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Bringing together the academic drug discovery community.

Nature reviews. Drug discovery

Slusher BS, Conn PJ, Frye S, Glicksman M, Arkin M.
PMID: 24172316
Nat Rev Drug Discov. 2013 Nov;12(11):811-2. doi: 10.1038/nrd4155.

The newly formed Academic Drug Discovery Consortium (ADDC) aims to support the growing numbers of university centres engaged in drug discovery that have emerged in response to recent changes in the drug discovery ecosystem.

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Slusher BS, Conn PJ, Frye S, et al. Bringing together the academic drug discovery community. Nat Rev Drug Discov. 2013;12(11):811-2doi: 10.1038/nrd4155.
Slusher, B. S., Conn, P. J., Frye, S., Glicksman, M., & Arkin, M. (2013). Bringing together the academic drug discovery community. Nature reviews. Drug discovery, 12(11), 811-2. https://doi.org/10.1038/nrd4155
Slusher, Barbara S, et al. "Bringing together the academic drug discovery community." Nature reviews. Drug discovery vol. 12,11 (2013): 811-2. doi: https://doi.org/10.1038/nrd4155
Slusher BS, Conn PJ, Frye S, Glicksman M, Arkin M. Bringing together the academic drug discovery community. Nat Rev Drug Discov. 2013 Nov;12(11):811-2. doi: 10.1038/nrd4155. PMID: 24172316; PMCID: PMC4076044.
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Profile of Tuberculosis among Foreign-born Asians Residing in Los Angeles County, California, 1985­1994.

Asian American and Pacific Islander journal of health

Makinodan T, Liu J, Yano E, Knowles LK, Davidson PT, Harada N.
PMID: 11567480
Asian Am Pac Isl J Health. 1999;7(1):38-46.

PURPOSE. To present a profile of tuberculosis %lpar;TB) among foreign& shy;born Asians residing in Los Angeles County and priorities in eliminating TB. SUMMARY OF METHODS UTILIZED. The demographic and disease­related data were analyzed from a total of 3,364 TB...

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Makinodan T, Liu J, Yano E, et al. Profile of Tuberculosis among Foreign-born Asians Residing in Los Angeles County, California, 1985­1994. Asian Am Pac Isl J Health. 1999;7(1):38-46
Makinodan, T., Liu, J., Yano, E., Knowles, L. K., Davidson, P. T., & Harada, N. (1999). Profile of Tuberculosis among Foreign-born Asians Residing in Los Angeles County, California, 1985­1994. Asian American and Pacific Islander journal of health, 7(1), 38-46.
Makinodan, Takashi, et al. "Profile of Tuberculosis among Foreign-born Asians Residing in Los Angeles County, California, 1985­1994." Asian American and Pacific Islander journal of health vol. 7,1 (1999): 38-46.
Makinodan T, Liu J, Yano E, Knowles LK, Davidson PT, Harada N. Profile of Tuberculosis among Foreign-born Asians Residing in Los Angeles County, California, 1985­1994. Asian Am Pac Isl J Health. 1999;7(1):38-46. PMID: 11567480.
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Theoretical studies of organometallic complexes of uranium involving nitrogen ligands using density functional approaches.

Faraday discussions

Hay PJ.
PMID: 14527211
Faraday Discuss. 2003;124:69-83; discussion 85-92, 453-5. doi: 10.1039/b211442a.

Density functional calculations are used to investigate the structure and bonding in several unusual cyclopentadienyl complexes of uranium with nitrogen-containing ligands. The U(VI) imido complex Cp2U(NPh)2 and the U(IV) amido complex Cp2(NHPh)2 are examined and the important orbitals involved...

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Hay PJ. Theoretical studies of organometallic complexes of uranium involving nitrogen ligands using density functional approaches. Faraday Discuss. 2003;124:69-83; discussion 85-92, 453-5doi: 10.1039/b211442a.
Hay, P. J. (2003). Theoretical studies of organometallic complexes of uranium involving nitrogen ligands using density functional approaches. Faraday discussions, 12469-83; discussion 85-92, 453-5. https://doi.org/10.1039/b211442a
Hay, P Jeffrey. "Theoretical studies of organometallic complexes of uranium involving nitrogen ligands using density functional approaches." Faraday discussions vol. 124 (2003): 69-83; discussion 85-92, 453-5. doi: https://doi.org/10.1039/b211442a
Hay PJ. Theoretical studies of organometallic complexes of uranium involving nitrogen ligands using density functional approaches. Faraday Discuss. 2003;124:69-83; discussion 85-92, 453-5. doi: 10.1039/b211442a. PMID: 14527211.
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Hydrogen evolution from organic "hydrides".

