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p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance.

Frontiers in oncology

Chen L, Tweddle DA.
PMID: 23226679
Front Oncol. 2012 Nov 28;2:173. doi: 10.3389/fonc.2012.00173. eCollection 2012.

Neuroblastoma is the most common extra-cranial solid tumor of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. MYCN...

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Chen L, Tweddle DA. p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance. Front Oncol. 2012;2:173doi: 10.3389/fonc.2012.00173.
Chen, L., & Tweddle, D. A. (2012). p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance. Frontiers in oncology, 2173. https://doi.org/10.3389/fonc.2012.00173
Chen, Lindi, and Tweddle, Deborah A. "p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance." Frontiers in oncology vol. 2 (2012): 173. doi: https://doi.org/10.3389/fonc.2012.00173
Chen L, Tweddle DA. p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance. Front Oncol. 2012 Nov 28;2:173. doi: 10.3389/fonc.2012.00173. eCollection 2012. PMID: 23226679; PMCID: PMC3508619.
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Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

Oncotarget

Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR.
PMID: 30774766
Oncotarget. 2019 Jan 18;10(6):685. doi: 10.18632/oncotarget.26625. eCollection 2019 Jan 18.

[This corrects the article DOI: 10.18632/oncotarget.25497.].

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Evans JP, Winiarski BK, Sutton PA, et al. Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget. 2019;10(6):685doi: 10.18632/oncotarget.26625.
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., Pritchard, D. M., Lin, Z. X., Fretwell, V. L., Tweedle, E. M., Costello, E., Goldring, C. E., Copple, I. M., Park, B. K., Palmer, D. H., & Kitteringham, N. R. (2019). Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget, 10(6), 685. https://doi.org/10.18632/oncotarget.26625
Evans, Jonathan P, et al. "Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer." Oncotarget vol. 10,6 (2019): 685. doi: https://doi.org/10.18632/oncotarget.26625
Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR. Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget. 2019 Jan 18;10(6):685. doi: 10.18632/oncotarget.26625. eCollection 2019 Jan 18. PMID: 30774766; PMCID: PMC6363008.
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An unusual case of acute otitis media resulting in Gradenigo syndrome: CT and MRI findings.

Radiology case reports

Quesada J, Kong A, Tweddle E.
PMID: 34703515
Radiol Case Rep. 2021 Oct 14;16(12):3903-3907. doi: 10.1016/j.radcr.2021.09.026. eCollection 2021 Dec.

With the widespread use of antibiotics, Gradenigo syndrome is a rare complication of acute otitis media (AOM) and acute mastoiditis. It is an uncommon form of petrous apicitis and can be life-threatening. We report the case of a 14-year-old...

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Quesada J, Kong A, Tweddle E. An unusual case of acute otitis media resulting in Gradenigo syndrome: CT and MRI findings. Radiol Case Rep. 2021;16(12):3903-3907doi: 10.1016/j.radcr.2021.09.026.
Quesada, J., Kong, A., & Tweddle, E. (2021). An unusual case of acute otitis media resulting in Gradenigo syndrome: CT and MRI findings. Radiology case reports, 16(12), 3903-3907. https://doi.org/10.1016/j.radcr.2021.09.026
Quesada, Juan, et al. "An unusual case of acute otitis media resulting in Gradenigo syndrome: CT and MRI findings." Radiology case reports vol. 16,12 (2021): 3903-3907. doi: https://doi.org/10.1016/j.radcr.2021.09.026
Quesada J, Kong A, Tweddle E. An unusual case of acute otitis media resulting in Gradenigo syndrome: CT and MRI findings. Radiol Case Rep. 2021 Oct 14;16(12):3903-3907. doi: 10.1016/j.radcr.2021.09.026. eCollection 2021 Dec. PMID: 34703515; PMCID: PMC8523869.
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Evaluation of marine spatial planning requires fit for purpose monitoring strategies.

Journal of environmental management

Stelzenmüller V, Cormier R, Gee K, Shucksmith R, Gubbins M, Yates KL, Morf A, Nic Aonghusa C, Mikkelsen E, Tweddle JF, Pecceu E, Kannen A, Clarke SA.
PMID: 33202370
J Environ Manage. 2021 Jan 15;278:111545. doi: 10.1016/j.jenvman.2020.111545. Epub 2020 Nov 14.

Marine spatial planning (MSP) has rapidly become the most widely used integrated, place-based management approach in the marine environment. Monitoring and evaluation of MSP is key to inform best practices, adaptive management and plan iteration. While standardised evaluation frameworks...

