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Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications.

Molecular therapy. Nucleic acids

Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS.
PMID: 25602582
Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69.

Evaluation of species differences and systemic exposure multiples (or ratios) in toxicological animal species versus human is an ongoing exercise during the course of drug development. The systemic exposure ratios are best estimated by directly comparing area under the...

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Yu RZ, Grundy JS, Henry SP, et al. Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Mol Ther Nucleic Acids. 2015;4:e218doi: 10.1038/mtna.2014.69.
Yu, R. Z., Grundy, J. S., Henry, S. P., Kim, T. W., Norris, D. A., Burkey, J., Wang, Y., Vick, A., & Geary, R. S. (2015). Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Molecular therapy. Nucleic acids, 4e218. https://doi.org/10.1038/mtna.2014.69
Yu, Rosie Z, et al. "Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications." Molecular therapy. Nucleic acids vol. 4 (2015): e218. doi: https://doi.org/10.1038/mtna.2014.69
Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS. Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69. PMID: 25602582; PMCID: PMC4345302.
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ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow.

International journal of biomedical data mining

Borthwick KM, Smelser DT, Bock JA, Elmore JR, Ryer EJ, Ye Z, Pacheco JA, Carrell DS, Michalkiewicz M, Thompson WK, Pathak J, Bielinski SJ, Denny JC, Linneman JG, Peissig PL, Kho AN, Gottesman O, Parmar H, Kullo IJ, McCarty CA, Böttinger EP, Larson EB, Jarvik GP, Harley JB, Bajwa T, Franklin DP, Carey DJ, Kuivaniemi H, Tromp G.
PMID: 27054044
Int J Biomed Data Min. 2015 Dec;4(1). Epub 2015 Jul 30.

BACKGROUND AND OBJECTIVE: We designed an algorithm to identify abdominal aortic aneurysm cases and controls from electronic health records to be shared and executed within the "electronic Medical Records and Genomics" (eMERGE) Network.MATERIALS AND METHODS: Structured Query Language, was...

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Borthwick KM, Smelser DT, Bock JA, et al. ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow. Int J Biomed Data Min. 2015;4(1)
Borthwick, K. M., Smelser, D. T., Bock, J. A., Elmore, J. R., Ryer, E. J., Ye, Z., Pacheco, J. A., Carrell, D. S., Michalkiewicz, M., Thompson, W. K., Pathak, J., Bielinski, S. J., Denny, J. C., Linneman, J. G., Peissig, P. L., Kho, A. N., Gottesman, O., Parmar, H., Kullo, I. J., McCarty, C. A., Böttinger, E. P., Larson, E. B., Jarvik, G. P., Harley, J. B., Bajwa, T., Franklin, D. P., Carey, D. J., Kuivaniemi, H., & Tromp, G. (2015). ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow. International journal of biomedical data mining, 4(1), .
Borthwick, Kenneth M, et al. "ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow." International journal of biomedical data mining vol. 4,1 (2015).
Borthwick KM, Smelser DT, Bock JA, Elmore JR, Ryer EJ, Ye Z, Pacheco JA, Carrell DS, Michalkiewicz M, Thompson WK, Pathak J, Bielinski SJ, Denny JC, Linneman JG, Peissig PL, Kho AN, Gottesman O, Parmar H, Kullo IJ, McCarty CA, Böttinger EP, Larson EB, Jarvik GP, Harley JB, Bajwa T, Franklin DP, Carey DJ, Kuivaniemi H, Tromp G. ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow. Int J Biomed Data Min. 2015 Dec;4(1). Epub 2015 Jul 30. PMID: 27054044; PMCID: PMC4820287.
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1-O-alk-1'-enyl-2-acyl-glycerophosphoethanolamine content and molecular species composition in fish brain.

Lipids

Bell MV, Dick JR.
PMID: 27519764
Lipids. 1993 Jan;28(1):19-22. doi: 10.1007/BF02536354.

