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Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force.

The journal of prevention of Alzheimer's disease

Vellas B, Bateman R, Blennow K, Frisoni G, Johnson K, Katz R, Langbaum J, Marson D, Sperling R, Wessels A, Salloway S, Doody R, Aisen P.
PMID: 26247004
J Prev Alzheimers Dis. 2015 Jun;2(2):128-135. doi: 10.14283/jpad.2015.55.

For Alzheimer's disease treatment trials that focus on the pre-dementia stage of disease, outcome measures are needed that will enable assessment of disease progression in patients who are clinically normal. The EU/US CTAD Task Force, an international collaboration of...

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Vellas B, Bateman R, Blennow K, et al. Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force. J Prev Alzheimers Dis. 2015;2(2):128-135doi: 10.14283/jpad.2015.55.
Vellas, B., Bateman, R., Blennow, K., Frisoni, G., Johnson, K., Katz, R., Langbaum, J., Marson, D., Sperling, R., Wessels, A., Salloway, S., Doody, R., Aisen, P. (2015). Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force. The journal of prevention of Alzheimer's disease, 2(2), 128-135. https://doi.org/10.14283/jpad.2015.55
Vellas, B, et al. "Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force." The journal of prevention of Alzheimer's disease vol. 2,2 (2015): 128-135. doi: https://doi.org/10.14283/jpad.2015.55
Vellas B, Bateman R, Blennow K, Frisoni G, Johnson K, Katz R, Langbaum J, Marson D, Sperling R, Wessels A, Salloway S, Doody R, Aisen P. Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force. J Prev Alzheimers Dis. 2015 Jun;2(2):128-135. doi: 10.14283/jpad.2015.55. PMID: 26247004; PMCID: PMC4523051.
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The role of mediastinoscopy for diagnosis of isolated mediastinal lymphadenopathy.

The Indian journal of surgery

Nalladaru ZM, Wessels A.
PMID: 22851842
Indian J Surg. 2011 Aug;73(4):284-6. doi: 10.1007/s12262-011-0282-x. Epub 2011 Apr 30.

To determine the role of mediastinoscopy (MDS) in the histological diagnosis of isolated mediastinal lymphadenopathy in a centre where more sophisticated investigations, like positron emitting tomography (PET) scan and endobronchial ultrasound guided trans-bronchial needle aspiration (EBUS-TBNA) is not available....

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Nalladaru ZM, Wessels A. The role of mediastinoscopy for diagnosis of isolated mediastinal lymphadenopathy. Indian J Surg. 2011;73(4):284-6doi: 10.1007/s12262-011-0282-x.
Nalladaru, Z. M., & Wessels, A. (2011). The role of mediastinoscopy for diagnosis of isolated mediastinal lymphadenopathy. The Indian journal of surgery, 73(4), 284-6. https://doi.org/10.1007/s12262-011-0282-x
Nalladaru, Zubin M, and Wessels, Andre. "The role of mediastinoscopy for diagnosis of isolated mediastinal lymphadenopathy." The Indian journal of surgery vol. 73,4 (2011): 284-6. doi: https://doi.org/10.1007/s12262-011-0282-x
Nalladaru ZM, Wessels A. The role of mediastinoscopy for diagnosis of isolated mediastinal lymphadenopathy. Indian J Surg. 2011 Aug;73(4):284-6. doi: 10.1007/s12262-011-0282-x. Epub 2011 Apr 30. PMID: 22851842; PMCID: PMC3144348.
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Breslow Intermediates from Aromatic N-Heterocyclic Carbenes (Benzimidazolin-2-ylidenes, Thiazolin-2-ylidenes).

Angewandte Chemie (International ed. in English)

Paul M, Sudkaow P, Wessels A, Schlörer NE, Neudörfl JM, Berkessel A.
PMID: 29645334
Angew Chem Int Ed Engl. 2018 Jul 02;57(27):8310-8315. doi: 10.1002/anie.201801676. Epub 2018 Jun 07.

We report the first generation and characterization of elusive Breslow intermediates derived from aromatic N-heterocyclic carbenes (NHCs), namely benzimidazolin-2-ylidenes (NMR, X-ray analysis) and thiazolin-2-ylidenes (NMR). In the former case, the diamino enols were generated by reaction of the free...

