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Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.

Human genomics

Ganel L, Chen L, Christ R, Vangipurapu J, Young E, Das I, Kanchi K, Larson D, Regier A, Abel H, Kang CJ, Scott A, Havulinna A, Chiang CWK, Service S, Freimer N, Palotie A, Ripatti S, Kuusisto J, Boehnke M, Laakso M, Locke A, Stitziel NO, Hall IM.
PMID: 34099068
Hum Genomics. 2021 Jun 07;15(1):34. doi: 10.1186/s40246-021-00335-2.

BACKGROUND: Mitochondrial genome copy number (MT-CN) varies among humans and across tissues and is highly heritable, but its causes and consequences are not well understood. When measured by bulk DNA sequencing in blood, MT-CN may reflect a combination of...

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Ganel L, Chen L, Christ R, et al. Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences. Hum Genomics. 2021;15(1):34doi: 10.1186/s40246-021-00335-2.
Ganel, L., Chen, L., Christ, R., Vangipurapu, J., Young, E., Das, I., Kanchi, K., Larson, D., Regier, A., Abel, H., Kang, C. J., Scott, A., Havulinna, A., Chiang, C. W. K., Service, S., Freimer, N., Palotie, A., Ripatti, S., Kuusisto, J., Boehnke, M., Laakso, M., Locke, A., Stitziel, N. O., & Hall, I. M. (2021). Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences. Human genomics, 15(1), 34. https://doi.org/10.1186/s40246-021-00335-2
Ganel, Liron, et al. "Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences." Human genomics vol. 15,1 (2021): 34. doi: https://doi.org/10.1186/s40246-021-00335-2
Ganel L, Chen L, Christ R, Vangipurapu J, Young E, Das I, Kanchi K, Larson D, Regier A, Abel H, Kang CJ, Scott A, Havulinna A, Chiang CWK, Service S, Freimer N, Palotie A, Ripatti S, Kuusisto J, Boehnke M, Laakso M, Locke A, Stitziel NO, Hall IM. Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences. Hum Genomics. 2021 Jun 07;15(1):34. doi: 10.1186/s40246-021-00335-2. PMID: 34099068; PMCID: PMC8185936.
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The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study.

The Journal of clinical endocrinology and metabolism

Jauhiainen R, Vangipurapu J, Laakso A, Kuulasmaa T, Kuusisto J, Laakso M.
PMID: 34346487
J Clin Endocrinol Metab. 2021 Nov 19;106(12):3448-3454. doi: 10.1210/clinem/dgab562.

BACKGROUND AND AIMS: To investigate the significance of 9 amino acids as risk factors for incident cardiovascular disease events in 9584 Finnish men.MATERIALS AND METHODS: A total of 9584 men (age 57.4 ± 7.0 years, body mass index 27.2...

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Jauhiainen R, Vangipurapu J, Laakso A, et al. The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study. J Clin Endocrinol Metab. 2021;106(12):3448-3454doi: 10.1210/clinem/dgab562.
Jauhiainen, R., Vangipurapu, J., Laakso, A., Kuulasmaa, T., Kuusisto, J., & Laakso, M. (2021). The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study. The Journal of clinical endocrinology and metabolism, 106(12), 3448-3454. https://doi.org/10.1210/clinem/dgab562
Jauhiainen, Raimo, et al. "The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study." The Journal of clinical endocrinology and metabolism vol. 106,12 (2021): 3448-3454. doi: https://doi.org/10.1210/clinem/dgab562
Jauhiainen R, Vangipurapu J, Laakso A, Kuulasmaa T, Kuusisto J, Laakso M. The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study. J Clin Endocrinol Metab. 2021 Nov 19;106(12):3448-3454. doi: 10.1210/clinem/dgab562. PMID: 34346487; PMCID: PMC8634085.
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The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study.

The Journal of clinical endocrinology and metabolism

Jauhiainen R, Vangipurapu J, Laakso A, Kuulasmaa T, Kuusisto J, Laakso M.
PMID: 34346487
J Clin Endocrinol Metab. 2021 Nov 19;106(12):3448-3454. doi: 10.1210/clinem/dgab562.

BACKGROUND AND AIMS: To investigate the significance of 9 amino acids as risk factors for incident cardiovascular disease events in 9584 Finnish men.MATERIALS AND METHODS: A total of 9584 men (age 57.4 ± 7.0 years, body mass index 27.2...

