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Intravenous immune globulin suppresses angiogenesis in mice and humans.

Signal transduction and targeted therapy

Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, Kerur N, Li S, Yasuma T, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Bastos-Carvalho A, De Falco S, Ambati J.
PMID: 26925256
Signal Transduct Target Ther. 2016;1. doi: 10.1038/sigtrans.2015.2. Epub 2016 Jan 28.

Human intravenous immune globulin (IVIg), a purified IgG fraction composed of ~ 60% IgG1 and obtained from the pooled plasma of thousands of donors, is clinically used for a wide range of diseases. The biological actions of IVIg are...

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Yasuma R, Cicatiello V, Mizutani T, et al. Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal Transduct Target Ther. 2016;1doi: 10.1038/sigtrans.2015.2.
Yasuma, R., Cicatiello, V., Mizutani, T., Tudisco, L., Kim, Y., Tarallo, V., Bogdanovich, S., Hirano, Y., Kerur, N., Li, S., Yasuma, T., Fowler, B. J., Wright, C. B., Apicella, I., Greco, A., Brunetti, A., Ambati, B. K., Helmers, S. B., Lundberg, I. E., Viklicky, O., Leusen, J. H., Verbeek, J. S., Gelfand, B. D., Bastos-Carvalho, A., De Falco, S., & Ambati, J. (2016). Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal transduction and targeted therapy, 1. https://doi.org/10.1038/sigtrans.2015.2
Yasuma, Reo, et al. "Intravenous immune globulin suppresses angiogenesis in mice and humans." Signal transduction and targeted therapy vol. 1 (2016). doi: https://doi.org/10.1038/sigtrans.2015.2
Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, Kerur N, Li S, Yasuma T, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Bastos-Carvalho A, De Falco S, Ambati J. Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal Transduct Target Ther. 2016;1. doi: 10.1038/sigtrans.2015.2. Epub 2016 Jan 28. PMID: 26925256; PMCID: PMC4768485.
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Development of piezoelectric immunosensors for measurement of albuminuria.

Talanta

Navrátilová I, Skládal P, Viklický V.
PMID: 18968431
Talanta. 2001 Oct 31;55(4):831-9.

The development of piezoelectric immunosensors for human serum albumin (HSA) is reported. The piezoelectric crystals were modified either with monoclonal antibody AL-01 (direct assay) or with HSA (competitive assay). Measurements were carried out in the flow-through mode. Affinity interaction...

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Navrátilová I, Skládal P, Viklický V. Development of piezoelectric immunosensors for measurement of albuminuria. Talanta. 2001;55(4):831-9
Navrátilová, I., Skládal, P., & Viklický, V. (2001). Development of piezoelectric immunosensors for measurement of albuminuria. Talanta, 55(4), 831-9.
Navrátilová, I, et al. "Development of piezoelectric immunosensors for measurement of albuminuria." Talanta vol. 55,4 (2001): 831-9.
Navrátilová I, Skládal P, Viklický V. Development of piezoelectric immunosensors for measurement of albuminuria. Talanta. 2001 Oct 31;55(4):831-9. PMID: 18968431.
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Humoral response to SARS-CoV-2 is well preserved and symptom dependent in kidney transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Magicova M, Fialova M, Zahradka I, Rajnochova-Bloudickova S, Hackajlo D, Raska P, Striz I, Viklicky O.
PMID: 34212497
Am J Transplant. 2021 Dec;21(12):3926-3935. doi: 10.1111/ajt.16746. Epub 2021 Jul 19.

Data on the immune response to SARS-CoV-2 in kidney transplant recipients are scarce. Thus, we conducted a single-center observational study to assess the anti-SARS-CoV-2 IgG seroprevalence in outpatient kidney transplant recipients (KTR; n = 1037) and healthcare workers (HCW;...

