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Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying.

Analytical chemistry

Brouckaert D, De Meyer L, Vanbillemont B, Van Bockstal PJ, Lammens J, Mortier S, Corver J, Vervaet C, Nopens I, De Beer T.
PMID: 29528218
Anal Chem. 2018 Apr 03;90(7):4354-4362. doi: 10.1021/acs.analchem.7b03647. Epub 2018 Mar 16.

Near-infrared chemical imaging (NIR-CI) is an emerging tool for process monitoring because it combines the chemical selectivity of vibrational spectroscopy with spatial information. Whereas traditional near-infrared spectroscopy is an attractive technique for water content determination and solid-state investigation of...

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Brouckaert D, De Meyer L, Vanbillemont B, et al. Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying. Anal Chem. 2018;90(7):4354-4362doi: 10.1021/acs.analchem.7b03647.
Brouckaert, D., De Meyer, L., Vanbillemont, B., Van Bockstal, P. J., Lammens, J., Mortier, S., Corver, J., Vervaet, C., Nopens, I., & De Beer, T. (2018). Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying. Analytical chemistry, 90(7), 4354-4362. https://doi.org/10.1021/acs.analchem.7b03647
Brouckaert, Davinia, et al. "Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying." Analytical chemistry vol. 90,7 (2018): 4354-4362. doi: https://doi.org/10.1021/acs.analchem.7b03647
Brouckaert D, De Meyer L, Vanbillemont B, Van Bockstal PJ, Lammens J, Mortier S, Corver J, Vervaet C, Nopens I, De Beer T. Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying. Anal Chem. 2018 Apr 03;90(7):4354-4362. doi: 10.1021/acs.analchem.7b03647. Epub 2018 Mar 16. PMID: 29528218.
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Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process.

Pharmaceutics

Vandevivere L, Vangampelaere M, Portier C, de Backere C, Häusler O, De Beer T, Vervaet C, Vanhoorne V.
PMID: 33546383
Pharmaceutics. 2021 Feb 03;13(2). doi: 10.3390/pharmaceutics13020210.

The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely on a scientific approach to enable...

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Vandevivere L, Vangampelaere M, Portier C, et al. Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process. Pharmaceutics. 2021;13(2)doi: 10.3390/pharmaceutics13020210.
Vandevivere, L., Vangampelaere, M., Portier, C., de Backere, C., Häusler, O., De Beer, T., Vervaet, C., & Vanhoorne, V. (2021). Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process. Pharmaceutics, 13(2), . https://doi.org/10.3390/pharmaceutics13020210
Vandevivere, Lise, et al. "Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process." Pharmaceutics vol. 13,2 (2021). doi: https://doi.org/10.3390/pharmaceutics13020210
Vandevivere L, Vangampelaere M, Portier C, de Backere C, Häusler O, De Beer T, Vervaet C, Vanhoorne V. Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process. Pharmaceutics. 2021 Feb 03;13(2). doi: 10.3390/pharmaceutics13020210. PMID: 33546383; PMCID: PMC7913514.
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A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying.

Pharmaceutics

Leys L, Nuytten G, Lammens J, Van Bockstal PJ, Corver J, Vervaet C, De Beer T.
PMID: 34959449
Pharmaceutics. 2021 Dec 16;13(12). doi: 10.3390/pharmaceutics13122168.

The pharmaceutical industry is progressing toward the development of more continuous manufacturing techniques. At the same time, the industry is striving toward more process understanding and improved process control, which requires the implementation of process analytical technology tools (PAT)....

