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Preclinical assessment of pain: improving models in discovery research.

Current topics in behavioral neurosciences

King T, Porreca F.
PMID: 25012511
Curr Top Behav Neurosci. 2014;20:101-20. doi: 10.1007/7854_2014_330.

To date, animal models have not sufficiently "filtered" targets for new analgesics, increasing the failure rate and cost of drug development. Preclinical assessment of "pain" has historically relied on measures of evoked behavioral responses to sensory stimuli in animals....

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King T, Porreca F. Preclinical assessment of pain: improving models in discovery research. Curr Top Behav Neurosci. 2014;20:101-20doi: 10.1007/7854_2014_330.
King, T., & Porreca, F. (2014). Preclinical assessment of pain: improving models in discovery research. Current topics in behavioral neurosciences, 20101-20. https://doi.org/10.1007/7854_2014_330
King, Tamara, and Porreca, Frank. "Preclinical assessment of pain: improving models in discovery research." Current topics in behavioral neurosciences vol. 20 (2014): 101-20. doi: https://doi.org/10.1007/7854_2014_330
King T, Porreca F. Preclinical assessment of pain: improving models in discovery research. Curr Top Behav Neurosci. 2014;20:101-20. doi: 10.1007/7854_2014_330. PMID: 25012511.
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Bimetallic Pt/Ru complexes as catalysts for the electrooxidation of methanol.

Inorganic chemistry

Tess ME, Hill PL, Torraca KE, Kerr ME, Abboud KA, McElwee-White L.
PMID: 11196795
Inorg Chem. 2000 Aug 21;39(17):3942-4. doi: 10.1021/ic0004434.

No abstract available.

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Tess ME, Hill PL, Torraca KE, et al. Bimetallic Pt/Ru complexes as catalysts for the electrooxidation of methanol. Inorg Chem. 2000;39(17):3942-4doi: 10.1021/ic0004434.
Tess, M. E., Hill, P. L., Torraca, K. E., Kerr, M. E., Abboud, K. A., & McElwee-White, L. (2000). Bimetallic Pt/Ru complexes as catalysts for the electrooxidation of methanol. Inorganic chemistry, 39(17), 3942-4. https://doi.org/10.1021/ic0004434
Tess, M E, et al. "Bimetallic Pt/Ru complexes as catalysts for the electrooxidation of methanol." Inorganic chemistry vol. 39,17 (2000): 3942-4. doi: https://doi.org/10.1021/ic0004434
Tess ME, Hill PL, Torraca KE, Kerr ME, Abboud KA, McElwee-White L. Bimetallic Pt/Ru complexes as catalysts for the electrooxidation of methanol. Inorg Chem. 2000 Aug 21;39(17):3942-4. doi: 10.1021/ic0004434. PMID: 11196795.
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[Centenaries of medical & surgical history to be celebrated in 1958].

La Riforma medica

TORRACA L.
PMID: 13528594
Riforma Med. 1958 Jan 04;72(1):23-5.

No abstract available.

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TORRACA L. Dei centenari interessanti la storia delle scienze mediche e chirurgiche che dovranno essere celebrati nel 1958. [Centenaries of medical & surgical history to be celebrated in 1958]. Riforma Med. 1958;72(1):23-5
TORRACA, L. (1958). Dei centenari interessanti la storia delle scienze mediche e chirurgiche che dovranno essere celebrati nel 1958. [Centenaries of medical & surgical history to be celebrated in 1958]. La Riforma medica, 72(1), 23-5.
TORRACA, L. "Dei centenari interessanti la storia delle scienze mediche e chirurgiche che dovranno essere celebrati nel 1958." [Centenaries of medical & surgical history to be celebrated in 1958]. La Riforma medica vol. 72,1 (1958): 23-5.
TORRACA L. Dei centenari interessanti la storia delle scienze mediche e chirurgiche che dovranno essere celebrati nel 1958. [Centenaries of medical & surgical history to be celebrated in 1958]. Riforma Med. 1958 Jan 04;72(1):23-5. Italian. PMID: 13528594.
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Surgery in the Bologna office from its origins to the entire 19th century.

Giornale italiano di chirurgia

TORRACA L.
PMID: 18149055
G Ital Chir. 1949 Aug;5(8):517-9.

No abstract available.

