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Regulatory developmental neurotoxicity testing: a model study focussing on conventional neuropathology endpoints and other perspectives.

Environmental toxicology and pharmacology

de Groot DM, Bos-Kuijpers MH, Kaufmann WS, Lammers JH, O'Callaghan JP, Pakkenberg B, Pelgrim MT, Waalkens-Berendsen ID, Waanders MM, Gundersen HJ.
PMID: 21783551
Environ Toxicol Pharmacol. 2005 May;19(3):745-55. doi: 10.1016/j.etap.2004.12.039.

Our aim was to investigate a model of the morphologic approach proposed in guidelines for developmental neurotoxicity testing (DNT). Hereto, a limited DNT study [EPA Health Effects Test Guidelines OPPTS 870.6300, 1996a. Developmental Neurotoxicity Study "Public Draft", United States...

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de Groot DM, Bos-Kuijpers MH, Kaufmann WS, et al. Regulatory developmental neurotoxicity testing: a model study focussing on conventional neuropathology endpoints and other perspectives. Environ Toxicol Pharmacol. 2005;19(3):745-55doi: 10.1016/j.etap.2004.12.039.
de Groot, D. M., Bos-Kuijpers, M. H., Kaufmann, W. S., Lammers, J. H., O'Callaghan, J. P., Pakkenberg, B., Pelgrim, M. T., Waalkens-Berendsen, I. D., Waanders, M. M., & Gundersen, H. J. (2005). Regulatory developmental neurotoxicity testing: a model study focussing on conventional neuropathology endpoints and other perspectives. Environmental toxicology and pharmacology, 19(3), 745-55. https://doi.org/10.1016/j.etap.2004.12.039
de Groot, Didima M G, et al. "Regulatory developmental neurotoxicity testing: a model study focussing on conventional neuropathology endpoints and other perspectives." Environmental toxicology and pharmacology vol. 19,3 (2005): 745-55. doi: https://doi.org/10.1016/j.etap.2004.12.039
de Groot DM, Bos-Kuijpers MH, Kaufmann WS, Lammers JH, O'Callaghan JP, Pakkenberg B, Pelgrim MT, Waalkens-Berendsen ID, Waanders MM, Gundersen HJ. Regulatory developmental neurotoxicity testing: a model study focussing on conventional neuropathology endpoints and other perspectives. Environ Toxicol Pharmacol. 2005 May;19(3):745-55. doi: 10.1016/j.etap.2004.12.039. PMID: 21783551.
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Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Gott D, Leblanc JC, Smeraldi C, Tard A, Castle L.
PMID: 32626247
EFSA J. 2019 Mar 08;17(3):e05621. doi: 10.2903/j.efsa.2019.5621. eCollection 2019 Mar.

The present scientific opinion deals with the evaluation of the safety of the food additive ethyl lauroyl arginate (E 243) in the light of a new interpretation of the available toxicological data and with respect to the proposed changes...

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, Younes M, Aquilina G, et al. Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use. EFSA J. 2019;17(3):e05621doi: 10.2903/j.efsa.2019.5621.
, Younes, M., Aquilina, G., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gürtler, R., Gundert-Remy, U., Husøy, T., Mennes, W., Moldeus, P., Oskarsson, A., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Gott, D., Leblanc, J. C., Smeraldi, C., Tard, A., & Castle, L. (2019). Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use. EFSA journal. European Food Safety Authority, 17(3), e05621. https://doi.org/10.2903/j.efsa.2019.5621
, et al. "Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use." EFSA journal. European Food Safety Authority vol. 17,3 (2019): e05621. doi: https://doi.org/10.2903/j.efsa.2019.5621
, Younes M, Aquilina G, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Gott D, Leblanc JC, Smeraldi C, Tard A, Castle L. Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use. EFSA J. 2019 Mar 08;17(3):e05621. doi: 10.2903/j.efsa.2019.5621. eCollection 2019 Mar. PMID: 32626247; PMCID: PMC7009305.
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Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carfì M, Vianello G, Mennes W.
PMID: 32626370
EFSA J. 2019 Jul 17;17(7):e05750. doi: 10.2903/j.efsa.2019.5750. eCollection 2019 Jul.

