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Free Radical Self-Immolative 1,2-Elimination and Reductive Desulfonylation of Aryl Sulfones Promoted by Intramolecular Reactions with Ortho-Attached Carbon-Centered Radicals(1).

The Journal of organic chemistry

Van Dort PC, Fuchs PL.
PMID: 11671818
J Org Chem. 1997 Oct 17;62(21):7142-7147. doi: 10.1021/jo970445e.

Aryl sulfones bearing an o-(bromomethyl)dimethylsilyl moiety (1), when heated with AIBN and tributyltin hydride, suffer radical elimination under mild conditions to give olefins and stannyl sulfinate 7 in high yield. The mechanism is shown to proceed via intramolecular beta-sulfonyl...

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Van Dort PC, Fuchs PL. Free Radical Self-Immolative 1,2-Elimination and Reductive Desulfonylation of Aryl Sulfones Promoted by Intramolecular Reactions with Ortho-Attached Carbon-Centered Radicals(1). J Org Chem. 1997;62(21):7142-7147doi: 10.1021/jo970445e.
Van Dort, P. C., & Fuchs, P. L. (1997). Free Radical Self-Immolative 1,2-Elimination and Reductive Desulfonylation of Aryl Sulfones Promoted by Intramolecular Reactions with Ortho-Attached Carbon-Centered Radicals(1). The Journal of organic chemistry, 62(21), 7142-7147. https://doi.org/10.1021/jo970445e
Van Dort, P. C., and Fuchs, P. L.. "Free Radical Self-Immolative 1,2-Elimination and Reductive Desulfonylation of Aryl Sulfones Promoted by Intramolecular Reactions with Ortho-Attached Carbon-Centered Radicals(1)." The Journal of organic chemistry vol. 62,21 (1997): 7142-7147. doi: https://doi.org/10.1021/jo970445e
Van Dort PC, Fuchs PL. Free Radical Self-Immolative 1,2-Elimination and Reductive Desulfonylation of Aryl Sulfones Promoted by Intramolecular Reactions with Ortho-Attached Carbon-Centered Radicals(1). J Org Chem. 1997 Oct 17;62(21):7142-7147. doi: 10.1021/jo970445e. PMID: 11671818.
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PET and SPECT Imaging of Tumor Biology: New Approaches towards Oncology Drug Discovery and Development.

Current computer-aided drug design

Van Dort ME, Rehemtulla A, Ross BD.
PMID: 19809593
Curr Comput Aided Drug Des. 2008;4(1):46-53. doi: 10.2174/157340908783769265.

Spiraling drug developmental costs and lengthy time-to-market introduction are two critical challenges facing the pharmaceutical industry. The clinical trials success rate for oncology drugs is reported to be 5% as compared to other therapeutic categories (11%) with most failures...

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Van Dort ME, Rehemtulla A, Ross BD. PET and SPECT Imaging of Tumor Biology: New Approaches towards Oncology Drug Discovery and Development. Curr Comput Aided Drug Des. 2008;4(1):46-53doi: 10.2174/157340908783769265.
Van Dort, M. E., Rehemtulla, A., & Ross, B. D. (2008). PET and SPECT Imaging of Tumor Biology: New Approaches towards Oncology Drug Discovery and Development. Current computer-aided drug design, 4(1), 46-53. https://doi.org/10.2174/157340908783769265
Van Dort, Marcian E, et al. "PET and SPECT Imaging of Tumor Biology: New Approaches towards Oncology Drug Discovery and Development." Current computer-aided drug design vol. 4,1 (2008): 46-53. doi: https://doi.org/10.2174/157340908783769265
Van Dort ME, Rehemtulla A, Ross BD. PET and SPECT Imaging of Tumor Biology: New Approaches towards Oncology Drug Discovery and Development. Curr Comput Aided Drug Des. 2008;4(1):46-53. doi: 10.2174/157340908783769265. PMID: 19809593; PMCID: PMC2756754.
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Computing equilibrium concentrations for large heterodimerization networks.

