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Simulation system SONCHES-based toxicokinetic model and data bank as a tool in biological monitoring and risk assessment.

The Science of the total environment

Wünscher G, Kersting H, Heberer H, Westmeier I, Wenzel V, Flechsig M, Matthaeus E.
PMID: 2057758
Sci Total Environ. 1991 Jan 01;101(1):101-9. doi: 10.1016/0048-9697(91)90108-q.

This paper describes the use of an interactive simulation system (SONCHES) as a model and databank system. The basic model is a physiologically based toxicokinetic model (partition coefficient concept). This model takes circulation times into consideration and includes a...

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Wünscher G, Kersting H, Heberer H, et al. Simulation system SONCHES-based toxicokinetic model and data bank as a tool in biological monitoring and risk assessment. Sci Total Environ. 1991;101(1):101-9doi: 10.1016/0048-9697(91)90108-q.
Wünscher, G., Kersting, H., Heberer, H., Westmeier, I., Wenzel, V., Flechsig, M., & Matthaeus, E. (1991). Simulation system SONCHES-based toxicokinetic model and data bank as a tool in biological monitoring and risk assessment. The Science of the total environment, 101(1), 101-9. https://doi.org/10.1016/0048-9697(91)90108-q
Wünscher, G, et al. "Simulation system SONCHES-based toxicokinetic model and data bank as a tool in biological monitoring and risk assessment." The Science of the total environment vol. 101,1 (1991): 101-9. doi: https://doi.org/10.1016/0048-9697(91)90108-q
Wünscher G, Kersting H, Heberer H, Westmeier I, Wenzel V, Flechsig M, Matthaeus E. Simulation system SONCHES-based toxicokinetic model and data bank as a tool in biological monitoring and risk assessment. Sci Total Environ. 1991 Jan 01;101(1):101-9. doi: 10.1016/0048-9697(91)90108-q. PMID: 2057758.
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Measurements of the strong-interaction widths of the kaonic (3)He and (4)He 2p levels.

Physics letters. [Part B]

, Bazzi M, Beer G, Bombelli L, Bragadireanu AM, Cargnelli M, Curceanu Petrascu C, Dʼuffizi A, Fiorini C, Frizzi T, Ghio F, Guaraldo C, Hayano RS, Iliescu M, Ishiwatari T, Iwasaki M, Kienle P, Levi Sandri P, Longoni A, Marton J, Okada S, Pietreanu D, Ponta T, Rizzo A, Romero Vidal A, Sbardella E, Scordo A, Shi H, Sirghi DL, Sirghi F, Tatsuno H, Tudorache A, Tudorache V, Vazquez Doce O, Wünschek B, Widmann E, Zmeskal J.
PMID: 22876000
Phys Lett B. 2012 Jul 24;714(1):40-43. doi: 10.1016/j.physletb.2012.06.071.

The kaonic (3)He and (4)He X-rays emitted in the [Formula: see text] transitions were measured in the SIDDHARTA experiment. The widths of the kaonic (3)He and (4)He 2p states were determined to be [Formula: see text], and [Formula: see...

