer M, Mancini G, Lindner W.
PMID: 11746796
Chirality. 2001;13(10):641-7. doi: 10.1002/chir.10015.

The reversible enantiomerization of axially chiral 2'-dodecyloxy-6-nitrobiphenyl-2-carboxylic acid was studied in the presence of a brush type chiral stationary phase based on O-(tert-butylcarbamoyl) quinine as chiral selector unit by stopped-flow high-performance liquid chromatography (sfHPLC) and capillary electrochromatography (sfCEC). After...

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Tobler E, Lämmerhofer M, Mancini G, et al. On-column deracemization of an atropisomeric biphenyl by quinine-based stationary phase and determination of rotational energy barrier by enantioselective stopped-flow HPLC and CEC. Chirality. 2001;13(10):641-7doi: 10.1002/chir.10015.
Tobler, E., Lämmerhofer, M., Mancini, G., & Lindner, W. (2001). On-column deracemization of an atropisomeric biphenyl by quinine-based stationary phase and determination of rotational energy barrier by enantioselective stopped-flow HPLC and CEC. Chirality, 13(10), 641-7. https://doi.org/10.1002/chir.10015
Tobler, E, et al. "On-column deracemization of an atropisomeric biphenyl by quinine-based stationary phase and determination of rotational energy barrier by enantioselective stopped-flow HPLC and CEC." Chirality vol. 13,10 (2001): 641-7. doi: https://doi.org/10.1002/chir.10015
Tobler E, Lämmerhofer M, Mancini G, Lindner W. On-column deracemization of an atropisomeric biphenyl by quinine-based stationary phase and determination of rotational energy barrier by enantioselective stopped-flow HPLC and CEC. Chirality. 2001;13(10):641-7. doi: 10.1002/chir.10015. PMID: 11746796.
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Arsenic concentrations in successive needle age classes of Norway spruce ( Picea abies [L.] Karst.).

Analytical and bioanalytical chemistry

Wyttenbach A, Bajo S, Tobler L.
PMID: 15067468
Anal Bioanal Chem. 1996 Mar;354(5):668-71. doi: 10.1007/s0021663540668.

Arsenic has been determined in needles of Norway spruce by neutron activation analysis. Trees from 8 sites grown under different soil and environmental situations have been sampled. Trees and needle age classes have been treated individually. Endogenous As concentrations...

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Wyttenbach A, Bajo S, Tobler L. Arsenic concentrations in successive needle age classes of Norway spruce ( Picea abies [L.] Karst.). Anal Bioanal Chem. 1996;354(5):668-71doi: 10.1007/s0021663540668.
Wyttenbach, A., Bajo, S., & Tobler, L. (1996). Arsenic concentrations in successive needle age classes of Norway spruce ( Picea abies [L.] Karst.). Analytical and bioanalytical chemistry, 354(5), 668-71. https://doi.org/10.1007/s0021663540668
Wyttenbach, A, et al. "Arsenic concentrations in successive needle age classes of Norway spruce ( Picea abies [L.] Karst.)." Analytical and bioanalytical chemistry vol. 354,5 (1996): 668-71. doi: https://doi.org/10.1007/s0021663540668
Wyttenbach A, Bajo S, Tobler L. Arsenic concentrations in successive needle age classes of Norway spruce ( Picea abies [L.] Karst.). Anal Bioanal Chem. 1996 Mar;354(5):668-71. doi: 10.1007/s0021663540668. PMID: 15067468.
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Striatal BOLD Response Reflects the Impact of Herd Information on Financial Decisions.

Frontiers in human neuroscience

Burke CJ, Tobler PN, Schultz W, Baddeley M.
PMID: 20589242
Front Hum Neurosci. 2010 Jun 07;4:48. doi: 10.3389/fnhum.2010.00048. eCollection 2010.

Like other species, humans are sensitive to the decisions and actions of conspecifics, which can lead to herd behavior and undesirable outcomes such as stock market bubbles and bank runs. However, how the brain processes this socially derived influence...

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Burke CJ, Tobler PN, Schultz W, et al. Striatal BOLD Response Reflects the Impact of Herd Information on Financial Decisions. Front Hum Neurosci. 2010;4:48doi: 10.3389/fnhum.2010.00048.
Burke, C. J., Tobler, P. N., Schultz, W., & Baddeley, M. (2010). Striatal BOLD Response Reflects the Impact of Herd Information on Financial Decisions. Frontiers in human neuroscience, 448. https://doi.org/10.3389/fnhum.2010.00048
Burke, Christopher J, et al. "Striatal BOLD Response Reflects the Impact of Herd Information on Financial Decisions." Frontiers in human neuroscience vol. 4 (2010): 48. doi: https://doi.org/10.3389/fnhum.2010.00048
Burke CJ, Tobler PN, Schultz W, Baddeley M. Striatal BOLD Response Reflects the Impact of Herd Information on Financial Decisions. Front Hum Neurosci. 2010 Jun 07;4:48. doi: 10.3389/fnhum.2010.00048. eCollection 2010. PMID: 20589242; PMCID: PMC2892997.
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Mayer-rokitansky-kuster-hauser syndrome associated with severe inferior vena cava stenosis.