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Paul M, Sudkaow P, Wessels A, et al. Breslow Intermediates from Aromatic N-Heterocyclic Carbenes (Benzimidazolin-2-ylidenes, Thiazolin-2-ylidenes). Angew Chem Int Ed Engl. 2018;57(27):8310-8315doi: 10.1002/anie.201801676.
Paul, M., Sudkaow, P., Wessels, A., Schlörer, N. E., Neudörfl, J. M., & Berkessel, A. (2018). Breslow Intermediates from Aromatic N-Heterocyclic Carbenes (Benzimidazolin-2-ylidenes, Thiazolin-2-ylidenes). Angewandte Chemie (International ed. in English), 57(27), 8310-8315. https://doi.org/10.1002/anie.201801676
Paul, Mathias, et al. "Breslow Intermediates from Aromatic N-Heterocyclic Carbenes (Benzimidazolin-2-ylidenes, Thiazolin-2-ylidenes)." Angewandte Chemie (International ed. in English) vol. 57,27 (2018): 8310-8315. doi: https://doi.org/10.1002/anie.201801676
Paul M, Sudkaow P, Wessels A, Schlörer NE, Neudörfl JM, Berkessel A. Breslow Intermediates from Aromatic N-Heterocyclic Carbenes (Benzimidazolin-2-ylidenes, Thiazolin-2-ylidenes). Angew Chem Int Ed Engl. 2018 Jul 02;57(27):8310-8315. doi: 10.1002/anie.201801676. Epub 2018 Jun 07. PMID: 29645334.
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Network Analysis of Genome-Wide Association Studies for Chronic Obstructive Pulmonary Disease in the Context of Biological Pathways.

American journal of respiratory and critical care medicine

Mount S, Cirillo E, Stewart K, Coort S, Evelo CT, Wesselius A, Zeegers MP, Schols AMWJ.
PMID: 31343902
Am J Respir Crit Care Med. 2019 Dec 01;200(11):1439-1441. doi: 10.1164/rccm.201904-0902LE.

No abstract available.

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Mount S, Cirillo E, Stewart K, et al. Network Analysis of Genome-Wide Association Studies for Chronic Obstructive Pulmonary Disease in the Context of Biological Pathways. Am J Respir Crit Care Med. 2019;200(11):1439-1441doi: 10.1164/rccm.201904-0902LE.
Mount, S., Cirillo, E., Stewart, K., Coort, S., Evelo, C. T., Wesselius, A., Zeegers, M. P., & Schols, A. M. W. J. (2019). Network Analysis of Genome-Wide Association Studies for Chronic Obstructive Pulmonary Disease in the Context of Biological Pathways. American journal of respiratory and critical care medicine, 200(11), 1439-1441. https://doi.org/10.1164/rccm.201904-0902LE
Mount, Sarah, et al. "Network Analysis of Genome-Wide Association Studies for Chronic Obstructive Pulmonary Disease in the Context of Biological Pathways." American journal of respiratory and critical care medicine vol. 200,11 (2019): 1439-1441. doi: https://doi.org/10.1164/rccm.201904-0902LE
Mount S, Cirillo E, Stewart K, Coort S, Evelo CT, Wesselius A, Zeegers MP, Schols AMWJ. Network Analysis of Genome-Wide Association Studies for Chronic Obstructive Pulmonary Disease in the Context of Biological Pathways. Am J Respir Crit Care Med. 2019 Dec 01;200(11):1439-1441. doi: 10.1164/rccm.201904-0902LE. PMID: 31343902.
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Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size.

Translational andrology and urology

Lipunova N, Wesselius A, Cheng KK, van Schooten FJ, Bryan RT, Cazier JB, Zeegers MP.
PMID: 32676417
Transl Androl Urol. 2020 Jun;9(3):1329-1337. doi: 10.21037/tau-19-523.

BACKGROUND: Urinary bladder cancer (UBC) is one of few cancers with an established gene-environment interaction (GxE) with smoking. However, it is unknown whether the interaction with tobacco use is present non-muscle invasive bladder cancer (NMIBC) and characteristics of prognostic...