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Stelzenmüller V, Cormier R, Gee K, et al. Evaluation of marine spatial planning requires fit for purpose monitoring strategies. J Environ Manage. 2020;278:111545doi: 10.1016/j.jenvman.2020.111545.
Stelzenmüller, V., Cormier, R., Gee, K., Shucksmith, R., Gubbins, M., Yates, K. L., Morf, A., Nic Aonghusa, C., Mikkelsen, E., Tweddle, J. F., Pecceu, E., Kannen, A., & Clarke, S. A. (2021). Evaluation of marine spatial planning requires fit for purpose monitoring strategies. Journal of environmental management, 278111545. https://doi.org/10.1016/j.jenvman.2020.111545
Stelzenmüller, V, et al. "Evaluation of marine spatial planning requires fit for purpose monitoring strategies." Journal of environmental management vol. 278 (2021): 111545. doi: https://doi.org/10.1016/j.jenvman.2020.111545
Stelzenmüller V, Cormier R, Gee K, Shucksmith R, Gubbins M, Yates KL, Morf A, Nic Aonghusa C, Mikkelsen E, Tweddle JF, Pecceu E, Kannen A, Clarke SA. Evaluation of marine spatial planning requires fit for purpose monitoring strategies. J Environ Manage. 2021 Jan 15;278:111545. doi: 10.1016/j.jenvman.2020.111545. Epub 2020 Nov 14. PMID: 33202370.
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Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance.

European journal of cancer (Oxford, England : 1990)

Nijstad AL, Barnett S, Lalmohamed A, Bérénos IM, Parke E, Carruthers V, Tweddle DA, Kong J, Zwaan CM, Huitema ADR, Veal GJ.
PMID: 34865945
Eur J Cancer. 2021 Dec 02; doi: 10.1016/j.ejca.2021.11.001. Epub 2021 Dec 02.

Cancer in neonates and infants is a rare but challenging entity. Treatment is complicated by marked physiological changes during the first year of life, excess rates of toxicity, mortality, and late effects. Dose optimisation of chemotherapeutics may be an...

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Nijstad AL, Barnett S, Lalmohamed A, et al. Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance. Eur J Cancer. 2021;doi: 10.1016/j.ejca.2021.11.001.
Nijstad, A. L., Barnett, S., Lalmohamed, A., Bérénos, I. M., Parke, E., Carruthers, V., Tweddle, D. A., Kong, J., Zwaan, C. M., Huitema, A. D. R., & Veal, G. J. (2021). Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance. European journal of cancer (Oxford, England : 1990), . https://doi.org/10.1016/j.ejca.2021.11.001
Nijstad, A Laura, et al. "Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance." European journal of cancer (Oxford, England : 1990) vol. (2021). doi: https://doi.org/10.1016/j.ejca.2021.11.001
Nijstad AL, Barnett S, Lalmohamed A, Bérénos IM, Parke E, Carruthers V, Tweddle DA, Kong J, Zwaan CM, Huitema ADR, Veal GJ. Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance. Eur J Cancer. 2021 Dec 02; doi: 10.1016/j.ejca.2021.11.001. Epub 2021 Dec 02. PMID: 34865945.
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Designing and Evaluating an Interprofessional Practice Experience Involving Dental and Pharmacy Students.

American journal of pharmaceutical education

Theodorou J, Rotz M, Macphail L, Idahosa C, Fornatora ML, Tweddale E, Virtue SM.
PMID: 30181669
Am J Pharm Educ. 2018 Aug;82(6):6298. doi: 10.5688/ajpe6298.

No abstract available.

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Theodorou J, Rotz M, Macphail L, et al. Designing and Evaluating an Interprofessional Practice Experience Involving Dental and Pharmacy Students. Am J Pharm Educ. 2018;82(6):6298doi: 10.5688/ajpe6298.
Theodorou, J., Rotz, M., Macphail, L., Idahosa, C., Fornatora, M. L., Tweddale, E., & Virtue, S. M. (2018). Designing and Evaluating an Interprofessional Practice Experience Involving Dental and Pharmacy Students. American journal of pharmaceutical education, 82(6), 6298. https://doi.org/10.5688/ajpe6298
Theodorou, Jacqueline, et al. "Designing and Evaluating an Interprofessional Practice Experience Involving Dental and Pharmacy Students." American journal of pharmaceutical education vol. 82,6 (2018): 6298. doi: https://doi.org/10.5688/ajpe6298
Theodorou J, Rotz M, Macphail L, Idahosa C, Fornatora ML, Tweddale E, Virtue SM. Designing and Evaluating an Interprofessional Practice Experience Involving Dental and Pharmacy Students. Am J Pharm Educ. 2018 Aug;82(6):6298. doi: 10.5688/ajpe6298. PMID: 30181669; PMCID: PMC6116879.
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ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms.