Physical review. E, Statistical, nonlinear, and soft matter physics

van Dorp MG, Berger F, Carlon E.
PMID: 22060463
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Sep;84(3):036114. doi: 10.1103/PhysRevE.84.036114. Epub 2011 Sep 26.

We consider a chemical reaction network governed by mass action kinetics and composed of N different species which can reversibly form heterodimers. A fast iterative algorithm is introduced to compute te equilibrium concentrations of such networks. We show that...

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van Dorp MG, Berger F, Carlon E. Computing equilibrium concentrations for large heterodimerization networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2011;84(3):036114doi: 10.1103/PhysRevE.84.036114.
van Dorp, M. G., Berger, F., & Carlon, E. (2011). Computing equilibrium concentrations for large heterodimerization networks. Physical review. E, Statistical, nonlinear, and soft matter physics, 84(3), 036114. https://doi.org/10.1103/PhysRevE.84.036114
van Dorp, M G A, et al. "Computing equilibrium concentrations for large heterodimerization networks." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 84,3 (2011): 036114. doi: https://doi.org/10.1103/PhysRevE.84.036114
van Dorp MG, Berger F, Carlon E. Computing equilibrium concentrations for large heterodimerization networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Sep;84(3):036114. doi: 10.1103/PhysRevE.84.036114. Epub 2011 Sep 26. PMID: 22060463.
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High-resolution optical study of a point-contact-induced phonon hot spot in ruby.

Physical review. B, Condensed matter

de Wijn HW, Dijkhuis JI, Troost KZ, van Dort MJ.
PMID: 9996194
Phys Rev B Condens Matter. 1991 Jan 01;43(1):98-105. doi: 10.1103/physrevb.43.98.

No abstract available.

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de Wijn HW, Dijkhuis JI, Troost KZ, et al. High-resolution optical study of a point-contact-induced phonon hot spot in ruby. Phys Rev B Condens Matter. 1991;43(1):98-105doi: 10.1103/physrevb.43.98.
de Wijn HW, Dijkhuis, J. I., Troost, K. Z., & van Dort MJ. (1991). High-resolution optical study of a point-contact-induced phonon hot spot in ruby. Physical review. B, Condensed matter, 43(1), 98-105. https://doi.org/10.1103/physrevb.43.98
de Wijn HW, et al. "High-resolution optical study of a point-contact-induced phonon hot spot in ruby." Physical review. B, Condensed matter vol. 43,1 (1991): 98-105. doi: https://doi.org/10.1103/physrevb.43.98
de Wijn HW, Dijkhuis JI, Troost KZ, van Dort MJ. High-resolution optical study of a point-contact-induced phonon hot spot in ruby. Phys Rev B Condens Matter. 1991 Jan 01;43(1):98-105. doi: 10.1103/physrevb.43.98. PMID: 9996194.
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Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism.

Open forum infectious diseases

Kruize Z, Maurer I, van Dort KA, van den Elshout MAM, Hoornenborg E, Booiman T, Prins M, Kootstra NA.
PMID: 32782910
Open Forum Infect Dis. 2020 Jul 05;7(8):ofaa284. doi: 10.1093/ofid/ofaa284. eCollection 2020 Aug.

BACKGROUND: We recently reported that the levels of activation, exhaustion, and terminal differentiation within the peripheral T-cell compartment were increased in men who have sex with men (MSM) compared with blood bank donors. During activation and differentiation, T cells...

