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Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis.

JACC. Basic to translational science

Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S.
PMID: 29147686
JACC Basic Transl Sci. 2017 Jun;2(3):229-240. doi: 10.1016/j.jacbts.2017.02.004. Epub 2017 Jun 26.

The

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Torzewski M, Ravandi A, Yeang C, et al. Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017;2(3):229-240doi: 10.1016/j.jacbts.2017.02.004.
Torzewski, M., Ravandi, A., Yeang, C., Edel, A., Bhindi, R., Kath, S., Twardowski, L., Schmid, J., Yang, X., Franke, U. F. W., Witztum, J. L., & Tsimikas, S. (2017). Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC. Basic to translational science, 2(3), 229-240. https://doi.org/10.1016/j.jacbts.2017.02.004
Torzewski, Michael, et al. "Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis." JACC. Basic to translational science vol. 2,3 (2017): 229-240. doi: https://doi.org/10.1016/j.jacbts.2017.02.004
Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S. Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017 Jun;2(3):229-240. doi: 10.1016/j.jacbts.2017.02.004. Epub 2017 Jun 26. PMID: 29147686; PMCID: PMC5685511.
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Comparative health assessment of urban and non-urban free-ranging mule deer (.

PeerJ

Mathieu A, Flint M, Stent PM, Schwantje HM, Wittum TE.
PMID: 29942678
PeerJ. 2018 Jun 20;6:e4968. doi: 10.7717/peerj.4968. eCollection 2018.

BACKGROUND: The provincial wildlife management agency, British Columbia Ministry of Forests, Lands, Natural Resource Operations and Rural Development, performed a translocation to control the urban mule deer (METHODS: Two hundred free-ranging mule deer were captured in urban and non-urban...

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Mathieu A, Flint M, Stent PM, et al. Comparative health assessment of urban and non-urban free-ranging mule deer (. PeerJ. 2018;6:e4968doi: 10.7717/peerj.4968.
Mathieu, A., Flint, M., Stent, P. M., Schwantje, H. M., & Wittum, T. E. (2018). Comparative health assessment of urban and non-urban free-ranging mule deer (. PeerJ, 6e4968. https://doi.org/10.7717/peerj.4968
Mathieu, Amélie, et al. "Comparative health assessment of urban and non-urban free-ranging mule deer (." PeerJ vol. 6 (2018): e4968. doi: https://doi.org/10.7717/peerj.4968
Mathieu A, Flint M, Stent PM, Schwantje HM, Wittum TE. Comparative health assessment of urban and non-urban free-ranging mule deer (. PeerJ. 2018 Jun 20;6:e4968. doi: 10.7717/peerj.4968. eCollection 2018. PMID: 29942678; PMCID: PMC6015483.
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Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Nature

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.
PMID: 30013121
Nature. 2018 Sep;561(7724):E43. doi: 10.1038/s41586-018-0313-x.

In this Letter, affiliation number 1 was originally missing from the HTML; the affiliations were missing for author Ming-Yow Hung in the HTML; and the Fig. 4 legend erroneously referred to panels a-h, instead of a-g. These errors have...

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Que X, Hung MY, Yeang C, et al. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018;561(7724):E43doi: 10.1038/s41586-018-0313-x.
Que, X., Hung, M. Y., Yeang, C., Gonen, A., Prohaska, T. A., Sun, X., Diehl, C., Määttä, A., Gaddis, D. E., Bowden, K., Pattison, J., MacDonald, J. G., Ylä-Herttuala, S., Mellon, P. L., Hedrick, C. C., Ley, K., Miller, Y. I., Glass, C. K., Peterson, K. L., Binder, C. J., Tsimikas, S., & Witztum, J. L. (2018). Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature, 561(7724), E43. https://doi.org/10.1038/s41586-018-0313-x
Que, Xuchu, et al. "Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice." Nature vol. 561,7724 (2018): E43. doi: https://doi.org/10.1038/s41586-018-0313-x
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 Sep;561(7724):E43. doi: 10.1038/s41586-018-0313-x. PMID: 30013121.
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Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles.

Journal of the Endocrine Society

O'Dea LSL, MacDougall J, Alexander VJ, Digenio A, Hubbard B, Arca M, Moriarty PM, Kastelein JJP, Bruckert E, Soran H, Witztum JL, Hegele RA, Gaudet D.
PMID: 31777768
J Endocr Soc. 2019 Oct 11;3(12):2397-2410. doi: 10.1210/js.2019-00214. eCollection 2019 Dec 01.

