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Showing 1 to 12 of 100 entries
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Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis.

Frontiers in pharmacology

Schon HT, Bartneck M, Borkham-Kamphorst E, Nattermann J, Lammers T, Tacke F, Weiskirchen R.
PMID: 26941644
Front Pharmacol. 2016 Feb 24;7:33. doi: 10.3389/fphar.2016.00033. eCollection 2016.

The activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) are central events in hepatic fibrogenesis. These processes are driven by autocrine- and paracrine-acting soluble factors (i.e., cytokines and chemokines). Proof-of-concept studies of the last...

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Schon HT, Bartneck M, Borkham-Kamphorst E, et al. Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis. Front Pharmacol. 2016;7:33doi: 10.3389/fphar.2016.00033.
Schon, H. T., Bartneck, M., Borkham-Kamphorst, E., Nattermann, J., Lammers, T., Tacke, F., & Weiskirchen, R. (2016). Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis. Frontiers in pharmacology, 733. https://doi.org/10.3389/fphar.2016.00033
Schon, Hans-Theo, et al. "Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis." Frontiers in pharmacology vol. 7 (2016): 33. doi: https://doi.org/10.3389/fphar.2016.00033
Schon HT, Bartneck M, Borkham-Kamphorst E, Nattermann J, Lammers T, Tacke F, Weiskirchen R. Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis. Front Pharmacol. 2016 Feb 24;7:33. doi: 10.3389/fphar.2016.00033. eCollection 2016. PMID: 26941644; PMCID: PMC4764688.
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Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!.

Frontiers in pharmacology

Meurer SK, Weiskirchen R.
PMID: 29483873
Front Pharmacol. 2018 Feb 12;9:98. doi: 10.3389/fphar.2018.00098. eCollection 2018.

We have identified a phenomenon occurring in the usage of proposed "specific" Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous...

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Meurer SK, Weiskirchen R. Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!. Front Pharmacol. 2018;9:98doi: 10.3389/fphar.2018.00098.
Meurer, S. K., & Weiskirchen, R. (2018). Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!. Frontiers in pharmacology, 998. https://doi.org/10.3389/fphar.2018.00098
Meurer, Steffen K, and Weiskirchen, Ralf. "Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!." Frontiers in pharmacology vol. 9 (2018): 98. doi: https://doi.org/10.3389/fphar.2018.00098
Meurer SK, Weiskirchen R. Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!. Front Pharmacol. 2018 Feb 12;9:98. doi: 10.3389/fphar.2018.00098. eCollection 2018. PMID: 29483873; PMCID: PMC5816342.
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Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology.

Hepatobiliary surgery and nutrition

Weiskirchen R, Tacke F.
PMID: 25568859
Hepatobiliary Surg Nutr. 2014 Dec;3(6):344-63. doi: 10.3978/j.issn.2304-3881.2014.11.03.

The liver is a central immunological organ. Liver resident macrophages, Kupffer cells (KC), but also sinusoidal endothelial cells, dendritic cells (DC) and other immune cells are involved in balancing immunity and tolerance against pathogens, commensals or food antigens. Hepatic...

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Weiskirchen R, Tacke F. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg Nutr. 2014;3(6):344-63doi: 10.3978/j.issn.2304-3881.2014.11.03.
Weiskirchen, R., & Tacke, F. (2014). Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary surgery and nutrition, 3(6), 344-63. https://doi.org/10.3978/j.issn.2304-3881.2014.11.03
Weiskirchen, Ralf, and Tacke, Frank. "Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology." Hepatobiliary surgery and nutrition vol. 3,6 (2014): 344-63. doi: https://doi.org/10.3978/j.issn.2304-3881.2014.11.03
Weiskirchen R, Tacke F. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg Nutr. 2014 Dec;3(6):344-63. doi: 10.3978/j.issn.2304-3881.2014.11.03. PMID: 25568859; PMCID: PMC4273119.
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Immunomodulatory effects of transforming growth factor-β in the liver.

Hepatobiliary surgery and nutrition

Schon HT, Weiskirchen R.
PMID: 25568862
Hepatobiliary Surg Nutr. 2014 Dec;3(6):386-406. doi: 10.3978/j.issn.2304-3881.2014.11.06.

Members of the transforming growth factor-β (TGF-β) family are potent regulatory cytokines that affect multiple cell types of the immune system mediating pro-inflammatory or anti-inflammatory responses. In the liver, TGF-β is produced by a multitude of non-parenchymal liver cells...