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Kruize Z, Maurer I, van Dort KA, et al. Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism. Open Forum Infect Dis. 2020;7(8):ofaa284doi: 10.1093/ofid/ofaa284.
Kruize, Z., Maurer, I., van Dort, K. A., van den Elshout, M. A. M., Hoornenborg, E., Booiman, T., Prins, M., & Kootstra, N. A. (2020). Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism. Open forum infectious diseases, 7(8), ofaa284. https://doi.org/10.1093/ofid/ofaa284
Kruize, Zita, et al. "Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism." Open forum infectious diseases vol. 7,8 (2020): ofaa284. doi: https://doi.org/10.1093/ofid/ofaa284
Kruize Z, Maurer I, van Dort KA, van den Elshout MAM, Hoornenborg E, Booiman T, Prins M, Kootstra NA. Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism. Open Forum Infect Dis. 2020 Jul 05;7(8):ofaa284. doi: 10.1093/ofid/ofaa284. eCollection 2020 Aug. PMID: 32782910; PMCID: PMC7408207.
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Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors.

European journal of medicinal chemistry

Van Dort ME, Jang Y, Bonham CA, Heist K, Palagama DSW, McDonald L, Zhang EZ, Chenevert TL, Luker GD, Ross BD.
PMID: 34802837
Eur J Med Chem. 2021 Nov 14;113996. doi: 10.1016/j.ejmech.2021.113996. Epub 2021 Nov 14.

Established roles for PI3K and MAPK signaling pathways in tumorigenesis has prompted extensive research towards the discovery of small-molecule inhibitors as cancer therapeutics. However, significant compensatory regulation exists between these two signaling cascades, leading to redundancy among survival pathways....

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Van Dort ME, Jang Y, Bonham CA, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2021;113996doi: 10.1016/j.ejmech.2021.113996.
Van Dort, M. E., Jang, Y., Bonham, C. A., Heist, K., Palagama, D. S. W., McDonald, L., Zhang, E. Z., Chenevert, T. L., Luker, G. D., & Ross, B. D. (2021). Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. European journal of medicinal chemistry, 113996. https://doi.org/10.1016/j.ejmech.2021.113996
Van Dort, Marcian E, et al. "Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors." European journal of medicinal chemistry vol. (2021): 113996. doi: https://doi.org/10.1016/j.ejmech.2021.113996
Van Dort ME, Jang Y, Bonham CA, Heist K, Palagama DSW, McDonald L, Zhang EZ, Chenevert TL, Luker GD, Ross BD. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2021 Nov 14;113996. doi: 10.1016/j.ejmech.2021.113996. Epub 2021 Nov 14. PMID: 34802837.
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Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders.

Journal of clinical medicine

van Dorst MEG, Rensen YCM, Husain M, Kessels RPC.
PMID: 34072955
J Clin Med. 2021 May 31;10(11). doi: 10.3390/jcm10112447.

Apathy is a fundamental neuropsychiatric symptom of Korsakoff's syndrome (KS) and has also been reported in patients with alcohol use disorder with no (AUD) or less severe cognitive impairments (ARCI). However, research on the nature of apathy is limited...

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van Dorst MEG, Rensen YCM, Husain M, et al. Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders. J Clin Med. 2021;10(11)doi: 10.3390/jcm10112447.
van Dorst, M. E. G., Rensen, Y. C. M., Husain, M., & Kessels, R. P. C. (2021). Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders. Journal of clinical medicine, 10(11), . https://doi.org/10.3390/jcm10112447
van Dorst, Maud E G, et al. "Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders." Journal of clinical medicine vol. 10,11 (2021). doi: https://doi.org/10.3390/jcm10112447
van Dorst MEG, Rensen YCM, Husain M, Kessels RPC. Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders. J Clin Med. 2021 May 31;10(11). doi: 10.3390/jcm10112447. PMID: 34072955; PMCID: PMC8197845.
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Anti-voltage-Gated Potassium Channel (VGKC) Antibodies and Acquired Neuromyotonia in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy X-Lined (IPEX) Syndrome.

Journal of clinical immunology

Moseley N, King J, Van Dort B, Williams S, Rodriguez-Casero V, Ramachandran S, Choo S, Cole T, McLean-Tooke A.
PMID: 34478044
J Clin Immunol. 2021 Nov;41(8):1972-1974. doi: 10.1007/s10875-021-01128-x. Epub 2021 Sep 03.