CONTEXT: Differentiation between familial chylomicronemia syndrome (FCS, type 1 hyperlipoproteinemia), a rare metabolic disorder, and the more common multifactorial severe hypertriglyceridemia (sHTG, type 5 hyperlipoproteinemia) is challenging because of their overlapping symptoms but important in patient management.OBJECTIVE: To assess...

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O'Dea LSL, MacDougall J, Alexander VJ, et al. Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles. J Endocr Soc. 2019;3(12):2397-2410doi: 10.1210/js.2019-00214.
O'Dea, L. S. L., MacDougall, J., Alexander, V. J., Digenio, A., Hubbard, B., Arca, M., Moriarty, P. M., Kastelein, J. J. P., Bruckert, E., Soran, H., Witztum, J. L., Hegele, R. A., & Gaudet, D. (2019). Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles. Journal of the Endocrine Society, 3(12), 2397-2410. https://doi.org/10.1210/js.2019-00214
O'Dea, Louis St L, et al. "Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles." Journal of the Endocrine Society vol. 3,12 (2019): 2397-2410. doi: https://doi.org/10.1210/js.2019-00214
O'Dea LSL, MacDougall J, Alexander VJ, Digenio A, Hubbard B, Arca M, Moriarty PM, Kastelein JJP, Bruckert E, Soran H, Witztum JL, Hegele RA, Gaudet D. Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles. J Endocr Soc. 2019 Oct 11;3(12):2397-2410. doi: 10.1210/js.2019-00214. eCollection 2019 Dec 01. PMID: 31777768; PMCID: PMC6864364.
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Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis.

Preventive veterinary medicine

Parker EM, Parker AJ, Short G, O'Connor AM, Wittum TE.
PMID: 34826732
Prev Vet Med. 2022 Jan;198:105546. doi: 10.1016/j.prevetmed.2021.105546. Epub 2021 Nov 18.

Salmonella contamination of livestock feed is a serious veterinary and public health issue. In this study we used a systematic review to assess the prevalence and characterization of Salmonella isolates detected in raw feed components, feed milling equipment and...

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Parker EM, Parker AJ, Short G, et al. Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis. Prev Vet Med. 2021;198:105546doi: 10.1016/j.prevetmed.2021.105546.
Parker, E. M., Parker, A. J., Short, G., O'Connor, A. M., & Wittum, T. E. (2022). Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis. Preventive veterinary medicine, 198105546. https://doi.org/10.1016/j.prevetmed.2021.105546
Parker, Elizabeth M, et al. "Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis." Preventive veterinary medicine vol. 198 (2022): 105546. doi: https://doi.org/10.1016/j.prevetmed.2021.105546
Parker EM, Parker AJ, Short G, O'Connor AM, Wittum TE. Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis. Prev Vet Med. 2022 Jan;198:105546. doi: 10.1016/j.prevetmed.2021.105546. Epub 2021 Nov 18. PMID: 34826732.
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Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis.

Preventive veterinary medicine

Parker EM, Parker AJ, Short G, O'Connor AM, Wittum TE.
PMID: 34826732
Prev Vet Med. 2021 Nov 18;198:105546. doi: 10.1016/j.prevetmed.2021.105546. Epub 2021 Nov 18.

Salmonella contamination of livestock feed is a serious veterinary and public health issue. In this study we used a systematic review to assess the prevalence and characterization of Salmonella isolates detected in raw feed components, feed milling equipment and...

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Parker EM, Parker AJ, Short G, et al. Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis. Prev Vet Med. 2021;198:105546doi: 10.1016/j.prevetmed.2021.105546.
Parker, E. M., Parker, A. J., Short, G., O'Connor, A. M., & Wittum, T. E. (2021). Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis. Preventive veterinary medicine, 198105546. https://doi.org/10.1016/j.prevetmed.2021.105546
Parker, Elizabeth M, et al. "Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis." Preventive veterinary medicine vol. 198 (2021): 105546. doi: https://doi.org/10.1016/j.prevetmed.2021.105546
Parker EM, Parker AJ, Short G, O'Connor AM, Wittum TE. Salmonella detection in commercially prepared livestock feed and the raw ingredients and equipment used to manufacture the feed: A systematic review and meta-analysis. Prev Vet Med. 2021 Nov 18;198:105546. doi: 10.1016/j.prevetmed.2021.105546. Epub 2021 Nov 18. PMID: 34826732.
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Traumatic Bereavements: Rebalancing the Relationship to the Deceased and the Death Story Using the Two-Track Model of Bereavement.