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Schon HT, Weiskirchen R. Immunomodulatory effects of transforming growth factor-β in the liver. Hepatobiliary Surg Nutr. 2014;3(6):386-406doi: 10.3978/j.issn.2304-3881.2014.11.06.
Schon, H. T., & Weiskirchen, R. (2014). Immunomodulatory effects of transforming growth factor-β in the liver. Hepatobiliary surgery and nutrition, 3(6), 386-406. https://doi.org/10.3978/j.issn.2304-3881.2014.11.06
Schon, Hans-Theo, and Weiskirchen, Ralf. "Immunomodulatory effects of transforming growth factor-β in the liver." Hepatobiliary surgery and nutrition vol. 3,6 (2014): 386-406. doi: https://doi.org/10.3978/j.issn.2304-3881.2014.11.06
Schon HT, Weiskirchen R. Immunomodulatory effects of transforming growth factor-β in the liver. Hepatobiliary Surg Nutr. 2014 Dec;3(6):386-406. doi: 10.3978/j.issn.2304-3881.2014.11.06. PMID: 25568862; PMCID: PMC4273109.
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High-dose Re-186 stent implantation for prevention of neointimal proliferation after balloon angioplasty.

Cardiovascular radiation medicine

Tepe G, Dinkelborg LM, Muschik P, Dietrich T, Claussen CD, Noll B, Wiskirchen J, Duda SH.
PMID: 11068267
Cardiovasc Radiat Med. 2001 Jan 01;2(1):54. doi: 10.1016/s1522-1865(00)00054-8.

No abstract available.

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Tepe G, Dinkelborg LM, Muschik P, et al. High-dose Re-186 stent implantation for prevention of neointimal proliferation after balloon angioplasty. Cardiovasc Radiat Med. 2001;2(1):54doi: 10.1016/s1522-1865(00)00054-8.
Tepe, G., Dinkelborg, L. M., Muschik, P., Dietrich, T., Claussen, C. D., Noll, B., Wiskirchen, J., & Duda, S. H. (2001). High-dose Re-186 stent implantation for prevention of neointimal proliferation after balloon angioplasty. Cardiovascular radiation medicine, 2(1), 54. https://doi.org/10.1016/s1522-1865(00)00054-8
Tepe, et al. "High-dose Re-186 stent implantation for prevention of neointimal proliferation after balloon angioplasty." Cardiovascular radiation medicine vol. 2,1 (2001): 54. doi: https://doi.org/10.1016/s1522-1865(00)00054-8
Tepe G, Dinkelborg LM, Muschik P, Dietrich T, Claussen CD, Noll B, Wiskirchen J, Duda SH. High-dose Re-186 stent implantation for prevention of neointimal proliferation after balloon angioplasty. Cardiovasc Radiat Med. 2001 Jan 01;2(1):54. doi: 10.1016/s1522-1865(00)00054-8. PMID: 11068267.
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When sleeping beauty wakes up and jumps into a cancer-minded environment.

Hepatology (Baltimore, Md.)

Weiskirchen R, Liedtke C, Trautwein C.
PMID: 19479787
Hepatology. 2009 Jun;49(6):2122-4. doi: 10.1002/hep.23030.

No abstract available.

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Weiskirchen R, Liedtke C, Trautwein C. When sleeping beauty wakes up and jumps into a cancer-minded environment. Hepatology. 2009;49(6):2122-4doi: 10.1002/hep.23030.
Weiskirchen, R., Liedtke, C., & Trautwein, C. (2009). When sleeping beauty wakes up and jumps into a cancer-minded environment. Hepatology (Baltimore, Md.), 49(6), 2122-4. https://doi.org/10.1002/hep.23030
Weiskirchen, Ralf, et al. "When sleeping beauty wakes up and jumps into a cancer-minded environment." Hepatology (Baltimore, Md.) vol. 49,6 (2009): 2122-4. doi: https://doi.org/10.1002/hep.23030
Weiskirchen R, Liedtke C, Trautwein C. When sleeping beauty wakes up and jumps into a cancer-minded environment. Hepatology. 2009 Jun;49(6):2122-4. doi: 10.1002/hep.23030. PMID: 19479787.
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Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease.