Ethanolamine glycerophospholipids from the brains of both trout and cod comprised 36-38% of 1-O-alk-1'-enyl-2-acyl-glycerophosphoethanolamine (GPE) determined using two methods. In 1-O-alk-1'-enyl-2-acyl-GPE from trout brain, the main molecular species were 18∶1a/18∶1, 18∶0a/18∶1 and 16∶0a/18∶1, which totalled 63.3%, while polyunsaturated fatty...

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Bell MV, Dick JR. 1-O-alk-1'-enyl-2-acyl-glycerophosphoethanolamine content and molecular species composition in fish brain. Lipids. 1993;28(1):19-22doi: 10.1007/BF02536354.
Bell, M. V., & Dick, J. R. (1993). 1-O-alk-1'-enyl-2-acyl-glycerophosphoethanolamine content and molecular species composition in fish brain. Lipids, 28(1), 19-22. https://doi.org/10.1007/BF02536354
Bell, M V, and Dick, J R. "1-O-alk-1'-enyl-2-acyl-glycerophosphoethanolamine content and molecular species composition in fish brain." Lipids vol. 28,1 (1993): 19-22. doi: https://doi.org/10.1007/BF02536354
Bell MV, Dick JR. 1-O-alk-1'-enyl-2-acyl-glycerophosphoethanolamine content and molecular species composition in fish brain. Lipids. 1993 Jan;28(1):19-22. doi: 10.1007/BF02536354. PMID: 27519764.
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Dystonia Associated with Idiopathic Slow Orthostatic Tremor.

Tremor and other hyperkinetic movements (New York, N.Y.)

Kobylecki C, Silverdale MA, Dick JP, Kellett MW, Marshall AG.
PMID: 26877891
Tremor Other Hyperkinet Mov (N Y). 2016 Feb 01;5:351. doi: 10.7916/D8RF5TP4. eCollection 2015.

BACKGROUND: We aimed to characterize the clinical and electrophysiological features of patients with slow orthostatic tremor.CASE REPORT: The clinical and neurophysiological data of patients referred for lower limb tremor on standing were reviewed. Patients with symptomatic or primary orthostatic...

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Kobylecki C, Silverdale MA, Dick JP, et al. Dystonia Associated with Idiopathic Slow Orthostatic Tremor. Tremor Other Hyperkinet Mov (N Y). 2016;5:351doi: 10.7916/D8RF5TP4.
Kobylecki, C., Silverdale, M. A., Dick, J. P., Kellett, M. W., & Marshall, A. G. (2015). Dystonia Associated with Idiopathic Slow Orthostatic Tremor. Tremor and other hyperkinetic movements (New York, N.Y.), 5351. https://doi.org/10.7916/D8RF5TP4
Kobylecki, Christopher, et al. "Dystonia Associated with Idiopathic Slow Orthostatic Tremor." Tremor and other hyperkinetic movements (New York, N.Y.) vol. 5 (2015): 351. doi: https://doi.org/10.7916/D8RF5TP4
Kobylecki C, Silverdale MA, Dick JP, Kellett MW, Marshall AG. Dystonia Associated with Idiopathic Slow Orthostatic Tremor. Tremor Other Hyperkinet Mov (N Y). 2016 Feb 01;5:351. doi: 10.7916/D8RF5TP4. eCollection 2015. PMID: 26877891; PMCID: PMC4749092.
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Toward the Digital Electrochemical Recognition of Cobalt, Iridium, Nickel, and Iron Ion Collisions by Catalytic Amplification.

Journal of the American Chemical Society

Dick JE, Bard AJ.
PMID: 27295309
J Am Chem Soc. 2016 Jul 13;138(27):8446-52. doi: 10.1021/jacs.6b03202. Epub 2016 Jul 01.

We report the electrochemical detection of femtomolar amounts of cobalt, iridium, nickel, and iron ions in solution by electrocatalyst formation and amplification. The metal oxides of these ions can be formed electrochemically and can catalyze the oxidation of water....