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Leys L, Nuytten G, Lammens J, et al. A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying. Pharmaceutics. 2021;13(12)doi: 10.3390/pharmaceutics13122168.
Leys, L., Nuytten, G., Lammens, J., Van Bockstal, P. J., Corver, J., Vervaet, C., & De Beer, T. (2021). A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying. Pharmaceutics, 13(12), . https://doi.org/10.3390/pharmaceutics13122168
Leys, Laurens, et al. "A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying." Pharmaceutics vol. 13,12 (2021). doi: https://doi.org/10.3390/pharmaceutics13122168
Leys L, Nuytten G, Lammens J, Van Bockstal PJ, Corver J, Vervaet C, De Beer T. A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying. Pharmaceutics. 2021 Dec 16;13(12). doi: 10.3390/pharmaceutics13122168. PMID: 34959449; PMCID: PMC8708275.
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In-depth analysis of the long-term processability of materials during continuous feeding.

International journal of pharmaceutics

Bekaert B, Van Snick B, Pandelaere K, Dhondt J, Di Pretoro G, De Beer T, Vervaet C, Vanhoorne V.
PMID: 35026314
Int J Pharm. 2022 Jan 10;121454. doi: 10.1016/j.ijpharm.2022.121454. Epub 2022 Jan 10.

This study determined the feasibility of long-term continuous powder feeding and its effect on the overall process performance. Additionally, quantitative relationships were established between material properties, process settings and screw feeding responses during gravimetric feeding. Twelve divergent raw materials...

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Bekaert B, Van Snick B, Pandelaere K, et al. In-depth analysis of the long-term processability of materials during continuous feeding. Int J Pharm. 2022;121454doi: 10.1016/j.ijpharm.2022.121454.
Bekaert, B., Van Snick, B., Pandelaere, K., Dhondt, J., Di Pretoro, G., De Beer, T., Vervaet, C., & Vanhoorne, V. (2022). In-depth analysis of the long-term processability of materials during continuous feeding. International journal of pharmaceutics, 121454. https://doi.org/10.1016/j.ijpharm.2022.121454
Bekaert, B, et al. "In-depth analysis of the long-term processability of materials during continuous feeding." International journal of pharmaceutics vol. (2022): 121454. doi: https://doi.org/10.1016/j.ijpharm.2022.121454
Bekaert B, Van Snick B, Pandelaere K, Dhondt J, Di Pretoro G, De Beer T, Vervaet C, Vanhoorne V. In-depth analysis of the long-term processability of materials during continuous feeding. Int J Pharm. 2022 Jan 10;121454. doi: 10.1016/j.ijpharm.2022.121454. Epub 2022 Jan 10. PMID: 35026314.
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Accelerated theta burst stimulation in a case of therapy-resistant depression developed after left anterior temporal lobectomy.

Brain stimulation

Baeken C, De Witte S, Tandt H, Vervaet J, Lemmens GM.
PMID: 32871262
Brain Stimul. 2020 Nov - Dec;13(6):1519-1520. doi: 10.1016/j.brs.2020.08.010. Epub 2020 Aug 29.

No abstract available.

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Baeken C, De Witte S, Tandt H, et al. Accelerated theta burst stimulation in a case of therapy-resistant depression developed after left anterior temporal lobectomy. Brain Stimul. 2020;13(6):1519-1520doi: 10.1016/j.brs.2020.08.010.
Baeken, C., De Witte, S., Tandt, H., Vervaet, J., & Lemmens, G. M. (2020). Accelerated theta burst stimulation in a case of therapy-resistant depression developed after left anterior temporal lobectomy. Brain stimulation, 13(6), 1519-1520. https://doi.org/10.1016/j.brs.2020.08.010
Baeken, Chris, et al. "Accelerated theta burst stimulation in a case of therapy-resistant depression developed after left anterior temporal lobectomy." Brain stimulation vol. 13,6 (2020): 1519-1520. doi: https://doi.org/10.1016/j.brs.2020.08.010
Baeken C, De Witte S, Tandt H, Vervaet J, Lemmens GM. Accelerated theta burst stimulation in a case of therapy-resistant depression developed after left anterior temporal lobectomy. Brain Stimul. 2020 Nov - Dec;13(6):1519-1520. doi: 10.1016/j.brs.2020.08.010. Epub 2020 Aug 29. PMID: 32871262.
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A new rigid gas-permeable semi-scleral contact lens for treatment of corneal surface disorders.