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Magicova M, Fialova M, Zahradka I, et al. Humoral response to SARS-CoV-2 is well preserved and symptom dependent in kidney transplant recipients. Am J Transplant. 2021;21(12):3926-3935doi: 10.1111/ajt.16746.
Magicova, M., Fialova, M., Zahradka, I., Rajnochova-Bloudickova, S., Hackajlo, D., Raska, P., Striz, I., & Viklicky, O. (2021). Humoral response to SARS-CoV-2 is well preserved and symptom dependent in kidney transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 21(12), 3926-3935. https://doi.org/10.1111/ajt.16746
Magicova, Maria, et al. "Humoral response to SARS-CoV-2 is well preserved and symptom dependent in kidney transplant recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons vol. 21,12 (2021): 3926-3935. doi: https://doi.org/10.1111/ajt.16746
Magicova M, Fialova M, Zahradka I, Rajnochova-Bloudickova S, Hackajlo D, Raska P, Striz I, Viklicky O. Humoral response to SARS-CoV-2 is well preserved and symptom dependent in kidney transplant recipients. Am J Transplant. 2021 Dec;21(12):3926-3935. doi: 10.1111/ajt.16746. Epub 2021 Jul 19. PMID: 34212497.
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Predictive Potential of Flow Cytometry Crossmatching in Deceased Donor Kidney Transplant Recipients Subjected to Peritransplant Desensitization.

Frontiers in medicine

Osickova K, Hruba P, Kabrtova K, Klema J, Maluskova J, Slavcev A, Slatinska J, Marada T, Böhmig GA, Viklicky O.
PMID: 34970564
Front Med (Lausanne). 2021 Dec 14;8:780636. doi: 10.3389/fmed.2021.780636. eCollection 2021.

Recipient sensitization is a major risk factor of antibody-mediated rejection (ABMR) and inferior graft survival. The predictive effect of solid-phase human leukocyte antigen antibody testing and flow cytometry crossmatch (FCXM) in the era of peritransplant desensitization remains poorly understood....

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Osickova K, Hruba P, Kabrtova K, et al. Predictive Potential of Flow Cytometry Crossmatching in Deceased Donor Kidney Transplant Recipients Subjected to Peritransplant Desensitization. Front Med (Lausanne). 2021;8:780636doi: 10.3389/fmed.2021.780636.
Osickova, K., Hruba, P., Kabrtova, K., Klema, J., Maluskova, J., Slavcev, A., Slatinska, J., Marada, T., Böhmig, G. A., & Viklicky, O. (2021). Predictive Potential of Flow Cytometry Crossmatching in Deceased Donor Kidney Transplant Recipients Subjected to Peritransplant Desensitization. Frontiers in medicine, 8780636. https://doi.org/10.3389/fmed.2021.780636
Osickova, Klara, et al. "Predictive Potential of Flow Cytometry Crossmatching in Deceased Donor Kidney Transplant Recipients Subjected to Peritransplant Desensitization." Frontiers in medicine vol. 8 (2021): 780636. doi: https://doi.org/10.3389/fmed.2021.780636
Osickova K, Hruba P, Kabrtova K, Klema J, Maluskova J, Slavcev A, Slatinska J, Marada T, Böhmig GA, Viklicky O. Predictive Potential of Flow Cytometry Crossmatching in Deceased Donor Kidney Transplant Recipients Subjected to Peritransplant Desensitization. Front Med (Lausanne). 2021 Dec 14;8:780636. doi: 10.3389/fmed.2021.780636. eCollection 2021. PMID: 34970564; PMCID: PMC8712553.
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Waiting Time for Second Kidney Transplantation and Mortality.

Clinical journal of the American Society of Nephrology : CJASN

Kainz A, Kammer M, Reindl-Schwaighofer R, Strohmaier S, Petr V, Viklicky O, Abramowicz D, Naik M, Mayer G, Oberbauer R.
PMID: 34965955
Clin J Am Soc Nephrol. 2022 Jan;17(1):90-97. doi: 10.2215/CJN.07620621. Epub 2021 Dec 29.

BACKGROUND AND OBJECTIVES: The median kidney transplant half-life is 10-15 years. Because of the scarcity of donor organs and immunologic sensitization of candidates for retransplantation, there is a need for quantitative information on if and when a second transplantation...

