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Showing 1 to 12 of 57 entries
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Journal of investigative medicine high impact case reports

Wallace JA, Hussain J, Unzueta A, Morelli G.
PMID: 28890902
J Investig Med High Impact Case Rep. 2017 Aug 30;5(3):2324709617726103. doi: 10.1177/2324709617726103. eCollection 2017.

A 58-year-old male with nonalcoholic steatohepatitis cirrhosis presents with right lower extremity cellulitis, abdominal tenderness, and severe sepsis after sustaining puncture injury from a cactus on a property with feral cats. Blood cultures and diagnostic paracentesis were consistent with...

Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism.

Evidence-based complementary and alternative medicine : eCAM

Negrette-Guzmán M, García-Niño WR, Tapia E, Zazueta C, Huerta-Yepez S, León-Contreras JC, Hernández-Pando R, Aparicio-Trejo OE, Madero M, Pedraza-Chaverri J.
PMID: 26345660
Evid Based Complement Alternat Med. 2015;2015:917435. doi: 10.1155/2015/917435. Epub 2015 Aug 05.

It has been shown that curcumin (CUR), a polyphenol derived from Curcuma longa, exerts a protective effect against gentamicin- (GM-) induced nephrotoxicity in rats, associated with a preservation of the antioxidant status. Although mitochondrial dysfunction is a hallmark in...

Cardioprotective effects of Prolame and SNAP are related with nitric oxide production and with diminution of caspases and calpain-1 activities in reperfused rat hearts.

PeerJ

Román-Anguiano NG, Correa F, Cano-Martínez A, de la Peña-Díaz A, Zazueta C.
PMID: 31392096
PeerJ. 2019 Jul 29;7:e7348. doi: 10.7717/peerj.7348. eCollection 2019.

Cardiac tissue undergoes changes during ischemia-reperfusion (I-R) that compromise its normal function. Cell death is one of the consequences of such damage, as well as diminution in nitric oxide (NO) content. This signaling molecule regulates the function of the...

Charge states and lattice sites of dilute implanted Sn in ZnO.

Journal of physics. Condensed matter : an Institute of Physics journal

Mølholt TE, Gunnlaugsson HP, Johnston K, Mantovan R, Röder J, Adoons V, Mokhles Gerami A, Masenda H, Matveyev YA, Ncube M, Unzueta I, Bharuth-Ram K, Gislason HP, Krastev P, Langouche G, Naidoo D, Ólafsson S, Zenkevich A.
PMID: 28165333
J Phys Condens Matter. 2017 Apr 20;29(15):155701. doi: 10.1088/1361-648X/aa5e95. Epub 2017 Feb 06.

The common charge states of Sn are 2+  and 4+. While charge neutrality considerations favour 2+  to be the natural charge state of Sn in ZnO, there are several reports suggesting the 4+  state instead. In order to investigate...

Artificial Inclusion Bodies for Clinical Development.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sánchez JM, López-Laguna H, Álamo P, Serna N, Sánchez-Chardi A, Nolan V, Cano-Garrido O, Casanova I, Unzueta U, Vazquez E, Mangues R, Villaverde A.
PMID: 32042562
Adv Sci (Weinh). 2019 Nov 27;7(3):1902420. doi: 10.1002/advs.201902420. eCollection 2020 Feb.

Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow-protein-releasing amyloids. Upon exposure to cultured cells or upon subcutaneous or intratumor injection, these protein materials secrete functional IB polypeptides, functionally mimicking the...

Leptin Modifies the Rat Heart Performance Associated with Mitochondrial Dysfunction Independently of Its Prohypertrophic Effects.

International journal of endocrinology

Berzabá-Evoli E, Zazueta C, Cruz Hernández JH, Gómez-Crisóstomo NP, Juárez-Rojop IE, De la Cruz-Hernández EN, Martínez-Abundis E.
PMID: 30154842
Int J Endocrinol. 2018 Aug 01;2018:6081415. doi: 10.1155/2018/6081415. eCollection 2018.

