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Showing 1 to 12 of 99 entries
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The eXtraordinarY Kids Clinic: an interdisciplinary model of care for children and adolescents with sex chromosome aneuploidy.

Journal of multidisciplinary healthcare

Tartaglia N, Howell S, Wilson R, Janusz J, Boada R, Martin S, Frazier JB, Pfeiffer M, Regan K, McSwegin S, Zeitler P.
PMID: 26229481
J Multidiscip Healthc. 2015 Jul 17;8:323-34. doi: 10.2147/JMDH.S80242. eCollection 2015.

PURPOSE: Individuals with sex chromosome aneuploidies (SCAs) are born with an atypical number of X and/or Y chromosomes, and present with a range of medical, developmental, educational, behavioral, and psychological concerns. Rates of SCA diagnoses in infants and children...

Sensitivity of seafloor bathymetry to climate-driven fluctuations in mid-ocean ridge magma supply.

Science (New York, N.Y.)

Olive JA, Behn MD, Ito G, Buck WR, Escartín J, Howell S.
PMID: 26472905
Science. 2015 Oct 16;350(6258):310-3. doi: 10.1126/science.aad0715.

Recent studies have proposed that the bathymetric fabric of the seafloor formed at mid-ocean ridges records rapid (23,000 to 100,000 years) fluctuations in ridge magma supply caused by sealevel changes that modulate melt production in the underlying mantle. Using...

The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening.

BJU international

Benafif S, Ni Raghallaigh H, McGrowder E, Saunders EJ, Brook MN, Saya S, Rageevakumar R, Wakerell S, James D, Chamberlain A, Taylor N, Hogben M, Benton B, D'Mello L, Myhill K, Mikropoulos C, Bowen-Perkins H, Rafi I, Ferris M, Beattie A, Kuganolipava S, Sevenoaks T, Bower J, Kumar P, Hazell S, deSouza NM, Antoniou A, Bancroft E, Kote-Jarai Z, Eeles R.
PMID: 34214236
BJU Int. 2021 Jul 02; doi: 10.1111/bju.15535. Epub 2021 Jul 02.

OBJECTIVES: To assess the feasibility and uptake of a community-based prostate cancer (PCa) screening programme selecting men according to their genetic risk of PCa. To assess the uptake of PCa screening investigations by men invited for screening. The uptake...

A Structural Investigation of Organic Battery Anode Materials by NMR Crystallography.

Magnetic resonance in chemistry : MRC

Whewell T, Seymour VR, Griffiths K, Halcovitch NR, Desai AV, Morris RE, Armstrong AR, Griffin JM.
PMID: 35023583
Magn Reson Chem. 2022 Jan 12; doi: 10.1002/mrc.5249. Epub 2022 Jan 12.

Conjugated alkali metal dicarboxylates have recently received attention for applications as organic anode materials in lithium and sodium-ion batteries. In order to understand and optimise these materials, it is important to be able to characterise both the long-range and...

Uptake and efficacy of bilateral risk reducing surgery in unaffected female .

Journal of medical genetics

Marcinkute R, Woodward ER, Gandhi A, Howell S, Crosbie EJ, Wissely J, Harvey J, Highton L, Murphy J, Holland C, Edmondson R, Clayton R, Barr L, Harkness EF, Howell A, Lalloo F, Evans DG.
PMID: 33568438
J Med Genet. 2021 Feb 10; doi: 10.1136/jmedgenet-2020-107356. Epub 2021 Feb 10.

BACKGROUND: Women testing positive for METHODS: Women were prospectively followed up from positive genetic test (GT) result to censor date. χ² testing compared categorical variables; Cox regression model estimated HRs and 95% CI for BC/ovarian cancer cases associated with...

Comparison of Satisfaction With Penile Prosthesis Implantation in Patients With Radical Prostatectomy or Radical Cystoprostatectomy to the General Population.

Sexual medicine

Howell S, Palasi S, Green T, Kannady C, Panuganti S, Slaughter K, Blum K, Yang B, Saavedra-Belaunde JA, Wang R.
PMID: 33429244
Sex Med. 2021 Feb;9(1):100300. doi: 10.1016/j.esxm.2020.100300. Epub 2021 Jan 08.