Cite
Jauhiainen R, Vangipurapu J, Laakso A, et al. The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study. J Clin Endocrinol Metab. 2021;106(12):3448-3454doi: 10.1210/clinem/dgab562.
Jauhiainen, R., Vangipurapu, J., Laakso, A., Kuulasmaa, T., Kuusisto, J., & Laakso, M. (2021). The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study. The Journal of clinical endocrinology and metabolism, 106(12), 3448-3454. https://doi.org/10.1210/clinem/dgab562
Jauhiainen, Raimo, et al. "The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study." The Journal of clinical endocrinology and metabolism vol. 106,12 (2021): 3448-3454. doi: https://doi.org/10.1210/clinem/dgab562
Jauhiainen R, Vangipurapu J, Laakso A, Kuulasmaa T, Kuusisto J, Laakso M. The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study. J Clin Endocrinol Metab. 2021 Nov 19;106(12):3448-3454. doi: 10.1210/clinem/dgab562. PMID: 34346487; PMCID: PMC8634085.
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Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kazi A, Chen L, Xiang S, Vangipurapu R, Yang H, Beato F, Fang B, Williams TM, Husain K, Underwood P, Fleming JB, Malafa M, Welsh EA, Koomen J, Trevino J, Sebti SM.
PMID: 33879459
Clin Cancer Res. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20.

PURPOSE: Among human cancers that harbor mutant (mt) KRas, some, but not all, are dependent on mt KRas. However, little is known about what drives KRas dependency.EXPERIMENTAL DESIGN: Global phosphoproteomics, screening of a chemical library of FDA drugs, and...

Cite
Kazi A, Chen L, Xiang S, et al. Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clin Cancer Res. 2021;27(14):4012-4024doi: 10.1158/1078-0432.CCR-20-4781.
Kazi, A., Chen, L., Xiang, S., Vangipurapu, R., Yang, H., Beato, F., Fang, B., Williams, T. M., Husain, K., Underwood, P., Fleming, J. B., Malafa, M., Welsh, E. A., Koomen, J., Trevino, J., & Sebti, S. M. (2021). Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(14), 4012-4024. https://doi.org/10.1158/1078-0432.CCR-20-4781
Kazi, Aslamuzzaman, et al. "Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,14 (2021): 4012-4024. doi: https://doi.org/10.1158/1078-0432.CCR-20-4781
Kazi A, Chen L, Xiang S, Vangipurapu R, Yang H, Beato F, Fang B, Williams TM, Husain K, Underwood P, Fleming JB, Malafa M, Welsh EA, Koomen J, Trevino J, Sebti SM. Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clin Cancer Res. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20. PMID: 33879459; PMCID: PMC8493485.
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Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kazi A, Chen L, Xiang S, Vangipurapu R, Yang H, Beato F, Fang B, Williams TM, Husain K, Underwood P, Fleming JB, Malafa M, Welsh EA, Koomen J, Trevino J, Sebti SM.
PMID: 33879459
Clin Cancer Res. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20.

PURPOSE: Among human cancers that harbor mutant (mt) KRas, some, but not all, are dependent on mt KRas. However, little is known about what drives KRas dependency.EXPERIMENTAL DESIGN: Global phosphoproteomics, screening of a chemical library of FDA drugs, and...

Cite
Kazi A, Chen L, Xiang S, et al. Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clin Cancer Res. 2021;27(14):4012-4024doi: 10.1158/1078-0432.CCR-20-4781.
Kazi, A., Chen, L., Xiang, S., Vangipurapu, R., Yang, H., Beato, F., Fang, B., Williams, T. M., Husain, K., Underwood, P., Fleming, J. B., Malafa, M., Welsh, E. A., Koomen, J., Trevino, J., & Sebti, S. M. (2021). Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(14), 4012-4024. https://doi.org/10.1158/1078-0432.CCR-20-4781
Kazi, Aslamuzzaman, et al. "Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,14 (2021): 4012-4024. doi: https://doi.org/10.1158/1078-0432.CCR-20-4781
Kazi A, Chen L, Xiang S, Vangipurapu R, Yang H, Beato F, Fang B, Williams TM, Husain K, Underwood P, Fleming JB, Malafa M, Welsh EA, Koomen J, Trevino J, Sebti SM. Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clin Cancer Res. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20. PMID: 33879459; PMCID: PMC8493485.
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Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kazi A, Chen L, Xiang S, Vangipurapu R, Yang H, Beato F, Fang B, Williams TM, Husain K, Underwood P, Fleming JB, Malafa M, Welsh EA, Koomen J, Trevino J, Sebti SM.
PMID: 33879459
Clin Cancer Res. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20.

PURPOSE: Among human cancers that harbor mutant (mt) KRas, some, but not all, are dependent on mt KRas. However, little is known about what drives KRas dependency.EXPERIMENTAL DESIGN: Global phosphoproteomics, screening of a chemical library of FDA drugs, and...