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TORRACA L. La chirurgia nello studio di Bologna dalle origini a tutto il secolo XIX. Surgery in the Bologna office from its origins to the entire 19th century. G Ital Chir. 1949;5(8):517-9
TORRACA, L. (1949). La chirurgia nello studio di Bologna dalle origini a tutto il secolo XIX. Surgery in the Bologna office from its origins to the entire 19th century. Giornale italiano di chirurgia, 5(8), 517-9.
TORRACA, L. "La chirurgia nello studio di Bologna dalle origini a tutto il secolo XIX." Surgery in the Bologna office from its origins to the entire 19th century. Giornale italiano di chirurgia vol. 5,8 (1949): 517-9.
TORRACA L. La chirurgia nello studio di Bologna dalle origini a tutto il secolo XIX. Surgery in the Bologna office from its origins to the entire 19th century. G Ital Chir. 1949 Aug;5(8):517-9. Italian. PMID: 18149055.
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Los Carros Dormitorios no Lleman las Condiciones que la Higiene Exige.

Public health papers and reports

Tárraga F.
PMID: 19600530
Public Health Pap Rep. 1893;19:220-3.

No abstract available.

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Tárraga F. Los Carros Dormitorios no Lleman las Condiciones que la Higiene Exige. Public Health Pap Rep. 1893;19:220-3
Tárraga, F. (1893). Los Carros Dormitorios no Lleman las Condiciones que la Higiene Exige. Public health papers and reports, 19220-3.
Tárraga, F. "Los Carros Dormitorios no Lleman las Condiciones que la Higiene Exige." Public health papers and reports vol. 19 (1893): 220-3.
Tárraga F. Los Carros Dormitorios no Lleman las Condiciones que la Higiene Exige. Public Health Pap Rep. 1893;19:220-3. PMID: 19600530; PMCID: PMC2266307.
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Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease.

PLoS neglected tropical diseases

Llewellyn MS, Lewis MD, Acosta N, Yeo M, Carrasco HJ, Segovia M, Vargas J, Torrico F, Miles MA, Gaunt MW.
PMID: 19721699
PLoS Negl Trop Dis. 2009 Sep 01;3(9):e510. doi: 10.1371/journal.pntd.0000510.

Trypanosoma cruzi, the etiological agent of Chagas disease, is highly genetically diverse. Numerous lines of evidence point to the existence of six stable genetic lineages or DTUs: TcI, TcIIa, TcIIb, TcIIc, TcIId, and TcIIe. Molecular dating suggests that T....

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Llewellyn MS, Lewis MD, Acosta N, et al. Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease. PLoS Negl Trop Dis. 2009;3(9):e510doi: 10.1371/journal.pntd.0000510.
Llewellyn, M. S., Lewis, M. D., Acosta, N., Yeo, M., Carrasco, H. J., Segovia, M., Vargas, J., Torrico, F., Miles, M. A., & Gaunt, M. W. (2009). Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease. PLoS neglected tropical diseases, 3(9), e510. https://doi.org/10.1371/journal.pntd.0000510
Llewellyn, Martin S, et al. "Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease." PLoS neglected tropical diseases vol. 3,9 (2009): e510. doi: https://doi.org/10.1371/journal.pntd.0000510
Llewellyn MS, Lewis MD, Acosta N, Yeo M, Carrasco HJ, Segovia M, Vargas J, Torrico F, Miles MA, Gaunt MW. Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease. PLoS Negl Trop Dis. 2009 Sep 01;3(9):e510. doi: 10.1371/journal.pntd.0000510. PMID: 19721699; PMCID: PMC2727949.
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[Gentlemen, let us talk about cancer].

La Riforma medica

TORRACA L.
PMID: 14921615
Riforma Med. 1952 Feb 09;66(6):159-61.

No abstract available.

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TORRACA L. Signori, parliamo del cancro. [Gentlemen, let us talk about cancer]. Riforma Med. 1952;66(6):159-61
TORRACA, L. (1952). Signori, parliamo del cancro. [Gentlemen, let us talk about cancer]. La Riforma medica, 66(6), 159-61.
TORRACA, L. "Signori, parliamo del cancro." [Gentlemen, let us talk about cancer]. La Riforma medica vol. 66,6 (1952): 159-61.
TORRACA L. Signori, parliamo del cancro. [Gentlemen, let us talk about cancer]. Riforma Med. 1952 Feb 09;66(6):159-61. Undetermined. PMID: 14921615.
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Plasma Tryptophan/Large Neutral Amino Acids Ratio in Domestic Dogs Is Affected by a Single Meal with High Carbohydrates Level.