Frontiers in psychiatry

Rubin SS, Malkinson R, Witztum E.
PMID: 33093833
Front Psychiatry. 2020 Sep 15;11:537596. doi: 10.3389/fpsyt.2020.537596. eCollection 2020.

Bereavements that occur under external traumatic circumstances increase the risk for dysfunction, trauma symptomatology, as well as disordered and prolonged grief. While the majority of individuals who have experienced traumatic bereavements do not meet formal criteria for posttraumatic stress...

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Rubin SS, Malkinson R, Witztum E. Traumatic Bereavements: Rebalancing the Relationship to the Deceased and the Death Story Using the Two-Track Model of Bereavement. Front Psychiatry. 2020;11:537596doi: 10.3389/fpsyt.2020.537596.
Rubin, S. S., Malkinson, R., & Witztum, E. (2020). Traumatic Bereavements: Rebalancing the Relationship to the Deceased and the Death Story Using the Two-Track Model of Bereavement. Frontiers in psychiatry, 11537596. https://doi.org/10.3389/fpsyt.2020.537596
Rubin, Simon Shimshon, et al. "Traumatic Bereavements: Rebalancing the Relationship to the Deceased and the Death Story Using the Two-Track Model of Bereavement." Frontiers in psychiatry vol. 11 (2020): 537596. doi: https://doi.org/10.3389/fpsyt.2020.537596
Rubin SS, Malkinson R, Witztum E. Traumatic Bereavements: Rebalancing the Relationship to the Deceased and the Death Story Using the Two-Track Model of Bereavement. Front Psychiatry. 2020 Sep 15;11:537596. doi: 10.3389/fpsyt.2020.537596. eCollection 2020. PMID: 33093833; PMCID: PMC7523537.
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Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.

Circulation

Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR.
PMID: 34846914
Circulation. 2021 Dec 14;144(24):1940-1954. doi: 10.1161/CIRCULATIONAHA.121.056414. Epub 2021 Nov 30.

CONCLUSIONS: Hematopoietic

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Dou H, Kotini A, Liu W, et al. Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Circulation. 2021;144(24):1940-1954doi: 10.1161/CIRCULATIONAHA.121.056414.
Dou, H., Kotini, A., Liu, W., Fidler, T., Endo-Umeda, K., Sun, X., Olszewska, M., Xiao, T., Abramowicz, S., Yalcinkaya, M., Hardaway, B., Tsimikas, S., Que, X., Bick, A., Emdin, C., Natarajan, P., Papapetrou, E. P., Witztum, J. L., Wang, N., & Tall, A. R. (2021). Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Circulation, 144(24), 1940-1954. https://doi.org/10.1161/CIRCULATIONAHA.121.056414
Dou, Huijuan, et al. "Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency." Circulation vol. 144,24 (2021): 1940-1954. doi: https://doi.org/10.1161/CIRCULATIONAHA.121.056414
Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR. Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Circulation. 2021 Dec 14;144(24):1940-1954. doi: 10.1161/CIRCULATIONAHA.121.056414. Epub 2021 Nov 30. PMID: 34846914; PMCID: PMC8663540.
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CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in .

Antibodies (Basel, Switzerland)

Biswas TK, VanderLaan PA, Que X, Gonen A, Krishack P, Binder CJ, Witztum JL, Getz GS, Reardon CA.
PMID: 32635160
Antibodies (Basel). 2020 Jul 03;9(3). doi: 10.3390/antib9030030.

Natural antibodies (NAbs) are important regulators of tissue homeostasis and inflammation and are thought to have diverse protective roles in a variety of pathological states. E06 is a T15 idiotype IgM NAb exclusively produced by B-1 cells, which recognizes...

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Biswas TK, VanderLaan PA, Que X, et al. CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in . Antibodies (Basel). 2020;9(3)doi: 10.3390/antib9030030.
Biswas, T. K., VanderLaan, P. A., Que, X., Gonen, A., Krishack, P., Binder, C. J., Witztum, J. L., Getz, G. S., & Reardon, C. A. (2020). CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in . Antibodies (Basel, Switzerland), 9(3), . https://doi.org/10.3390/antib9030030
Biswas, Tapan K, et al. "CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in ." Antibodies (Basel, Switzerland) vol. 9,3 (2020). doi: https://doi.org/10.3390/antib9030030
Biswas TK, VanderLaan PA, Que X, Gonen A, Krishack P, Binder CJ, Witztum JL, Getz GS, Reardon CA. CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in . Antibodies (Basel). 2020 Jul 03;9(3). doi: 10.3390/antib9030030. PMID: 32635160; PMCID: PMC7551411.
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Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography.