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Kainz A, Kammer M, Reindl-Schwaighofer R, et al. Waiting Time for Second Kidney Transplantation and Mortality. Clin J Am Soc Nephrol. 2021;17(1):90-97doi: 10.2215/CJN.07620621.
Kainz, A., Kammer, M., Reindl-Schwaighofer, R., Strohmaier, S., Petr, V., Viklicky, O., Abramowicz, D., Naik, M., Mayer, G., & Oberbauer, R. (2022). Waiting Time for Second Kidney Transplantation and Mortality. Clinical journal of the American Society of Nephrology : CJASN, 17(1), 90-97. https://doi.org/10.2215/CJN.07620621
Kainz, Alexander, et al. "Waiting Time for Second Kidney Transplantation and Mortality." Clinical journal of the American Society of Nephrology : CJASN vol. 17,1 (2022): 90-97. doi: https://doi.org/10.2215/CJN.07620621
Kainz A, Kammer M, Reindl-Schwaighofer R, Strohmaier S, Petr V, Viklicky O, Abramowicz D, Naik M, Mayer G, Oberbauer R. Waiting Time for Second Kidney Transplantation and Mortality. Clin J Am Soc Nephrol. 2022 Jan;17(1):90-97. doi: 10.2215/CJN.07620621. Epub 2021 Dec 29. PMID: 34965955.
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Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies.

Frontiers in medicine

Novotny M, Hruba P, Kment M, Voska L, Kabrtova K, Slavcev A, Viklicky O.
PMID: 34957155
Front Med (Lausanne). 2021 Dec 08;8:781206. doi: 10.3389/fmed.2021.781206. eCollection 2021.

No abstract available.

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Novotny M, Hruba P, Kment M, et al. Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies. Front Med (Lausanne). 2021;8:781206doi: 10.3389/fmed.2021.781206.
Novotny, M., Hruba, P., Kment, M., Voska, L., Kabrtova, K., Slavcev, A., & Viklicky, O. (2021). Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies. Frontiers in medicine, 8781206. https://doi.org/10.3389/fmed.2021.781206
Novotny, Marek, et al. "Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies." Frontiers in medicine vol. 8 (2021): 781206. doi: https://doi.org/10.3389/fmed.2021.781206
Novotny M, Hruba P, Kment M, Voska L, Kabrtova K, Slavcev A, Viklicky O. Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies. Front Med (Lausanne). 2021 Dec 08;8:781206. doi: 10.3389/fmed.2021.781206. eCollection 2021. PMID: 34957155; PMCID: PMC8692297.
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Changes in phenotypic patterns of blood monocytes after kidney transplantation and during acute rejection.

Physiological research

Švachová V, Krupičková L, Novotný M, Fialová M, Mezerová K, Čečrdlová E, Lánská V, Slavčev A, Viklický O, Viklický O, Stříž I.
PMID: 34505523
Physiol Res. 2021 Nov 29;70(5):709-721. doi: 10.33549/physiolres.934700. Epub 2021 Sep 10.

Peripheral blood monocytes, which serve as precursors for tissue macrophages and dendritic cells (DC), play a key role in the immune response to kidney allograft, reparation processes and homeostasis regulation. In this prospective study, we used multicolor flow cytometry...

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Švachová V, Krupičková L, Novotný M, et al. Changes in phenotypic patterns of blood monocytes after kidney transplantation and during acute rejection. Physiol Res. 2021;70(5):709-721doi: 10.33549/physiolres.934700.
Švachová, V., Krupičková, L., Novotný, M., Fialová, M., Mezerová, K., Čečrdlová, E., Lánská, V., Slavčev, A., Viklický, O., Viklický, O., & Stříž, I. (2021). Changes in phenotypic patterns of blood monocytes after kidney transplantation and during acute rejection. Physiological research, 70(5), 709-721. https://doi.org/10.33549/physiolres.934700
Švachová, V, et al. "Changes in phenotypic patterns of blood monocytes after kidney transplantation and during acute rejection." Physiological research vol. 70,5 (2021): 709-721. doi: https://doi.org/10.33549/physiolres.934700
Švachová V, Krupičková L, Novotný M, Fialová M, Mezerová K, Čečrdlová E, Lánská V, Slavčev A, Viklický O, Viklický O, Stříž I. Changes in phenotypic patterns of blood monocytes after kidney transplantation and during acute rejection. Physiol Res. 2021 Nov 29;70(5):709-721. doi: 10.33549/physiolres.934700. Epub 2021 Sep 10. PMID: 34505523.
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Corrigendum to "Process efficiency and ventilation requirement in black soldier fly larvae composting of substrates with high water content" [Sci. Total Environ. 729 (2020) 138968].

The Science of the total environment

Lalander C, Ermolaev E, Wiklicky V, Vinnerås B.
PMID: 33358179
Sci Total Environ. 2021 Mar 10;759:144422. doi: 10.1016/j.scitotenv.2020.144422. Epub 2020 Dec 24.

No abstract available.