Case reports in obstetrics and gynecology

Londra L, Tobler K, Wu J, Kolp L.
PMID: 25136466
Case Rep Obstet Gynecol. 2014;2014:745658. doi: 10.1155/2014/745658. Epub 2014 Jul 23.

Precis. The postoperative course of a neovagina creation procedure in a young woman with Meyer-Rokitansky-Kuster-Hauser syndrome was complicated, despite prophylaxis, by extensive pelvic deep venous thrombosis secondary to unsuspected severe inferior vena cava stenosis. Background. Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is...

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Londra L, Tobler K, Wu J, et al. Mayer-rokitansky-kuster-hauser syndrome associated with severe inferior vena cava stenosis. Case Rep Obstet Gynecol. 2014;2014:745658doi: 10.1155/2014/745658.
Londra, L., Tobler, K., Wu, J., & Kolp, L. (2014). Mayer-rokitansky-kuster-hauser syndrome associated with severe inferior vena cava stenosis. Case reports in obstetrics and gynecology, 2014745658. https://doi.org/10.1155/2014/745658
Londra, Laura, et al. "Mayer-rokitansky-kuster-hauser syndrome associated with severe inferior vena cava stenosis." Case reports in obstetrics and gynecology vol. 2014 (2014): 745658. doi: https://doi.org/10.1155/2014/745658
Londra L, Tobler K, Wu J, Kolp L. Mayer-rokitansky-kuster-hauser syndrome associated with severe inferior vena cava stenosis. Case Rep Obstet Gynecol. 2014;2014:745658. doi: 10.1155/2014/745658. Epub 2014 Jul 23. PMID: 25136466; PMCID: PMC4129964.
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Clinical and radiographic outcomes with L4-S1 axial lumbar interbody fusion (AxiaLIF) and posterior instrumentation: a multicenter study.

Medical devices (Auckland, N.Z.)

Tobler WD, Melgar MA, Raley TJ, Anand N, Miller LE, Nasca RJ.
PMID: 24092998
Med Devices (Auckl). 2013 Sep 18;6:155-61. doi: 10.2147/MDER.S48442. eCollection 2013.

INTRODUCTION: Previous studies have confirmed the benefits and limitations of the presacral retroperitoneal approach for L5-S1 interbody fusion. The purpose of this study was to determine the safety and effectiveness of the minimally invasive axial lumbar interbody approach (AxiaLIF)...

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Tobler WD, Melgar MA, Raley TJ, et al. Clinical and radiographic outcomes with L4-S1 axial lumbar interbody fusion (AxiaLIF) and posterior instrumentation: a multicenter study. Med Devices (Auckl). 2013;6:155-61doi: 10.2147/MDER.S48442.
Tobler, W. D., Melgar, M. A., Raley, T. J., Anand, N., Miller, L. E., & Nasca, R. J. (2013). Clinical and radiographic outcomes with L4-S1 axial lumbar interbody fusion (AxiaLIF) and posterior instrumentation: a multicenter study. Medical devices (Auckland, N.Z.), 6155-61. https://doi.org/10.2147/MDER.S48442
Tobler, William D, et al. "Clinical and radiographic outcomes with L4-S1 axial lumbar interbody fusion (AxiaLIF) and posterior instrumentation: a multicenter study." Medical devices (Auckland, N.Z.) vol. 6 (2013): 155-61. doi: https://doi.org/10.2147/MDER.S48442
Tobler WD, Melgar MA, Raley TJ, Anand N, Miller LE, Nasca RJ. Clinical and radiographic outcomes with L4-S1 axial lumbar interbody fusion (AxiaLIF) and posterior instrumentation: a multicenter study. Med Devices (Auckl). 2013 Sep 18;6:155-61. doi: 10.2147/MDER.S48442. eCollection 2013. PMID: 24092998; PMCID: PMC3787926.
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Overcoming Therapeutic Inertia in Multiple Sclerosis Care: A Pilot Randomized Trial Applying the Traffic Light System in Medical Education.

Frontiers in neurology

Saposnik G, Maurino J, Sempere AP, Terzaghi MA, Ruff CC, Mamdani M, Tobler PN, Montalban X.
PMID: 28871238
Front Neurol. 2017 Aug 21;8:430. doi: 10.3389/fneur.2017.00430. eCollection 2017.

BACKGROUND: Physicians often do not initiate or intensify treatments when clearly warranted, a phenomenon known as therapeutic inertia (TI). Limited information is available on educational interventions to ameliorate knowledge-to-action gaps in TI.OBJECTIVES: To evaluate the feasibility and efficacy of...