CJC open

Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ.
PMID: 32159096
CJC Open. 2019 Apr 12;1(3):131-140. doi: 10.1016/j.cjco.2019.03.004. eCollection 2019 May.

BACKGROUND: Lipoprotein(a) (Lp[a]) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification in individuals without CAVS is unknown. Our objective was...

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Després AA, Perrot N, Poulin A, et al. Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography. CJC Open. 2019;1(3):131-140doi: 10.1016/j.cjco.2019.03.004.
Després, A. A., Perrot, N., Poulin, A., Tastet, L., Shen, M., Chen, H. Y., Bourgeois, R., Trottier, M., Tessier, M., Guimond, J., Nadeau, M., Engert, J. C., Thériault, S., Bossé, Y., Witztum, J. L., Couture, P., Mathieu, P., Dweck, M. R., Tsimikas, S., Thanassoulis, G., Pibarot, P., Clavel, M. A., & Arsenault, B. J. (2019). Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography. CJC open, 1(3), 131-140. https://doi.org/10.1016/j.cjco.2019.03.004
Després, Audrey-Anne, et al. "Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography." CJC open vol. 1,3 (2019): 131-140. doi: https://doi.org/10.1016/j.cjco.2019.03.004
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ. Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography. CJC Open. 2019 Apr 12;1(3):131-140. doi: 10.1016/j.cjco.2019.03.004. eCollection 2019 May. PMID: 32159096; PMCID: PMC7063623.
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RNA-Targeted Therapeutics.

Cell metabolism

Crooke ST, Witztum JL, Bennett CF, Baker BF.
PMID: 30726759
Cell Metab. 2019 Feb 05;29(2):501. doi: 10.1016/j.cmet.2019.01.001.

No abstract available.

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Crooke ST, Witztum JL, Bennett CF, et al. RNA-Targeted Therapeutics. Cell Metab. 2019;29(2):501doi: 10.1016/j.cmet.2019.01.001.
Crooke, S. T., Witztum, J. L., Bennett, C. F., & Baker, B. F. (2019). RNA-Targeted Therapeutics. Cell metabolism, 29(2), 501. https://doi.org/10.1016/j.cmet.2019.01.001
Crooke, Stanley T, et al. "RNA-Targeted Therapeutics." Cell metabolism vol. 29,2 (2019): 501. doi: https://doi.org/10.1016/j.cmet.2019.01.001
Crooke ST, Witztum JL, Bennett CF, Baker BF. RNA-Targeted Therapeutics. Cell Metab. 2019 Feb 05;29(2):501. doi: 10.1016/j.cmet.2019.01.001. PMID: 30726759.
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A three-dimensional mathematical model for the signal propagation on a neuron's membrane.

Frontiers in computational neuroscience

Xylouris K, Wittum G.
PMID: 26236230
Front Comput Neurosci. 2015 Jul 17;9:94. doi: 10.3389/fncom.2015.00094. eCollection 2015.

In order to be able to examine the extracellular potential's influence on network activity and to better understand dipole properties of the extracellular potential, we present and analyze a three-dimensional formulation of the cable equation which facilitates numeric simulations....

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Xylouris K, Wittum G. A three-dimensional mathematical model for the signal propagation on a neuron's membrane. Front Comput Neurosci. 2015;9:94doi: 10.3389/fncom.2015.00094.
Xylouris, K., & Wittum, G. (2015). A three-dimensional mathematical model for the signal propagation on a neuron's membrane. Frontiers in computational neuroscience, 994. https://doi.org/10.3389/fncom.2015.00094
Xylouris, Konstantinos, and Wittum, Gabriel. "A three-dimensional mathematical model for the signal propagation on a neuron's membrane." Frontiers in computational neuroscience vol. 9 (2015): 94. doi: https://doi.org/10.3389/fncom.2015.00094
Xylouris K, Wittum G. A three-dimensional mathematical model for the signal propagation on a neuron's membrane. Front Comput Neurosci. 2015 Jul 17;9:94. doi: 10.3389/fncom.2015.00094. eCollection 2015. PMID: 26236230; PMCID: PMC4505111.
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