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B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice.

The Open bone journal

Li Y, Terauchi M, Vikulina T, Roser-Page S, Weitzmann MN.
PMID: 25984250
Open Bone J. 2014;6:8-17. doi: 10.2174/1876525401406010008.

Aging is a risk factor for osteoclastic bone loss and bone fracture. Receptor activator of NF-κB ligand (RANKL) is the key effector cytokine for osteoclastogenesis and bone resorption, and is moderated by its decoy receptor osteoprotegerin (OPG). The development...

Immune Reconstitution Bone Loss Exacerbates Bone Degeneration Due to Natural Aging in a Mouse Model.

The Journal of infectious diseases

Weitzmann MN, Weiss D, Vikulina T, Roser-Page S, Yu K, McGee-Lawrence ME, Tu CL, Chang W, Ofotokun I.
PMID: 34962571
J Infect Dis. 2021 Dec 28; doi: 10.1093/infdis/jiab631. Epub 2021 Dec 28.

BACKGROUND: Immune reconstitution bone loss (IRBL) is a common side-effect of antiretroviral therapy (ART) in people living with HIV (PWH). IRBL acts through CD4 + T-cell/immune reconstitution-induced inflammation and is independent of antiviral regimen. IRBL may contribute to the...

Body composition and grip strength are improved in transgenic sickle mice fed a high-protein diet.

Journal of nutritional science

Capers PL, Hyacinth HI, Cue S, Chappa P, Vikulina T, Roser-Page S, Weitzmann MN, Archer DR, Newman GW, Quarshie A, Stiles JK, Hibbert JM.
PMID: 26090102
J Nutr Sci. 2015 Feb 27;4:e6. doi: 10.1017/jns.2014.63. eCollection 2015.

Key pathophysiology of sickle cell anaemia includes compensatory erythropoiesis, vascular injury and chronic inflammation, which divert amino acids from tissue deposition for growth/weight gain and muscle formation. We hypothesised that sickle mice maintained on an isoenergetic diet with a...

Showing 1 to 3 of 3 entries