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5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT.

Frontiers in neuroscience

Sia TC, Whiting M, Kyloh M, Nicholas SJ, Oliver J, Brookes SJ, Dinning PG, Wattchow DA, Spencer NJ.
PMID: 23935564
Front Neurosci. 2013 Aug 05;7:136. doi: 10.3389/fnins.2013.00136. eCollection 2013.

Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit peristalsis and GI-transit in mammals, including humans. This raises the...

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Sia TC, Whiting M, Kyloh M, et al. 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Front Neurosci. 2013;7:136doi: 10.3389/fnins.2013.00136.
Sia, T. C., Whiting, M., Kyloh, M., Nicholas, S. J., Oliver, J., Brookes, S. J., Dinning, P. G., Wattchow, D. A., & Spencer, N. J. (2013). 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Frontiers in neuroscience, 7136. https://doi.org/10.3389/fnins.2013.00136
Sia, Tiong C, et al. "5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT." Frontiers in neuroscience vol. 7 (2013): 136. doi: https://doi.org/10.3389/fnins.2013.00136
Sia TC, Whiting M, Kyloh M, Nicholas SJ, Oliver J, Brookes SJ, Dinning PG, Wattchow DA, Spencer NJ. 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Front Neurosci. 2013 Aug 05;7:136. doi: 10.3389/fnins.2013.00136. eCollection 2013. PMID: 23935564; PMCID: PMC3732893.
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High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Heitmann PT, Mohd Rosli R, Maslen L, Wiklendt L, Kumar R, Omari TI, Wattchow D, Costa M, Brookes SJ, Dinning PG.
PMID: 34076936
Neurogastroenterol Motil. 2022 Jan;34(1):e14178. doi: 10.1111/nmo.14178. Epub 2021 Jun 02.

BACKGROUND: The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high-resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a...

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Heitmann PT, Mohd Rosli R, Maslen L, et al. High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit. Neurogastroenterol Motil. 2021;34(1):e14178doi: 10.1111/nmo.14178.
Heitmann, P. T., Mohd Rosli, R., Maslen, L., Wiklendt, L., Kumar, R., Omari, T. I., Wattchow, D., Costa, M., Brookes, S. J., & Dinning, P. G. (2022). High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 34(1), e14178. https://doi.org/10.1111/nmo.14178
Heitmann, Paul T, et al. "High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit." Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society vol. 34,1 (2022): e14178. doi: https://doi.org/10.1111/nmo.14178
Heitmann PT, Mohd Rosli R, Maslen L, Wiklendt L, Kumar R, Omari TI, Wattchow D, Costa M, Brookes SJ, Dinning PG. High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit. Neurogastroenterol Motil. 2022 Jan;34(1):e14178. doi: 10.1111/nmo.14178. Epub 2021 Jun 02. PMID: 34076936.
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Dynamin regulates L cell secretion in human gut.

Molecular and cellular endocrinology

Sun EW, Matusica D, Wattchow DA, McCluskey A, Robinson PJ, Keating DJ.
PMID: 34274446
Mol Cell Endocrinol. 2021 Sep 15;535:111398. doi: 10.1016/j.mce.2021.111398. Epub 2021 Jul 15.

BACKGROUND: The mechanochemical enzyme dynamin mediates endocytosis and regulates neuroendocrine cell exocytosis. Enteroendocrine L cells co-secrete the anorectic gut hormones glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) postprandially and is a potential therapeutic target for metabolic diseases. In...

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Sun EW, Matusica D, Wattchow DA, et al. Dynamin regulates L cell secretion in human gut. Mol Cell Endocrinol. 2021;535:111398doi: 10.1016/j.mce.2021.111398.
Sun, E. W., Matusica, D., Wattchow, D. A., McCluskey, A., Robinson, P. J., & Keating, D. J. (2021). Dynamin regulates L cell secretion in human gut. Molecular and cellular endocrinology, 535111398. https://doi.org/10.1016/j.mce.2021.111398
Sun, Emily Wl, et al. "Dynamin regulates L cell secretion in human gut." Molecular and cellular endocrinology vol. 535 (2021): 111398. doi: https://doi.org/10.1016/j.mce.2021.111398
Sun EW, Matusica D, Wattchow DA, McCluskey A, Robinson PJ, Keating DJ. Dynamin regulates L cell secretion in human gut. Mol Cell Endocrinol. 2021 Sep 15;535:111398. doi: 10.1016/j.mce.2021.111398. Epub 2021 Jul 15. PMID: 34274446.
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Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro.

Frontiers in physiology

Carbone SE, Wattchow DA, Spencer NJ, Hibberd TJ, Brookes SJ.
PMID: 25202280
Front Physiol. 2014 Aug 22;5:319. doi: 10.3389/fphys.2014.00319. eCollection 2014.

Excitatory and inhibitory junction potentials of circular smooth muscle cells in guinea pig ileum and colon are suppressed 30-90 min after setting up in vitro preparations. We have previously shown this "unresponsive" period is associated with a transient loss...