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Dick JE, Bard AJ. Toward the Digital Electrochemical Recognition of Cobalt, Iridium, Nickel, and Iron Ion Collisions by Catalytic Amplification. J Am Chem Soc. 2016;138(27):8446-52doi: 10.1021/jacs.6b03202.
Dick, J. E., & Bard, A. J. (2016). Toward the Digital Electrochemical Recognition of Cobalt, Iridium, Nickel, and Iron Ion Collisions by Catalytic Amplification. Journal of the American Chemical Society, 138(27), 8446-52. https://doi.org/10.1021/jacs.6b03202
Dick, Jeffrey E, and Bard, Allen J. "Toward the Digital Electrochemical Recognition of Cobalt, Iridium, Nickel, and Iron Ion Collisions by Catalytic Amplification." Journal of the American Chemical Society vol. 138,27 (2016): 8446-52. doi: https://doi.org/10.1021/jacs.6b03202
Dick JE, Bard AJ. Toward the Digital Electrochemical Recognition of Cobalt, Iridium, Nickel, and Iron Ion Collisions by Catalytic Amplification. J Am Chem Soc. 2016 Jul 13;138(27):8446-52. doi: 10.1021/jacs.6b03202. Epub 2016 Jul 01. PMID: 27295309.
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Phosphorylcholine-based polymer coatings for stent drug delivery.

Journal of materials science. Materials in medicine

Lewis AL, Vick TA, Collias AC, Hughes LG, Palmer RR, Leppard SW, Furze JD, Taylor AS, Stratford PW.
PMID: 15348331
J Mater Sci Mater Med. 2001 Oct-Dec;12(10):865-70. doi: 10.1023/a:1012803503667.

Phosphorylcholine-based polymers have been used commercially to improve the biocompatibility of coronary stents. In this study, one particular polymer is assessed for its suitability as a drug delivery vehicle. Membranes of the material are characterized in terms of water...

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Lewis AL, Vick TA, Collias AC, et al. Phosphorylcholine-based polymer coatings for stent drug delivery. J Mater Sci Mater Med. 2001;12(10):865-70doi: 10.1023/a:1012803503667.
Lewis, A. L., Vick, T. A., Collias, A. C., Hughes, L. G., Palmer, R. R., Leppard, S. W., Furze, J. D., Taylor, A. S., & Stratford, P. W. (2001). Phosphorylcholine-based polymer coatings for stent drug delivery. Journal of materials science. Materials in medicine, 12(10), 865-70. https://doi.org/10.1023/a:1012803503667
Lewis, A L, et al. "Phosphorylcholine-based polymer coatings for stent drug delivery." Journal of materials science. Materials in medicine vol. 12,10 (2001): 865-70. doi: https://doi.org/10.1023/a:1012803503667
Lewis AL, Vick TA, Collias AC, Hughes LG, Palmer RR, Leppard SW, Furze JD, Taylor AS, Stratford PW. Phosphorylcholine-based polymer coatings for stent drug delivery. J Mater Sci Mater Med. 2001 Oct-Dec;12(10):865-70. doi: 10.1023/a:1012803503667. PMID: 15348331.
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Lipoxygenase and hydroperoxide lyase in germinating watermelon seedlings.

Plant physiology

Vick BA, Zimmerman DC.
PMID: 16659569
Plant Physiol. 1976 May;57(5):780-8. doi: 10.1104/pp.57.5.780.

Lipoxygenase (EC 1.13.1.13) was found in seedlings of Citrullus lanatus (Thunb.) Matsum. and Nakai (watermelon). The enzyme has pH optima of 4.4 and 5.5 and is inhibited by 0.2 mM nordihydroguaiaretic acid. It is present in two functional units...

