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Showing 1 to 12 of 17 entries
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Intramuscular Contributions to Low-Frequency Force Potentiation Induced by a High-Frequency Conditioning Stimulation.

Frontiers in physiology

Cheng AJ, Neyroud D, Kayser B, Westerblad H, Place N.
PMID: 28979214
Front Physiol. 2017 Sep 20;8:712. doi: 10.3389/fphys.2017.00712. eCollection 2017.

Electrically-evoked low-frequency (submaximal) force is increased immediately following high-frequency stimulation in human skeletal muscle. Although central mechanisms have been suggested to be the major cause of this low-frequency force potentiation, intramuscular factors might contribute. Thus, we hypothesized that two...

An updated h-index measures both the primary and total scientific output of a researcher.

Discoveries (Craiova, Romania)

Bucur O, Almasan A, Zubarev R, Friedman M, Nicolson GL, Sumazin P, Leabu M, Nikolajczyk BS, Avram D, Kunej T, Calin GA, Godwin AK, Adami HO, Zaphiropoulos PG, Richardson DR, Schmitt-Ulms G, Westerblad H, Keniry M, Grau GE, Carbonetto S, Stan RV, Popa-Wagner A, Takhar K, Baron BW, Galardy PJ, Yang F, Data D, Fadare O, Yeo KJ, Gabreanu GR, Andrei S, Soare GR, Nelson MA, Liehn EA.
PMID: 26504901
Discoveries (Craiova). 2015 Jul-Sep;3(3). doi: 10.15190/d.2015.42. Epub 2015 Sep 30.

The growing interest in scientometry stems from ethical concerns related to the proper evaluation of scientific contributions of an author working in a hard science. In the absence of a consensus, institutions may use arbitrary methods for evaluating scientists...

Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model.

Disease models & mechanisms

Chatel B, Ducreux S, Harhous Z, Bendridi N, Varlet I, Ogier AC, Bernard M, Gondin J, Rieusset J, Westerblad H, Bendahan D, Gineste C.
PMID: 34378772
Dis Model Mech. 2021 Sep 01;14(9). doi: 10.1242/dmm.048981. Epub 2021 Sep 15.

Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle weakness. In mice, deletion of the fast-twitch...

Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model.

Disease models & mechanisms

Chatel B, Ducreux S, Harhous Z, Bendridi N, Varlet I, Ogier AC, Bernard M, Gondin J, Rieusset J, Westerblad H, Bendahan D, Gineste C.
PMID: 34378772
Dis Model Mech. 2021 Sep 01;14(9). doi: 10.1242/dmm.048981. Epub 2021 Sep 15.

Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle weakness. In mice, deletion of the fast-twitch...

Antioxidants and Skeletal Muscle Performance: "Common Knowledge" vs. Experimental Evidence.

Frontiers in physiology

Hernández A, Cheng A, Westerblad H.
PMID: 22416234
Front Physiol. 2012 Mar 12;3:46. doi: 10.3389/fphys.2012.00046. eCollection 2012.

Antioxidants are assumed to provide numerous benefits, including better health, a reduced rate of aging, and improved exercise performance. Specifically, antioxidants are commonly "prescribed" by the media, supplement industry, and "fitness experts" for individuals prior to training and performance,...

Muscle Fatigue Affects the Interpolated Twitch Technique When Assessed Using Electrically-Induced Contractions in Human and Rat Muscles.

Frontiers in physiology

Neyroud D, Cheng AJ, Bourdillon N, Kayser B, Place N, Westerblad H.
PMID: 27445844
Front Physiol. 2016 Jun 28;7:252. doi: 10.3389/fphys.2016.00252. eCollection 2016.

The interpolated twitch technique (ITT) is the gold standard to assess voluntary activation and central fatigue. Yet, its validity has been questioned. Here we studied how peripheral fatigue can affect the ITT. Repeated contractions at submaximal frequencies were produced...

Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes.

