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Evaluation of the Prognostic Value of RANK, OPG, and RANKL mRNA Expression in Early Breast Cancer Patients Treated with Anthracycline-Based Adjuvant Chemotherapy.

Translational oncology

Timotheadou E, Kalogeras KT, Koliou GA, Wirtz RM, Zagouri F, Koutras A, Veltrup E, Christodoulou C, Pentheroudakis G, Tsiftsoglou A, Papakostas P, Aravantinos G, Venizelos V, Pectasides D, Kosmidis P, Karanikiotis C, Markopoulos C, Gogas H, Fountzilas G.
PMID: 28666187
Transl Oncol. 2017 Aug;10(4):589-598. doi: 10.1016/j.tranon.2017.05.006. Epub 2017 Jun 27.

BACKGROUND: Prevention of bone metastases is a major issue for breast cancer patients, as it would improve quality of life in a population where long survival is anticipated.PATIENTS AND METHODS: Early breast cancer patients, who had been treated with...

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Timotheadou E, Kalogeras KT, Koliou GA, et al. Evaluation of the Prognostic Value of RANK, OPG, and RANKL mRNA Expression in Early Breast Cancer Patients Treated with Anthracycline-Based Adjuvant Chemotherapy. Transl Oncol. 2017;10(4):589-598doi: 10.1016/j.tranon.2017.05.006.
Timotheadou, E., Kalogeras, K. T., Koliou, G. A., Wirtz, R. M., Zagouri, F., Koutras, A., Veltrup, E., Christodoulou, C., Pentheroudakis, G., Tsiftsoglou, A., Papakostas, P., Aravantinos, G., Venizelos, V., Pectasides, D., Kosmidis, P., Karanikiotis, C., Markopoulos, C., Gogas, H., & Fountzilas, G. (2017). Evaluation of the Prognostic Value of RANK, OPG, and RANKL mRNA Expression in Early Breast Cancer Patients Treated with Anthracycline-Based Adjuvant Chemotherapy. Translational oncology, 10(4), 589-598. https://doi.org/10.1016/j.tranon.2017.05.006
Timotheadou, Eleni, et al. "Evaluation of the Prognostic Value of RANK, OPG, and RANKL mRNA Expression in Early Breast Cancer Patients Treated with Anthracycline-Based Adjuvant Chemotherapy." Translational oncology vol. 10,4 (2017): 589-598. doi: https://doi.org/10.1016/j.tranon.2017.05.006
Timotheadou E, Kalogeras KT, Koliou GA, Wirtz RM, Zagouri F, Koutras A, Veltrup E, Christodoulou C, Pentheroudakis G, Tsiftsoglou A, Papakostas P, Aravantinos G, Venizelos V, Pectasides D, Kosmidis P, Karanikiotis C, Markopoulos C, Gogas H, Fountzilas G. Evaluation of the Prognostic Value of RANK, OPG, and RANKL mRNA Expression in Early Breast Cancer Patients Treated with Anthracycline-Based Adjuvant Chemotherapy. Transl Oncol. 2017 Aug;10(4):589-598. doi: 10.1016/j.tranon.2017.05.006. Epub 2017 Jun 27. PMID: 28666187; PMCID: PMC5491451.
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The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders.

Pharmaceuticals (Basel, Switzerland)

Papadopoulou LC, Tsiftsoglou AS.
PMID: 24275786
Pharmaceuticals (Basel). 2013 Jan 07;6(1):32-53. doi: 10.3390/ph6010032.

The erythroid related disorders (ERDs) represent a large group of hematological diseases, which in most cases are attributed either to the deficiency or malfunction of biosynthetic enzymes or oxygen transport proteins. Current treatments for these disorders include histo-compatible erythrocyte...