Cancers

Southgate HED, Chen L, Tweddle DA, Curtin NJ.
PMID: 32354033
Cancers (Basel). 2020 Apr 28;12(5). doi: 10.3390/cancers12051095.

No abstract available.

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Southgate HED, Chen L, Tweddle DA, et al. ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms. Cancers (Basel). 2020;12(5)doi: 10.3390/cancers12051095.
Southgate, H. E. D., Chen, L., Tweddle, D. A., & Curtin, N. J. (2020). ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms. Cancers, 12(5), . https://doi.org/10.3390/cancers12051095
Southgate, Harriet E D, et al. "ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms." Cancers vol. 12,5 (2020). doi: https://doi.org/10.3390/cancers12051095
Southgate HED, Chen L, Tweddle DA, Curtin NJ. ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms. Cancers (Basel). 2020 Apr 28;12(5). doi: 10.3390/cancers12051095. PMID: 32354033; PMCID: PMC7281288.
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The Al+ -H(2) cation complex: rotationally resolved infrared spectrum, potential energy surface, and rovibrational calculations.

The Journal of chemical physics

Emmeluth C, Poad BL, Thompson CD, Weddle G, Bieske EJ, Buchachenko AA, Grinev TA, Kłos J.
PMID: 17979341
J Chem Phys. 2007 Oct 28;127(16):164310. doi: 10.1063/1.2778422.

The infrared spectrum of the Al(+)-H(2) complex is recorded in the H-H stretch region (4075-4110 cm(-1)) by monitoring Al(+) photofragments. The H-H stretch band is centered at 4095.2 cm(-1), a shift of -66.0 cm(-1) from the Q(1)(0) transition of...

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Emmeluth C, Poad BL, Thompson CD, et al. The Al+ -H(2) cation complex: rotationally resolved infrared spectrum, potential energy surface, and rovibrational calculations. J Chem Phys. 2007;127(16):164310doi: 10.1063/1.2778422.
Emmeluth, C., Poad, B. L., Thompson, C. D., Weddle, G., Bieske, E. J., Buchachenko, A. A., Grinev, T. A., & Kłos, J. (2007). The Al+ -H(2) cation complex: rotationally resolved infrared spectrum, potential energy surface, and rovibrational calculations. The Journal of chemical physics, 127(16), 164310. https://doi.org/10.1063/1.2778422
Emmeluth, C, et al. "The Al+ -H(2) cation complex: rotationally resolved infrared spectrum, potential energy surface, and rovibrational calculations." The Journal of chemical physics vol. 127,16 (2007): 164310. doi: https://doi.org/10.1063/1.2778422
Emmeluth C, Poad BL, Thompson CD, Weddle G, Bieske EJ, Buchachenko AA, Grinev TA, Kłos J. The Al+ -H(2) cation complex: rotationally resolved infrared spectrum, potential energy surface, and rovibrational calculations. J Chem Phys. 2007 Oct 28;127(16):164310. doi: 10.1063/1.2778422. PMID: 17979341.
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Pharmacokinetics and Safety of a Novel Oral Liquid Formulation of 13-.

Cancers

Veal GJ, Tweddle DA, Visser J, Errington J, Buck H, Marange J, Moss J, Joseph S, Mulla H.
PMID: 33919763
Cancers (Basel). 2021 Apr 14;13(8). doi: 10.3390/cancers13081868.

(1) Background: 13-

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Veal GJ, Tweddle DA, Visser J, et al. Pharmacokinetics and Safety of a Novel Oral Liquid Formulation of 13-. Cancers (Basel). 2021;13(8)doi: 10.3390/cancers13081868.
Veal, G. J., Tweddle, D. A., Visser, J., Errington, J., Buck, H., Marange, J., Moss, J., Joseph, S., & Mulla, H. (2021). Pharmacokinetics and Safety of a Novel Oral Liquid Formulation of 13-. Cancers, 13(8), . https://doi.org/10.3390/cancers13081868
Veal, Gareth J, et al. "Pharmacokinetics and Safety of a Novel Oral Liquid Formulation of 13-." Cancers vol. 13,8 (2021). doi: https://doi.org/10.3390/cancers13081868
Veal GJ, Tweddle DA, Visser J, Errington J, Buck H, Marange J, Moss J, Joseph S, Mulla H. Pharmacokinetics and Safety of a Novel Oral Liquid Formulation of 13-. Cancers (Basel). 2021 Apr 14;13(8). doi: 10.3390/cancers13081868. PMID: 33919763; PMCID: PMC8070696.
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Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients.

