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Showing 1 to 12 of 19 entries
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Pulmonary thromboembolism presenting as asthma.

British medical journal

Windebank WJ, Boyd G, Moran F.
PMID: 20791880
Br Med J. 1973 Jan 13;1(5845):90-4. doi: 10.1136/bmj.1.5845.90.

When a patient presents with wheezing, pulmonary embolism is not usually considered as a possible cause. However, undoubtedly bronchoconstriction can be caused by pulmonary emboli and occasionally wheezing may be so obvious as to suggest a diagnosis of bronchial...

Comprehensive Method for Culturing Embryonic Dorsal Root Ganglion Neurons for Seahorse Extracellular Flux XF24 Analysis.

Frontiers in neurology

Lange M, Zeng Y, Knight A, Windebank A, Trushina E.
PMID: 23248613
Front Neurol. 2012 Dec 14;3:175. doi: 10.3389/fneur.2012.00175. eCollection 2012.

Changes in mitochondrial dynamics and function contribute to progression of multiple neurodegenerative diseases including peripheral neuropathies. The Seahorse Extracellular Flux XF24 analyzer provides a comprehensive assessment of the relative state of glycolytic and aerobic metabolism in live cells making...

Population of Monocyte-Derived Macrophages.

Immunity

McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Miranda-Saavedra D, Larbi A, Wasan PS, Kaibo D, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M.
PMID: 28843277
Immunity. 2015 Feb 17;42(2):391. doi: 10.1016/j.immuni.2015.01.018. Epub 2015 Feb 17.

No abstract available.

A novel triple immunoenzyme staining enables simultaneous identification of all muscle fiber types on a single skeletal muscle cryosection from normal, denervated or reinnervated rats.

Neural regeneration research

Wu P, Zhang S, Spinner RJ, Lizardi MT, Gu Y, Yu C, Yaszemski MJ, Windebank AJ, Wang H.
PMID: 28966653
Neural Regen Res. 2017 Aug;12(8):1357-1364. doi: 10.4103/1673-5374.213560.

Triple immunofluorescence staining has recently been developed to simultaneously identify all muscle fibers on a single cryosection which is helpful for clinical and basic research, but it has disadvantages such as fast photobleaching and unclear outlines of muscle fibers....

Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord.

Frontiers in cell and developmental biology

Nelson CM, Lennon VA, Lee H, Krug RG, Kamalova A, Madigan NN, Clark KJ, Windebank AJ, Henley JR.
PMID: 31069223
Front Cell Dev Biol. 2019 Apr 24;7:56. doi: 10.3389/fcell.2019.00056. eCollection 2019.

Following injury, the mammalian spinal cord forms a glial scar and fails to regenerate. In contrast, vertebrate fish spinal cord tissue regenerates significantly to restore function. Cord transection in zebrafish (

A Randomized Placebo-Controlled Phase 3 Study of Mesenchymal stem cells induced to secrete high levels of neurotrophic factors in Amyotrophic Lateral Sclerosis.

Muscle & nerve

Cudkowicz ME, Lindborg SR, Goyal NA, Miller RG, Burford MJ, Berry JD, Nicholson KA, Mozaffar T, Katz JS, Jenkins LJ, Baloh RH, Lewis RA, Staff N, Owegi MA, Berry DA, Gothelf Y, Levy YS, Aricha R, Kern RZ, Windebank AJ, Brown RH.
PMID: 34890069
Muscle Nerve. 2021 Dec 10; doi: 10.1002/mus.27472. Epub 2021 Dec 10.

INTRODUCTION/AIMS: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative illness with great unmet patient need. We aimed to evaluate whether mesenchymal stem cells induced to secrete high levels of neurotrophic factors (MSC-NTF), a novel autologous cell-therapy capable of targeting...

Genetic Reduction of Mitochondria Complex I Subunits is Protective Against Cisplatin-Induced Neurotoxicity in .

The Journal of neuroscience : the official journal of the Society for Neuroscience

Groen CM, Podratz JL, Pathoulas J, Staff N, Windebank AJ.
PMID: 34893548
J Neurosci. 2021 Dec 10; doi: 10.1523/JNEUROSCI.1479-20.2021. Epub 2021 Dec 10.

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent side effect of widely used platinum-based anti-cancer agents. There are few predictable risk factors to identify susceptible patients. Effective preventive measures or treatments are not available. Here, we have used a model...

Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.

NPJ Regenerative medicine

Siddiqui AM, Islam R, Cuellar CA, Silvernail JL, Knudsen B, Curley DE, Strickland T, Manske E, Suwan PT, Latypov T, Akhmetov N, Zhang S, Summer P, Nesbitt JJ, Chen BK, Grahn PJ, Madigan NN, Yaszemski MJ, Windebank AJ, Lavrov IA.
PMID: 34671050
NPJ Regen Med. 2021 Oct 20;6(1):66. doi: 10.1038/s41536-021-00176-6.

Here, we report the effect of newly regenerated axons via scaffolds on reorganization of spinal circuitry and restoration of motor functions with epidural electrical stimulation (EES). Motor recovery was evaluated for 7 weeks after spinal transection and following implantation...

The Translesional Spinal Network and Its Reorganization after Spinal Cord Injury.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

Krupa P, Siddiqui AM, Grahn PJ, Islam R, Chen BK, Madigan NN, Windebank AJ, Lavrov IA.
PMID: 33089762
Neuroscientist. 2020 Oct 22;1073858420966276. doi: 10.1177/1073858420966276. Epub 2020 Oct 22.

Evidence from preclinical and clinical research suggest that neuromodulation technologies can facilitate the sublesional spinal networks, isolated from supraspinal commands after spinal cord injury (SCI), by reestablishing the levels of excitability and enabling descending motor signals via residual connections....

Translating stem cell research to the clinic: a primer on translational considerations for your first stem cell protocol.

Stem cell research & therapy

O'Brien T, Creane M, Windebank AJ, Terzic A, Dietz AB.
PMID: 26296990
Stem Cell Res Ther. 2015 Aug 22;6:146. doi: 10.1186/s13287-015-0145-7.

Over the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate the symptoms of disease, clinicians may...

Time-to-enrollment in clinical trials investigating neurological recovery in chronic spinal cord injury: observations from a systematic review and ClinicalTrials.gov database.

Neural regeneration research

Moinuddin FM, Yolcu YU, Wahood W, Zreik J, Goncalves S, Windebank AJ, Qu W, Bydon M.
PMID: 34558507
Neural Regen Res. 2022 May;17(5):953-958. doi: 10.4103/1673-5374.324826.

Currently, large numbers of clinical trials are performed to investigate different forms of experimental therapy for patients suffering from chronic spinal cord injury (SCI). However, for the enrollment process, there are different views on how the time period between...

A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products.

Regulatory toxicology and pharmacology : RTP

Reynolds G, Reynolds J, Gilmour N, Cubberley R, Spriggs S, Aptula A, Przybylak K, Windebank S, Maxwell G, Baltazar MT.
PMID: 34728330
Regul Toxicol Pharmacol. 2021 Dec;127:105075. doi: 10.1016/j.yrtph.2021.105075. Epub 2021 Oct 30.

Next generation Risk Assessment (NGRA) is an exposure-led, hypothesis-driven approach which integrates new approach methodologies (NAMs) to assure safety without generating animal data. This hypothetical skin allergy risk assessment of two consumer products - face cream containing 0.1% coumarin...

Showing 1 to 12 of 19 entries