The Panel on Food Additives and Flavourings (FAF Panel) of the European Food Safety Authority was requested to evaluate the genotoxic potential of the flavouring substances from subgroup 1.2.1 of FGE.19 in the Flavouring Group Evaluation 204 (FGE.204). In...

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19. EFSA J. 2019;17(7):e05750doi: 10.2903/j.efsa.2019.5750.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Gürtler, R., Husøy, T., Moldeus, P., Oskarsson, A., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Benigni, R., Bolognesi, C., Chipman, K., Cordelli, E., Degen, G., Marzin, D., Svendsen, C., Carfì, M., Vianello, G., & Mennes, W. (2019). Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19. EFSA journal. European Food Safety Authority, 17(7), e05750. https://doi.org/10.2903/j.efsa.2019.5750
, et al. "Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19." EFSA journal. European Food Safety Authority vol. 17,7 (2019): e05750. doi: https://doi.org/10.2903/j.efsa.2019.5750
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carfì M, Vianello G, Mennes W. Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19. EFSA J. 2019 Jul 17;17(7):e05750. doi: 10.2903/j.efsa.2019.5750. eCollection 2019 Jul. PMID: 32626370; PMCID: PMC7009293.
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Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Carfì M, Vianello G, Gürtler R.
PMID: 32625707
EFSA J. 2018 Oct 19;16(10):e05422. doi: 10.2903/j.efsa.2018.5422. eCollection 2018 Oct.

The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of 74 flavouring substances from subgroup 1.1.1 of FGE.19 in the Flavouring Group Evaluation 200 Revision 1 (FGE.200 Rev1)....

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19. EFSA J. 2018;16(10):e05422doi: 10.2903/j.efsa.2018.5422.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Husøy, T., Mennes, W., Moldeus, P., Oskarsson, A., Rainieri, S., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Binderup, M. L., Bolognesi, C., Marcon, F., Marzin, D., Mosesso, P., Carfì, M., Vianello, G., & Gürtler, R. (2018). Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19. EFSA journal. European Food Safety Authority, 16(10), e05422. https://doi.org/10.2903/j.efsa.2018.5422
, et al. "Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19." EFSA journal. European Food Safety Authority vol. 16,10 (2018): e05422. doi: https://doi.org/10.2903/j.efsa.2018.5422
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Carfì M, Vianello G, Gürtler R. Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19. EFSA J. 2018 Oct 19;16(10):e05422. doi: 10.2903/j.efsa.2018.5422. eCollection 2018 Oct. PMID: 32625707; PMCID: PMC7009627.
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Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Anastassiadou M, Carfì M, Vianello G, Gürtler R.
PMID: 32625708
EFSA J. 2018 Oct 17;16(10):e05423. doi: 10.2903/j.efsa.2018.5423. eCollection 2018 Oct.

The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to consider in this revision 2 of Flavouring Group Evaluation 201, the additional data on genotoxicity submitted by the Industry on two substances, 2-methylpent-2-enal...

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19. EFSA J. 2018;16(10):e05423doi: 10.2903/j.efsa.2018.5423.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Husøy, T., Mennes, W., Moldeus, P., Oskarsson, A., Rainieri, S., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Binderup, M. L., Bolognesi, C., Marcon, F., Marzin, D., Mosesso, P., Anastassiadou, M., Carfì, M., Vianello, G., & Gürtler, R. (2018). Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19. EFSA journal. European Food Safety Authority, 16(10), e05423. https://doi.org/10.2903/j.efsa.2018.5423
, et al. "Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19." EFSA journal. European Food Safety Authority vol. 16,10 (2018): e05423. doi: https://doi.org/10.2903/j.efsa.2018.5423
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Anastassiadou M, Carfì M, Vianello G, Gürtler R. Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19. EFSA J. 2018 Oct 17;16(10):e05423. doi: 10.2903/j.efsa.2018.5423. eCollection 2018 Oct. PMID: 32625708; PMCID: PMC7009377.
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Re-evaluation of gellan gum (E 418) as food additive.

EFSA journal. European Food Safety Authority

, Younes M, Aggett P, Aguilar F, Crebelli R, Filipic M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Brimer L, Mosesso P, Christodoulidou A, Cascio C, Tard A, Lodi F, Dusemund B.
PMID: 32625935
EFSA J. 2018 Jun 20;16(6):e05296. doi: 10.2903/j.efsa.2018.5296. eCollection 2018 Jun.