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, Bazzi M, Beer G, et al. Measurements of the strong-interaction widths of the kaonic (3)He and (4)He 2p levels. Phys Lett B. 2012;714(1):40-43doi: 10.1016/j.physletb.2012.06.071.
, Bazzi, M., Beer, G., Bombelli, L., Bragadireanu, A. M., Cargnelli, M., Curceanu Petrascu, C., Dʼuffizi, A., Fiorini, C., Frizzi, T., Ghio, F., Guaraldo, C., Hayano, R. S., Iliescu, M., Ishiwatari, T., Iwasaki, M., Kienle, P., Levi Sandri, P., Longoni, A., Marton, J., Okada, S., Pietreanu, D., Ponta, T., Rizzo, A., Romero Vidal, A., Sbardella, E., Scordo, A., Shi, H., Sirghi, D. L., Sirghi, F., Tatsuno, H., Tudorache, A., Tudorache, V., Vazquez Doce, O., Wünschek, B., Widmann, E., & Zmeskal, J. (2012). Measurements of the strong-interaction widths of the kaonic (3)He and (4)He 2p levels. Physics letters. [Part B], 714(1), 40-43. https://doi.org/10.1016/j.physletb.2012.06.071
, et al. "Measurements of the strong-interaction widths of the kaonic (3)He and (4)He 2p levels." Physics letters. [Part B] vol. 714,1 (2012): 40-43. doi: https://doi.org/10.1016/j.physletb.2012.06.071
, Bazzi M, Beer G, Bombelli L, Bragadireanu AM, Cargnelli M, Curceanu Petrascu C, Dʼuffizi A, Fiorini C, Frizzi T, Ghio F, Guaraldo C, Hayano RS, Iliescu M, Ishiwatari T, Iwasaki M, Kienle P, Levi Sandri P, Longoni A, Marton J, Okada S, Pietreanu D, Ponta T, Rizzo A, Romero Vidal A, Sbardella E, Scordo A, Shi H, Sirghi DL, Sirghi F, Tatsuno H, Tudorache A, Tudorache V, Vazquez Doce O, Wünschek B, Widmann E, Zmeskal J. Measurements of the strong-interaction widths of the kaonic (3)He and (4)He 2p levels. Phys Lett B. 2012 Jul 24;714(1):40-43. doi: 10.1016/j.physletb.2012.06.071. PMID: 22876000; PMCID: PMC3405488.
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Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation.

Scientific reports

Fuchs S, Rödel C, Blinne A, Zastrau U, Wünsche M, Hilbert V, Glaser L, Viefhaus J, Frumker E, Corkum P, Förster E, Paulus GG.
PMID: 26860894
Sci Rep. 2016 Feb 10;6:20658. doi: 10.1038/srep20658.

Optical coherence tomography (OCT) is a non-invasive technique for cross-sectional imaging. It is particularly advantageous for applications where conventional microscopy is not able to image deeper layers of samples in a reasonable time, e.g. in fast moving, deeper lying...

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Fuchs S, Rödel C, Blinne A, et al. Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation. Sci Rep. 2016;6:20658doi: 10.1038/srep20658.
Fuchs, S., Rödel, C., Blinne, A., Zastrau, U., Wünsche, M., Hilbert, V., Glaser, L., Viefhaus, J., Frumker, E., Corkum, P., Förster, E., & Paulus, G. G. (2016). Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation. Scientific reports, 620658. https://doi.org/10.1038/srep20658
Fuchs, Silvio, et al. "Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation." Scientific reports vol. 6 (2016): 20658. doi: https://doi.org/10.1038/srep20658
Fuchs S, Rödel C, Blinne A, Zastrau U, Wünsche M, Hilbert V, Glaser L, Viefhaus J, Frumker E, Corkum P, Förster E, Paulus GG. Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation. Sci Rep. 2016 Feb 10;6:20658. doi: 10.1038/srep20658. PMID: 26860894; PMCID: PMC4748318.
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Electronic properties of neutral dyes in the channels of zeolite L: a combined spectroscopic and quantum chemical study.

The journal of physical chemistry. B

Bussemer B, Munsel D, Wünscher H, Mohr GJ, Grummt UW.
PMID: 17201423
J Phys Chem B. 2007 Jan 11;111(1):8-15. doi: 10.1021/jp064986w.

Three low molecular weight model compounds for poly(phenylene-ethynylene)s were inserted into the channels of zeolite L by using gas phase insertion. The absorption and emission spectra in solution and dye/zeolite L are reported. Two compounds show emission properties in...