Animals : an open access journal from MDPI

Gazzano A, Ogi A, Torracca B, Mariti C, Casini L.
PMID: 29693620
Animals (Basel). 2018 Apr 25;8(5). doi: 10.3390/ani8050063.

Aim of this study was to evaluate the plasma ratio between l-tryptophan (TRP) and five large neutral amino acids (isoleucine + leucine + phenylalanine + tyrosine + valine) (5LNAAs) after a single meal with high carbohydrates level. Five female...

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Gazzano A, Ogi A, Torracca B, et al. Plasma Tryptophan/Large Neutral Amino Acids Ratio in Domestic Dogs Is Affected by a Single Meal with High Carbohydrates Level. Animals (Basel). 2018;8(5)doi: 10.3390/ani8050063.
Gazzano, A., Ogi, A., Torracca, B., Mariti, C., & Casini, L. (2018). Plasma Tryptophan/Large Neutral Amino Acids Ratio in Domestic Dogs Is Affected by a Single Meal with High Carbohydrates Level. Animals : an open access journal from MDPI, 8(5), . https://doi.org/10.3390/ani8050063
Gazzano, Angelo, et al. "Plasma Tryptophan/Large Neutral Amino Acids Ratio in Domestic Dogs Is Affected by a Single Meal with High Carbohydrates Level." Animals : an open access journal from MDPI vol. 8,5 (2018). doi: https://doi.org/10.3390/ani8050063
Gazzano A, Ogi A, Torracca B, Mariti C, Casini L. Plasma Tryptophan/Large Neutral Amino Acids Ratio in Domestic Dogs Is Affected by a Single Meal with High Carbohydrates Level. Animals (Basel). 2018 Apr 25;8(5). doi: 10.3390/ani8050063. PMID: 29693620; PMCID: PMC5981274.
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A hydrated ion model of [UO.

The Journal of chemical physics

Pérez-Conesa S, Torrico F, Martínez JM, Pappalardo RR, Sánchez Marcos E.
PMID: 27984897
J Chem Phys. 2016 Dec 14;145(22):224502. doi: 10.1063/1.4971432.

A new ab initio interaction potential based on the hydrated ion concept has been developed to obtain the structure, energetics, and dynamics of the hydration of uranyl in aqueous solution. It is the first force field that explicitly parameterizes...

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Pérez-Conesa S, Torrico F, Martínez JM, et al. A hydrated ion model of [UO. J Chem Phys. 2016;145(22):224502doi: 10.1063/1.4971432.
Pérez-Conesa, S., Torrico, F., Martínez, J. M., Pappalardo, R. R., & Sánchez Marcos, E. (2016). A hydrated ion model of [UO. The Journal of chemical physics, 145(22), 224502. https://doi.org/10.1063/1.4971432
Pérez-Conesa, Sergio, et al. "A hydrated ion model of [UO." The Journal of chemical physics vol. 145,22 (2016): 224502. doi: https://doi.org/10.1063/1.4971432
Pérez-Conesa S, Torrico F, Martínez JM, Pappalardo RR, Sánchez Marcos E. A hydrated ion model of [UO. J Chem Phys. 2016 Dec 14;145(22):224502. doi: 10.1063/1.4971432. PMID: 27984897.
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The opioid crisis and … reconsidering the use of drugs that affect body temperature.

Temperature (Austin, Tex.)

Patwardhan A, Porreca F, Schmidt WK, Romanovsky AA.
PMID: 29687038
Temperature (Austin). 2018 Mar 06;5(1):1-3. doi: 10.1080/23328940.2018.1437312. eCollection 2018.

No abstract available.