INTRODUCTION: Penile prosthesis implantation is a widely used treatment option for erectile dysfunction. Data is limited with regard to patient satisfaction with a penile prosthesis following radical prostatectomy/cystoprostatectomy vs patients with erectile dysfunction of other etiologies.AIM: To examine patient...

It's time to look again at GP funding.

The British journal of general practice : the journal of the Royal College of General Practitioners

Howell S, Torabi P.
PMID: 33372100
Br J Gen Pract. 2020 Dec 28;71(702):12-13. doi: 10.3399/bjgp21X714401. Print 2021 Jan.

No abstract available.

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-.

Journal of medicinal chemistry

Johannes JW, Balazs A, Barratt D, Bista M, Chuba MD, Cosulich S, Critchlow SE, Degorce SL, Di Fruscia P, Edmondson SD, Embrey K, Fawell S, Ghosh A, Gill SJ, Gunnarsson A, Hande SM, Heightman TD, Hemsley P, Illuzzi G, Lane J, Larner C, Leo E, Liu L, Madin A, Martin S, McWilliams L, O'Connor MJ, Orme JP, Pachl F, Packer MJ, Pei X, Pike A, Schimpl M, She H, Staniszewska AD, Talbot V, Underwood E, Varnes JG, Xue L, Yao T, Zhang K, Zhang AX, Zheng X.
PMID: 34570508
J Med Chem. 2021 Oct 14;64(19):14498-14512. doi: 10.1021/acs.jmedchem.1c01012. Epub 2021 Sep 27.

Poly-ADP-ribose-polymerase (PARP) inhibitors have achieved regulatory approval in oncology for homologous recombination repair deficient tumors including BRCA mutation. However, some have failed in combination with first-line chemotherapies, usually due to overlapping hematological toxicities. Currently approved PARP inhibitors lack selectivity...

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.

Cancer cell

Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M, Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S.
PMID: 34715028
Cancer Cell. 2021 Nov 08;39(11):1497-1518.e11. doi: 10.1016/j.ccell.2021.10.001. Epub 2021 Oct 28.

ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response. Genomic analyses show no correlation...

Eosinophilic esophagitis in individuals with sex chromosome aneuploidies: Clinical presentations and management implications.

Molecular genetics & genomic medicine

Howell S, Buchanan C, Davis SM, Miyazawa H, Furuta GT, Tartaglia NR, Nguyen N.
PMID: 34738344
Mol Genet Genomic Med. 2021 Dec;9(12):e1833. doi: 10.1002/mgg3.1833. Epub 2021 Nov 05.

BACKGROUND: Supernumerary sex chromosome aneuploidies (SCA) are common genetic conditions characterized by additional X or Y chromosome, affecting ~1/500 individuals, with the most frequent karyotypes of 47,XXY (Klinefelter syndrome), 47,XXX (Trisomy X), and 47,XYY (Jacob syndrome). Although there is...

Gender-affirming care, mental health, and economic stability in the time of COVID-19: a global cross-sectional study of transgender and non-binary people.

medRxiv : the preprint server for health sciences

Jarrett BA, Peitzmeier SM, Restar A, Adamson T, Howell S, Baral S, Beckham SW.
PMID: 33173876
medRxiv. 2020 Nov 04; doi: 10.1101/2020.11.02.20224709.

BACKGROUND: Transgender and non-binary people are disproportionately burdened by barriers to quality healthcare, mental health challenges, and economic hardship. This study examined the impact of the novel coronavirus disease (COVID-19) pandemic and subsequent control measures on gender-affirming care, mental...

Flying after diving: a questionnaire-based evaluation of pre-flight diving behaviour in a recreational diving cohort.

Diving and hyperbaric medicine

St Leger Dowse M, Howell S, Smerdon GR.
PMID: 34897601
Diving Hyperb Med. 2021 Dec 20;51(4):361-367. doi: 10.28920/dhm51.4.361-367.

INTRODUCTION: Divers are recommended to observe a pre-flight surface interval (PFSI) ≥ 24 hours before boarding a plane following a diving vacation. Decompression sickness (DCS) symptoms may occur during or post-flight. This study aimed to examine the adherence of...

Showing 1 to 12 of 99 entries