No abstract available.

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Moseley N, King J, Van Dort B, et al. Anti-voltage-Gated Potassium Channel (VGKC) Antibodies and Acquired Neuromyotonia in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy X-Lined (IPEX) Syndrome. J Clin Immunol. 2021;41(8):1972-1974doi: 10.1007/s10875-021-01128-x.
Moseley, N., King, J., Van Dort, B., Williams, S., Rodriguez-Casero, V., Ramachandran, S., Choo, S., Cole, T., & McLean-Tooke, A. (2021). Anti-voltage-Gated Potassium Channel (VGKC) Antibodies and Acquired Neuromyotonia in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy X-Lined (IPEX) Syndrome. Journal of clinical immunology, 41(8), 1972-1974. https://doi.org/10.1007/s10875-021-01128-x
Moseley, Natasha, et al. "Anti-voltage-Gated Potassium Channel (VGKC) Antibodies and Acquired Neuromyotonia in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy X-Lined (IPEX) Syndrome." Journal of clinical immunology vol. 41,8 (2021): 1972-1974. doi: https://doi.org/10.1007/s10875-021-01128-x
Moseley N, King J, Van Dort B, Williams S, Rodriguez-Casero V, Ramachandran S, Choo S, Cole T, McLean-Tooke A. Anti-voltage-Gated Potassium Channel (VGKC) Antibodies and Acquired Neuromyotonia in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy X-Lined (IPEX) Syndrome. J Clin Immunol. 2021 Nov;41(8):1972-1974. doi: 10.1007/s10875-021-01128-x. Epub 2021 Sep 03. PMID: 34478044.
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The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study.

PloS one

Menon JML, Ritskes-Hoitinga M, Pound P, van Oort E.
PMID: 34898637
PLoS One. 2021 Dec 13;16(12):e0260619. doi: 10.1371/journal.pone.0260619. eCollection 2021.

BACKGROUND: Systematic reviews (SRs) are cornerstones of evidence-based medicine and have contributed significantly to breakthroughs since the 1980's. However, preclinical SRs remain relatively rare despite their many advantages. Since 2011 the Dutch health funding organisation (ZonMw) has run a...

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Menon JML, Ritskes-Hoitinga M, Pound P, et al. The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PLoS One. 2021;16(12):e0260619doi: 10.1371/journal.pone.0260619.
Menon, J. M. L., Ritskes-Hoitinga, M., Pound, P., & van Oort, E. (2021). The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PloS one, 16(12), e0260619. https://doi.org/10.1371/journal.pone.0260619
Menon, Julia M L, et al. "The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study." PloS one vol. 16,12 (2021): e0260619. doi: https://doi.org/10.1371/journal.pone.0260619
Menon JML, Ritskes-Hoitinga M, Pound P, van Oort E. The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PLoS One. 2021 Dec 13;16(12):e0260619. doi: 10.1371/journal.pone.0260619. eCollection 2021. PMID: 34898637; PMCID: PMC8668092.
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The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study.

PloS one

Menon JML, Ritskes-Hoitinga M, Pound P, van Oort E.
PMID: 34898637
PLoS One. 2021 Dec 13;16(12):e0260619. doi: 10.1371/journal.pone.0260619. eCollection 2021.

BACKGROUND: Systematic reviews (SRs) are cornerstones of evidence-based medicine and have contributed significantly to breakthroughs since the 1980's. However, preclinical SRs remain relatively rare despite their many advantages. Since 2011 the Dutch health funding organisation (ZonMw) has run a...