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Patwardhan A, Porreca F, Schmidt WK, et al. The opioid crisis and … reconsidering the use of drugs that affect body temperature. Temperature (Austin). 2018;5(1):1-3doi: 10.1080/23328940.2018.1437312.
Patwardhan, A., Porreca, F., Schmidt, W. K., & Romanovsky, A. A. (2018). The opioid crisis and … reconsidering the use of drugs that affect body temperature. Temperature (Austin, Tex.), 5(1), 1-3. https://doi.org/10.1080/23328940.2018.1437312
Patwardhan, Amol, et al. "The opioid crisis and … reconsidering the use of drugs that affect body temperature." Temperature (Austin, Tex.) vol. 5,1 (2018): 1-3. doi: https://doi.org/10.1080/23328940.2018.1437312
Patwardhan A, Porreca F, Schmidt WK, Romanovsky AA. The opioid crisis and … reconsidering the use of drugs that affect body temperature. Temperature (Austin). 2018 Mar 06;5(1):1-3. doi: 10.1080/23328940.2018.1437312. eCollection 2018. PMID: 29687038; PMCID: PMC5902230.
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Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons.

Molecular brain

Sato D, Narita M, Hamada Y, Mori T, Tanaka K, Tamura H, Yamanaka A, Matsui R, Watanabe D, Suda Y, Senba E, Watanabe M, Navratilova E, Porreca F, Kuzumaki N, Narita M.
PMID: 34991655
Mol Brain. 2022 Jan 06;15(1):10. doi: 10.1186/s13041-021-00896-2.

Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated with hypodopaminergic tone in the nucleus accumbens (NAc), we evaluated the effects of increasing signaling at dopamine...

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Sato D, Narita M, Hamada Y, et al. Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons. Mol Brain. 2022;15(1):10doi: 10.1186/s13041-021-00896-2.
Sato, D., Narita, M., Hamada, Y., Mori, T., Tanaka, K., Tamura, H., Yamanaka, A., Matsui, R., Watanabe, D., Suda, Y., Senba, E., Watanabe, M., Navratilova, E., Porreca, F., Kuzumaki, N., & Narita, M. (2022). Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons. Molecular brain, 15(1), 10. https://doi.org/10.1186/s13041-021-00896-2
Sato, Daisuke, et al. "Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons." Molecular brain vol. 15,1 (2022): 10. doi: https://doi.org/10.1186/s13041-021-00896-2
Sato D, Narita M, Hamada Y, Mori T, Tanaka K, Tamura H, Yamanaka A, Matsui R, Watanabe D, Suda Y, Senba E, Watanabe M, Navratilova E, Porreca F, Kuzumaki N, Narita M. Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons. Mol Brain. 2022 Jan 06;15(1):10. doi: 10.1186/s13041-021-00896-2. PMID: 34991655; PMCID: PMC8740378.
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Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents.

Cellular and molecular neurobiology

Kopruszinski CM, Swiokla J, Lee YS, Navratilova E, VanderVeen L, Yang M, Liu Y, Miyazaki T, Schmidt WK, Zalevsky J, Porreca F.
PMID: 32107752
Cell Mol Neurobiol. 2021 Jul;41(5):949-960. doi: 10.1007/s10571-020-00816-3. Epub 2020 Feb 27.

OBJECTIVE: Pharmacological evaluation of the mu-opioid receptor (MOR) agonist properties of NKTR-181 in rodent models.METHODS: Graded noxious stimulus intensities were used in rats to establish the antinociceptive potency and efficacy of NKTR-181 relative to morphine, fentanyl, and oxycodone. Characteristics...

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Kopruszinski CM, Swiokla J, Lee YS, et al. Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents. Cell Mol Neurobiol. 2020;41(5):949-960doi: 10.1007/s10571-020-00816-3.
Kopruszinski, C. M., Swiokla, J., Lee, Y. S., Navratilova, E., VanderVeen, L., Yang, M., Liu, Y., Miyazaki, T., Schmidt, W. K., Zalevsky, J., & Porreca, F. (2021). Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents. Cellular and molecular neurobiology, 41(5), 949-960. https://doi.org/10.1007/s10571-020-00816-3
Kopruszinski, Caroline M, et al. "Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents." Cellular and molecular neurobiology vol. 41,5 (2021): 949-960. doi: https://doi.org/10.1007/s10571-020-00816-3
Kopruszinski CM, Swiokla J, Lee YS, Navratilova E, VanderVeen L, Yang M, Liu Y, Miyazaki T, Schmidt WK, Zalevsky J, Porreca F. Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents. Cell Mol Neurobiol. 2021 Jul;41(5):949-960. doi: 10.1007/s10571-020-00816-3. Epub 2020 Feb 27. PMID: 32107752.
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Showing 1 to 12 of 98 entries