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Vick BA, Zimmerman DC. Lipoxygenase and hydroperoxide lyase in germinating watermelon seedlings. Plant Physiol. 1976;57(5):780-8doi: 10.1104/pp.57.5.780.
Vick, B. A., & Zimmerman, D. C. (1976). Lipoxygenase and hydroperoxide lyase in germinating watermelon seedlings. Plant physiology, 57(5), 780-8. https://doi.org/10.1104/pp.57.5.780
Vick, B A, and Zimmerman, D C. "Lipoxygenase and hydroperoxide lyase in germinating watermelon seedlings." Plant physiology vol. 57,5 (1976): 780-8. doi: https://doi.org/10.1104/pp.57.5.780
Vick BA, Zimmerman DC. Lipoxygenase and hydroperoxide lyase in germinating watermelon seedlings. Plant Physiol. 1976 May;57(5):780-8. doi: 10.1104/pp.57.5.780. PMID: 16659569; PMCID: PMC542117.
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Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?.

Cell division

Dick FA.
PMID: 17854503
Cell Div. 2007 Sep 13;2:26. doi: 10.1186/1747-1028-2-26.

Biochemical analysis of the retinoblastoma protein's function has received considerable attention since it was cloned just over 20 years ago. During this time pRB has emerged as a key regulator of the cell division cycle and its ability to...

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Dick FA. Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?. Cell Div. 2007;2:26doi: 10.1186/1747-1028-2-26.
Dick, F. A. (2007). Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?. Cell division, 226. https://doi.org/10.1186/1747-1028-2-26
Dick, Frederick A. "Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?." Cell division vol. 2 (2007): 26. doi: https://doi.org/10.1186/1747-1028-2-26
Dick FA. Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?. Cell Div. 2007 Sep 13;2:26. doi: 10.1186/1747-1028-2-26. PMID: 17854503; PMCID: PMC2082274.
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Cerebral Cysticercosis Simulating Epilepsy.

British medical journal

Dick JC.
PMID: 20779765
Br Med J. 1936 Feb 22;1(3920):364. doi: 10.1136/bmj.1.3920.364.

No abstract available.

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Dick JC. Cerebral Cysticercosis Simulating Epilepsy. Br Med J. 1936;1(3920):364doi: 10.1136/bmj.1.3920.364.
Dick, J. C. (1936). Cerebral Cysticercosis Simulating Epilepsy. British medical journal, 1(3920), 364. https://doi.org/10.1136/bmj.1.3920.364
Dick, J C. "Cerebral Cysticercosis Simulating Epilepsy." British medical journal vol. 1,3920 (1936): 364. doi: https://doi.org/10.1136/bmj.1.3920.364
Dick JC. Cerebral Cysticercosis Simulating Epilepsy. Br Med J. 1936 Feb 22;1(3920):364. doi: 10.1136/bmj.1.3920.364. PMID: 20779765; PMCID: PMC2122499.
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Biochemical and molecular characterization of sucrose and amino acid carriers in Ricinus communis.

Journal of experimental botany

Williams LE, Bick JA, Neelam A, Weston KN, Hall JL.
PMID: 21245251
J Exp Bot. 1996 Aug;47:1211-6. doi: 10.1093/jxb/47.Special_Issue.1211.

The use of energized plasma membrane vesicle preparations from cotyledons and roots of Ricinus communis seedlings is described, and evidence is presented for the existence of plasma membrane H(+)/sucrose and H(+)/amino acid symporters. Using fractions isolated from roots, there...

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Williams LE, Bick JA, Neelam A, et al. Biochemical and molecular characterization of sucrose and amino acid carriers in Ricinus communis. J Exp Bot. 1996;47:1211-6doi: 10.1093/jxb/47.Special_Issue.1211.
Williams, L. E., Bick, J. A., Neelam, A., Weston, K. N., & Hall, J. L. (1996). Biochemical and molecular characterization of sucrose and amino acid carriers in Ricinus communis. Journal of experimental botany, 471211-6. https://doi.org/10.1093/jxb/47.Special_Issue.1211
Williams, L E, et al. "Biochemical and molecular characterization of sucrose and amino acid carriers in Ricinus communis." Journal of experimental botany vol. 47 (1996): 1211-6. doi: https://doi.org/10.1093/jxb/47.Special_Issue.1211
Williams LE, Bick JA, Neelam A, Weston KN, Hall JL. Biochemical and molecular characterization of sucrose and amino acid carriers in Ricinus communis. J Exp Bot. 1996 Aug;47:1211-6. doi: 10.1093/jxb/47.Special_Issue.1211. PMID: 21245251.
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The effect of treatment with whole bee venom on cage activity and plasma cortisol levels in the arthritic dog.

