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DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.

Science immunology

Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J.
PMID: 34860583
Sci Immunol. 2021 Dec 03;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 03.

[Figure: see text].

Cite
Wang SB, Narendran S, Hirahara S, et al. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Sci Immunol. 2021;6(66):eabi4493doi: 10.1126/sciimmunol.abi4493.
Wang, S. B., Narendran, S., Hirahara, S., Varshney, A., Pereira, F., Apicella, I., Ambati, M., Ambati, V. L., Yerramothu, P., Ambati, K., Nagasaka, Y., Argyle, D., Huang, P., Baker, K. L., Marion, K. M., Gupta, K., Liu, B., Hinton, D. R., Canna, S. W., Sallam, T., Sadda, S. R., Kerur, N., Gelfand, B. D., & Ambati, J. (2021). DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Science immunology, 6(66), eabi4493. https://doi.org/10.1126/sciimmunol.abi4493
Wang, Shao-Bin, et al. "DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs." Science immunology vol. 6,66 (2021): eabi4493. doi: https://doi.org/10.1126/sciimmunol.abi4493
Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Sci Immunol. 2021 Dec 03;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 03. PMID: 34860583.
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Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration.

Signal transduction and targeted therapy

Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati VL, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker KL, Marion KM, Deussing JM, Sadda SR, Gelfand BD, Ambati J.
PMID: 33850097
Signal Transduct Target Ther. 2021 Apr 14;6(1):149. doi: 10.1038/s41392-021-00537-z.

Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cause of global blindness. We report that AβOs induce RPE degeneration, a clinical hallmark...

Cite
Narendran S, Pereira F, Yerramothu P, et al. Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. Signal Transduct Target Ther. 2021;6(1):149doi: 10.1038/s41392-021-00537-z.
Narendran, S., Pereira, F., Yerramothu, P., Apicella, I., Wang, S. B., Ambati, K., Hirahara, S., Kim, Y., Ambati, M., Ambati, V. L., Huang, P., Varshney, A., Nagasaka, Y., Fukuda, S., Baker, K. L., Marion, K. M., Deussing, J. M., Sadda, S. R., Gelfand, B. D., & Ambati, J. (2021). Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. Signal transduction and targeted therapy, 6(1), 149. https://doi.org/10.1038/s41392-021-00537-z
Narendran, Siddharth, et al. "Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration." Signal transduction and targeted therapy vol. 6,1 (2021): 149. doi: https://doi.org/10.1038/s41392-021-00537-z
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati VL, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker KL, Marion KM, Deussing JM, Sadda SR, Gelfand BD, Ambati J. Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. Signal Transduct Target Ther. 2021 Apr 14;6(1):149. doi: 10.1038/s41392-021-00537-z. PMID: 33850097; PMCID: PMC8044134.
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A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling.

Nature communications

Banerjee D, Langberg K, Abbas S, Odermatt E, Yerramothu P, Volaric M, Reidenbach MA, Krentz KJ, Rubinstein CD, Brautigan DL, Abbas T, Gelfand BD, Ambati J, Kerur N.
PMID: 34707113
Nat Commun. 2021 Oct 27;12(1):6207. doi: 10.1038/s41467-021-26240-9.

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), produced by cyclic GMP-AMP synthase (cGAS), stimulates the production of type I interferons (IFN). Here we show that cGAMP activates DNA damage response (DDR) signaling independently of its canonical IFN pathways. Loss of cGAS...

Cite
Banerjee D, Langberg K, Abbas S, et al. A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. Nat Commun. 2021;12(1):6207doi: 10.1038/s41467-021-26240-9.
Banerjee, D., Langberg, K., Abbas, S., Odermatt, E., Yerramothu, P., Volaric, M., Reidenbach, M. A., Krentz, K. J., Rubinstein, C. D., Brautigan, D. L., Abbas, T., Gelfand, B. D., Ambati, J., & Kerur, N. (2021). A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. Nature communications, 12(1), 6207. https://doi.org/10.1038/s41467-021-26240-9
Banerjee, Daipayan, et al. "A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling." Nature communications vol. 12,1 (2021): 6207. doi: https://doi.org/10.1038/s41467-021-26240-9
Banerjee D, Langberg K, Abbas S, Odermatt E, Yerramothu P, Volaric M, Reidenbach MA, Krentz KJ, Rubinstein CD, Brautigan DL, Abbas T, Gelfand BD, Ambati J, Kerur N. A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. Nat Commun. 2021 Oct 27;12(1):6207. doi: 10.1038/s41467-021-26240-9. PMID: 34707113; PMCID: PMC8551335.
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New Therapies of Neovascular AMD-Beyond Anti-VEGFs.