Skeletal muscle

Olsson K, Cheng AJ, Alam S, Al-Ameri M, Rullman E, Westerblad H, Lanner JT, Bruton JD, Gustafsson T.
PMID: 26301072
Skelet Muscle. 2015 Aug 20;5:26. doi: 10.1186/s13395-015-0050-x. eCollection 2015.

BACKGROUND: In skeletal muscle, intracellular Ca(2+) is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, human myotubes have been extensively employed for studies of...

Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats.

Frontiers in physiology

Yamada T, Himori K, Tatebayashi D, Yamada R, Ashida Y, Imai T, Akatsuka M, Masuda Y, Kanzaki K, Watanabe D, Wada M, Westerblad H, Lanner JT.
PMID: 30147660
Front Physiol. 2018 Aug 10;9:1111. doi: 10.3389/fphys.2018.01111. eCollection 2018.

Severe muscle weakness concomitant with preferential depletion of myosin has been observed in several pathological conditions. Here, we used the steroid-denervation (S-D) rat model, which shows dramatic decrease in myosin content and force production, to test whether electrical stimulation...

Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment.

Skeletal muscle

Yamada T, Abe M, Lee J, Tatebayashi D, Himori K, Kanzaki K, Wada M, Bruton JD, Westerblad H, Lanner JT.
PMID: 26161253
Skelet Muscle. 2015 Jul 09;5:20. doi: 10.1186/s13395-015-0045-7. eCollection 2015.

BACKGROUND: In addition to the primary symptoms arising from inflamed joints, muscle weakness is prominent and frequent in patients with rheumatoid arthritis (RA). Here, we investigated the mechanisms of arthritis-induced muscle dysfunction in rats with adjuvant-induced arthritis (AIA).METHODS: AIA...

Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans.

Antioxidants (Basel, Switzerland)

Wyckelsma VL, Trepci A, Schwieler L, Venckunas T, Brazaitis M, Kamandulis S, Paulauskas H, Gapeyeva H, Pääsuke M, Gastaldello S, Imbeault S, Westerblad H, Erhardt S, Andersson DC.
PMID: 34573075
Antioxidants (Basel). 2021 Sep 10;10(9). doi: 10.3390/antiox10091443.

The kynurenine pathway (KP) is gaining attention in several clinical fields. Recent studies show that physical exercise offers a therapeutic way to improve ratios of neurotoxic to neuroprotective KP metabolites. Antioxidant supplementation can blunt beneficial responses to physical exercise....

A Mechanism for Statin-Induced Susceptibility to Myopathy.

JACC. Basic to translational science

Lotteau S, Ivarsson N, Yang Z, Restagno D, Colyer J, Hopkins P, Weightman A, Himori K, Yamada T, Bruton J, Steele D, Westerblad H, Calaghan S.
PMID: 31468006
JACC Basic Transl Sci. 2019 Aug 26;4(4):509-523. doi: 10.1016/j.jacbts.2019.03.012. eCollection 2019 Aug.

This study aimed to identify a mechanism for statin-induced myopathy that explains its prevalence and selectivity for skeletal muscle, and to understand its interaction with moderate exercise. Statin-associated adverse muscle symptoms reduce adherence to statin therapy; this limits the...

Vitamin C and E Treatment Blunts Sprint Interval Training-Induced Changes in Inflammatory Mediator-, Calcium-, and Mitochondria-Related Signaling in Recreationally Active Elderly Humans.

Antioxidants (Basel, Switzerland)

Wyckelsma VL, Venckunas T, Brazaitis M, Gastaldello S, Snieckus A, Eimantas N, Baranauskiene N, Subocius A, Skurvydas A, Pääsuke M, Gapeyeva H, Kaasik P, Pääsuke R, Jürimäe J, Graf BA, Kayser B, Place N, Andersson DC, Kamandulis S, Westerblad H.
PMID: 32957522
Antioxidants (Basel). 2020 Sep 17;9(9). doi: 10.3390/antiox9090879.

Sprint interval training (SIT) has emerged as a time-efficient training regimen for young individuals. Here, we studied whether SIT is effective also in elderly individuals and whether the training response was affected by treatment with the antioxidants vitamin C...

Showing 1 to 12 of 17 entries