Contact lens & anterior eye : the journal of the British Contact Lens Association

Vreugdenhil W, Geerards AJ, Vervaet CJ.
PMID: 16303383
Cont Lens Anterior Eye. 1998;21(3):85-8. doi: 10.1016/s1367-0484(98)80028-3.

Some extreme corneal irregularities cannot be treated adequately with corneal contact lenses. For such cases a rigid semi-scleral lens can be prescribed. We evaluated the use of a highly gas permeable rigid semi scleral lens in patients with diseased...

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Vreugdenhil W, Geerards AJ, Vervaet CJ. A new rigid gas-permeable semi-scleral contact lens for treatment of corneal surface disorders. Cont Lens Anterior Eye. 1998;21(3):85-8doi: 10.1016/s1367-0484(98)80028-3.
Vreugdenhil, W., Geerards, A. J., & Vervaet, C. J. (1998). A new rigid gas-permeable semi-scleral contact lens for treatment of corneal surface disorders. Contact lens & anterior eye : the journal of the British Contact Lens Association, 21(3), 85-8. https://doi.org/10.1016/s1367-0484(98)80028-3
Vreugdenhil, W, et al. "A new rigid gas-permeable semi-scleral contact lens for treatment of corneal surface disorders." Contact lens & anterior eye : the journal of the British Contact Lens Association vol. 21,3 (1998): 85-8. doi: https://doi.org/10.1016/s1367-0484(98)80028-3
Vreugdenhil W, Geerards AJ, Vervaet CJ. A new rigid gas-permeable semi-scleral contact lens for treatment of corneal surface disorders. Cont Lens Anterior Eye. 1998;21(3):85-8. doi: 10.1016/s1367-0484(98)80028-3. PMID: 16303383.
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Development of a fluid bed granulation process control strategy based on real-time process and product measurements.

Talanta

Burggraeve A, Silva AF, Van den Kerkhof T, Hellings M, Vervaet C, Remon JP, Vander Heyden Y, De Beer T.
PMID: 23141340
Talanta. 2012 Oct 15;100:293-302. doi: 10.1016/j.talanta.2012.07.054. Epub 2012 Jul 27.

This article describes the results of three case studies conducted consecutively, in order to develop a process control strategy for a top-spray fluid bed granulation process. The use of several real-time particle size (i.e., spatial filter velocimetry and focused...

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Burggraeve A, Silva AF, Van den Kerkhof T, et al. Development of a fluid bed granulation process control strategy based on real-time process and product measurements. Talanta. 2012;100:293-302doi: 10.1016/j.talanta.2012.07.054.
Burggraeve, A., Silva, A. F., Van den Kerkhof, T., Hellings, M., Vervaet, C., Remon, J. P., Vander Heyden, Y., & De Beer, T. (2012). Development of a fluid bed granulation process control strategy based on real-time process and product measurements. Talanta, 100293-302. https://doi.org/10.1016/j.talanta.2012.07.054
Burggraeve, Anneleen, et al. "Development of a fluid bed granulation process control strategy based on real-time process and product measurements." Talanta vol. 100 (2012): 293-302. doi: https://doi.org/10.1016/j.talanta.2012.07.054
Burggraeve A, Silva AF, Van den Kerkhof T, Hellings M, Vervaet C, Remon JP, Vander Heyden Y, De Beer T. Development of a fluid bed granulation process control strategy based on real-time process and product measurements. Talanta. 2012 Oct 15;100:293-302. doi: 10.1016/j.talanta.2012.07.054. Epub 2012 Jul 27. PMID: 23141340.
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In-depth analysis of the long-term processability of materials during continuous feeding.