Vision (Basel, Switzerland)

Yerramothu P.
PMID: 31735894
Vision (Basel). 2018 Jul 30;2(3). doi: 10.3390/vision2030031.

Neovascular age-related macular degeneration (nAMD) is one of the leading causes of blindness among the aging population. The current treatment options for nAMD include intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF). However, standardized frequent administration of anti-VEGF injections...

Cite
Yerramothu P. New Therapies of Neovascular AMD-Beyond Anti-VEGFs. Vision (Basel). 2018;2(3)doi: 10.3390/vision2030031.
Yerramothu, P. (2018). New Therapies of Neovascular AMD-Beyond Anti-VEGFs. Vision (Basel, Switzerland), 2(3), . https://doi.org/10.3390/vision2030031
Yerramothu, Praveen. "New Therapies of Neovascular AMD-Beyond Anti-VEGFs." Vision (Basel, Switzerland) vol. 2,3 (2018). doi: https://doi.org/10.3390/vision2030031
Yerramothu P. New Therapies of Neovascular AMD-Beyond Anti-VEGFs. Vision (Basel). 2018 Jul 30;2(3). doi: 10.3390/vision2030031. PMID: 31735894; PMCID: PMC6835305.
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Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration.

Signal transduction and targeted therapy

Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati VL, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker KL, Marion KM, Deussing JM, Sadda SR, Gelfand BD, Ambati J.
PMID: 33850097
Signal Transduct Target Ther. 2021 Apr 14;6(1):149. doi: 10.1038/s41392-021-00537-z.

Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cause of global blindness. We report that AβOs induce RPE degeneration, a clinical hallmark...

Cite
Narendran S, Pereira F, Yerramothu P, et al. Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. Signal Transduct Target Ther. 2021;6(1):149doi: 10.1038/s41392-021-00537-z.
Narendran, S., Pereira, F., Yerramothu, P., Apicella, I., Wang, S. B., Ambati, K., Hirahara, S., Kim, Y., Ambati, M., Ambati, V. L., Huang, P., Varshney, A., Nagasaka, Y., Fukuda, S., Baker, K. L., Marion, K. M., Deussing, J. M., Sadda, S. R., Gelfand, B. D., & Ambati, J. (2021). Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. Signal transduction and targeted therapy, 6(1), 149. https://doi.org/10.1038/s41392-021-00537-z
Narendran, Siddharth, et al. "Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration." Signal transduction and targeted therapy vol. 6,1 (2021): 149. doi: https://doi.org/10.1038/s41392-021-00537-z
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati VL, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker KL, Marion KM, Deussing JM, Sadda SR, Gelfand BD, Ambati J. Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. Signal Transduct Target Ther. 2021 Apr 14;6(1):149. doi: 10.1038/s41392-021-00537-z. PMID: 33850097; PMCID: PMC8044134.
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DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.

Science immunology

Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J.
PMID: 34860583
Sci Immunol. 2021 Dec 03;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 03.

[Figure: see text].

Cite
Wang SB, Narendran S, Hirahara S, et al. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Sci Immunol. 2021;6(66):eabi4493doi: 10.1126/sciimmunol.abi4493.
Wang, S. B., Narendran, S., Hirahara, S., Varshney, A., Pereira, F., Apicella, I., Ambati, M., Ambati, V. L., Yerramothu, P., Ambati, K., Nagasaka, Y., Argyle, D., Huang, P., Baker, K. L., Marion, K. M., Gupta, K., Liu, B., Hinton, D. R., Canna, S. W., Sallam, T., Sadda, S. R., Kerur, N., Gelfand, B. D., & Ambati, J. (2021). DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Science immunology, 6(66), eabi4493. https://doi.org/10.1126/sciimmunol.abi4493
Wang, Shao-Bin, et al. "DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs." Science immunology vol. 6,66 (2021): eabi4493. doi: https://doi.org/10.1126/sciimmunol.abi4493
Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Sci Immunol. 2021 Dec 03;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 03. PMID: 34860583.
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[No title available]