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Lipunova N, Wesselius A, Cheng KK, et al. Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size. Transl Androl Urol. 2020;9(3):1329-1337doi: 10.21037/tau-19-523.
Lipunova, N., Wesselius, A., Cheng, K. K., van Schooten, F. J., Bryan, R. T., Cazier, J. B., & Zeegers, M. P. (2020). Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size. Translational andrology and urology, 9(3), 1329-1337. https://doi.org/10.21037/tau-19-523
Lipunova, Nadezda, et al. "Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size." Translational andrology and urology vol. 9,3 (2020): 1329-1337. doi: https://doi.org/10.21037/tau-19-523
Lipunova N, Wesselius A, Cheng KK, van Schooten FJ, Bryan RT, Cazier JB, Zeegers MP. Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size. Transl Androl Urol. 2020 Jun;9(3):1329-1337. doi: 10.21037/tau-19-523. PMID: 32676417; PMCID: PMC7354298.
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Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains.

Aging

Mount S, Ferrucci L, Wesselius A, Zeegers MP, Schols AM.
PMID: 31128067
Aging (Albany NY). 2019 May 24;11(10):3023-3040. doi: 10.18632/aging.101957.

Advocating continued health into old age, so called successful aging, is a growing public health goal. However, the development of tools to measure aging is limited by the lack of appropriate outcome measures, and operational definitions of successful aging....

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Mount S, Ferrucci L, Wesselius A, et al. Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains. Aging (Albany NY). 2019;11(10):3023-3040doi: 10.18632/aging.101957.
Mount, S., Ferrucci, L., Wesselius, A., Zeegers, M. P., & Schols, A. M. (2019). Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains. Aging, 11(10), 3023-3040. https://doi.org/10.18632/aging.101957
Mount, Sarah, et al. "Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains." Aging vol. 11,10 (2019): 3023-3040. doi: https://doi.org/10.18632/aging.101957
Mount S, Ferrucci L, Wesselius A, Zeegers MP, Schols AM. Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains. Aging (Albany NY). 2019 May 24;11(10):3023-3040. doi: 10.18632/aging.101957. PMID: 31128067; PMCID: PMC6555461.
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Dietary patterns and risk of bladder cancer: a systematic review and meta-analysis.

BMC public health

Dianatinasab M, Forozani E, Akbari A, Azmi N, Bastam D, Fararouei M, Wesselius A, Zeegres MP.
PMID: 35016647
BMC Public Health. 2022 Jan 11;22(1):73. doi: 10.1186/s12889-022-12516-2.

BACKGROUND: Several studies have investigated the relationship between dietary patterns and the risk of bladder cancer (BC) in different regions including Europe, the United States, and Asia, with no conclusive evidence. A meta-analysis was undertaken to integrate the most...

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Dianatinasab M, Forozani E, Akbari A, et al. Dietary patterns and risk of bladder cancer: a systematic review and meta-analysis. BMC Public Health. 2022;22(1):73doi: 10.1186/s12889-022-12516-2.
Dianatinasab, M., Forozani, E., Akbari, A., Azmi, N., Bastam, D., Fararouei, M., Wesselius, A., & Zeegres, M. P. (2022). Dietary patterns and risk of bladder cancer: a systematic review and meta-analysis. BMC public health, 22(1), 73. https://doi.org/10.1186/s12889-022-12516-2
Dianatinasab, Mostafa, et al. "Dietary patterns and risk of bladder cancer: a systematic review and meta-analysis." BMC public health vol. 22,1 (2022): 73. doi: https://doi.org/10.1186/s12889-022-12516-2
Dianatinasab M, Forozani E, Akbari A, Azmi N, Bastam D, Fararouei M, Wesselius A, Zeegres MP. Dietary patterns and risk of bladder cancer: a systematic review and meta-analysis. BMC Public Health. 2022 Jan 11;22(1):73. doi: 10.1186/s12889-022-12516-2. PMID: 35016647.
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Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.

Brain sciences

Mazumder AH, Barnett J, Isometsä ET, Lindberg N, Torniainen-Holm M, Lähteenvuo M, Lahdensuo K, Kerkelä M, Ahola-Olli A, Hietala J, Kampman O, Kieseppä T, Jukuri T, Häkkinen K, Cederlöf E, Haaki W, Kajanne R, Wegelius A, Männynsalo T, Niemi-Pynttäri J, Suokas K, Lönnqvist J, Tiihonen J, Paunio T, Vainio SJ, Palotie A, Niemelä S, Suvisaari J, Veijola J.
PMID: 34827421
Brain Sci. 2021 Oct 27;11(11). doi: 10.3390/brainsci11111422.

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred...

