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Mediation and spillover effects in group-randomized trials: a case study of the 4Rs educational intervention

Educational trials

VanderWeele TJ, Hong G, Jones SM.
GSID: eXEVyqfs75cJ
TJ VanderWeele, G Hong, SM Jones… - Journal of the American …, 2013 - Taylor & Francis

Peer influence and social interactions can give rise to spillover effects in which the exposure of one individual may affect outcomes of other individuals. Even if the intervention under study occurs at the group or cluster level as in...

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VanderWeele, T. J., Hong, G., Jones, S. M., & Brown, J. L. (2013). Mediation and spillover effects in group-randomized trials: a case study of the 4Rs educational intervention. Journal of the American Statistical Association, 108(502), 469-482.
VanderWeele, Tyler J., et al. "Mediation and spillover effects in group-randomized trials: a case study of the 4Rs educational intervention." Journal of the American Statistical Association 108.502 (2013): 469-482.
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On the definition of a confounder.

Annals of statistics

VanderWeele TJ, Shpitser I.
PMID: 25544784
Ann Stat. 2013 Feb;41(1):196-220. doi: 10.1214/12-aos1058.

The causal inference literature has provided a clear formal definition of confounding expressed in terms of counterfactual independence. The causal inference literature has not, however, produced a clear formal definition of a confounder, as it has given priority to...

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VanderWeele TJ, Shpitser I. On the definition of a confounder. Ann Stat. 2013;41(1):196-220doi: 10.1214/12-aos1058.
VanderWeele, T. J., & Shpitser, I. (2013). On the definition of a confounder. Annals of statistics, 41(1), 196-220. https://doi.org/10.1214/12-aos1058
VanderWeele, Tyler J, and Shpitser, Ilya. "On the definition of a confounder." Annals of statistics vol. 41,1 (2013): 196-220. doi: https://doi.org/10.1214/12-aos1058
VanderWeele TJ, Shpitser I. On the definition of a confounder. Ann Stat. 2013 Feb;41(1):196-220. doi: 10.1214/12-aos1058. PMID: 25544784; PMCID: PMC4276366.
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Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders.

Epidemiology, biostatistics and public health

VanderWeele TJ, Chiba Y.
PMID: 25580387
Epidemiol Biostat Public Health. 2014;11(2). doi: 10.2427/9027.

Questions of mediation are often of interest in reasoning about mechanisms, and methods have been developed to address these questions. However, these methods make strong assumptions about the absence of confounding. Even if exposure is randomized, there may be...

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VanderWeele TJ, Chiba Y. Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders. Epidemiol Biostat Public Health. 2014;11(2)doi: 10.2427/9027.
VanderWeele, T. J., & Chiba, Y. (2014). Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders. Epidemiology, biostatistics and public health, 11(2), . https://doi.org/10.2427/9027
VanderWeele, Tyler J, and Chiba, Yasutaka. "Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders." Epidemiology, biostatistics and public health vol. 11,2 (2014). doi: https://doi.org/10.2427/9027
VanderWeele TJ, Chiba Y. Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders. Epidemiol Biostat Public Health. 2014;11(2). doi: 10.2427/9027. PMID: 25580387; PMCID: PMC4287391.
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Sensitivity analysis for contagion effects in social networks.

Sociological methods & research

VanderWeele TJ.
PMID: 25580037
Sociol Methods Res. 2011 May;40(2):240-255. doi: 10.1177/0049124111404821.

Analyses of social network data have suggested that obesity, smoking, happiness and loneliness all travel through social networks. Individuals exert "contagion effects" on one another through social ties and association. These analyses have come under critique because of the...