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Papadopoulou LC, Tsiftsoglou AS. The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders. Pharmaceuticals (Basel). 2013;6(1):32-53doi: 10.3390/ph6010032.
Papadopoulou, L. C., & Tsiftsoglou, A. S. (2013). The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders. Pharmaceuticals (Basel, Switzerland), 6(1), 32-53. https://doi.org/10.3390/ph6010032
Papadopoulou, Lefkothea C, and Tsiftsoglou, Asterios S. "The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders." Pharmaceuticals (Basel, Switzerland) vol. 6,1 (2013): 32-53. doi: https://doi.org/10.3390/ph6010032
Papadopoulou LC, Tsiftsoglou AS. The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders. Pharmaceuticals (Basel). 2013 Jan 07;6(1):32-53. doi: 10.3390/ph6010032. PMID: 24275786; PMCID: PMC3816679.
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Hemangiopericytoma/solitary fibrous tumor of pectoralis major muscle mimicking a breast mass.

International journal of surgery case reports

Dragoumis D, Desiris K, Kyropoulou A, Malandri M, Assimaki A, Tsiftsoglou A.
PMID: 23416503
Int J Surg Case Rep. 2013;4(3):338-41. doi: 10.1016/j.ijscr.2013.01.013. Epub 2013 Jan 26.

INTRODUCTION: Hemangiopericytoma (HPC)/solitary fibrous tumor (SFT) is a very uncommon tumor of uncertain malignant behavior. In 1942, Stout and Murray first characterized these neoplasms as "vascular tumors arising from Zimmerman's pericytes" and till now hemangiopericytomas and solitary fibrous tumors...

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Dragoumis D, Desiris K, Kyropoulou A, et al. Hemangiopericytoma/solitary fibrous tumor of pectoralis major muscle mimicking a breast mass. Int J Surg Case Rep. 2013;4(3):338-41doi: 10.1016/j.ijscr.2013.01.013.
Dragoumis, D., Desiris, K., Kyropoulou, A., Malandri, M., Assimaki, A., & Tsiftsoglou, A. (2013). Hemangiopericytoma/solitary fibrous tumor of pectoralis major muscle mimicking a breast mass. International journal of surgery case reports, 4(3), 338-41. https://doi.org/10.1016/j.ijscr.2013.01.013
Dragoumis, Dimitrios, et al. "Hemangiopericytoma/solitary fibrous tumor of pectoralis major muscle mimicking a breast mass." International journal of surgery case reports vol. 4,3 (2013): 338-41. doi: https://doi.org/10.1016/j.ijscr.2013.01.013
Dragoumis D, Desiris K, Kyropoulou A, Malandri M, Assimaki A, Tsiftsoglou A. Hemangiopericytoma/solitary fibrous tumor of pectoralis major muscle mimicking a breast mass. Int J Surg Case Rep. 2013;4(3):338-41. doi: 10.1016/j.ijscr.2013.01.013. Epub 2013 Jan 26. PMID: 23416503; PMCID: PMC3604679.
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Axillary silicone lymphadenopathy secondary to augmentation mammaplasty.

Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India

Dragoumis DM, Assimaki AS, Vrizas TI, Tsiftsoglou AP.
PMID: 21217983
Indian J Plast Surg. 2010 Jul;43(2):206-9. doi: 10.4103/0970-0358.73453.

We report a case involving a 45-year-old woman, who presented with an axillary mass 10 years after bilateral cosmetic augmentation mammaplasty. A lump was detected in the left axilla, and subsequent mammography and magnetic resonance imaging demonstrated intracapsular rupture...

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Dragoumis DM, Assimaki AS, Vrizas TI, et al. Axillary silicone lymphadenopathy secondary to augmentation mammaplasty. Indian J Plast Surg. 2010;43(2):206-9doi: 10.4103/0970-0358.73453.
Dragoumis, D. M., Assimaki, A. S., Vrizas, T. I., & Tsiftsoglou, A. P. (2010). Axillary silicone lymphadenopathy secondary to augmentation mammaplasty. Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India, 43(2), 206-9. https://doi.org/10.4103/0970-0358.73453
Dragoumis, Dimitrios M, et al. "Axillary silicone lymphadenopathy secondary to augmentation mammaplasty." Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India vol. 43,2 (2010): 206-9. doi: https://doi.org/10.4103/0970-0358.73453
Dragoumis DM, Assimaki AS, Vrizas TI, Tsiftsoglou AP. Axillary silicone lymphadenopathy secondary to augmentation mammaplasty. Indian J Plast Surg. 2010 Jul;43(2):206-9. doi: 10.4103/0970-0358.73453. PMID: 21217983; PMCID: PMC3010785.
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[No title available]