BACKGROUND: Functional receptors for leptin were described on the surface of cardiomyocytes, and there was a prohypertrophic effect with high concentrations of the cytokine. Therefore, leptin could be a link between obesity and the prevalence of cardiovascular diseases. On...

Sub-nanoscale free volume and local elastic modulus of chitosan-carbon nanotube biomimetic nanocomposite scaffold-materials.

Journal of materials chemistry. B

Axpe E, Bugnicourt L, Merida D, Goiriena-Goikoetxea M, Unzueta I, Sanchez-Eugenia R, Garcia JA, Plazaola F, Contera S.
PMID: 32262310
J Mater Chem B. 2015 Apr 28;3(16):3169-3176. doi: 10.1039/c5tb00154d. Epub 2015 Mar 18.

Future progress in materials for tissue engineering and 3D cell cultures applications requires control of two key physical properties: nanoscale mechanical properties and mass transport. These requirements remain uncontrolled partly due to a lack of physical parameters and quantitative...

A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model.

Biomaterials

Pallarès V, Unzueta U, Falgàs A, Aviñó A, Núñez Y, García-León A, Sánchez-García L, Serna N, Gallardo A, Alba-Castellón L, Álamo P, Sierra J, Cedó L, Eritja R, Villaverde A, Vázquez E, Casanova I, Mangues R.
PMID: 34847435
Biomaterials. 2021 Nov 24;280:121258. doi: 10.1016/j.biomaterials.2021.121258. Epub 2021 Nov 24.

Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjugate that combines a self-assembled,...

[Significance of exosomes in cardiology: heralds of cardioprotection].

Archivos de cardiologia de Mexico

Arroyo-Campuzano M, Zazueta C.
PMID: 33661872
Arch Cardiol Mex. 2021;91(1):105-113. doi: 10.24875/ACM.20000335.

Los exosomas tienen un papel clave en la comunicación intercelular. Debido a sus múltiples interacciones, estas estructuras cumplen con el papel de «mensajeros» de forma dinámica, transportando su contenido a células blanco específicas y generando nuevas señales celulares. En...

Predicting Density Functional Theory-Quality Nuclear Magnetic Resonance Chemical Shifts via Δ-Machine Learning.

Journal of chemical theory and computation

Unzueta PA, Greenwell CS, Beran GJO.
PMID: 33428408
J Chem Theory Comput. 2021 Feb 09;17(2):826-840. doi: 10.1021/acs.jctc.0c00979. Epub 2021 Jan 11.

First-principles prediction of nuclear magnetic resonance chemical shifts plays an increasingly important role in the interpretation of experimental spectra, but the required density functional theory (DFT) calculations can be computationally expensive. Promising machine learning models for predicting chemical shieldings...

Insights on the emerging biotechnology of histidine-rich peptides.

Biotechnology advances

López-Laguna H, Voltà-Durán E, Parladé E, Villaverde A, Vázquez E, Unzueta U.
PMID: 34418503
Biotechnol Adv. 2021 Aug 19;107817. doi: 10.1016/j.biotechadv.2021.107817. Epub 2021 Aug 19.

In the late 70's, the discovery of the restriction enzymes made possible the biological production of functional proteins by recombinant DNA technologies, a fact that largely empowered both biotechnological and pharmaceutical industries. Short peptides or small protein domains, with...

A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model.

Biomaterials

Pallarès V, Unzueta U, Falgàs A, Aviñó A, Núñez Y, García-León A, Sánchez-García L, Serna N, Gallardo A, Alba-Castellón L, Álamo P, Sierra J, Cedó L, Eritja R, Villaverde A, Vázquez E, Casanova I, Mangues R.
PMID: 34847435
Biomaterials. 2021 Nov 24;280:121258. doi: 10.1016/j.biomaterials.2021.121258. Epub 2021 Nov 24.

Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjugate that combines a self-assembled,...

Showing 1 to 12 of 57 entries