The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of gellan gum (E 418) as a food additive. Following the conceptual framework for the risk assessment of certain food...

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, Younes M, Aggett P, et al. Re-evaluation of gellan gum (E 418) as food additive. EFSA J. 2018;16(6):e05296doi: 10.2903/j.efsa.2018.5296.
, Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Filipic, M., Frutos, M. J., Galtier, P., Gott, D., Gundert-Remy, U., Kuhnle, G. G., Lambré, C., Leblanc, J. C., Lillegaard, I. T., Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Woutersen, R. A., Wright, M., Brimer, L., Mosesso, P., Christodoulidou, A., Cascio, C., Tard, A., Lodi, F., & Dusemund, B. (2018). Re-evaluation of gellan gum (E 418) as food additive. EFSA journal. European Food Safety Authority, 16(6), e05296. https://doi.org/10.2903/j.efsa.2018.5296
, et al. "Re-evaluation of gellan gum (E 418) as food additive." EFSA journal. European Food Safety Authority vol. 16,6 (2018): e05296. doi: https://doi.org/10.2903/j.efsa.2018.5296
, Younes M, Aggett P, Aguilar F, Crebelli R, Filipic M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Brimer L, Mosesso P, Christodoulidou A, Cascio C, Tard A, Lodi F, Dusemund B. Re-evaluation of gellan gum (E 418) as food additive. EFSA J. 2018 Jun 20;16(6):e05296. doi: 10.2903/j.efsa.2018.5296. eCollection 2018 Jun. PMID: 32625935; PMCID: PMC7009714.
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Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171).

EFSA journal. European Food Safety Authority

, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Wright M, Lodi F, Rincon AM, Smeraldi C, Woutersen RA.
PMID: 32625996
EFSA J. 2018 Jul 04;16(7):e05366. doi: 10.2903/j.efsa.2018.5366. eCollection 2018 Jul.

The European Commission requested EFSA to carry out a scientific evaluation on four studies on the potential toxicity of titanium dioxide (TiO

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, Younes M, Aggett P, et al. Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171). EFSA J. 2018;16(7):e05366doi: 10.2903/j.efsa.2018.5366.
, Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Dusemund, B., Filipič, M., Frutos, M. J., Galtier, P., Gott, D., Gundert-Remy, U., Kuhnle, G. G., Lambré, C., Leblanc, J. C., Lillegaard, I. T., Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Wright, M., Lodi, F., Rincon, A. M., Smeraldi, C., & Woutersen, R. A. (2018). Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171). EFSA journal. European Food Safety Authority, 16(7), e05366. https://doi.org/10.2903/j.efsa.2018.5366
, et al. "Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171)." EFSA journal. European Food Safety Authority vol. 16,7 (2018): e05366. doi: https://doi.org/10.2903/j.efsa.2018.5366
, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Wright M, Lodi F, Rincon AM, Smeraldi C, Woutersen RA. Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171). EFSA J. 2018 Jul 04;16(7):e05366. doi: 10.2903/j.efsa.2018.5366. eCollection 2018 Jul. PMID: 32625996; PMCID: PMC7009373.
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Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives.

EFSA journal. European Food Safety Authority

, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Boon P, Gürtler R, Mosesso P, Parent-Massin D, Tobback P, Chrysafidis D, Rincon AM, Tard A, Lambré C.
PMID: 32626019
EFSA J. 2018 Aug 02;16(8):e05375. doi: 10.2903/j.efsa.2018.5375. eCollection 2018 Aug.

The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of calcium silicate (E 552), magnesium silicate (E 553a) and talc (E 553b) when used as food additives. In...