Chemical communications (Cambridge, England)

Schwarz DE, Cameron TM, Hay PJ, Scott BL, Tumas W, Thorn DL.
PMID: 16317475
Chem Commun (Camb). 2005 Dec 21;(47):5919-21. doi: 10.1039/b511884k. Epub 2005 Oct 20.

Benzimidazolines (dihydrobenzimidazoles) are shown for the first time to eliminate hydrogen (H2) by catalyzed reaction with protic compounds.

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Schwarz DE, Cameron TM, Hay PJ, et al. Hydrogen evolution from organic "hydrides". Chem Commun (Camb). 2005;(47):5919-21doi: 10.1039/b511884k.
Schwarz, D. E., Cameron, T. M., Hay, P. J., Scott, B. L., Tumas, W., & Thorn, D. L. (2005). Hydrogen evolution from organic "hydrides". Chemical communications (Cambridge, England), (47), 5919-21. https://doi.org/10.1039/b511884k
Schwarz, Daniel E, et al. "Hydrogen evolution from organic "hydrides"." Chemical communications (Cambridge, England) vol. ,47 (2005): 5919-21. doi: https://doi.org/10.1039/b511884k
Schwarz DE, Cameron TM, Hay PJ, Scott BL, Tumas W, Thorn DL. Hydrogen evolution from organic "hydrides". Chem Commun (Camb). 2005 Dec 21;(47):5919-21. doi: 10.1039/b511884k. Epub 2005 Oct 20. PMID: 16317475.
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Density functional investigations of the properties and thermochemistry of UF6 and UF5 using valence-electron and all-electron approaches.

The Journal of chemical physics

Batista ER, Martin RL, Hay PJ, Peralta JE, Scuseria GE.
PMID: 15260768
J Chem Phys. 2004 Aug 01;121(5):2144-50. doi: 10.1063/1.1768518.

The structural properties and thermochemistry of UF6 and UF5 have been investigated using both Hartree-Fock and density functional theory (DFT) approximations. Within the latter approach, the local spin-density approximation, the generalized gradient approximation, and hybrid density functionals were considered....

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Batista ER, Martin RL, Hay PJ, et al. Density functional investigations of the properties and thermochemistry of UF6 and UF5 using valence-electron and all-electron approaches. J Chem Phys. 2004;121(5):2144-50doi: 10.1063/1.1768518.
Batista, E. R., Martin, R. L., Hay, P. J., Peralta, J. E., & Scuseria, G. E. (2004). Density functional investigations of the properties and thermochemistry of UF6 and UF5 using valence-electron and all-electron approaches. The Journal of chemical physics, 121(5), 2144-50. https://doi.org/10.1063/1.1768518
Batista, Enrique R, et al. "Density functional investigations of the properties and thermochemistry of UF6 and UF5 using valence-electron and all-electron approaches." The Journal of chemical physics vol. 121,5 (2004): 2144-50. doi: https://doi.org/10.1063/1.1768518
Batista ER, Martin RL, Hay PJ, Peralta JE, Scuseria GE. Density functional investigations of the properties and thermochemistry of UF6 and UF5 using valence-electron and all-electron approaches. J Chem Phys. 2004 Aug 01;121(5):2144-50. doi: 10.1063/1.1768518. PMID: 15260768.
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Synthesis and reactivity of the imido analogues of the uranyl ion.

Journal of the American Chemical Society

Hayton TW, Boncella JM, Scott BL, Batista ER, Hay PJ.
PMID: 16895423
J Am Chem Soc. 2006 Aug 16;128(32):10549-59. doi: 10.1021/ja0629155.

Addition of 1.5 equiv of I2 to a THF solution of UI3(THF)4, containing either 6 equiv of tBuNH2 or 2 equiv of RNH2 (R = Ph, 3,5-(CF3)2C6H3, 2,6-(iPr)2C6H3) and 4 equiv of NEt3, generates orange solutions containing U(NtBu)2I2(THF)2 (1)...

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Hayton TW, Boncella JM, Scott BL, et al. Synthesis and reactivity of the imido analogues of the uranyl ion. J Am Chem Soc. 2006;128(32):10549-59doi: 10.1021/ja0629155.
Hayton, T. W., Boncella, J. M., Scott, B. L., Batista, E. R., & Hay, P. J. (2006). Synthesis and reactivity of the imido analogues of the uranyl ion. Journal of the American Chemical Society, 128(32), 10549-59. https://doi.org/10.1021/ja0629155
Hayton, Trevor W, et al. "Synthesis and reactivity of the imido analogues of the uranyl ion." Journal of the American Chemical Society vol. 128,32 (2006): 10549-59. doi: https://doi.org/10.1021/ja0629155
Hayton TW, Boncella JM, Scott BL, Batista ER, Hay PJ. Synthesis and reactivity of the imido analogues of the uranyl ion. J Am Chem Soc. 2006 Aug 16;128(32):10549-59. doi: 10.1021/ja0629155. PMID: 16895423.
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Synthesis and reactivity of the hydrido- and alkylrhenium methylidene complexes Cp*(PMe3)2(R)Re=CH2 (R = H, CH3).