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Lalander C, Ermolaev E, Wiklicky V, et al. Corrigendum to "Process efficiency and ventilation requirement in black soldier fly larvae composting of substrates with high water content" [Sci. Total Environ. 729 (2020) 138968]. Sci Total Environ. 2020;759:144422doi: 10.1016/j.scitotenv.2020.144422.
Lalander, C., Ermolaev, E., Wiklicky, V., & Vinnerås, B. (2021). Corrigendum to "Process efficiency and ventilation requirement in black soldier fly larvae composting of substrates with high water content" [Sci. Total Environ. 729 (2020) 138968]. The Science of the total environment, 759144422. https://doi.org/10.1016/j.scitotenv.2020.144422
Lalander, C, et al. "Corrigendum to "Process efficiency and ventilation requirement in black soldier fly larvae composting of substrates with high water content" [Sci. Total Environ. 729 (2020) 138968]." The Science of the total environment vol. 759 (2021): 144422. doi: https://doi.org/10.1016/j.scitotenv.2020.144422
Lalander C, Ermolaev E, Wiklicky V, Vinnerås B. Corrigendum to "Process efficiency and ventilation requirement in black soldier fly larvae composting of substrates with high water content" [Sci. Total Environ. 729 (2020) 138968]. Sci Total Environ. 2021 Mar 10;759:144422. doi: 10.1016/j.scitotenv.2020.144422. Epub 2020 Dec 24. PMID: 33358179.
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Do low GDP neutral pH solutions prevent or retard peritoneal membrane alterations in long-term peritoneal dialysis?.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Parikova A, Michalickova K, van Diepen AT, Voska L, Viklicky O, Krediet RT.
PMID: 34259088
Perit Dial Int. 2021 Jul 14;8968608211027008. doi: 10.1177/08968608211027008. Epub 2021 Jul 14.

Several studies have been published in the last decade on the effects of low glucose degradation product (GDP) neutral pH (L-GDP/N-pH) dialysis solutions on peritoneal morphology and function during the long-term PD treatment. Compared to conventional solutions, the impact...

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Parikova A, Michalickova K, van Diepen AT, et al. Do low GDP neutral pH solutions prevent or retard peritoneal membrane alterations in long-term peritoneal dialysis?. Perit Dial Int. 2021;8968608211027008doi: 10.1177/08968608211027008.
Parikova, A., Michalickova, K., van Diepen, A. T., Voska, L., Viklicky, O., & Krediet, R. T. (2021). Do low GDP neutral pH solutions prevent or retard peritoneal membrane alterations in long-term peritoneal dialysis?. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 8968608211027008. https://doi.org/10.1177/08968608211027008
Parikova, Alena, et al. "Do low GDP neutral pH solutions prevent or retard peritoneal membrane alterations in long-term peritoneal dialysis?." Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis vol. (2021): 8968608211027008. doi: https://doi.org/10.1177/08968608211027008
Parikova A, Michalickova K, van Diepen AT, Voska L, Viklicky O, Krediet RT. Do low GDP neutral pH solutions prevent or retard peritoneal membrane alterations in long-term peritoneal dialysis?. Perit Dial Int. 2021 Jul 14;8968608211027008. doi: 10.1177/08968608211027008. Epub 2021 Jul 14. PMID: 34259088.
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Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection.

Journal of the American Society of Nephrology : JASN

Madill-Thomsen KS, Böhmig GA, Bromberg J, Einecke G, Eskandary F, Gupta G, Hidalgo LG, Myslak M, Viklicky O, Perkowska-Ptasinska A, Halloran PF.
PMID: 34253587
J Am Soc Nephrol. 2021 Nov;32(11):2743-2758. doi: 10.1681/ASN.2021040433. Epub 2021 Jul 12.

BACKGROUND: Donor -specific HLA antibody (DSA) is present in many kidney transplant patients whose biopsies are classified as no rejection (NR). We explored whether in some NR kidneys DSA has subtle effects not currently being recognized.METHODS: We used microarrays...