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, Younes M, Aggett P, et al. Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives. EFSA J. 2018;16(8):e05375doi: 10.2903/j.efsa.2018.5375.
, Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Dusemund, B., Filipič, M., Frutos, M. J., Galtier, P., Gott, D., Gundert-Remy, U., Kuhnle, G. G., Leblanc, J. C., Lillegaard, I. T., Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Woutersen, R. A., Wright, M., Boon, P., Gürtler, R., Mosesso, P., Parent-Massin, D., Tobback, P., Chrysafidis, D., Rincon, A. M., Tard, A., & Lambré, C. (2018). Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives. EFSA journal. European Food Safety Authority, 16(8), e05375. https://doi.org/10.2903/j.efsa.2018.5375
, et al. "Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives." EFSA journal. European Food Safety Authority vol. 16,8 (2018): e05375. doi: https://doi.org/10.2903/j.efsa.2018.5375
, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Boon P, Gürtler R, Mosesso P, Parent-Massin D, Tobback P, Chrysafidis D, Rincon AM, Tard A, Lambré C. Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives. EFSA J. 2018 Aug 02;16(8):e05375. doi: 10.2903/j.efsa.2018.5375. eCollection 2018 Aug. PMID: 32626019; PMCID: PMC7009349.
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Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, α,β-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Martino C, Mennes W.
PMID: 32626481
EFSA J. 2020 Jan 09;18(1):e05924. doi: 10.2903/j.efsa.2020.5924. eCollection 2020 Jan.

The EFSA Panel on Food Additives and Flavourings was requested to evaluate 39 flavouring substances assigned to the Flavouring Group Evaluation 71 (FGE.71), using the Procedure in Commission Regulation (EC) No 1565/2000. Nine substances have already been considered in...

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, α,β-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3. EFSA J. 2020;18(1):e05924doi: 10.2903/j.efsa.2020.5924.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Gürtler, R., Husøy, T., Moldeus, P., Oskarsson, A., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Benigni, R., Bolognesi, C., Chipman, K., Cordelli, E., Degen, G., Marzin, D., Svendsen, C., Martino, C., & Mennes, W. (2020). Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, α,β-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3. EFSA journal. European Food Safety Authority, 18(1), e05924. https://doi.org/10.2903/j.efsa.2020.5924
, et al. "Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, α,β-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3." EFSA journal. European Food Safety Authority vol. 18,1 (2020): e05924. doi: https://doi.org/10.2903/j.efsa.2020.5924
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Martino C, Mennes W. Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, α,β-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3. EFSA J. 2020 Jan 09;18(1):e05924. doi: 10.2903/j.efsa.2020.5924. eCollection 2020 Jan. PMID: 32626481; PMCID: PMC7008796.
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Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable).

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carfì M, Martino C, Mennes W.
PMID: 32626304
EFSA J. 2019 May 24;17(5):e05675. doi: 10.2903/j.efsa.2019.5675. eCollection 2019 May.

The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to deliver a scientific opinion on the implications for human health of the product Grill flavour concentrate (vegetable) [FL-no: 21.002] in the Flavouring Group...

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable). EFSA J. 2019;17(5):e05675doi: 10.2903/j.efsa.2019.5675.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Gürtler, R., Husøy, T., Moldeus, P., Oskarsson, A., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Benigni, R., Bolognesi, C., Chipman, K., Cordelli, E., Degen, G., Marzin, D., Svendsen, C., Carfì, M., Martino, C., & Mennes, W. (2019). Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable). EFSA journal. European Food Safety Authority, 17(5), e05675. https://doi.org/10.2903/j.efsa.2019.5675
, et al. "Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable)." EFSA journal. European Food Safety Authority vol. 17,5 (2019): e05675. doi: https://doi.org/10.2903/j.efsa.2019.5675
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carfì M, Martino C, Mennes W. Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable). EFSA J. 2019 May 24;17(5):e05675. doi: 10.2903/j.efsa.2019.5675. eCollection 2019 May. PMID: 32626304; PMCID: PMC7009177.
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Re-evaluation of fatty acids (E 570) as a food additive.

EFSA journal. European Food Safety Authority

, Mortensen A, Aguilar F, Crebelli R, Di Domenico A, Dusemund B, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Leblanc JC, Lindtner O, Moldeus P, Mosesso P, Parent-Massin D, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Younes M, Boon P, Chrysafidis D, Gürtler R, Tobback P, Gergelova P, Rincon AM, Lambré C.
PMID: 32625490
EFSA J. 2017 May 05;15(5):e04785. doi: 10.2903/j.efsa.2017.4785. eCollection 2017 May.

The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of fatty acids (E 570) when used as a food additive. The food additive includes caprylic- (C8), capric- (C10),...