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Bussemer B, Munsel D, Wünscher H, et al. Electronic properties of neutral dyes in the channels of zeolite L: a combined spectroscopic and quantum chemical study. J Phys Chem B. 2007;111(1):8-15doi: 10.1021/jp064986w.
Bussemer, B., Munsel, D., Wünscher, H., Mohr, G. J., & Grummt, U. W. (2007). Electronic properties of neutral dyes in the channels of zeolite L: a combined spectroscopic and quantum chemical study. The journal of physical chemistry. B, 111(1), 8-15. https://doi.org/10.1021/jp064986w
Bussemer, Beate, et al. "Electronic properties of neutral dyes in the channels of zeolite L: a combined spectroscopic and quantum chemical study." The journal of physical chemistry. B vol. 111,1 (2007): 8-15. doi: https://doi.org/10.1021/jp064986w
Bussemer B, Munsel D, Wünscher H, Mohr GJ, Grummt UW. Electronic properties of neutral dyes in the channels of zeolite L: a combined spectroscopic and quantum chemical study. J Phys Chem B. 2007 Jan 11;111(1):8-15. doi: 10.1021/jp064986w. PMID: 17201423.
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A source of antihydrogen for in-flight hyperfine spectroscopy.

Nature communications

Kuroda N, Ulmer S, Murtagh DJ, Van Gorp S, Nagata Y, Diermaier M, Federmann S, Leali M, Malbrunot C, Mascagna V, Massiczek O, Michishio K, Mizutani T, Mohri A, Nagahama H, Ohtsuka M, Radics B, Sakurai S, Sauerzopf C, Suzuki K, Tajima M, Torii HA, Venturelli L, Wünschek B, Zmeskal J, Zurlo N, Higaki H, Kanai Y, Lodi Rizzini E, Nagashima Y, Matsuda Y, Widmann E, Yamazaki Y.
PMID: 24448273
Nat Commun. 2014;5:3089. doi: 10.1038/ncomms4089.

Antihydrogen, a positron bound to an antiproton, is the simplest antiatom. Its counterpart-hydrogen--is one of the most precisely investigated and best understood systems in physics research. High-resolution comparisons of both systems provide sensitive tests of CPT symmetry, which is...

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Kuroda N, Ulmer S, Murtagh DJ, et al. A source of antihydrogen for in-flight hyperfine spectroscopy. Nat Commun. 2014;5:3089doi: 10.1038/ncomms4089.
Kuroda, N., Ulmer, S., Murtagh, D. J., Van Gorp, S., Nagata, Y., Diermaier, M., Federmann, S., Leali, M., Malbrunot, C., Mascagna, V., Massiczek, O., Michishio, K., Mizutani, T., Mohri, A., Nagahama, H., Ohtsuka, M., Radics, B., Sakurai, S., Sauerzopf, C., Suzuki, K., Tajima, M., Torii, H. A., Venturelli, L., Wünschek, B., Zmeskal, J., Zurlo, N., Higaki, H., Kanai, Y., Lodi Rizzini, E., Nagashima, Y., Matsuda, Y., Widmann, E., & Yamazaki, Y. (2014). A source of antihydrogen for in-flight hyperfine spectroscopy. Nature communications, 53089. https://doi.org/10.1038/ncomms4089
Kuroda, N, et al. "A source of antihydrogen for in-flight hyperfine spectroscopy." Nature communications vol. 5 (2014): 3089. doi: https://doi.org/10.1038/ncomms4089
Kuroda N, Ulmer S, Murtagh DJ, Van Gorp S, Nagata Y, Diermaier M, Federmann S, Leali M, Malbrunot C, Mascagna V, Massiczek O, Michishio K, Mizutani T, Mohri A, Nagahama H, Ohtsuka M, Radics B, Sakurai S, Sauerzopf C, Suzuki K, Tajima M, Torii HA, Venturelli L, Wünschek B, Zmeskal J, Zurlo N, Higaki H, Kanai Y, Lodi Rizzini E, Nagashima Y, Matsuda Y, Widmann E, Yamazaki Y. A source of antihydrogen for in-flight hyperfine spectroscopy. Nat Commun. 2014;5:3089. doi: 10.1038/ncomms4089. PMID: 24448273; PMCID: PMC3945878.
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Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation.