Molecular genetics and metabolism reports

Kaiafas GC, Papagiannopoulou D, Miliotou ΑN, Tsingotjidou AS, Chalkidou PC, Tsika AC, Spyroulias GA, Tsiftsoglou AS, Papadopoulou LC.
PMID: 33318931
Mol Genet Metab Rep. 2020 Dec 08;25:100683. doi: 10.1016/j.ymgmr.2020.100683. eCollection 2020 Dec.

The rapid progress achieved in the development of many biopharmaceuticals had a tremendous impact on the therapy of many metabolic/genetic disorders. This type of fruitful approach, called protein replacement therapy (PRT), aimed to either replace the deficient or malfunctional...

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Kaiafas GC, Papagiannopoulou D, Miliotou ΑN, et al. . Mol Genet Metab Rep. 2020;25:100683doi: 10.1016/j.ymgmr.2020.100683.
Kaiafas, G. C., Papagiannopoulou, D., Miliotou, �. �. N., Tsingotjidou, A. S., Chalkidou, P. C., Tsika, A. C., Spyroulias, G. A., Tsiftsoglou, A. S., & Papadopoulou, L. C. (2020). . Molecular genetics and metabolism reports, 25100683. https://doi.org/10.1016/j.ymgmr.2020.100683
Kaiafas, Georgios C, et al. "." Molecular genetics and metabolism reports vol. 25 (2020): 100683. doi: https://doi.org/10.1016/j.ymgmr.2020.100683
Kaiafas GC, Papagiannopoulou D, Miliotou ΑN, Tsingotjidou AS, Chalkidou PC, Tsika AC, Spyroulias GA, Tsiftsoglou AS, Papadopoulou LC. . Mol Genet Metab Rep. 2020 Dec 08;25:100683. doi: 10.1016/j.ymgmr.2020.100683. eCollection 2020 Dec. PMID: 33318931; PMCID: PMC7726716.
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PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients' RBCs ex vivo in the frame of Protein Replacement Therapy.

Journal of biological research (Thessalonike, Greece)

Miliotou AN, Papagiannopoulou D, Vlachaki E, Samiotaki M, Laspa D, Theodoridou S, Tsiftsoglou AS, Papadopoulou LC.
PMID: 34284828
J Biol Res (Thessalon). 2021 Jul 20;28(1):16. doi: 10.1186/s40709-021-00148-3.

BACKGROUND: α-Thalassemia, a congenital hemoglobinopathy, is characterized by deficiency and/or reduced levels of α-globin chains in serious forms of α-thalassemia (HbH disease/Hb Bart's). This research work deals with a Protein Replacement Therapy approach in order to manage α-thalassemia manifestations,...

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Miliotou AN, Papagiannopoulou D, Vlachaki E, et al. PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients' RBCs ex vivo in the frame of Protein Replacement Therapy. J Biol Res (Thessalon). 2021;28(1):16doi: 10.1186/s40709-021-00148-3.
Miliotou, A. N., Papagiannopoulou, D., Vlachaki, E., Samiotaki, M., Laspa, D., Theodoridou, S., Tsiftsoglou, A. S., & Papadopoulou, L. C. (2021). PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients' RBCs ex vivo in the frame of Protein Replacement Therapy. Journal of biological research (Thessalonike, Greece), 28(1), 16. https://doi.org/10.1186/s40709-021-00148-3
Miliotou, Androulla N, et al. "PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients' RBCs ex vivo in the frame of Protein Replacement Therapy." Journal of biological research (Thessalonike, Greece) vol. 28,1 (2021): 16. doi: https://doi.org/10.1186/s40709-021-00148-3
Miliotou AN, Papagiannopoulou D, Vlachaki E, Samiotaki M, Laspa D, Theodoridou S, Tsiftsoglou AS, Papadopoulou LC. PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients' RBCs ex vivo in the frame of Protein Replacement Therapy. J Biol Res (Thessalon). 2021 Jul 20;28(1):16. doi: 10.1186/s40709-021-00148-3. PMID: 34284828; PMCID: PMC8290593.
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Follow-up of tissue genomics in BRCA1/2 carriers who underwent prophylactic surgeries.