Cite
Menon JML, Ritskes-Hoitinga M, Pound P, et al. The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PLoS One. 2021;16(12):e0260619doi: 10.1371/journal.pone.0260619.
Menon, J. M. L., Ritskes-Hoitinga, M., Pound, P., & van Oort, E. (2021). The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PloS one, 16(12), e0260619. https://doi.org/10.1371/journal.pone.0260619
Menon, Julia M L, et al. "The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study." PloS one vol. 16,12 (2021): e0260619. doi: https://doi.org/10.1371/journal.pone.0260619
Menon JML, Ritskes-Hoitinga M, Pound P, van Oort E. The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PLoS One. 2021 Dec 13;16(12):e0260619. doi: 10.1371/journal.pone.0260619. eCollection 2021. PMID: 34898637.
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A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts.

The International journal of artificial organs

van Dort DI, Thannhauser J, Morshuis WJ, Geuzebroek GS, Duncker DJ.
PMID: 33818165
Int J Artif Organs. 2021 Apr 05;3913988211003912. doi: 10.1177/03913988211003912. Epub 2021 Apr 05.

BACKGROUND: We recently demonstrated that a novel intra-ventricular membrane pump (IVMP) was able to increase the pump function of isolated beating porcine hearts. In follow-up, we now investigated the impact of the IVMP on myocardial oxygen consumption and total...

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van Dort DI, Thannhauser J, Morshuis WJ, et al. A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts. Int J Artif Organs. 2021;3913988211003912doi: 10.1177/03913988211003912.
van Dort, D. I., Thannhauser, J., Morshuis, W. J., Geuzebroek, G. S., & Duncker, D. J. (2021). A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts. The International journal of artificial organs, 3913988211003912. https://doi.org/10.1177/03913988211003912
van Dort, Daniël Im, et al. "A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts." The International journal of artificial organs vol. (2021): 3913988211003912. doi: https://doi.org/10.1177/03913988211003912
van Dort DI, Thannhauser J, Morshuis WJ, Geuzebroek GS, Duncker DJ. A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts. Int J Artif Organs. 2021 Apr 05;3913988211003912. doi: 10.1177/03913988211003912. Epub 2021 Apr 05. PMID: 33818165.
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Purification and Characterization of a [beta]-D-Xylosidase and an Endo-Xylanase from Wheat Flour.

Plant physiology

Cleemput G, Hessing M, Van Oort M, Deconynck M, Delcour JA.
PMID: 12223612
Plant Physiol. 1997 Feb;113(2):377-386. doi: 10.1104/pp.113.2.377.

A [beta]-D-xylosidase and an endo-xylanase were purified from European wheat (Triticum aestivum) flour. The [beta]-D-xylosidase had a molecular weight of approximately 64,000 and an isoelectric point of 5.5. It hydrolyzed p-nitrophenyl-[beta]-D-xylopyranoside and xylo-oligosaccharides and released D-xylose units from wheat...

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Cleemput G, Hessing M, Van Oort M, et al. Purification and Characterization of a [beta]-D-Xylosidase and an Endo-Xylanase from Wheat Flour. Plant Physiol. 1997;113(2):377-386doi: 10.1104/pp.113.2.377.
Cleemput, G., Hessing, M., Van Oort, M., Deconynck, M., & Delcour, J. A. (1997). Purification and Characterization of a [beta]-D-Xylosidase and an Endo-Xylanase from Wheat Flour. Plant physiology, 113(2), 377-386. https://doi.org/10.1104/pp.113.2.377
Cleemput, G., et al. "Purification and Characterization of a [beta]-D-Xylosidase and an Endo-Xylanase from Wheat Flour." Plant physiology vol. 113,2 (1997): 377-386. doi: https://doi.org/10.1104/pp.113.2.377
Cleemput G, Hessing M, Van Oort M, Deconynck M, Delcour JA. Purification and Characterization of a [beta]-D-Xylosidase and an Endo-Xylanase from Wheat Flour. Plant Physiol. 1997 Feb;113(2):377-386. doi: 10.1104/pp.113.2.377. PMID: 12223612; PMCID: PMC158151.
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Showing 1 to 12 of 43 entries