European journal of cancer (Oxford, England : 1990)

Barnett S, Hellmann F, Parke E, Makin G, Tweddle DA, Osborne C, Hempel G, Veal GJ.
PMID: 34657763
Eur J Cancer. 2021 Oct 14; doi: 10.1016/j.ejca.2021.09.014. Epub 2021 Oct 14.

BACKGROUND: The anticancer drug vincristine is associated with potentially dose-limiting side-effects, including neurotoxicity and myelosuppression. However, there currently exists a lack of published clinical pharmacology data relating to its use in neonate and infant patients. We report a study...

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Barnett S, Hellmann F, Parke E, et al. Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients. Eur J Cancer. 2021;doi: 10.1016/j.ejca.2021.09.014.
Barnett, S., Hellmann, F., Parke, E., Makin, G., Tweddle, D. A., Osborne, C., Hempel, G., & Veal, G. J. (2021). Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients. European journal of cancer (Oxford, England : 1990), . https://doi.org/10.1016/j.ejca.2021.09.014
Barnett, Shelby, et al. "Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients." European journal of cancer (Oxford, England : 1990) vol. (2021). doi: https://doi.org/10.1016/j.ejca.2021.09.014
Barnett S, Hellmann F, Parke E, Makin G, Tweddle DA, Osborne C, Hempel G, Veal GJ. Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients. Eur J Cancer. 2021 Oct 14; doi: 10.1016/j.ejca.2021.09.014. Epub 2021 Oct 14. PMID: 34657763.
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What's in a name?.

Nursing management (Harrow, London, England : 1994)

Tweddle V.
PMID: 27736421
Nurs Manag (Harrow). 2009 Mar 10;15(10):11. doi: 10.7748/nm.15.10.11.s15.

WHAT IS the 2gether NHS Foundation Trust? I have been asked this many times since the trust for which I work, formerly the Gloucestershire Partnership NHS Foundation Trust, was re-branded last April.

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Tweddle V. What's in a name?. Nurs Manag (Harrow). 2009;15(10):11doi: 10.7748/nm.15.10.11.s15.
Tweddle, V. (2009). What's in a name?. Nursing management (Harrow, London, England : 1994), 15(10), 11. https://doi.org/10.7748/nm.15.10.11.s15
Tweddle, Vikki. "What's in a name?." Nursing management (Harrow, London, England : 1994) vol. 15,10 (2009): 11. doi: https://doi.org/10.7748/nm.15.10.11.s15
Tweddle V. What's in a name?. Nurs Manag (Harrow). 2009 Mar 10;15(10):11. doi: 10.7748/nm.15.10.11.s15. PMID: 27736421.
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Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells.

Cancers

King D, Southgate HED, Roetschke S, Gravells P, Fields L, Watson JB, Chen L, Chapman D, Harrison D, Yeomanson D, Curtin NJ, Tweddle DA, Bryant HE.
PMID: 34944835
Cancers (Basel). 2021 Dec 10;13(24). doi: 10.3390/cancers13246215.

Despite intensive high-dose multimodal therapy, high-risk neuroblastoma (NB) confers a less than 50% survival rate. This study investigates the role of replication stress in sensitivity to inhibition of Ataxia telangiectasia and Rad3-related (ATR) in pre-clinical models of high-risk NB....

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King D, Southgate HED, Roetschke S, et al. Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells. Cancers (Basel). 2021;13(24)doi: 10.3390/cancers13246215.
King, D., Southgate, H. E. D., Roetschke, S., Gravells, P., Fields, L., Watson, J. B., Chen, L., Chapman, D., Harrison, D., Yeomanson, D., Curtin, N. J., Tweddle, D. A., & Bryant, H. E. (2021). Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells. Cancers, 13(24), . https://doi.org/10.3390/cancers13246215
King, David, et al. "Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells." Cancers vol. 13,24 (2021). doi: https://doi.org/10.3390/cancers13246215
King D, Southgate HED, Roetschke S, Gravells P, Fields L, Watson JB, Chen L, Chapman D, Harrison D, Yeomanson D, Curtin NJ, Tweddle DA, Bryant HE. Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells. Cancers (Basel). 2021 Dec 10;13(24). doi: 10.3390/cancers13246215. PMID: 34944835; PMCID: PMC8699051.
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Showing 1 to 12 of 19 entries