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VanderWeele TJ. Sensitivity analysis for contagion effects in social networks. Sociol Methods Res. 2011;40(2):240-255doi: 10.1177/0049124111404821.
VanderWeele, T. J. (2011). Sensitivity analysis for contagion effects in social networks. Sociological methods & research, 40(2), 240-255. https://doi.org/10.1177/0049124111404821
VanderWeele, Tyler J. "Sensitivity analysis for contagion effects in social networks." Sociological methods & research vol. 40,2 (2011): 240-255. doi: https://doi.org/10.1177/0049124111404821
VanderWeele TJ. Sensitivity analysis for contagion effects in social networks. Sociol Methods Res. 2011 May;40(2):240-255. doi: 10.1177/0049124111404821. PMID: 25580037; PMCID: PMC4288024.
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Physical Activity and Physical and Mental Well-Being in Church Settings.

American journal of public health

VanderWeele TJ.
PMID: 28590873
Am J Public Health. 2017 Jul;107(7):1023-1024. doi: 10.2105/AJPH.2017.303843.

No abstract available.

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VanderWeele TJ. Physical Activity and Physical and Mental Well-Being in Church Settings. Am J Public Health. 2017;107(7):1023-1024doi: 10.2105/AJPH.2017.303843.
VanderWeele, T. J. (2017). Physical Activity and Physical and Mental Well-Being in Church Settings. American journal of public health, 107(7), 1023-1024. https://doi.org/10.2105/AJPH.2017.303843
VanderWeele, Tyler J. "Physical Activity and Physical and Mental Well-Being in Church Settings." American journal of public health vol. 107,7 (2017): 1023-1024. doi: https://doi.org/10.2105/AJPH.2017.303843
VanderWeele TJ. Physical Activity and Physical and Mental Well-Being in Church Settings. Am J Public Health. 2017 Jul;107(7):1023-1024. doi: 10.2105/AJPH.2017.303843. PMID: 28590873; PMCID: PMC5463232.
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Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report.

Frontiers in oncology

VanderWeele DJ, Paner GP, Fleming GF, Szmulewitz RZ.
PMID: 26258074
Front Oncol. 2015 Jul 22;5:169. doi: 10.3389/fonc.2015.00169. eCollection 2015.

Solid tumors harboring BRCA1 or BRCA2 mutations have been shown to respond to PARP inhibitors. These responses are partial and transient. In this case report, we describe an 82-year-old male with poorly differentiated prostate cancer with metastases to the...

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VanderWeele DJ, Paner GP, Fleming GF, et al. Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report. Front Oncol. 2015;5:169doi: 10.3389/fonc.2015.00169.
VanderWeele, D. J., Paner, G. P., Fleming, G. F., & Szmulewitz, R. Z. (2015). Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report. Frontiers in oncology, 5169. https://doi.org/10.3389/fonc.2015.00169
VanderWeele, David J, et al. "Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report." Frontiers in oncology vol. 5 (2015): 169. doi: https://doi.org/10.3389/fonc.2015.00169
VanderWeele DJ, Paner GP, Fleming GF, Szmulewitz RZ. Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report. Front Oncol. 2015 Jul 22;5:169. doi: 10.3389/fonc.2015.00169. eCollection 2015. PMID: 26258074; PMCID: PMC4510409.
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Sharp sensitivity bounds for mediation under unmeasured mediator-outcome confounding.

Biometrika

Ding P, Vanderweele TJ.
PMID: 27279672
Biometrika. 2016 Jun;103(2):483-490. doi: 10.1093/biomet/asw012. Epub 2016 Apr 30.

It is often of interest to decompose the total effect of an exposure into a component that acts on the outcome through some mediator and a component that acts independently through other pathways. Said another way, we are interested...