International journal of pharmaceutics

Bekaert B, Van Snick B, Pandelaere K, Dhondt J, Di Pretoro G, De Beer T, Vervaet C, Vanhoorne V.
PMID: 35026314
Int J Pharm. 2022 Jan 10;614:121454. doi: 10.1016/j.ijpharm.2022.121454. Epub 2022 Jan 10.

This study determined the feasibility of long-term continuous powder feeding and its effect on the overall process performance. Additionally, quantitative relationships were established between material properties, process settings and screw feeding responses during gravimetric feeding. Twelve divergent raw materials...

Cite
Bekaert B, Van Snick B, Pandelaere K, et al. In-depth analysis of the long-term processability of materials during continuous feeding. Int J Pharm. 2022;614:121454doi: 10.1016/j.ijpharm.2022.121454.
Bekaert, B., Van Snick, B., Pandelaere, K., Dhondt, J., Di Pretoro, G., De Beer, T., Vervaet, C., & Vanhoorne, V. (2022). In-depth analysis of the long-term processability of materials during continuous feeding. International journal of pharmaceutics, 614121454. https://doi.org/10.1016/j.ijpharm.2022.121454
Bekaert, B, et al. "In-depth analysis of the long-term processability of materials during continuous feeding." International journal of pharmaceutics vol. 614 (2022): 121454. doi: https://doi.org/10.1016/j.ijpharm.2022.121454
Bekaert B, Van Snick B, Pandelaere K, Dhondt J, Di Pretoro G, De Beer T, Vervaet C, Vanhoorne V. In-depth analysis of the long-term processability of materials during continuous feeding. Int J Pharm. 2022 Jan 10;614:121454. doi: 10.1016/j.ijpharm.2022.121454. Epub 2022 Jan 10. PMID: 35026314.
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In-depth analysis of the long-term processability of materials during continuous feeding.

International journal of pharmaceutics

Bekaert B, Van Snick B, Pandelaere K, Dhondt J, Di Pretoro G, De Beer T, Vervaet C, Vanhoorne V.
PMID: 35026314
Int J Pharm. 2022 Jan 10;614:121454. doi: 10.1016/j.ijpharm.2022.121454. Epub 2022 Jan 10.

This study determined the feasibility of long-term continuous powder feeding and its effect on the overall process performance. Additionally, quantitative relationships were established between material properties, process settings and screw feeding responses during gravimetric feeding. Twelve divergent raw materials...

Cite
Bekaert B, Van Snick B, Pandelaere K, et al. In-depth analysis of the long-term processability of materials during continuous feeding. Int J Pharm. 2022;614:121454doi: 10.1016/j.ijpharm.2022.121454.
Bekaert, B., Van Snick, B., Pandelaere, K., Dhondt, J., Di Pretoro, G., De Beer, T., Vervaet, C., & Vanhoorne, V. (2022). In-depth analysis of the long-term processability of materials during continuous feeding. International journal of pharmaceutics, 614121454. https://doi.org/10.1016/j.ijpharm.2022.121454
Bekaert, B, et al. "In-depth analysis of the long-term processability of materials during continuous feeding." International journal of pharmaceutics vol. 614 (2022): 121454. doi: https://doi.org/10.1016/j.ijpharm.2022.121454
Bekaert B, Van Snick B, Pandelaere K, Dhondt J, Di Pretoro G, De Beer T, Vervaet C, Vanhoorne V. In-depth analysis of the long-term processability of materials during continuous feeding. Int J Pharm. 2022 Jan 10;614:121454. doi: 10.1016/j.ijpharm.2022.121454. Epub 2022 Jan 10. PMID: 35026314.
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Impact of blend properties and process variables on the blending performance.

International journal of pharmaceutics

Bekaert B, Grymonpré W, Novikova A, Vervaet C, Vanhoorne V.
PMID: 34954006
Int J Pharm. 2021 Dec 22;121421. doi: 10.1016/j.ijpharm.2021.121421. Epub 2021 Dec 22.

In this study, quantitative relationships were established between blend properties, process settings and blending responses via multivariate data-analysis. Four divergent binary blends were composed in three different ratios and processed at various throughputs and impeller speeds. Additionally, different impeller...