Journal of the American Chemical Society

Krumper JR, Martin RL, Hay PJ, Yung CM, Veltheer J, Bergman RG.
PMID: 15535706
J Am Chem Soc. 2004 Nov 17;126(45):14804-15. doi: 10.1021/ja0468877.

Protonolysis of the dimethylrhenium(III) compound Cp(PMe(3))(2)Re(CH(3))(2) (3) led to formation of the highly reactive hydridorhenium methylidene compound [Cp(PMe(3))(2)Re(CH(2))(H)][OTf] (4), which was characterized spectroscopically at low temperature. Although 4 decomposed above -30 degrees C, reactivity studies performed at low temperature...

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Krumper JR, Martin RL, Hay PJ, et al. Synthesis and reactivity of the hydrido- and alkylrhenium methylidene complexes Cp*(PMe3)2(R)Re=CH2 (R = H, CH3). J Am Chem Soc. 2004;126(45):14804-15doi: 10.1021/ja0468877.
Krumper, J. R., Martin, R. L., Hay, P. J., Yung, C. M., Veltheer, J., & Bergman, R. G. (2004). Synthesis and reactivity of the hydrido- and alkylrhenium methylidene complexes Cp*(PMe3)2(R)Re=CH2 (R = H, CH3). Journal of the American Chemical Society, 126(45), 14804-15. https://doi.org/10.1021/ja0468877
Krumper, Jennifer R, et al. "Synthesis and reactivity of the hydrido- and alkylrhenium methylidene complexes Cp*(PMe3)2(R)Re=CH2 (R = H, CH3)." Journal of the American Chemical Society vol. 126,45 (2004): 14804-15. doi: https://doi.org/10.1021/ja0468877
Krumper JR, Martin RL, Hay PJ, Yung CM, Veltheer J, Bergman RG. Synthesis and reactivity of the hydrido- and alkylrhenium methylidene complexes Cp*(PMe3)2(R)Re=CH2 (R = H, CH3). J Am Chem Soc. 2004 Nov 17;126(45):14804-15. doi: 10.1021/ja0468877. PMID: 15535706.
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Comparison of noninvasive models of fibrosis in chronic hepatitis B.

Hepatology international

Raftopoulos SC, George J, Bourliere M, Rossi E, de Boer WB, Jeffrey GP, Bulsara M, Speers DJ, MacQuillan G, Ching HL, Kontorinis N, Cheng W, Flexman J, Fermoyle S, Rigby P, Walsh L, McLeod D, Adams LA.
PMID: 21748376
Hepatol Int. 2012 Apr;6(2):457-67. doi: 10.1007/s12072-011-9296-5. Epub 2011 Jul 12.

BACKGROUND AND GOALS: Liver fibrosis influences treatment and surveillance strategies in chronic hepatitis B (CHB). This multicenter study aimed to examine the accuracy of serum fibrosis models in CHB patients including those with low alanine aminotransferase (ALT) levels and...

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Raftopoulos SC, George J, Bourliere M, et al. Comparison of noninvasive models of fibrosis in chronic hepatitis B. Hepatol Int. 2011;6(2):457-67doi: 10.1007/s12072-011-9296-5.
Raftopoulos, S. C., George, J., Bourliere, M., Rossi, E., de Boer, W. B., Jeffrey, G. P., Bulsara, M., Speers, D. J., MacQuillan, G., Ching, H. L., Kontorinis, N., Cheng, W., Flexman, J., Fermoyle, S., Rigby, P., Walsh, L., McLeod, D., & Adams, L. A. (2012). Comparison of noninvasive models of fibrosis in chronic hepatitis B. Hepatology international, 6(2), 457-67. https://doi.org/10.1007/s12072-011-9296-5
Raftopoulos, S C, et al. "Comparison of noninvasive models of fibrosis in chronic hepatitis B." Hepatology international vol. 6,2 (2012): 457-67. doi: https://doi.org/10.1007/s12072-011-9296-5
Raftopoulos SC, George J, Bourliere M, Rossi E, de Boer WB, Jeffrey GP, Bulsara M, Speers DJ, MacQuillan G, Ching HL, Kontorinis N, Cheng W, Flexman J, Fermoyle S, Rigby P, Walsh L, McLeod D, Adams LA. Comparison of noninvasive models of fibrosis in chronic hepatitis B. Hepatol Int. 2012 Apr;6(2):457-67. doi: 10.1007/s12072-011-9296-5. Epub 2011 Jul 12. PMID: 21748376.
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Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation.

