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Showing 1 to 12 of 129 entries
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Measurements of ionic structure in shock compressed lithium hydride from ultrafast x-ray Thomson scattering.

Physical review letters

Kritcher AL, Neumayer P, Brown CR, Davis P, Döppner T, Falcone RW, Gericke DO, Gregori G, Holst B, Landen OL, Lee HJ, Morse EC, Pelka A, Redmer R, Roth M, Vorberger J, Wünsch K, Glenzer SH.
PMID: 20366206
Phys Rev Lett. 2009 Dec 11;103(24):245004. doi: 10.1103/PhysRevLett.103.245004. Epub 2009 Dec 10.

We present the first ultrafast temporally, spectrally, and angularly resolved x-ray scattering measurements from shock-compressed matter. The experimental spectra yield the absolute elastic and inelastic scattering intensities from the measured density of free electrons. Laser-compressed lithium-hydride samples are well...

X-ray scattering measurements of strong ion-ion correlations in shock-compressed aluminum.

Physical review letters

Ma T, Döppner T, Falcone RW, Fletcher L, Fortmann C, Gericke DO, Landen OL, Lee HJ, Pak A, Vorberger J, Wünsch K, Glenzer SH.
PMID: 23432260
Phys Rev Lett. 2013 Feb 08;110(6):065001. doi: 10.1103/PhysRevLett.110.065001. Epub 2013 Feb 05.

The strong ion-ion correlation peak characteristic of warm dense matter (WDM) is observed for the first time using simultaneous angularly, temporally, and spectrally resolved x-ray scattering measurements in laser-driven shock-compressed aluminum. Laser-produced molybdenum x-ray line emission at an energy...

The role of stepdown beds in hospital care.

American journal of respiratory and critical care medicine

Prin M, Wunsch H.
PMID: 25163008
Am J Respir Crit Care Med. 2014 Dec 01;190(11):1210-6. doi: 10.1164/rccm.201406-1117PP.

Stepdown beds provide an intermediate level of care for patients with requirements somewhere between that of the general ward and the intensive care unit. Models of care include incorporation of stepdown beds into intensive care units, stand-alone units, or...

Anisotropic rare-earth spin ensemble strongly coupled to a superconducting resonator.

Physical review letters

Probst S, Rotzinger H, Wünsch S, Jung P, Jerger M, Siegel M, Ustinov AV, Bushev PA.
PMID: 25167299
Phys Rev Lett. 2013 Apr 12;110(15):157001. doi: 10.1103/PhysRevLett.110.157001. Epub 2013 Apr 08.

Interfacing photonic and solid-state qubits within a hybrid quantum architecture offers a promising route towards large scale distributed quantum computing. Ideal candidates for coherent qubit interconversion are optically active spins, magnetically coupled to a superconducting resonator. We report on...

Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Haider A, Iten I, Ahmed H, Müller Herder A, Gruber S, Krämer SD, Keller C, Schibli R, Wünsch B, Mu L, Ametamey SM.
PMID: 30030340
J Nucl Med. 2018 Jul 20; doi: 10.2967/jnumed.118.212134. Epub 2018 Jul 20.

The previously reported carbon-11 labeled GluN2B PET radioligand

Optimizing administrative datasets to examine acute kidney injury in the era of big data: workgroup statement from the 15(th) ADQI Consensus Conference.

Canadian journal of kidney health and disease

Siew ED, Basu RK, Wunsch H, Shaw AD, Goldstein SL, Ronco C, Kellum JA, Bagshaw SM.
PMID: 26925248
Can J Kidney Health Dis. 2016 Feb 26;3:12. doi: 10.1186/s40697-016-0098-5. eCollection 2016.

PURPOSE OF REVIEW: The purpose of this review is to report how administrative data have been used to study AKI, identify current limitations, and suggest how these data sources might be enhanced to address knowledge gaps in the field.OBJECTIVES:...

Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold.

MedChemComm

Baumeister S, Schepmann D, Wünsch B.
PMID: 30881618
Medchemcomm. 2019 Jan 10;10(2):315-325. doi: 10.1039/c8md00545a. eCollection 2019 Feb 01.

The involvement of NMDA receptors containing the GluN2B subunit in neurodegenerative disorders including Alzheimer's and Parkinson's disease renders this NMDA receptor subtype an interesting pharmacological target. The aim of this study was the bioisosteric replacement of benzene, methoxybenzene and...

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB.

MedChemComm

Heimann D, Lueg C, de Vries H, Frehland B, Schepmann D, Heitman LH, Wünsch B.
PMID: 30108881
Medchemcomm. 2017 Jul 19;8(8):1697-1705. doi: 10.1039/c7md00296c. eCollection 2017 Aug 01.

It has been reported that bioisosteric replacement of an 1,2,4-oxadiazole ring by an 1,3,4-oxadiazole ring leads to higher polarity, reduced metabolic degradation by human liver microsomes and reduced interaction with hERG channels. In a seven to eight step synthesis...

2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.

European journal of medicinal chemistry

Chiaramonte N, Angeli A, Sgambellone S, Bonardi A, Nocentini A, Bartolucci G, Braconi L, Dei S, Lucarini L, Teodori E, Gratteri P, Wünsch B, Supuran CT, Romanelli MN.
PMID: 34920169
Eur J Med Chem. 2022 Jan 15;228:114026. doi: 10.1016/j.ejmech.2021.114026. Epub 2021 Dec 04.

Targeting Carbonic Anhydrases (CAs) represents a strategy to treat several diseases, from glaucoma to cancer. To widen the structure-activity relationships (SARs) of our series of piperazines endowed with potent human carbonic anhydrase (hCA) inhibition, a new series of chiral...

Psychooncological care for patients with cancer during 12 months of the Covid-19 pandemic: Views and experiences of senior psychooncologists at German Comprehensive Cancer Centers.

Psycho-oncology

Dinkel A, Goerling U, Hönig K, Karger A, Maatouk I, Petermann-Meyer A, Senf B, Woellert K, Wünsch A, Zimmermann T, Schulz-Kindermann F, Zientek LR.
PMID: 34184361
Psychooncology. 2021 Nov;30(11):1982-1985. doi: 10.1002/pon.5759. Epub 2021 Jul 14.

No abstract available.

Synthesis and pharmacological evaluation of enantiomerically pure .

Organic & biomolecular chemistry

Jonas H, Aiello D, Frehland B, Lehmkuhl K, Schepmann D, Köhler J, Diana P, Wünsch B.
PMID: 34528988
Org Biomol Chem. 2021 Oct 06;19(38):8384-8396. doi: 10.1039/d1ob01498f.

Conformationally restricted bicyclic KOR agonists 10 with an

Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy.

Translational stroke research

Fandler-Höfler S, Odler B, Kneihsl M, Wünsch G, Haidegger M, Poltrum B, Beitzke M, Deutschmann H, Enzinger C, Rosenkranz AR, Gattringer T.
PMID: 33398648
Transl Stroke Res. 2021 Oct;12(5):791-798. doi: 10.1007/s12975-020-00881-2. Epub 2021 Jan 04.

Data on the impact of kidney dysfunction on outcome in patients with stroke due to large vessel occlusion are scarce. The few available studies are limited by only considering single kidney parameters measured at one time point. We thus...

Showing 1 to 12 of 129 entries