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Ding P, Vanderweele TJ. Sharp sensitivity bounds for mediation under unmeasured mediator-outcome confounding. Biometrika. 2016;103(2):483-490doi: 10.1093/biomet/asw012.
Ding, P., & Vanderweele, T. J. (2016). Sharp sensitivity bounds for mediation under unmeasured mediator-outcome confounding. Biometrika, 103(2), 483-490. https://doi.org/10.1093/biomet/asw012
Ding, Peng, and Vanderweele, Tyler J. "Sharp sensitivity bounds for mediation under unmeasured mediator-outcome confounding." Biometrika vol. 103,2 (2016): 483-490. doi: https://doi.org/10.1093/biomet/asw012
Ding P, Vanderweele TJ. Sharp sensitivity bounds for mediation under unmeasured mediator-outcome confounding. Biometrika. 2016 Jun;103(2):483-490. doi: 10.1093/biomet/asw012. Epub 2016 Apr 30. PMID: 27279672; PMCID: PMC4890130.
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Directed acyclic graphs with edge-specific bounds.

Biometrika

Vanderweele TJ, Tan Z.
PMID: 23049135
Biometrika. 2012 Mar;99(1):115-126. doi: 10.1093/biomet/asr059. Epub 2011 Dec 20.

We give a definition of a bounded edge within the causal directed acyclic graph framework. A bounded edge generalizes the notion of a signed edge and is defined in terms of bounds on a ratio of survivor probabilities. We...

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Vanderweele TJ, Tan Z. Directed acyclic graphs with edge-specific bounds. Biometrika. 2011;99(1):115-126doi: 10.1093/biomet/asr059.
Vanderweele, T. J., & Tan, Z. (2012). Directed acyclic graphs with edge-specific bounds. Biometrika, 99(1), 115-126. https://doi.org/10.1093/biomet/asr059
Vanderweele, Tyler J, and Tan, Zhiqiang. "Directed acyclic graphs with edge-specific bounds." Biometrika vol. 99,1 (2012): 115-126. doi: https://doi.org/10.1093/biomet/asr059
Vanderweele TJ, Tan Z. Directed acyclic graphs with edge-specific bounds. Biometrika. 2012 Mar;99(1):115-126. doi: 10.1093/biomet/asr059. Epub 2011 Dec 20. PMID: 23049135; PMCID: PMC3412607.
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SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?.

American journal of epidemiology

VanderWeele TJ, Mathur MB.
PMID: 30452538
Am J Epidemiol. 2019 Mar 01;188(3):617-618. doi: 10.1093/aje/kwy250.

No abstract available.

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VanderWeele TJ, Mathur MB. SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?. Am J Epidemiol. 2019;188(3):617-618doi: 10.1093/aje/kwy250.
VanderWeele, T. J., & Mathur, M. B. (2019). SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?. American journal of epidemiology, 188(3), 617-618. https://doi.org/10.1093/aje/kwy250
VanderWeele, Tyler J, and Mathur, Maya B. "SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?." American journal of epidemiology vol. 188,3 (2019): 617-618. doi: https://doi.org/10.1093/aje/kwy250
VanderWeele TJ, Mathur MB. SOME DESIRABLE PROPERTIES OF THE BONFERRONI CORRECTION: IS THE BONFERRONI CORRECTION REALLY SO BAD?. Am J Epidemiol. 2019 Mar 01;188(3):617-618. doi: 10.1093/aje/kwy250. PMID: 30452538; PMCID: PMC6395159.
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Effect partitioning under interference in two-stage randomized vaccine trials.

Statistics & probability letters

Vanderweele TJ, Tchetgen Tchetgen EJ.
PMID: 21532912
Stat Probab Lett. 2011 Jul 01;81(7):861-869. doi: 10.1016/j.spl.2011.02.019.

In the presence of interference, the exposure of one individual may affect the outcomes of others. We provide new effect partitioning results under interferences that express the overall effect as a sum of (i) the indirect (or spillover) effect...