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Carbone SE, Wattchow DA, Spencer NJ, et al. Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro. Front Physiol. 2014;5:319doi: 10.3389/fphys.2014.00319.
Carbone, S. E., Wattchow, D. A., Spencer, N. J., Hibberd, T. J., & Brookes, S. J. (2014). Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro. Frontiers in physiology, 5319. https://doi.org/10.3389/fphys.2014.00319
Carbone, Simona E, et al. "Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro." Frontiers in physiology vol. 5 (2014): 319. doi: https://doi.org/10.3389/fphys.2014.00319
Carbone SE, Wattchow DA, Spencer NJ, Hibberd TJ, Brookes SJ. Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro. Front Physiol. 2014 Aug 22;5:319. doi: 10.3389/fphys.2014.00319. eCollection 2014. PMID: 25202280; PMCID: PMC4141521.
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Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa.

International journal of women's dermatology

Chaptini C, Casey G, Harris AG, Wattchow D, Gordon L, Murrell DF.
PMID: 28491983
Int J Womens Dermatol. 2015 Oct 23;1(4):167-169. doi: 10.1016/j.ijwd.2015.08.002. eCollection 2015 Dec.

We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the...

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Chaptini C, Casey G, Harris AG, et al. Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa. Int J Womens Dermatol. 2015;1(4):167-169doi: 10.1016/j.ijwd.2015.08.002.
Chaptini, C., Casey, G., Harris, A. G., Wattchow, D., Gordon, L., & Murrell, D. F. (2015). Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa. International journal of women's dermatology, 1(4), 167-169. https://doi.org/10.1016/j.ijwd.2015.08.002
Chaptini, Cassandra, et al. "Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa." International journal of women's dermatology vol. 1,4 (2015): 167-169. doi: https://doi.org/10.1016/j.ijwd.2015.08.002
Chaptini C, Casey G, Harris AG, Wattchow D, Gordon L, Murrell DF. Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa. Int J Womens Dermatol. 2015 Oct 23;1(4):167-169. doi: 10.1016/j.ijwd.2015.08.002. eCollection 2015 Dec. PMID: 28491983; PMCID: PMC5419760.
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Postoperative ileus-An ongoing conundrum.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Wattchow D, Heitmann P, Smolilo D, Spencer NJ, Parker D, Hibberd T, Brookes SSJ, Dinning PG, Costa M.
PMID: 33252179
Neurogastroenterol Motil. 2021 May;33(5):e14046. doi: 10.1111/nmo.14046. Epub 2020 Nov 30.

BACKGROUND: Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory animals. A wide variety of treatments have been tested to prevent or modify the course...

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Wattchow D, Heitmann P, Smolilo D, et al. Postoperative ileus-An ongoing conundrum. Neurogastroenterol Motil. 2020;33(5):e14046doi: 10.1111/nmo.14046.
Wattchow, D., Heitmann, P., Smolilo, D., Spencer, N. J., Parker, D., Hibberd, T., Brookes, S. S. J., Dinning, P. G., & Costa, M. (2021). Postoperative ileus-An ongoing conundrum. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 33(5), e14046. https://doi.org/10.1111/nmo.14046
Wattchow, David, et al. "Postoperative ileus-An ongoing conundrum." Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society vol. 33,5 (2021): e14046. doi: https://doi.org/10.1111/nmo.14046
Wattchow D, Heitmann P, Smolilo D, Spencer NJ, Parker D, Hibberd T, Brookes SSJ, Dinning PG, Costa M. Postoperative ileus-An ongoing conundrum. Neurogastroenterol Motil. 2021 May;33(5):e14046. doi: 10.1111/nmo.14046. Epub 2020 Nov 30. PMID: 33252179.
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A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans.

Gastroenterology

Sun EW, Iepsen EW, Pezos N, Lumsden AL, Martin AM, Schober G, Isaacs NJ, Rayner CK, Nguyen NQ, de Fontgalland D, Rabbitt P, Hollington P, Wattchow DA, Hansen T, Holm JC, Liou AP, Jackson VM, Torekov SS, Young RL, Keating DJ.
PMID: 33848536
Gastroenterology. 2021 Aug;161(2):536-547.e2. doi: 10.1053/j.gastro.2021.04.014. Epub 2021 Apr 20.

OBJECTIVE: Hypothalamic melanocortin 4 receptors (MC4R) are a key regulator of energy homeostasis. Brain-penetrant MC4R agonists have failed, as concentrations required to suppress food intake also increase blood pressure. However, peripherally located MC4R may also mediate metabolic benefits of...

