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Showing 1 to 12 of 41 entries
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Immunosuppressive serum levels in allogeneic hematopoietic stem cell transplantation: pharmaceutical care contribution.

Pharmacy practice

Corrêa PM, Zuckermann J, Fischer GB, Castro MS.
PMID: 27382420
Pharm Pract (Granada). 2016 Apr-Jun;14(2):683. doi: 10.18549/PharmPract.2016.02.683. Epub 2016 Jun 15.

BACKGROUND: Cyclosporine and tacrolimus are limited by a narrow therapeutic window. Maintaining immunosuppressive drugs at desired levels may be difficult. Pharmaceutical care emerges as a philosophy of practice that enhances medication use and leads to a better control of...

Reprints of Reprint Requests Requested.

Science (New York, N.Y.)

Hubel DH, Wiesel TN, Chen JY, Tobie JS, Tuckerman J, Crick MF, Goldberg A, Richardson L, Cooper M, Thach WT, Funkenstein HH, Blau S.
PMID: 17737778
Science. 1965 Jul 02;149(3679):8. doi: 10.1126/science.149.3679.8-a.

No abstract available.

Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis.

Osteoarthritis and cartilage

Cherifi C, Latourte A, Vettorazzi S, Tuckermann J, Provot S, Ea HK, Ledoux A, Casas J, Cuvillier O, Richette P, Ostertag A, Hay E, Cohen-Solal M.
PMID: 34144150
Osteoarthritis Cartilage. 2021 Sep;29(9):1335-1345. doi: 10.1016/j.joca.2021.06.001. Epub 2021 Jun 16.

OBJECTIVE: Cartilage loss observed in osteoarthritis (OA) is prevented when osteoclasts in the subchondral bone are inhibited in mice. Here, we investigated the role of the osteoclast secretome and of the lipid mediator sphingosine 1-phosphate (S1P) in chondrocyte metabolism...

A guide to changing paradigms of glucocorticoid receptor function-a model system for genome regulation and physiology.

The FEBS journal

Vettorazzi S, Nalbantoglu D, Gebhardt JCM, Tuckermann J.
PMID: 34213830
FEBS J. 2021 Jul 02; doi: 10.1111/febs.16100. Epub 2021 Jul 02.

The glucocorticoid receptor (GR) is a bona fide ligand-regulated transcription factor. Cloned in the 80s, the GR has become one of the best-studied and clinically most relevant members of the nuclear receptor superfamily. Cooperative activity of GR with other...

Overcoming COVID-19 vaccine hesitancy: can Australia reach the last 20 percent?.

Expert review of vaccines

Kaufman J, Tuckerman J, Danchin M.
PMID: 34854334
Expert Rev Vaccines. 2021 Dec 02; doi: 10.1080/14760584.2022.2013819. Epub 2021 Dec 02.

No abstract available.

Dexamethasone-mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells.

British journal of haematology

Ahmed HMM, Nimmagadda SC, Al-Matary YS, Fiori M, May T, Frank D, Patnana PK, Récher C, Schliemann C, Mikesch JH, Koenig T, Rosenbauer F, Hartmann W, Tuckermann J, Dührsen U, Lanying W, Dugas M, Opalka B, Lenz G, Khandanpour C.
PMID: 34792186
Br J Haematol. 2021 Nov 18; doi: 10.1111/bjh.17940. Epub 2021 Nov 18.

Acute myeloid leukaemia (AML) is a haematological malignancy characterized by a poor prognosis. Bone marrow mesenchymal stromal cells (BM MSCs) support leukaemic cells in preventing chemotherapy-induced apoptosis. This encouraged us to investigate leukaemia-BM niche-associated signalling and to identify signalling...

Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis.

Frontiers in cell and developmental biology

Elson A, Stein M, Rabie G, Barnea-Zohar M, Winograd-Katz S, Reuven N, Shalev M, Sekeres J, Kanaan M, Tuckermann J, Geiger B.
PMID: 34095139
Front Cell Dev Biol. 2021 May 20;9:671210. doi: 10.3389/fcell.2021.671210. eCollection 2021.

Bone homeostasis is a complex, multi-step process, which is based primarily on a tightly orchestrated interplay between bone formation and bone resorption that is executed by osteoblasts and osteoclasts (OCLs), respectively. The essential physiological balance between these cells is...

The Collaboration for Increasing Influenza Vaccination in Children (CIIVIC): a meeting report.

Australian and New Zealand journal of public health

Norman DA, Carlson SJ, Tuckerman J, Kaufman J, Moore HC, Seale H, Leask J, Marshall H, Hughes C, Blyth CC, Danchin M.
PMID: 33970524
Aust N Z J Public Health. 2021 Jun;45(3):193-196. doi: 10.1111/1753-6405.13088. Epub 2021 May 10.

No abstract available.

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.

Diabetologia

Giroud M, Tsokanos FF, Caratti G, Kotschi S, Khani S, Jouffe C, Vogl ES, Irmler M, Glantschnig C, Gil-Lozano M, Hass D, Khan AA, Garcia MR, Mattijssen F, Maida A, Tews D, Fischer-Posovszky P, Feuchtinger A, Virtanen KA, Beckers J, Wabitsch M, Uhlenhaut H, Blüher M, Tuckermann J, Scheideler M, Bartelt A, Herzig S.
PMID: 34014371
Diabetologia. 2021 Aug;64(8):1850-1865. doi: 10.1007/s00125-021-05470-y. Epub 2021 May 20.

AIMS/HYPOTHESIS: Adipocytes are critical cornerstones of energy metabolism. While obesity-induced adipocyte dysfunction is associated with insulin resistance and systemic metabolic disturbances, adipogenesis, the formation of new adipocytes and healthy adipose tissue expansion are associated with metabolic benefits. Understanding the...

Inhibition of 11β-HSD1 Expression by Insulin in Skin: Impact for Diabetic Wound Healing.

Journal of clinical medicine

Brazel CB, Simon JC, Tuckermann JP, Saalbach A.
PMID: 33260645
J Clin Med. 2020 Nov 28;9(12). doi: 10.3390/jcm9123878.

Chronic, non-healing wounds impose a great burden on patients, professionals and health care systems worldwide. Diabetes mellitus (DM) and obesity are globally highly prevalent metabolic disorders and increase the risk for developing chronic wounds. Glucocorticoids (GCs) are endogenous stress...

The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay.

Oncotarget

Baake T, Jörß K, Suennemann J, Roßmann L, Bohnenberger H, Tuckermann JP, Reichardt HM, Fischer HJ, Reichardt SD.
PMID: 29643984
Oncotarget. 2018 Mar 02;9(21):15437-15450. doi: 10.18632/oncotarget.24602. eCollection 2018 Mar 20.

Graft-versus-host disease (GvHD) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT), which is caused by allogeneic T cells recognizing molecules of the recipient as foreign. Endogenous glucocorticoids (GC) released from the adrenal gland are crucial in regulating...

RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk.

Cell death and differentiation

Najafova Z, Liu P, Wegwitz F, Ahmad M, Tamon L, Kosinsky RL, Xie W, Johnsen SA, Tuckermann J.
PMID: 32901120
Cell Death Differ. 2021 Feb;28(2):700-714. doi: 10.1038/s41418-020-00614-w. Epub 2020 Sep 08.

The role of histone ubiquitination in directing cell lineage specification is only poorly understood. Our previous work indicated a role of the histone 2B ubiquitin ligase RNF40 in controlling osteoblast differentiation in vitro. Here, we demonstrate that RNF40 has...

Showing 1 to 12 of 41 entries