Breast cancer (Tokyo, Japan)

Kotoula V, Papadopoulou K, Tikas I, Fostira F, Vrettou E, Chrisafi S, Fountzilas E, Koliou GA, Apostolou P, Papazisis K, Zaramboukas T, Asimaki-Vlachopoulou A, Miliaras S, Ananiadis A, Poulios C, Natsiopoulos I, Tsiftsoglou A, Demiri E, Fountzilas G.
PMID: 34304347
Breast Cancer. 2021 Nov;28(6):1367-1382. doi: 10.1007/s12282-021-01276-3. Epub 2021 Jul 24.

PURPOSE: The genomic status of non-malignant tissues from carriers of pathogenic germline BRCA1/2 (gBRCA1/2) variants may reveal information towards individualized prophylaxis. We performed spatiotemporal tissue genotype comparisons in a real-life cohort of gBRCA1/2 carriers of Greek origin, who underwent...

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Kotoula V, Papadopoulou K, Tikas I, et al. Follow-up of tissue genomics in BRCA1/2 carriers who underwent prophylactic surgeries. Breast Cancer. 2021;28(6):1367-1382doi: 10.1007/s12282-021-01276-3.
Kotoula, V., Papadopoulou, K., Tikas, I., Fostira, F., Vrettou, E., Chrisafi, S., Fountzilas, E., Koliou, G. A., Apostolou, P., Papazisis, K., Zaramboukas, T., Asimaki-Vlachopoulou, A., Miliaras, S., Ananiadis, A., Poulios, C., Natsiopoulos, I., Tsiftsoglou, A., Demiri, E., & Fountzilas, G. (2021). Follow-up of tissue genomics in BRCA1/2 carriers who underwent prophylactic surgeries. Breast cancer (Tokyo, Japan), 28(6), 1367-1382. https://doi.org/10.1007/s12282-021-01276-3
Kotoula, Vassiliki, et al. "Follow-up of tissue genomics in BRCA1/2 carriers who underwent prophylactic surgeries." Breast cancer (Tokyo, Japan) vol. 28,6 (2021): 1367-1382. doi: https://doi.org/10.1007/s12282-021-01276-3
Kotoula V, Papadopoulou K, Tikas I, Fostira F, Vrettou E, Chrisafi S, Fountzilas E, Koliou GA, Apostolou P, Papazisis K, Zaramboukas T, Asimaki-Vlachopoulou A, Miliaras S, Ananiadis A, Poulios C, Natsiopoulos I, Tsiftsoglou A, Demiri E, Fountzilas G. Follow-up of tissue genomics in BRCA1/2 carriers who underwent prophylactic surgeries. Breast Cancer. 2021 Nov;28(6):1367-1382. doi: 10.1007/s12282-021-01276-3. Epub 2021 Jul 24. PMID: 34304347.
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Effects of Cornus and Its Mixture with Oregano and Thyme Essential Oils on Dairy Sheep Performance and Milk, Yoghurt and Cheese Quality under Heat Stress.

Animals : an open access journal from MDPI

Kalaitsidis K, Sidiropoulou E, Tsiftsoglou O, Mourtzinos I, Moschakis T, Basdagianni Z, Vasilopoulos S, Chatzigavriel S, Lazari D, Giannenas I.
PMID: 33918077
Animals (Basel). 2021 Apr 08;11(4). doi: 10.3390/ani11041063.