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Sun EW, Iepsen EW, Pezos N, et al. A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans. Gastroenterology. 2021;161(2):536-547.e2doi: 10.1053/j.gastro.2021.04.014.
Sun, E. W., Iepsen, E. W., Pezos, N., Lumsden, A. L., Martin, A. M., Schober, G., Isaacs, N. J., Rayner, C. K., Nguyen, N. Q., de Fontgalland, D., Rabbitt, P., Hollington, P., Wattchow, D. A., Hansen, T., Holm, J. C., Liou, A. P., Jackson, V. M., Torekov, S. S., Young, R. L., & Keating, D. J. (2021). A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans. Gastroenterology, 161(2), 536-547.e2. https://doi.org/10.1053/j.gastro.2021.04.014
Sun, Emily W, et al. "A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans." Gastroenterology vol. 161,2 (2021): 536-547.e2. doi: https://doi.org/10.1053/j.gastro.2021.04.014
Sun EW, Iepsen EW, Pezos N, Lumsden AL, Martin AM, Schober G, Isaacs NJ, Rayner CK, Nguyen NQ, de Fontgalland D, Rabbitt P, Hollington P, Wattchow DA, Hansen T, Holm JC, Liou AP, Jackson VM, Torekov SS, Young RL, Keating DJ. A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans. Gastroenterology. 2021 Aug;161(2):536-547.e2. doi: 10.1053/j.gastro.2021.04.014. Epub 2021 Apr 20. PMID: 33848536.
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A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans.

Gastroenterology

Sun EW, Iepsen EW, Pezos N, Lumsden AL, Martin AM, Schober G, Isaacs NJ, Rayner CK, Nguyen NQ, de Fontgalland D, Rabbitt P, Hollington P, Wattchow DA, Hansen T, Holm JC, Liou AP, Jackson VM, Torekov SS, Young RL, Keating DJ.
PMID: 33848536
Gastroenterology. 2021 Aug;161(2):536-547.e2. doi: 10.1053/j.gastro.2021.04.014. Epub 2021 Apr 20.

OBJECTIVE: Hypothalamic melanocortin 4 receptors (MC4R) are a key regulator of energy homeostasis. Brain-penetrant MC4R agonists have failed, as concentrations required to suppress food intake also increase blood pressure. However, peripherally located MC4R may also mediate metabolic benefits of...

Cite
Sun EW, Iepsen EW, Pezos N, et al. A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans. Gastroenterology. 2021;161(2):536-547.e2doi: 10.1053/j.gastro.2021.04.014.
Sun, E. W., Iepsen, E. W., Pezos, N., Lumsden, A. L., Martin, A. M., Schober, G., Isaacs, N. J., Rayner, C. K., Nguyen, N. Q., de Fontgalland, D., Rabbitt, P., Hollington, P., Wattchow, D. A., Hansen, T., Holm, J. C., Liou, A. P., Jackson, V. M., Torekov, S. S., Young, R. L., & Keating, D. J. (2021). A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans. Gastroenterology, 161(2), 536-547.e2. https://doi.org/10.1053/j.gastro.2021.04.014
Sun, Emily W, et al. "A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans." Gastroenterology vol. 161,2 (2021): 536-547.e2. doi: https://doi.org/10.1053/j.gastro.2021.04.014
Sun EW, Iepsen EW, Pezos N, Lumsden AL, Martin AM, Schober G, Isaacs NJ, Rayner CK, Nguyen NQ, de Fontgalland D, Rabbitt P, Hollington P, Wattchow DA, Hansen T, Holm JC, Liou AP, Jackson VM, Torekov SS, Young RL, Keating DJ. A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans. Gastroenterology. 2021 Aug;161(2):536-547.e2. doi: 10.1053/j.gastro.2021.04.014. Epub 2021 Apr 20. PMID: 33848536.
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High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Heitmann PT, Mohd Rosli R, Maslen L, Wiklendt L, Kumar R, Omari TI, Wattchow D, Costa M, Brookes SJ, Dinning PG.
PMID: 34076936
Neurogastroenterol Motil. 2021 Jun 02;e14178. doi: 10.1111/nmo.14178. Epub 2021 Jun 02.

BACKGROUND: The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high-resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a...

Cite
Heitmann PT, Mohd Rosli R, Maslen L, et al. High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit. Neurogastroenterol Motil. 2021;e14178doi: 10.1111/nmo.14178.
Heitmann, P. T., Mohd Rosli, R., Maslen, L., Wiklendt, L., Kumar, R., Omari, T. I., Wattchow, D., Costa, M., Brookes, S. J., & Dinning, P. G. (2021). High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, e14178. https://doi.org/10.1111/nmo.14178
Heitmann, Paul T, et al. "High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit." Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society vol. (2021): e14178. doi: https://doi.org/10.1111/nmo.14178
Heitmann PT, Mohd Rosli R, Maslen L, Wiklendt L, Kumar R, Omari TI, Wattchow D, Costa M, Brookes SJ, Dinning PG. High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit. Neurogastroenterol Motil. 2021 Jun 02;e14178. doi: 10.1111/nmo.14178. Epub 2021 Jun 02. PMID: 34076936.
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