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Showing 1 to 12 of 31 entries
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Cryogenic Etching of Silicon: An Alternative Method For Fabrication of Vertical Microcantilever Master Molds.

Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems

Addae-Mensah KA, Retterer S, Opalenik SR, Thomas D, Lavrik NV, Wikswo JP.
PMID: 24223478
J Microelectromech Syst. 2009 Dec 20;19(1). doi: 10.1109/JMEMS.2009.2037440.

This paper examines the use of deep reactive ion etching (DRIE) of silicon with fluorine high-density plasmas at cryogenic temperatures to produce silicon master molds for vertical microcantilever arrays used for controlling substrate stiffness for culturing living cells. The...

Modeling the measurements of cellular fluxes in microbioreactor devices using thin enzyme electrodes.

Journal of mathematical chemistry

Velkovsky M, Snider R, Cliffel DE, Wikswo JP.
PMID: 24031115
J Math Chem. 2011 Jan 01;49(1):251-275. doi: 10.1007/s10910-010-9744-9.

An analytic approach to the modeling of stop-flow amperometric measurements of cellular metabolism with thin glucose oxidase and lactate oxidase electrodes would provide a mechanistic understanding of the various factors that affect the measured signals. We divide the problem...

Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment.

Biomicrofluidics

Rogers M, Sobolik T, Schaffer DK, Samson PC, Johnson AC, Owens P, Codreanu SG, Sherrod SD, McLean JA, Wikswo JP, Richmond A.
PMID: 29774083
Biomicrofluidics. 2018 May 07;12(3):034102. doi: 10.1063/1.5016433. eCollection 2018 May.

The interaction of cancer cells with the stromal cells and matrix in the tumor microenvironment plays a key role in progression to metastasis. A better understanding of the mechanisms underlying these interactions would aid in developing new therapeutic approaches...

Glutamine and glutamate limit the shortening of action potential duration in anoxia-challenged rabbit hearts.

Physiological reports

Drake KJ, Shotwell MS, Wikswo JP, Sidorov VY.
PMID: 26333831
Physiol Rep. 2015 Sep;3(9). doi: 10.14814/phy2.12535.

In clinical conditions, amino acid supplementation is applied to improve contractile function, minimize ischemia/reperfusion injury, and facilitate postoperative recovery. It has been shown that glutamine enhances myocardial ATP/APD (action potential duration) and glutathione/oxidized glutathione ratios, and can increase hexosamine...

Epidemiology of Foodborne Norovirus Outbreaks - United States, 2009-2015.

Food safety (Tokyo, Japan)

Marsh Z, Shah MP, Wikswo ME, Barclay L, Kisselburgh H, Kambhampati A, Cannon JL, Parashar UD, Vinjé J, Hall AJ.
PMID: 32231948
Food Saf (Tokyo). 2018 May 25;6(2):58-66. doi: 10.14252/foodsafetyfscj.2017028. eCollection 2018 Jun.

Noroviruses are the leading cause of acute gastroenteritis and foodborne disease in the United States (U.S.). About 1 in 5 reported norovirus outbreaks are spread through foodborne transmission, presenting opportunities for prevention. We describe the epidemiology of U.S. foodborne...

Correction for Cannon et al., "Genetic and Epidemiologic Trends of Norovirus Outbreaks in the United States from 2013 to 2016 Demonstrated Emergence of Novel GII.4 Recombinant Viruses".

Journal of clinical microbiology

Cannon JL, Barclay L, Collins NR, Wikswo ME, Castro CJ, Magaña LC, Gregoricus N, Marine RL, Chhabra P, Vinjé J.
PMID: 31239401
J Clin Microbiol. 2019 Jun 25;57(7). doi: 10.1128/JCM.00695-19. Print 2019 Jul.

No abstract available.

Comparative genomic analysis of genogroup 1 and genogroup 2 rotaviruses circulating in seven US cities, 2014-2016.