Inflammation

Vick JA, Warren GB, Brooks RB.
PMID: 24194426
Inflammation. 1976 Mar;1(2):167-74. doi: 10.1007/BF00917527.

A series of 24 mixed-breed dogs were used to study the physiological effects of whole bee venom on canine arthritic-like conditions. 16 were randomly selected normal dogs and 8 were suspect arthritic animals confirmed by X-ray examination and special...

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Vick JA, Warren GB, Brooks RB. The effect of treatment with whole bee venom on cage activity and plasma cortisol levels in the arthritic dog. Inflammation. 1976;1(2):167-74doi: 10.1007/BF00917527.
Vick, J. A., Warren, G. B., & Brooks, R. B. (1976). The effect of treatment with whole bee venom on cage activity and plasma cortisol levels in the arthritic dog. Inflammation, 1(2), 167-74. https://doi.org/10.1007/BF00917527
Vick, J A, et al. "The effect of treatment with whole bee venom on cage activity and plasma cortisol levels in the arthritic dog." Inflammation vol. 1,2 (1976): 167-74. doi: https://doi.org/10.1007/BF00917527
Vick JA, Warren GB, Brooks RB. The effect of treatment with whole bee venom on cage activity and plasma cortisol levels in the arthritic dog. Inflammation. 1976 Mar;1(2):167-74. doi: 10.1007/BF00917527. PMID: 24194426.
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Polyunsaturated fatty acid metabolism in cultured fish cells: Incorporation and metabolism of (n-3) and (n-6) series acids by Atlantic salmon (Salmo salar) cells.

Fish physiology and biochemistry

Tocher DR, Dick JR.
PMID: 24220920
Fish Physiol Biochem. 1990 Jul;8(4):311-9. doi: 10.1007/BF00003426.

The incorporation and metabolism of (n-3) and (n-6) polyunsaturated fatty acids (PUFA) supplemented to growing cultures were studied in Atlantic salmon (AS) cells. A fatty acid concentration of 25 μM considerably altered the fatty acid composition of AS cells...

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Tocher DR, Dick JR. Polyunsaturated fatty acid metabolism in cultured fish cells: Incorporation and metabolism of (n-3) and (n-6) series acids by Atlantic salmon (Salmo salar) cells. Fish Physiol Biochem. 1990;8(4):311-9doi: 10.1007/BF00003426.
Tocher, D. R., & Dick, J. R. (1990). Polyunsaturated fatty acid metabolism in cultured fish cells: Incorporation and metabolism of (n-3) and (n-6) series acids by Atlantic salmon (Salmo salar) cells. Fish physiology and biochemistry, 8(4), 311-9. https://doi.org/10.1007/BF00003426
Tocher, D R, and Dick, J R. "Polyunsaturated fatty acid metabolism in cultured fish cells: Incorporation and metabolism of (n-3) and (n-6) series acids by Atlantic salmon (Salmo salar) cells." Fish physiology and biochemistry vol. 8,4 (1990): 311-9. doi: https://doi.org/10.1007/BF00003426
Tocher DR, Dick JR. Polyunsaturated fatty acid metabolism in cultured fish cells: Incorporation and metabolism of (n-3) and (n-6) series acids by Atlantic salmon (Salmo salar) cells. Fish Physiol Biochem. 1990 Jul;8(4):311-9. doi: 10.1007/BF00003426. PMID: 24220920.
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Showing 1 to 12 of 187 entries