The effect of a diet supplemented with a novel cornus extract, enriched with essential oils of oregano and thyme, on the performance of Chios cross-bred dairy sheep was investigated during the summer period. The plant extracts were prepared using...

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Kalaitsidis K, Sidiropoulou E, Tsiftsoglou O, et al. Effects of Cornus and Its Mixture with Oregano and Thyme Essential Oils on Dairy Sheep Performance and Milk, Yoghurt and Cheese Quality under Heat Stress. Animals (Basel). 2021;11(4)doi: 10.3390/ani11041063.
Kalaitsidis, K., Sidiropoulou, E., Tsiftsoglou, O., Mourtzinos, I., Moschakis, T., Basdagianni, Z., Vasilopoulos, S., Chatzigavriel, S., Lazari, D., & Giannenas, I. (2021). Effects of Cornus and Its Mixture with Oregano and Thyme Essential Oils on Dairy Sheep Performance and Milk, Yoghurt and Cheese Quality under Heat Stress. Animals : an open access journal from MDPI, 11(4), . https://doi.org/10.3390/ani11041063
Kalaitsidis, Konstantinos, et al. "Effects of Cornus and Its Mixture with Oregano and Thyme Essential Oils on Dairy Sheep Performance and Milk, Yoghurt and Cheese Quality under Heat Stress." Animals : an open access journal from MDPI vol. 11,4 (2021). doi: https://doi.org/10.3390/ani11041063
Kalaitsidis K, Sidiropoulou E, Tsiftsoglou O, Mourtzinos I, Moschakis T, Basdagianni Z, Vasilopoulos S, Chatzigavriel S, Lazari D, Giannenas I. Effects of Cornus and Its Mixture with Oregano and Thyme Essential Oils on Dairy Sheep Performance and Milk, Yoghurt and Cheese Quality under Heat Stress. Animals (Basel). 2021 Apr 08;11(4). doi: 10.3390/ani11041063. PMID: 33918077; PMCID: PMC8069601.
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Hemin accumulation and identification of a heme-binding protein clan in K562 cells by proteomic and computational analysis.

Journal of cellular physiology

Tsolaki VC, Georgiou-Siafis SK, Tsamadou AI, Tsiftsoglou SA, Samiotaki M, Panayotou G, Tsiftsoglou AS.
PMID: 34617268
J Cell Physiol. 2021 Oct 07; doi: 10.1002/jcp.30595. Epub 2021 Oct 07.

Heme (iron protoporphyrin IX) is an essential regulator conserved in all known organisms. We investigated the kinetics of intracellular accumulation of hemin (oxidized form) in human transformed proerythroid K562 cells using [

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Tsolaki VC, Georgiou-Siafis SK, Tsamadou AI, et al. Hemin accumulation and identification of a heme-binding protein clan in K562 cells by proteomic and computational analysis. J Cell Physiol. 2021;doi: 10.1002/jcp.30595.
Tsolaki, V. C., Georgiou-Siafis, S. K., Tsamadou, A. I., Tsiftsoglou, S. A., Samiotaki, M., Panayotou, G., & Tsiftsoglou, A. S. (2021). Hemin accumulation and identification of a heme-binding protein clan in K562 cells by proteomic and computational analysis. Journal of cellular physiology, . https://doi.org/10.1002/jcp.30595
Tsolaki, Vasiliki-Dimitra C, et al. "Hemin accumulation and identification of a heme-binding protein clan in K562 cells by proteomic and computational analysis." Journal of cellular physiology vol. (2021). doi: https://doi.org/10.1002/jcp.30595
Tsolaki VC, Georgiou-Siafis SK, Tsamadou AI, Tsiftsoglou SA, Samiotaki M, Panayotou G, Tsiftsoglou AS. Hemin accumulation and identification of a heme-binding protein clan in K562 cells by proteomic and computational analysis. J Cell Physiol. 2021 Oct 07; doi: 10.1002/jcp.30595. Epub 2021 Oct 07. PMID: 34617268.
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Molecular analysis of ampicillin-resistant sporadic Salmonella typhi and Salmonella paratyphi B clinical isolates.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Tassios PT, Vatopoulos AC, Mainas E, Gennimata D, Papadakis J, Tsiftsoglou A, Kalapothaki V, Legakis NJ.
PMID: 11864127
Clin Microbiol Infect. 1997 Jun;3(3):317-323. doi: 10.1111/j.1469-0691.1997.tb00620.x.