Frontiers in physiology

Nybo L, Wanscher M, Secher NH.
PMID: 24578693
Front Physiol. 2014 Feb 27;5:79. doi: 10.3389/fphys.2014.00079. eCollection 2014.

The present study evaluated the influence of intranasal cooling with balloon catheters, increased nasal ventilation, or percutaneous cooling of the carotid arteries on cerebral temperature balance and oxygenation in six healthy male subjects. Aortic arch and internal jugular venous...

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Nybo L, Wanscher M, Secher NH. Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation. Front Physiol. 2014;5:79doi: 10.3389/fphys.2014.00079.
Nybo, L., Wanscher, M., & Secher, N. H. (2014). Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation. Frontiers in physiology, 579. https://doi.org/10.3389/fphys.2014.00079
Nybo, Lars, et al. "Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation." Frontiers in physiology vol. 5 (2014): 79. doi: https://doi.org/10.3389/fphys.2014.00079
Nybo L, Wanscher M, Secher NH. Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation. Front Physiol. 2014 Feb 27;5:79. doi: 10.3389/fphys.2014.00079. eCollection 2014. PMID: 24578693; PMCID: PMC3936139.
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Sensitivity calibration of an imaging extreme ultraviolet spectrometer-detector system for determining the efficiency of broadband extreme ultraviolet sources.

The Review of scientific instruments

Fuchs S, Rödel C, Krebs M, Hädrich S, Bierbach J, Paz AE, Kuschel S, Wünsche M, Hilbert V, Zastrau U, Förster E, Limpert J, Paulus GG.
PMID: 23464189
Rev Sci Instrum. 2013 Feb;84(2):023101. doi: 10.1063/1.4788732.

We report on the absolute sensitivity calibration of an extreme ultraviolet (XUV) spectrometer system that is frequently employed to study emission from short-pulse laser experiments. The XUV spectrometer, consisting of a toroidal mirror and a transmission grating, was characterized...

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Fuchs S, Rödel C, Krebs M, et al. Sensitivity calibration of an imaging extreme ultraviolet spectrometer-detector system for determining the efficiency of broadband extreme ultraviolet sources. Rev Sci Instrum. 2013;84(2):023101doi: 10.1063/1.4788732.
Fuchs, S., Rödel, C., Krebs, M., Hädrich, S., Bierbach, J., Paz, A. E., Kuschel, S., Wünsche, M., Hilbert, V., Zastrau, U., Förster, E., Limpert, J., & Paulus, G. G. (2013). Sensitivity calibration of an imaging extreme ultraviolet spectrometer-detector system for determining the efficiency of broadband extreme ultraviolet sources. The Review of scientific instruments, 84(2), 023101. https://doi.org/10.1063/1.4788732
Fuchs, S, et al. "Sensitivity calibration of an imaging extreme ultraviolet spectrometer-detector system for determining the efficiency of broadband extreme ultraviolet sources." The Review of scientific instruments vol. 84,2 (2013): 023101. doi: https://doi.org/10.1063/1.4788732
Fuchs S, Rödel C, Krebs M, Hädrich S, Bierbach J, Paz AE, Kuschel S, Wünsche M, Hilbert V, Zastrau U, Förster E, Limpert J, Paulus GG. Sensitivity calibration of an imaging extreme ultraviolet spectrometer-detector system for determining the efficiency of broadband extreme ultraviolet sources. Rev Sci Instrum. 2013 Feb;84(2):023101. doi: 10.1063/1.4788732. PMID: 23464189.
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High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis.

Analytical and bioanalytical chemistry

Leiterer C, Wünsche E, Singh P, Albert J, Köhler JM, Deckert V, Fritzsche W.
PMID: 26968565
Anal Bioanal Chem. 2016 May;408(13):3625-31. doi: 10.1007/s00216-016-9447-6. Epub 2016 Mar 11.