Science advances

Fukuda S, Narendran S, Varshney A, Nagasaka Y, Wang SB, Ambati K, Apicella I, Pereira F, Fowler BJ, Yasuma T, Hirahara S, Yasuma R, Huang P, Yerramothu P, Makin RD, Wang M, Baker KL, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Banerjee D, Bonilha VL, Tolstonog GV, Held U, Ogura Y, Terasaki H, Oshika T, Bhattarai D, Kim KB, Feldman SH, Aguirre JI, Hinton DR, Kerur N, Sadda SR, Schumann GG, Gelfand BD, Ambati J.
PMID: 34586848
Sci Adv. 2021 Oct;7(40):eabj3658. doi: 10.1126/sciadv.abj3658. Epub 2021 Sep 29.

[Figure: see text].

Cite
Fukuda S, Narendran S, Varshney A, et al. . Sci Adv. 2021;7(40):eabj3658doi: 10.1126/sciadv.abj3658.
Fukuda, S., Narendran, S., Varshney, A., Nagasaka, Y., Wang, S. B., Ambati, K., Apicella, I., Pereira, F., Fowler, B. J., Yasuma, T., Hirahara, S., Yasuma, R., Huang, P., Yerramothu, P., Makin, R. D., Wang, M., Baker, K. L., Marion, K. M., Huang, X., Baghdasaryan, E., Ambati, M., Ambati, V. L., Banerjee, D., Bonilha, V. L., Tolstonog, G. V., Held, U., Ogura, Y., Terasaki, H., Oshika, T., Bhattarai, D., Kim, K. B., Feldman, S. H., Aguirre, J. I., Hinton, D. R., Kerur, N., Sadda, S. R., Schumann, G. G., Gelfand, B. D., & Ambati, J. (2021). . Science advances, 7(40), eabj3658. https://doi.org/10.1126/sciadv.abj3658
Fukuda, Shinichi, et al. "." Science advances vol. 7,40 (2021): eabj3658. doi: https://doi.org/10.1126/sciadv.abj3658
Fukuda S, Narendran S, Varshney A, Nagasaka Y, Wang SB, Ambati K, Apicella I, Pereira F, Fowler BJ, Yasuma T, Hirahara S, Yasuma R, Huang P, Yerramothu P, Makin RD, Wang M, Baker KL, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Banerjee D, Bonilha VL, Tolstonog GV, Held U, Ogura Y, Terasaki H, Oshika T, Bhattarai D, Kim KB, Feldman SH, Aguirre JI, Hinton DR, Kerur N, Sadda SR, Schumann GG, Gelfand BD, Ambati J. . Sci Adv. 2021 Oct;7(40):eabj3658. doi: 10.1126/sciadv.abj3658. Epub 2021 Sep 29. PMID: 34586848; PMCID: PMC8480932.
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DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.

Science immunology

Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J.
PMID: 34860583
Sci Immunol. 2021 Dec 03;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 03.

[Figure: see text].

Cite
Wang SB, Narendran S, Hirahara S, et al. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Sci Immunol. 2021;6(66):eabi4493doi: 10.1126/sciimmunol.abi4493.
Wang, S. B., Narendran, S., Hirahara, S., Varshney, A., Pereira, F., Apicella, I., Ambati, M., Ambati, V. L., Yerramothu, P., Ambati, K., Nagasaka, Y., Argyle, D., Huang, P., Baker, K. L., Marion, K. M., Gupta, K., Liu, B., Hinton, D. R., Canna, S. W., Sallam, T., Sadda, S. R., Kerur, N., Gelfand, B. D., & Ambati, J. (2021). DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Science immunology, 6(66), eabi4493. https://doi.org/10.1126/sciimmunol.abi4493
Wang, Shao-Bin, et al. "DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs." Science immunology vol. 6,66 (2021): eabi4493. doi: https://doi.org/10.1126/sciimmunol.abi4493
Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Sci Immunol. 2021 Dec 03;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 03. PMID: 34860583.
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Showing 1 to 8 of 8 entries