OBJECTIVE: To study the mechanisms of antibiotic resistance in Salmonella typhi and Salmonella paratyphi B clinical isolates, and the clonality of resistant strains. METHODS: Antibiotic susceptibility was tested by disk-agar diffusion. Conjugation experiments and plasmid analysis by agarose gel...

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Tassios PT, Vatopoulos AC, Mainas E, et al. Molecular analysis of ampicillin-resistant sporadic Salmonella typhi and Salmonella paratyphi B clinical isolates. Clin Microbiol Infect. 1997;3(3):317-323doi: 10.1111/j.1469-0691.1997.tb00620.x.
Tassios, P. T., Vatopoulos, A. C., Mainas, E., Gennimata, D., Papadakis, J., Tsiftsoglou, A., Kalapothaki, V., & Legakis, N. J. (1997). Molecular analysis of ampicillin-resistant sporadic Salmonella typhi and Salmonella paratyphi B clinical isolates. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 3(3), 317-323. https://doi.org/10.1111/j.1469-0691.1997.tb00620.x
Tassios, Panayotis T., et al. "Molecular analysis of ampicillin-resistant sporadic Salmonella typhi and Salmonella paratyphi B clinical isolates." Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases vol. 3,3 (1997): 317-323. doi: https://doi.org/10.1111/j.1469-0691.1997.tb00620.x
Tassios PT, Vatopoulos AC, Mainas E, Gennimata D, Papadakis J, Tsiftsoglou A, Kalapothaki V, Legakis NJ. Molecular analysis of ampicillin-resistant sporadic Salmonella typhi and Salmonella paratyphi B clinical isolates. Clin Microbiol Infect. 1997 Jun;3(3):317-323. doi: 10.1111/j.1469-0691.1997.tb00620.x. PMID: 11864127.
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Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders.

Molecular therapy. Nucleic acids

Miliotou AN, Pappas IS, Spyroulias G, Vlachaki E, Tsiftsoglou AS, Vizirianakis IS, Papadopoulou LC.
PMID: 34703653
Mol Ther Nucleic Acids. 2021 Sep 20;26:694-710. doi: 10.1016/j.omtn.2021.09.008. eCollection 2021 Dec 03.

The potential clinical applications of the powerful

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Miliotou AN, Pappas IS, Spyroulias G, et al. Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders. Mol Ther Nucleic Acids. 2021;26:694-710doi: 10.1016/j.omtn.2021.09.008.
Miliotou, A. N., Pappas, I. S., Spyroulias, G., Vlachaki, E., Tsiftsoglou, A. S., Vizirianakis, I. S., & Papadopoulou, L. C. (2021). Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders. Molecular therapy. Nucleic acids, 26694-710. https://doi.org/10.1016/j.omtn.2021.09.008
Miliotou, Androulla N, et al. "Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders." Molecular therapy. Nucleic acids vol. 26 (2021): 694-710. doi: https://doi.org/10.1016/j.omtn.2021.09.008
Miliotou AN, Pappas IS, Spyroulias G, Vlachaki E, Tsiftsoglou AS, Vizirianakis IS, Papadopoulou LC. Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders. Mol Ther Nucleic Acids. 2021 Sep 20;26:694-710. doi: 10.1016/j.omtn.2021.09.008. eCollection 2021 Dec 03. PMID: 34703653; PMCID: PMC8517095.
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