AFM tips are modified with silver nanoparticles using an AC electrical field. The used technique works with sub-micron precision and also does not require chemical modification of the tip. Based on the electrical parameters applied in the process, particle...

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Leiterer C, Wünsche E, Singh P, et al. High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis. Anal Bioanal Chem. 2016;408(13):3625-31doi: 10.1007/s00216-016-9447-6.
Leiterer, C., Wünsche, E., Singh, P., Albert, J., Köhler, J. M., Deckert, V., & Fritzsche, W. (2016). High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis. Analytical and bioanalytical chemistry, 408(13), 3625-31. https://doi.org/10.1007/s00216-016-9447-6
Leiterer, Christian, et al. "High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis." Analytical and bioanalytical chemistry vol. 408,13 (2016): 3625-31. doi: https://doi.org/10.1007/s00216-016-9447-6
Leiterer C, Wünsche E, Singh P, Albert J, Köhler JM, Deckert V, Fritzsche W. High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis. Anal Bioanal Chem. 2016 May;408(13):3625-31. doi: 10.1007/s00216-016-9447-6. Epub 2016 Mar 11. PMID: 26968565.
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Marginal distributions of quasiprobabilities in quantum optics.

Physical review. A, Atomic, molecular, and optical physics

Orlowski A, Wünsche A.
PMID: 9910178
Phys Rev A. 1993 Dec;48(6):4697-4701. doi: 10.1103/physreva.48.4697.

No abstract available.

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Orlowski A, Wünsche A. Marginal distributions of quasiprobabilities in quantum optics. Phys Rev A. 1993;48(6):4697-4701doi: 10.1103/physreva.48.4697.
Orlowski, A., & Wünsche, A. (1993). Marginal distributions of quasiprobabilities in quantum optics. Physical review. A, Atomic, molecular, and optical physics, 48(6), 4697-4701. https://doi.org/10.1103/physreva.48.4697
Orlowski, and Wünsche. "Marginal distributions of quasiprobabilities in quantum optics." Physical review. A, Atomic, molecular, and optical physics vol. 48,6 (1993): 4697-4701. doi: https://doi.org/10.1103/physreva.48.4697
Orlowski A, Wünsche A. Marginal distributions of quasiprobabilities in quantum optics. Phys Rev A. 1993 Dec;48(6):4697-4701. doi: 10.1103/physreva.48.4697. PMID: 9910178.
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Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy.

Translational stroke research

Fandler-Höfler S, Odler B, Kneihsl M, Wünsch G, Haidegger M, Poltrum B, Beitzke M, Deutschmann H, Enzinger C, Rosenkranz AR, Gattringer T.
PMID: 33398648
Transl Stroke Res. 2021 Oct;12(5):791-798. doi: 10.1007/s12975-020-00881-2. Epub 2021 Jan 04.

Data on the impact of kidney dysfunction on outcome in patients with stroke due to large vessel occlusion are scarce. The few available studies are limited by only considering single kidney parameters measured at one time point. We thus...

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Fandler-Höfler S, Odler B, Kneihsl M, et al. Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy. Transl Stroke Res. 2021;12(5):791-798doi: 10.1007/s12975-020-00881-2.
Fandler-Höfler, S., Odler, B., Kneihsl, M., Wünsch, G., Haidegger, M., Poltrum, B., Beitzke, M., Deutschmann, H., Enzinger, C., Rosenkranz, A. R., & Gattringer, T. (2021). Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy. Translational stroke research, 12(5), 791-798. https://doi.org/10.1007/s12975-020-00881-2
Fandler-Höfler, Simon, et al. "Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy." Translational stroke research vol. 12,5 (2021): 791-798. doi: https://doi.org/10.1007/s12975-020-00881-2
Fandler-Höfler S, Odler B, Kneihsl M, Wünsch G, Haidegger M, Poltrum B, Beitzke M, Deutschmann H, Enzinger C, Rosenkranz AR, Gattringer T. Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy. Transl Stroke Res. 2021 Oct;12(5):791-798. doi: 10.1007/s12975-020-00881-2. Epub 2021 Jan 04. PMID: 33398648; PMCID: PMC8421282.
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Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer.