Journal of inflammation (London, England)

Boaru SG, Borkham-Kamphorst E, Tihaa L, Haas U, Weiskirchen R.
PMID: 23192004
J Inflamm (Lond). 2012 Nov 28;9(1):49. doi: 10.1186/1476-9255-9-49.

During inflammation, the inflammasomes representing a group of multi-protein complexes trigger the biological maturation of pro-inflammatory cytokines such as interleukin-1β and interleukin-18 by proteolytic activation of caspase-1 from its inactive proforms. The individual genes encoding components of the inflammasome...

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Boaru SG, Borkham-Kamphorst E, Tihaa L, et al. Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. J Inflamm (Lond). 2012;9(1):49doi: 10.1186/1476-9255-9-49.
Boaru, S. G., Borkham-Kamphorst, E., Tihaa, L., Haas, U., & Weiskirchen, R. (2012). Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. Journal of inflammation (London, England), 9(1), 49. https://doi.org/10.1186/1476-9255-9-49
Boaru, Sorina Georgiana, et al. "Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease." Journal of inflammation (London, England) vol. 9,1 (2012): 49. doi: https://doi.org/10.1186/1476-9255-9-49
Boaru SG, Borkham-Kamphorst E, Tihaa L, Haas U, Weiskirchen R. Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. J Inflamm (Lond). 2012 Nov 28;9(1):49. doi: 10.1186/1476-9255-9-49. PMID: 23192004; PMCID: PMC3599703.
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CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC.

Journal of cell communication and signaling

Borkham-Kamphorst E, van Roeyen CR, Van de Leur E, Floege J, Weiskirchen R.
PMID: 21748432
J Cell Commun Signal. 2012 Mar;6(1):11-25. doi: 10.1007/s12079-011-0141-3. Epub 2011 Jul 05.

Nephroblastoma overexpressed gene encodes a matricellular protein (CCN3/NOV) of the CCN family, comprising CCN1 (CYR61), CCN2 (CTGF), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3). CCN proteins are involved in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth...

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Borkham-Kamphorst E, van Roeyen CR, Van de Leur E, et al. CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. J Cell Commun Signal. 2011;6(1):11-25doi: 10.1007/s12079-011-0141-3.
Borkham-Kamphorst, E., van Roeyen, C. R., Van de Leur, E., Floege, J., & Weiskirchen, R. (2012). CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. Journal of cell communication and signaling, 6(1), 11-25. https://doi.org/10.1007/s12079-011-0141-3
Borkham-Kamphorst, Erawan, et al. "CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC." Journal of cell communication and signaling vol. 6,1 (2012): 11-25. doi: https://doi.org/10.1007/s12079-011-0141-3
Borkham-Kamphorst E, van Roeyen CR, Van de Leur E, Floege J, Weiskirchen R. CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. J Cell Commun Signal. 2012 Mar;6(1):11-25. doi: 10.1007/s12079-011-0141-3. Epub 2011 Jul 05. PMID: 21748432; PMCID: PMC3271194.
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Lipocalin-2 in Fructose-Induced Fatty Liver Disease.

Frontiers in physiology

Lambertz J, Berger T, Mak TW, van Helden J, Weiskirchen R.
PMID: 29234288
Front Physiol. 2017 Nov 28;8:964. doi: 10.3389/fphys.2017.00964. eCollection 2017.

The intake of excess dietary fructose most often leads to non-alcoholic fatty liver disease (NAFLD). Fructose is metabolized mainly in the liver and its chronic consumption results in lipogenic gene expression in this organ. However, precisely how fructose is...

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Lambertz J, Berger T, Mak TW, et al. Lipocalin-2 in Fructose-Induced Fatty Liver Disease. Front Physiol. 2017;8:964doi: 10.3389/fphys.2017.00964.
Lambertz, J., Berger, T., Mak, T. W., van Helden, J., & Weiskirchen, R. (2017). Lipocalin-2 in Fructose-Induced Fatty Liver Disease. Frontiers in physiology, 8964. https://doi.org/10.3389/fphys.2017.00964
Lambertz, Jessica, et al. "Lipocalin-2 in Fructose-Induced Fatty Liver Disease." Frontiers in physiology vol. 8 (2017): 964. doi: https://doi.org/10.3389/fphys.2017.00964
Lambertz J, Berger T, Mak TW, van Helden J, Weiskirchen R. Lipocalin-2 in Fructose-Induced Fatty Liver Disease. Front Physiol. 2017 Nov 28;8:964. doi: 10.3389/fphys.2017.00964. eCollection 2017. PMID: 29234288; PMCID: PMC5712346.
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High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss.