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Mazumder AH, Barnett J, Isometsä ET, et al. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. Brain Sci. 2021;11(11)doi: 10.3390/brainsci11111422.
Mazumder, A. H., Barnett, J., Isometsä, E. T., Lindberg, N., Torniainen-Holm, M., Lähteenvuo, M., Lahdensuo, K., Kerkelä, M., Ahola-Olli, A., Hietala, J., Kampman, O., Kieseppä, T., Jukuri, T., Häkkinen, K., Cederlöf, E., Haaki, W., Kajanne, R., Wegelius, A., Männynsalo, T., Niemi-Pynttäri, J., Suokas, K., Lönnqvist, J., Tiihonen, J., Paunio, T., Vainio, S. J., Palotie, A., Niemelä, S., Suvisaari, J., & Veijola, J. (2021). Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. Brain sciences, 11(11), . https://doi.org/10.3390/brainsci11111422
Mazumder, Atiqul Haq, et al. "Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder." Brain sciences vol. 11,11 (2021). doi: https://doi.org/10.3390/brainsci11111422
Mazumder AH, Barnett J, Isometsä ET, Lindberg N, Torniainen-Holm M, Lähteenvuo M, Lahdensuo K, Kerkelä M, Ahola-Olli A, Hietala J, Kampman O, Kieseppä T, Jukuri T, Häkkinen K, Cederlöf E, Haaki W, Kajanne R, Wegelius A, Männynsalo T, Niemi-Pynttäri J, Suokas K, Lönnqvist J, Tiihonen J, Paunio T, Vainio SJ, Palotie A, Niemelä S, Suvisaari J, Veijola J. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. Brain Sci. 2021 Oct 27;11(11). doi: 10.3390/brainsci11111422. PMID: 34827421; PMCID: PMC8615595.
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Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study.

Microcirculation (New York, N.Y. : 1994)

van der Heide FCT, Zhou TL, Henry RMA, Houben AJHM, Kroon AA, Dagnelie PC, van Dongen MCJM, Eussen SJPM, Berendschot TTJM, Schouten JSAG, Webers CAB, Schram MT, van Greevenbroek MMJ, Wesselius A, Schalkwijk CG, Koster A, Savelberg HHCM, Schaper NC, Reesink KD, Stehouwer CDA.
PMID: 33905576
Microcirculation. 2021 Aug;28(6):e12702. doi: 10.1111/micc.12702. Epub 2021 May 06.

OBJECTIVE: This study investigated whether arterial stiffening is a determinant of subtle retinal microvascular changes that precede diabetic retinopathy.RESEARCH DESIGN AND METHODS: This study used cross-sectional data from the Maastricht Study, a type 2 diabetes-enriched population-based cohort study. We...

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van der Heide FCT, Zhou TL, Henry RMA, et al. Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study. Microcirculation. 2021;28(6):e12702doi: 10.1111/micc.12702.
van der Heide, F. C. T., Zhou, T. L., Henry, R. M. A., Houben, A. J. H. M., Kroon, A. A., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Savelberg, H. H. C. M., Schaper, N. C., Reesink, K. D., & Stehouwer, C. D. A. (2021). Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study. Microcirculation (New York, N.Y. : 1994), 28(6), e12702. https://doi.org/10.1111/micc.12702
van der Heide, Frank C T, et al. "Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study." Microcirculation (New York, N.Y. : 1994) vol. 28,6 (2021): e12702. doi: https://doi.org/10.1111/micc.12702
van der Heide FCT, Zhou TL, Henry RMA, Houben AJHM, Kroon AA, Dagnelie PC, van Dongen MCJM, Eussen SJPM, Berendschot TTJM, Schouten JSAG, Webers CAB, Schram MT, van Greevenbroek MMJ, Wesselius A, Schalkwijk CG, Koster A, Savelberg HHCM, Schaper NC, Reesink KD, Stehouwer CDA. Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study. Microcirculation. 2021 Aug;28(6):e12702. doi: 10.1111/micc.12702. Epub 2021 May 06. PMID: 33905576; PMCID: PMC8459287.
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Mesothelium and Malignant Mesothelioma.

Journal of developmental biology

Hiriart E, Deepe R, Wessels A.
PMID: 30965570
J Dev Biol. 2019 Apr 08;7(2). doi: 10.3390/jdb7020007.

The mesothelium is an epithelial structure derived from the embryonic mesoderm. It plays an important role in the development of a number of different organs, including the heart, lungs, and intestines. In this publication, we discuss aspects of the...