Cancers

Wurlitzer M, Möckelmann N, Kriegs M, Vens M, Omidi M, Hoffer K, Bargen CV, Möller-Koop C, Witt M, Droste C, Oetting A, Petersen H, Busch CJ, Münscher A, Schlüter H, Clauditz TS, Rieckmann T.
PMID: 32545200
Cancers (Basel). 2020 Jun 11;12(6). doi: 10.3390/cancers12061531.

Squamous cell carcinoma of the head and neck (HNSCC) consist of two distinct biological entities. While the numbers of classical, tobacco-induced HNSCC are declining, tumors caused by human papillomavirus (HPV) infection are increasing in many countries. HPV-positive HNSCC mostly...

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Wurlitzer M, Möckelmann N, Kriegs M, et al. Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer. Cancers (Basel). 2020;12(6)doi: 10.3390/cancers12061531.
Wurlitzer, M., Möckelmann, N., Kriegs, M., Vens, M., Omidi, M., Hoffer, K., Bargen, C. V., Möller-Koop, C., Witt, M., Droste, C., Oetting, A., Petersen, H., Busch, C. J., Münscher, A., Schlüter, H., Clauditz, T. S., & Rieckmann, T. (2020). Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer. Cancers, 12(6), . https://doi.org/10.3390/cancers12061531
Wurlitzer, Marcus, et al. "Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer." Cancers vol. 12,6 (2020). doi: https://doi.org/10.3390/cancers12061531
Wurlitzer M, Möckelmann N, Kriegs M, Vens M, Omidi M, Hoffer K, Bargen CV, Möller-Koop C, Witt M, Droste C, Oetting A, Petersen H, Busch CJ, Münscher A, Schlüter H, Clauditz TS, Rieckmann T. Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer. Cancers (Basel). 2020 Jun 11;12(6). doi: 10.3390/cancers12061531. PMID: 32545200; PMCID: PMC7352546.
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Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics.

ChemMedChem

Gilpin IMF, Ullrich M, Wünsche T, Zarschler K, Lebeda O, Pietzsch J, Pietzsch HJ, Walther M.
PMID: 33949125
ChemMedChem. 2021 Sep 06;16(17):2645-2649. doi: 10.1002/cmdc.202100131. Epub 2021 Jun 16.

We show the synthesis of an in vivo stable mercury compound with functionality suitable for radiopharmaceuticals. The designed cyclic bisarylmercury was based on the water tolerance of organomercurials, higher bond dissociation energy of Hg-Ph to Hg-S, and the experimental...

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Gilpin IMF, Ullrich M, Wünsche T, et al. Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics. ChemMedChem. 2021;16(17):2645-2649doi: 10.1002/cmdc.202100131.
Gilpin, I. M. F., Ullrich, M., Wünsche, T., Zarschler, K., Lebeda, O., Pietzsch, J., Pietzsch, H. J., & Walther, M. (2021). Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics. ChemMedChem, 16(17), 2645-2649. https://doi.org/10.1002/cmdc.202100131
Gilpin, Ian Moore F, et al. "Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics." ChemMedChem vol. 16,17 (2021): 2645-2649. doi: https://doi.org/10.1002/cmdc.202100131
Gilpin IMF, Ullrich M, Wünsche T, Zarschler K, Lebeda O, Pietzsch J, Pietzsch HJ, Walther M. Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics. ChemMedChem. 2021 Sep 06;16(17):2645-2649. doi: 10.1002/cmdc.202100131. Epub 2021 Jun 16. PMID: 33949125; PMCID: PMC8518081.
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