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, Mortensen A, Aguilar F, et al. Re-evaluation of fatty acids (E 570) as a food additive. EFSA J. 2017;15(5):e04785doi: 10.2903/j.efsa.2017.4785.
, Mortensen, A., Aguilar, F., Crebelli, R., Di Domenico, A., Dusemund, B., Frutos, M. J., Galtier, P., Gott, D., Gundert-Remy, U., Leblanc, J. C., Lindtner, O., Moldeus, P., Mosesso, P., Parent-Massin, D., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Woutersen, R. A., Wright, M., Younes, M., Boon, P., Chrysafidis, D., Gürtler, R., Tobback, P., Gergelova, P., Rincon, A. M., & Lambré, C. (2017). Re-evaluation of fatty acids (E 570) as a food additive. EFSA journal. European Food Safety Authority, 15(5), e04785. https://doi.org/10.2903/j.efsa.2017.4785
, et al. "Re-evaluation of fatty acids (E 570) as a food additive." EFSA journal. European Food Safety Authority vol. 15,5 (2017): e04785. doi: https://doi.org/10.2903/j.efsa.2017.4785
, Mortensen A, Aguilar F, Crebelli R, Di Domenico A, Dusemund B, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Leblanc JC, Lindtner O, Moldeus P, Mosesso P, Parent-Massin D, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Younes M, Boon P, Chrysafidis D, Gürtler R, Tobback P, Gergelova P, Rincon AM, Lambré C. Re-evaluation of fatty acids (E 570) as a food additive. EFSA J. 2017 May 05;15(5):e04785. doi: 10.2903/j.efsa.2017.4785. eCollection 2017 May. PMID: 32625490; PMCID: PMC7009963.
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Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age.

EFSA journal. European Food Safety Authority

, Hardy A, Benford D, Halldorsson T, Jeger MJ, Knutsen HK, More S, Naegeli H, Noteborn H, Ockleford C, Ricci A, Rychen G, Schlatter JR, Silano V, Solecki R, Turck D, Bresson JL, Dusemund B, Gundert-Remy U, Kersting M, Lambré C, Penninks A, Tritscher A, Waalkens-Berendsen I, Woutersen R, Arcella D, Court Marques D, Dorne JL, Kass GE, Mortensen A.
PMID: 32625502
EFSA J. 2017 May 31;15(5):e04849. doi: 10.2903/j.efsa.2017.4849. eCollection 2017 May.

Following a request from the European Commission to EFSA, the EFSA Scientific Committee (SC) prepared a guidance for the risk assessment of substances present in food intended for infants below 16 weeks of age. In its approach to develop...

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, Hardy A, Benford D, et al. Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age. EFSA J. 2017;15(5):e04849doi: 10.2903/j.efsa.2017.4849.
, Hardy, A., Benford, D., Halldorsson, T., Jeger, M. J., Knutsen, H. K., More, S., Naegeli, H., Noteborn, H., Ockleford, C., Ricci, A., Rychen, G., Schlatter, J. R., Silano, V., Solecki, R., Turck, D., Bresson, J. L., Dusemund, B., Gundert-Remy, U., Kersting, M., Lambré, C., Penninks, A., Tritscher, A., Waalkens-Berendsen, I., Woutersen, R., Arcella, D., Court Marques, D., Dorne, J. L., Kass, G. E., & Mortensen, A. (2017). Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age. EFSA journal. European Food Safety Authority, 15(5), e04849. https://doi.org/10.2903/j.efsa.2017.4849
, et al. "Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age." EFSA journal. European Food Safety Authority vol. 15,5 (2017): e04849. doi: https://doi.org/10.2903/j.efsa.2017.4849
, Hardy A, Benford D, Halldorsson T, Jeger MJ, Knutsen HK, More S, Naegeli H, Noteborn H, Ockleford C, Ricci A, Rychen G, Schlatter JR, Silano V, Solecki R, Turck D, Bresson JL, Dusemund B, Gundert-Remy U, Kersting M, Lambré C, Penninks A, Tritscher A, Waalkens-Berendsen I, Woutersen R, Arcella D, Court Marques D, Dorne JL, Kass GE, Mortensen A. Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age. EFSA J. 2017 May 31;15(5):e04849. doi: 10.2903/j.efsa.2017.4849. eCollection 2017 May. PMID: 32625502; PMCID: PMC7010120.
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