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Bekaert B, Grymonpré W, Novikova A, et al. Impact of blend properties and process variables on the blending performance. Int J Pharm. 2021;121421doi: 10.1016/j.ijpharm.2021.121421.
Bekaert, B., Grymonpré, W., Novikova, A., Vervaet, C., & Vanhoorne, V. (2021). Impact of blend properties and process variables on the blending performance. International journal of pharmaceutics, 121421. https://doi.org/10.1016/j.ijpharm.2021.121421
Bekaert, B, et al. "Impact of blend properties and process variables on the blending performance." International journal of pharmaceutics vol. (2021): 121421. doi: https://doi.org/10.1016/j.ijpharm.2021.121421
Bekaert B, Grymonpré W, Novikova A, Vervaet C, Vanhoorne V. Impact of blend properties and process variables on the blending performance. Int J Pharm. 2021 Dec 22;121421. doi: 10.1016/j.ijpharm.2021.121421. Epub 2021 Dec 22. PMID: 34954006.
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Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy.

Analytical chemistry

Saerens L, Vervaet C, Remon JP, De Beer T.
PMID: 23662854
Anal Chem. 2013 Jun 04;85(11):5420-9. doi: 10.1021/ac400097t. Epub 2013 May 22.

The aim of this research was to improve understanding of material behavior in pharmaceutical hot-melt extrusion by implementing a Raman probe in each section of the barrel. Fourier-transform infrared spectroscopy measurements were performed to confirm the Raman observations. Metoprolol...

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Saerens L, Vervaet C, Remon JP, et al. Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy. Anal Chem. 2013;85(11):5420-9doi: 10.1021/ac400097t.
Saerens, L., Vervaet, C., Remon, J. P., & De Beer, T. (2013). Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy. Analytical chemistry, 85(11), 5420-9. https://doi.org/10.1021/ac400097t
Saerens, Lien, et al. "Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy." Analytical chemistry vol. 85,11 (2013): 5420-9. doi: https://doi.org/10.1021/ac400097t
Saerens L, Vervaet C, Remon JP, De Beer T. Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy. Anal Chem. 2013 Jun 04;85(11):5420-9. doi: 10.1021/ac400097t. Epub 2013 May 22. PMID: 23662854.
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Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying - A QbD approach.

International journal of pharmaceutics: X

Portier C, Vigh T, Di Pretoro G, Leys J, Klingeleers D, De Beer T, Vervaet C, Vanhoorne V.
PMID: 33870182
Int J Pharm X. 2021 Mar 19;3:100077. doi: 10.1016/j.ijpx.2021.100077. eCollection 2021 Dec.

Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of raw material properties, especially considering batch-to-batch variability. The importance of raw material variability and subsequent mitigation of the...

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Portier C, Vigh T, Di Pretoro G, et al. Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying - A QbD approach. Int J Pharm X. 2021;3:100077doi: 10.1016/j.ijpx.2021.100077.
Portier, C., Vigh, T., Di Pretoro, G., Leys, J., Klingeleers, D., De Beer, T., Vervaet, C., & Vanhoorne, V. (2021). Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying - A QbD approach. International journal of pharmaceutics: X, 3100077. https://doi.org/10.1016/j.ijpx.2021.100077
Portier, Christoph, et al. "Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying - A QbD approach." International journal of pharmaceutics: X vol. 3 (2021): 100077. doi: https://doi.org/10.1016/j.ijpx.2021.100077
Portier C, Vigh T, Di Pretoro G, Leys J, Klingeleers D, De Beer T, Vervaet C, Vanhoorne V. Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying - A QbD approach. Int J Pharm X. 2021 Mar 19;3:100077. doi: 10.1016/j.ijpx.2021.100077. eCollection 2021 Dec. PMID: 33870182; PMCID: PMC8044642.
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Showing 1 to 12 of 49 entries