Cite
Kazi A, Chen L, Xiang S, et al. Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clin Cancer Res. 2021;27(14):4012-4024doi: 10.1158/1078-0432.CCR-20-4781.
Kazi, A., Chen, L., Xiang, S., Vangipurapu, R., Yang, H., Beato, F., Fang, B., Williams, T. M., Husain, K., Underwood, P., Fleming, J. B., Malafa, M., Welsh, E. A., Koomen, J., Trevino, J., & Sebti, S. M. (2021). Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(14), 4012-4024. https://doi.org/10.1158/1078-0432.CCR-20-4781
Kazi, Aslamuzzaman, et al. "Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,14 (2021): 4012-4024. doi: https://doi.org/10.1158/1078-0432.CCR-20-4781
Kazi A, Chen L, Xiang S, Vangipurapu R, Yang H, Beato F, Fang B, Williams TM, Husain K, Underwood P, Fleming JB, Malafa M, Welsh EA, Koomen J, Trevino J, Sebti SM. Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer. Clin Cancer Res. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20. PMID: 33879459; PMCID: PMC8493485.
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The "Common Soil Hypothesis" Revisited-Risk Factors for Type 2 Diabetes and Cardiovascular Disease.

Metabolites

Fernandes Silva L, Vangipurapu J, Laakso M.
PMID: 34677406
Metabolites. 2021 Oct 09;11(10). doi: 10.3390/metabo11100691.

The prevalence and the incidence of type 2 diabetes (T2D), representing >90% of all cases of diabetes, are increasing rapidly worldwide. Identification of individuals at high risk of developing diabetes is of great importance, as early interventions might delay...

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Fernandes Silva L, Vangipurapu J, Laakso M. The "Common Soil Hypothesis" Revisited-Risk Factors for Type 2 Diabetes and Cardiovascular Disease. Metabolites. 2021;11(10)doi: 10.3390/metabo11100691.
Fernandes Silva, L., Vangipurapu, J., & Laakso, M. (2021). The "Common Soil Hypothesis" Revisited-Risk Factors for Type 2 Diabetes and Cardiovascular Disease. Metabolites, 11(10), . https://doi.org/10.3390/metabo11100691
Fernandes Silva, Lilian, et al. "The "Common Soil Hypothesis" Revisited-Risk Factors for Type 2 Diabetes and Cardiovascular Disease." Metabolites vol. 11,10 (2021). doi: https://doi.org/10.3390/metabo11100691
Fernandes Silva L, Vangipurapu J, Laakso M. The "Common Soil Hypothesis" Revisited-Risk Factors for Type 2 Diabetes and Cardiovascular Disease. Metabolites. 2021 Oct 09;11(10). doi: 10.3390/metabo11100691. PMID: 34677406; PMCID: PMC8540397.
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Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power.

Nature

Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H, Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, Freimer NB.
PMID: 31686056
Nature. 2019 Nov;575(7783):E4. doi: 10.1038/s41586-019-1726-x.

An Amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cite
Locke AE, Steinberg KM, Chiang CWK, et al. Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power. Nature. 2019;575(7783):E4doi: 10.1038/s41586-019-1726-x.
Locke, A. E., Steinberg, K. M., Chiang, C. W. K., Service, S. K., Havulinna, A. S., Stell, L., Pirinen, M., Abel, H. J., Chiang, C. C., Fulton, R. S., Jackson, A. U., Kang, C. J., Kanchi, K. L., Koboldt, D. C., Larson, D. E., Nelson, J., Nicholas, T. J., Pietilä, A., Ramensky, V., Ray, D., Scott, L. J., Stringham, H. M., Vangipurapu, J., Welch, R., Yajnik, P., Yin, X., Eriksson, J. G., Ala-Korpela, M., Järvelin, M. R., Männikkö, M., Laivuori, H., Dutcher, S. K., Stitziel, N. O., Wilson, R. K., Hall, I. M., Sabatti, C., Palotie, A., Salomaa, V., Laakso, M., Ripatti, S., Boehnke, M., & Freimer, N. B. (2019). Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power. Nature, 575(7783), E4. https://doi.org/10.1038/s41586-019-1726-x
Locke, Adam E, et al. "Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power." Nature vol. 575,7783 (2019): E4. doi: https://doi.org/10.1038/s41586-019-1726-x
Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H, Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, Freimer NB. Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power. Nature. 2019 Nov;575(7783):E4. doi: 10.1038/s41586-019-1726-x. PMID: 31686056.
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