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Saposnik G, Maurino J, Sempere AP, et al. Overcoming Therapeutic Inertia in Multiple Sclerosis Care: A Pilot Randomized Trial Applying the Traffic Light System in Medical Education. Front Neurol. 2017;8:430doi: 10.3389/fneur.2017.00430.
Saposnik, G., Maurino, J., Sempere, A. P., Terzaghi, M. A., Ruff, C. C., Mamdani, M., Tobler, P. N., & Montalban, X. (2017). Overcoming Therapeutic Inertia in Multiple Sclerosis Care: A Pilot Randomized Trial Applying the Traffic Light System in Medical Education. Frontiers in neurology, 8430. https://doi.org/10.3389/fneur.2017.00430
Saposnik, Gustavo, et al. "Overcoming Therapeutic Inertia in Multiple Sclerosis Care: A Pilot Randomized Trial Applying the Traffic Light System in Medical Education." Frontiers in neurology vol. 8 (2017): 430. doi: https://doi.org/10.3389/fneur.2017.00430
Saposnik G, Maurino J, Sempere AP, Terzaghi MA, Ruff CC, Mamdani M, Tobler PN, Montalban X. Overcoming Therapeutic Inertia in Multiple Sclerosis Care: A Pilot Randomized Trial Applying the Traffic Light System in Medical Education. Front Neurol. 2017 Aug 21;8:430. doi: 10.3389/fneur.2017.00430. eCollection 2017. PMID: 28871238; PMCID: PMC5567059.
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The Role of Prescribing Generic (Non-proprietary) Drugs in the Prevalence of Therapeutic Inertia in Multiple Sclerosis Care.

Frontiers in neurology

Saposnik G, Mamdani M, Terzaghi M, Saladino ML, Silva B, Tobler PN, Caceres F.
PMID: 30369904
Front Neurol. 2018 Oct 12;9:835. doi: 10.3389/fneur.2018.00835. eCollection 2018.

No abstract available.

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Saposnik G, Mamdani M, Terzaghi M, et al. The Role of Prescribing Generic (Non-proprietary) Drugs in the Prevalence of Therapeutic Inertia in Multiple Sclerosis Care. Front Neurol. 2018;9:835doi: 10.3389/fneur.2018.00835.
Saposnik, G., Mamdani, M., Terzaghi, M., Saladino, M. L., Silva, B., Tobler, P. N., & Caceres, F. (2018). The Role of Prescribing Generic (Non-proprietary) Drugs in the Prevalence of Therapeutic Inertia in Multiple Sclerosis Care. Frontiers in neurology, 9835. https://doi.org/10.3389/fneur.2018.00835
Saposnik, Gustavo, et al. "The Role of Prescribing Generic (Non-proprietary) Drugs in the Prevalence of Therapeutic Inertia in Multiple Sclerosis Care." Frontiers in neurology vol. 9 (2018): 835. doi: https://doi.org/10.3389/fneur.2018.00835
Saposnik G, Mamdani M, Terzaghi M, Saladino ML, Silva B, Tobler PN, Caceres F. The Role of Prescribing Generic (Non-proprietary) Drugs in the Prevalence of Therapeutic Inertia in Multiple Sclerosis Care. Front Neurol. 2018 Oct 12;9:835. doi: 10.3389/fneur.2018.00835. eCollection 2018. PMID: 30369904; PMCID: PMC6194175.
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Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces.

Chemical communications (Cambridge, England)

Jelavić S, Tobler DJ, Hassenkam T, De Yoreo JJ, Stipp SLS, Sand KK.
PMID: 29134988
Chem Commun (Camb). 2017 Nov 23;53(94):12700-12703. doi: 10.1039/c7cc04276k.

We measured the binding energy and bonding parameters between model nucleotide functional groups and model clay mineral surfaces in solutions of acidic pH. We demonstrate that basal surfaces of clay minerals interact most strongly with nucleobases and show that...

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Jelavić S, Tobler DJ, Hassenkam T, et al. Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces. Chem Commun (Camb). 2017;53(94):12700-12703doi: 10.1039/c7cc04276k.
Jelavić, S., Tobler, D. J., Hassenkam, T., De Yoreo, J. J., Stipp, S. L. S., & Sand, K. K. (2017). Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces. Chemical communications (Cambridge, England), 53(94), 12700-12703. https://doi.org/10.1039/c7cc04276k
Jelavić, S, et al. "Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces." Chemical communications (Cambridge, England) vol. 53,94 (2017): 12700-12703. doi: https://doi.org/10.1039/c7cc04276k
Jelavić S, Tobler DJ, Hassenkam T, De Yoreo JJ, Stipp SLS, Sand KK. Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces. Chem Commun (Camb). 2017 Nov 23;53(94):12700-12703. doi: 10.1039/c7cc04276k. PMID: 29134988.
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