Journal of clinical medicine

Yagmur E, Bast E, Mühlfeld AS, Koch A, Weiskirchen R, Tacke F, Neulen J.
PMID: 31466364
J Clin Med. 2019 Aug 28;8(9). doi: 10.3390/jcm8091328.

Platelet hyperaggregability, known as sticky platelet syndrome (SPS), is a prothrombotic disorder that has been increasingly associated with pregnancy loss. In this retrospective study, we aimed to investigate the clinical and diagnostic relevance of SPS in 208 patients with...

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Yagmur E, Bast E, Mühlfeld AS, et al. High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss. J Clin Med. 2019;8(9)doi: 10.3390/jcm8091328.
Yagmur, E., Bast, E., Mühlfeld, A. S., Koch, A., Weiskirchen, R., Tacke, F., & Neulen, J. (2019). High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss. Journal of clinical medicine, 8(9), . https://doi.org/10.3390/jcm8091328
Yagmur, Eray, et al. "High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss." Journal of clinical medicine vol. 8,9 (2019). doi: https://doi.org/10.3390/jcm8091328
Yagmur E, Bast E, Mühlfeld AS, Koch A, Weiskirchen R, Tacke F, Neulen J. High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss. J Clin Med. 2019 Aug 28;8(9). doi: 10.3390/jcm8091328. PMID: 31466364; PMCID: PMC6780264.
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Liver fibrosis: Which mechanisms matter?.

Clinical liver disease

Weiskirchen R, Tacke F.
PMID: 31041072
Clin Liver Dis (Hoboken). 2016 Oct 27;8(4):94-99. doi: 10.1002/cld.581. eCollection 2016 Oct.

No abstract available.

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Weiskirchen R, Tacke F. Liver fibrosis: Which mechanisms matter?. Clin Liver Dis (Hoboken). 2016;8(4):94-99doi: 10.1002/cld.581.
Weiskirchen, R., & Tacke, F. (2016). Liver fibrosis: Which mechanisms matter?. Clinical liver disease, 8(4), 94-99. https://doi.org/10.1002/cld.581
Weiskirchen, Ralf, and Tacke, Frank. "Liver fibrosis: Which mechanisms matter?." Clinical liver disease vol. 8,4 (2016): 94-99. doi: https://doi.org/10.1002/cld.581
Weiskirchen R, Tacke F. Liver fibrosis: Which mechanisms matter?. Clin Liver Dis (Hoboken). 2016 Oct 27;8(4):94-99. doi: 10.1002/cld.581. eCollection 2016 Oct. PMID: 31041072; PMCID: PMC6490207.
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TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells.

Cytokine

Schröder SK, Asimakopoulou A, Tillmann S, Koschmieder S, Weiskirchen R.
PMID: 32712458
Cytokine. 2020 Nov;135:155214. doi: 10.1016/j.cyto.2020.155214. Epub 2020 Jul 24.

Prostate cancer (PCa) is one of the most common and deadly cancers in men worldwide. The surrounding tumor microenvironment (TME) is important in tumor progression, as cytokines and soluble mediators including tumor necrosis factor (TNF-α) or lipocalin-2 (LCN2) can...

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Schröder SK, Asimakopoulou A, Tillmann S, et al. TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells. Cytokine. 2020;135:155214doi: 10.1016/j.cyto.2020.155214.
Schröder, S. K., Asimakopoulou, A., Tillmann, S., Koschmieder, S., & Weiskirchen, R. (2020). TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells. Cytokine, 135155214. https://doi.org/10.1016/j.cyto.2020.155214
Schröder, Sarah K, et al. "TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells." Cytokine vol. 135 (2020): 155214. doi: https://doi.org/10.1016/j.cyto.2020.155214
Schröder SK, Asimakopoulou A, Tillmann S, Koschmieder S, Weiskirchen R. TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells. Cytokine. 2020 Nov;135:155214. doi: 10.1016/j.cyto.2020.155214. Epub 2020 Jul 24. PMID: 32712458.
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Showing 1 to 12 of 100 entries