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Vanderweele TJ, Tchetgen Tchetgen EJ. Effect partitioning under interference in two-stage randomized vaccine trials. Stat Probab Lett. 2011;81(7):861-869doi: 10.1016/j.spl.2011.02.019.
Vanderweele, T. J., & Tchetgen Tchetgen, E. J. (2011). Effect partitioning under interference in two-stage randomized vaccine trials. Statistics & probability letters, 81(7), 861-869. https://doi.org/10.1016/j.spl.2011.02.019
Vanderweele, Tyler J, and Tchetgen Tchetgen, Eric J. "Effect partitioning under interference in two-stage randomized vaccine trials." Statistics & probability letters vol. 81,7 (2011): 861-869. doi: https://doi.org/10.1016/j.spl.2011.02.019
Vanderweele TJ, Tchetgen Tchetgen EJ. Effect partitioning under interference in two-stage randomized vaccine trials. Stat Probab Lett. 2011 Jul 01;81(7):861-869. doi: 10.1016/j.spl.2011.02.019. PMID: 21532912; PMCID: PMC3084013.
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Can post-neoadjuvant therapy molecular classification guide future treatment selection for muscle-invasive bladder cancer?.

Translational andrology and urology

VanderWeele DJ, Meeks JJ, Hussain M.
PMID: 31143677
Transl Androl Urol. 2019 Mar;8:S91-S92. doi: 10.21037/tau.2018.12.07.

No abstract available.

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VanderWeele DJ, Meeks JJ, Hussain M. Can post-neoadjuvant therapy molecular classification guide future treatment selection for muscle-invasive bladder cancer?. Transl Androl Urol. 2019;8:S91-S92doi: 10.21037/tau.2018.12.07.
VanderWeele, D. J., Meeks, J. J., & Hussain, M. (2019). Can post-neoadjuvant therapy molecular classification guide future treatment selection for muscle-invasive bladder cancer?. Translational andrology and urology, 8S91-S92. https://doi.org/10.21037/tau.2018.12.07
VanderWeele, David J, et al. "Can post-neoadjuvant therapy molecular classification guide future treatment selection for muscle-invasive bladder cancer?." Translational andrology and urology vol. 8 (2019): S91-S92. doi: https://doi.org/10.21037/tau.2018.12.07
VanderWeele DJ, Meeks JJ, Hussain M. Can post-neoadjuvant therapy molecular classification guide future treatment selection for muscle-invasive bladder cancer?. Transl Androl Urol. 2019 Mar;8:S91-S92. doi: 10.21037/tau.2018.12.07. PMID: 31143677; PMCID: PMC6511695.
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How to report E-values for meta-analyses: Recommended improvements and additions to the new GRADE approach.

Environment international

Mathur MB, VanderWeele TJ.
PMID: 34954645
Environ Int. 2021 Dec 24;160:107032. doi: 10.1016/j.envint.2021.107032. Epub 2021 Dec 24.

In a recent concept paper (Verbeek et al., 2021), the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group provides a preliminary proposal to improve its existing guidelines for assessing sensitivity to uncontrolled confounding in meta-analyses of nonrandomized...

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Mathur MB, VanderWeele TJ. How to report E-values for meta-analyses: Recommended improvements and additions to the new GRADE approach. Environ Int. 2021;160:107032doi: 10.1016/j.envint.2021.107032.
Mathur, M. B., & VanderWeele, T. J. (2021). How to report E-values for meta-analyses: Recommended improvements and additions to the new GRADE approach. Environment international, 160107032. https://doi.org/10.1016/j.envint.2021.107032
Mathur, Maya B, and VanderWeele, Tyler J. "How to report E-values for meta-analyses: Recommended improvements and additions to the new GRADE approach." Environment international vol. 160 (2021): 107032. doi: https://doi.org/10.1016/j.envint.2021.107032
Mathur MB, VanderWeele TJ. How to report E-values for meta-analyses: Recommended improvements and additions to the new GRADE approach. Environ Int. 2021 Dec 24;160:107032. doi: 10.1016/j.envint.2021.107032. Epub 2021 Dec 24. PMID: 34954645.
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Showing 1 to 12 of 148 entries