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Hiriart E, Deepe R, Wessels A. Mesothelium and Malignant Mesothelioma. J Dev Biol. 2019;7(2)doi: 10.3390/jdb7020007.
Hiriart, E., Deepe, R., & Wessels, A. (2019). Mesothelium and Malignant Mesothelioma. Journal of developmental biology, 7(2), . https://doi.org/10.3390/jdb7020007
Hiriart, Emilye, et al. "Mesothelium and Malignant Mesothelioma." Journal of developmental biology vol. 7,2 (2019). doi: https://doi.org/10.3390/jdb7020007
Hiriart E, Deepe R, Wessels A. Mesothelium and Malignant Mesothelioma. J Dev Biol. 2019 Apr 08;7(2). doi: 10.3390/jdb7020007. PMID: 30965570; PMCID: PMC6630312.
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Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study.

Diabetologia

Bakker L, Ramakers IHGB, van Boxtel MPJ, Schram MT, Stehouwer CDA, van der Kallen CJH, Dagnelie PC, van Greevenbroek MMJ, Wesselius A, Midttun Ø, Ueland PM, Verhey FRJ, Eussen SJPM, Köhler S.
PMID: 34409496
Diabetologia. 2021 Nov;64(11):2445-2457. doi: 10.1007/s00125-021-05521-4. Epub 2021 Aug 19.

AIMS/HYPOTHESIS: Studies investigating associations between kynurenines and cognitive function have generally been small, restricted to clinical samples or have found inconsistent results, and associations in the general adult population, and in individuals with type 2 diabetes in particular, are...

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Bakker L, Ramakers IHGB, van Boxtel MPJ, et al. Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. Diabetologia. 2021;64(11):2445-2457doi: 10.1007/s00125-021-05521-4.
Bakker, L., Ramakers, I. H. G. B., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., van der Kallen, C. J. H., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Midttun, �. �., Ueland, P. M., Verhey, F. R. J., Eussen, S. J. P. M., & Köhler, S. (2021). Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. Diabetologia, 64(11), 2445-2457. https://doi.org/10.1007/s00125-021-05521-4
Bakker, Lieke, et al. "Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study." Diabetologia vol. 64,11 (2021): 2445-2457. doi: https://doi.org/10.1007/s00125-021-05521-4
Bakker L, Ramakers IHGB, van Boxtel MPJ, Schram MT, Stehouwer CDA, van der Kallen CJH, Dagnelie PC, van Greevenbroek MMJ, Wesselius A, Midttun Ø, Ueland PM, Verhey FRJ, Eussen SJPM, Köhler S. Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. Diabetologia. 2021 Nov;64(11):2445-2457. doi: 10.1007/s00125-021-05521-4. Epub 2021 Aug 19. PMID: 34409496; PMCID: PMC8494700.
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Muscularization of the Mesenchymal Outlet Septum during Cardiac Development.

Journal of cardiovascular development and disease

van den Hoff MJB, Wessels A.
PMID: 33158304
J Cardiovasc Dev Dis. 2020 Nov 04;7(4). doi: 10.3390/jcdd7040051.

After the formation of the linear heart tube, it becomes divided into right and left components by the process of septation. Relatively late during this process, within the developing outflow tract, the initially mesenchymal outlet septum becomes muscularized as...

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van den Hoff MJB, Wessels A. Muscularization of the Mesenchymal Outlet Septum during Cardiac Development. J Cardiovasc Dev Dis. 2020;7(4)doi: 10.3390/jcdd7040051.
van den Hoff, M. J. B., & Wessels, A. (2020). Muscularization of the Mesenchymal Outlet Septum during Cardiac Development. Journal of cardiovascular development and disease, 7(4), . https://doi.org/10.3390/jcdd7040051
van den Hoff, Maurice J B, and Wessels, Andy. "Muscularization of the Mesenchymal Outlet Septum during Cardiac Development." Journal of cardiovascular development and disease vol. 7,4 (2020). doi: https://doi.org/10.3390/jcdd7040051
van den Hoff MJB, Wessels A. Muscularization of the Mesenchymal Outlet Septum during Cardiac Development. J Cardiovasc Dev Dis. 2020 Nov 04;7(4). doi: 10.3390/jcdd7040051. PMID: 33158304; PMCID: PMC7711588.
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