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Madill-Thomsen KS, Böhmig GA, Bromberg J, et al. Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection. J Am Soc Nephrol. 2021;32(11):2743-2758doi: 10.1681/ASN.2021040433.
Madill-Thomsen, K. S., Böhmig, G. A., Bromberg, J., Einecke, G., Eskandary, F., Gupta, G., Hidalgo, L. G., Myslak, M., Viklicky, O., Perkowska-Ptasinska, A., Halloran, P. F. (2021). Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection. Journal of the American Society of Nephrology : JASN, 32(11), 2743-2758. https://doi.org/10.1681/ASN.2021040433
Madill-Thomsen, Katelynn S, et al. "Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection." Journal of the American Society of Nephrology : JASN vol. 32,11 (2021): 2743-2758. doi: https://doi.org/10.1681/ASN.2021040433
Madill-Thomsen KS, Böhmig GA, Bromberg J, Einecke G, Eskandary F, Gupta G, Hidalgo LG, Myslak M, Viklicky O, Perkowska-Ptasinska A, Halloran PF. Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection. J Am Soc Nephrol. 2021 Nov;32(11):2743-2758. doi: 10.1681/ASN.2021040433. Epub 2021 Jul 12. PMID: 34253587.
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Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts.

Frontiers in immunology

Trailin A, Mrazova P, Hruba P, Voska L, Sticova E, Slavcev A, Novotny M, Kocik M, Viklicky O.
PMID: 34616398
Front Immunol. 2021 Sep 20;12:729558. doi: 10.3389/fimmu.2021.729558. eCollection 2021.

Molecular assessment of renal allografts has already been suggested in antibody-mediated rejection (ABMR), but little is known about the gene transcript patterns in particular renal compartments. We used laser capture microdissection coupled with quantitative RT-PCR to distinguish the transcript...

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Trailin A, Mrazova P, Hruba P, et al. Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts. Front Immunol. 2021;12:729558doi: 10.3389/fimmu.2021.729558.
Trailin, A., Mrazova, P., Hruba, P., Voska, L., Sticova, E., Slavcev, A., Novotny, M., Kocik, M., & Viklicky, O. (2021). Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts. Frontiers in immunology, 12729558. https://doi.org/10.3389/fimmu.2021.729558
Trailin, Andriy, et al. "Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts." Frontiers in immunology vol. 12 (2021): 729558. doi: https://doi.org/10.3389/fimmu.2021.729558
Trailin A, Mrazova P, Hruba P, Voska L, Sticova E, Slavcev A, Novotny M, Kocik M, Viklicky O. Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts. Front Immunol. 2021 Sep 20;12:729558. doi: 10.3389/fimmu.2021.729558. eCollection 2021. PMID: 34616398; PMCID: PMC8488163.
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Simultaneous living donor orthotopic renal transplantation and bilateral nephrectomy for recurrent renal cell carcinoma and renal failure: case report and review of literature.

Research and reports in urology

Novotny R, Marada T, Chlupac J, Viklicky O, Fronek J.
PMID: 30237991
Res Rep Urol. 2018 Sep 11;10:69-73. doi: 10.2147/RRU.S167507. eCollection 2018.

BACKGROUND: We report the case of a 43-year-old female patient with systemic lupus erythematosus, class III lupus nephritis, with predialysis creatinine levels around 350 μmol/L (3.95 mg/dL) after partial resection of the left kidney with histologically verified papillary carcinoma...

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Novotny R, Marada T, Chlupac J, et al. Simultaneous living donor orthotopic renal transplantation and bilateral nephrectomy for recurrent renal cell carcinoma and renal failure: case report and review of literature. Res Rep Urol. 2018;10:69-73doi: 10.2147/RRU.S167507.
Novotny, R., Marada, T., Chlupac, J., Viklicky, O., & Fronek, J. (2018). Simultaneous living donor orthotopic renal transplantation and bilateral nephrectomy for recurrent renal cell carcinoma and renal failure: case report and review of literature. Research and reports in urology, 1069-73. https://doi.org/10.2147/RRU.S167507
Novotny, Robert, et al. "Simultaneous living donor orthotopic renal transplantation and bilateral nephrectomy for recurrent renal cell carcinoma and renal failure: case report and review of literature." Research and reports in urology vol. 10 (2018): 69-73. doi: https://doi.org/10.2147/RRU.S167507
Novotny R, Marada T, Chlupac J, Viklicky O, Fronek J. Simultaneous living donor orthotopic renal transplantation and bilateral nephrectomy for recurrent renal cell carcinoma and renal failure: case report and review of literature. Res Rep Urol. 2018 Sep 11;10:69-73. doi: 10.2147/RRU.S167507. eCollection 2018. PMID: 30237991; PMCID: PMC6138972.
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