Virus evolution

Esona MD, Gautam R, Katz E, Jaime J, Ward ML, Wikswo ME, Betrapally NS, Rustempasic SM, Selvarangan R, Harrison CJ, Boom JA, Englund J, Klein EJ, Staat MA, McNeal MM, Halasa N, Chappell J, Weinberg GA, Payne DC, Parashar UD, Bowen MD.
PMID: 34522389
Virus Evol. 2021 Mar 12;7(1):veab023. doi: 10.1093/ve/veab023. eCollection 2021 Jan.

For over a decade, the New Vaccine Surveillance Network (NVSN) has conducted active rotavirus (RVA) strain surveillance in the USA. The evolution of RVA in the post-vaccine introduction era and the possible effects of vaccine pressure on contemporary circulating...

The need for cellular and molecular sensors and actuators.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Wikswo JP.
PMID: 17271563
Conf Proc IEEE Eng Med Biol Soc. 2004;2004:5393. doi: 10.1109/IEMBS.2004.1404506.

Systems biology may present the ultimate micro- and nanoengineering challenge: a single mammalian cell requires at least a hundred-thousand variables and equations to describe its dynamic state, cell-cell interactions are critical to system function, and some organs have a...

Multiplex PCR Pathogen Detection in Acute Gastroenteritis Among Hospitalized US Children Compared With Healthy Controls During 2011-2016 in the Post-Rotavirus Vaccine Era.

Open forum infectious diseases

Harrison CJ, Hassan F, Lee B, Boom J, Sahni LC, Johnson C, Dunn J, Payne DC, Wikswo ME, Parashar U, Selvarangan R.
PMID: 34988246
Open Forum Infect Dis. 2021 Nov 24;8(12):ofab592. doi: 10.1093/ofid/ofab592. eCollection 2021 Dec.

BACKGROUND: Despite vaccine-induced decreases in US rotavirus (RV) disease, acute gastroenteritis (AGE) remains relatively common. We evaluated AGE pathogen distribution in hospitalized US children in the post-RV vaccine era.METHODS: From December 2011 to June 2016, the New Vaccine Surveillance...

Rapid prototyping of cell culture microdevices using parylene-coated 3D prints.

Lab on a chip

O'Grady BJ, Geuy MD, Kim H, Balotin KM, Allchin ER, Florian DC, Bute NN, Scott TE, Lowen GB, Fricker CM, Fitzgerald ML, Guelcher SA, Wikswo JP, Bellan LM, Lippmann ES.
PMID: 34787148
Lab Chip. 2021 Dec 07;21(24):4814-4822. doi: 10.1039/d1lc00744k.

Fabrication of microfluidic devices by photolithography generally requires specialized training and access to a cleanroom. As an alternative, 3D printing enables cost-effective fabrication of microdevices with complex features that would be suitable for many biomedical applications. However, commonly used...

Engineered three-dimensional microfluidic device for interrogating cell-cell interactions in the tumor microenvironment.

Biomicrofluidics

Hockemeyer K, Janetopoulos C, Terekhov A, Hofmeister W, Vilgelm A, Costa L, Wikswo JP, Richmond A.
PMID: 25379090
Biomicrofluidics. 2014 Jul 15;8(4):044105. doi: 10.1063/1.4890330. eCollection 2014 Jul.

Stromal cells in the tumor microenvironment play a key role in the metastatic properties of a tumor. It is recognized that cancer-associated fibroblasts (CAFs) and endothelial cells secrete factors capable of influencing tumor cell migration into the blood or...

Rapid prototyping of cell culture microdevices using parylene-coated 3D prints.

Lab on a chip

O'Grady BJ, Geuy MD, Kim H, Balotin KM, Allchin ER, Florian DC, Bute NN, Scott TE, Lowen GB, Fricker CM, Fitzgerald ML, Guelcher SA, Wikswo JP, Bellan LM, Lippmann ES.
PMID: 34787148
Lab Chip. 2021 Dec 07;21(24):4814-4822. doi: 10.1039/d1lc00744k.

Fabrication of microfluidic devices by photolithography generally requires specialized training and access to a cleanroom. As an alternative, 3D printing enables cost-effective fabrication of microdevices with complex features that would be suitable for many biomedical applications. However, commonly used...

Showing 1 to 12 of 31 entries