ACS chemical neuroscience

Davis AA, Heilman CJ, Brady AE, Miller NR, Fuerstenau-Sharp M, Hanson BJ, Lindsley CW, Conn PJ, Lah JJ, Levey AI.
PMID: 20835371
ACS Chem Neurosci. 2010 Aug 18;1(8):542-551. doi: 10.1021/cn100011e.

Muscarinic acetylcholine receptors (mAChRs) are drug targets for multiple neurodegenerative and neuropsychiatric disorders, but the full therapeutic potential of mAChR-targeted drugs has not been realized, mainly because of a lack of subtype-selective agonists. Recent advances have allowed the development...

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Davis AA, Heilman CJ, Brady AE, et al. Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation. ACS Chem Neurosci. 2010;1(8):542-551doi: 10.1021/cn100011e.
Davis, A. A., Heilman, C. J., Brady, A. E., Miller, N. R., Fuerstenau-Sharp, M., Hanson, B. J., Lindsley, C. W., Conn, P. J., Lah, J. J., & Levey, A. I. (2010). Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation. ACS chemical neuroscience, 1(8), 542-551. https://doi.org/10.1021/cn100011e
Davis, Albert A, et al. "Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation." ACS chemical neuroscience vol. 1,8 (2010): 542-551. doi: https://doi.org/10.1021/cn100011e
Davis AA, Heilman CJ, Brady AE, Miller NR, Fuerstenau-Sharp M, Hanson BJ, Lindsley CW, Conn PJ, Lah JJ, Levey AI. Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation. ACS Chem Neurosci. 2010 Aug 18;1(8):542-551. doi: 10.1021/cn100011e. PMID: 20835371; PMCID: PMC2936488.
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MRI detection of forearm soft tissue injuries with radial head fractures.

Hand (New York, N.Y.)

McGinley JC, Gold G, Cheung E, Yao J.
PMID: 24570643
Hand (N Y). 2014 Mar;9(1):87-92. doi: 10.1007/s11552-013-9561-2.

BACKGROUND: This study aims to evaluate the incidence of forearm soft tissue abnormalities associated with radial head fracture severity based on the Mason classification system.METHODS: Eighteen patients (age 18-45 years) were prospectively evaluated with elbow radiographs and magnetic resonance...

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McGinley JC, Gold G, Cheung E, et al. MRI detection of forearm soft tissue injuries with radial head fractures. Hand (N Y). 2014;9(1):87-92doi: 10.1007/s11552-013-9561-2.
McGinley, J. C., Gold, G., Cheung, E., & Yao, J. (2014). MRI detection of forearm soft tissue injuries with radial head fractures. Hand (New York, N.Y.), 9(1), 87-92. https://doi.org/10.1007/s11552-013-9561-2
McGinley, Joseph C, et al. "MRI detection of forearm soft tissue injuries with radial head fractures." Hand (New York, N.Y.) vol. 9,1 (2014): 87-92. doi: https://doi.org/10.1007/s11552-013-9561-2
McGinley JC, Gold G, Cheung E, Yao J. MRI detection of forearm soft tissue injuries with radial head fractures. Hand (N Y). 2014 Mar;9(1):87-92. doi: 10.1007/s11552-013-9561-2. PMID: 24570643; PMCID: PMC3928382.
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Ulnar-sided wrist pain in the athlete (TFCC/DRUJ/ECU).

Current reviews in musculoskeletal medicine

Pang EQ, Yao J.
PMID: 28185125
Curr Rev Musculoskelet Med. 2017 Mar;10(1):53-61. doi: 10.1007/s12178-017-9384-9.

PURPOSE OF REVIEW: The goal of this manuscript is to review key historic and recent literature regarding extensor carpi ulnaris (ECU), triangular fibrocartilage complex (TFCC) and distal radioulnar joint (DRUJ) injuries, particularly in athletes.RECENT FINDINGS: Many recent studies examining...

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Pang EQ, Yao J. Ulnar-sided wrist pain in the athlete (TFCC/DRUJ/ECU). Curr Rev Musculoskelet Med. 2017;10(1):53-61doi: 10.1007/s12178-017-9384-9.
Pang, E. Q., & Yao, J. (2017). Ulnar-sided wrist pain in the athlete (TFCC/DRUJ/ECU). Current reviews in musculoskeletal medicine, 10(1), 53-61. https://doi.org/10.1007/s12178-017-9384-9
Pang, Eric Quan, and Yao, Jeffrey. "Ulnar-sided wrist pain in the athlete (TFCC/DRUJ/ECU)." Current reviews in musculoskeletal medicine vol. 10,1 (2017): 53-61. doi: https://doi.org/10.1007/s12178-017-9384-9
Pang EQ, Yao J. Ulnar-sided wrist pain in the athlete (TFCC/DRUJ/ECU). Curr Rev Musculoskelet Med. 2017 Mar;10(1):53-61. doi: 10.1007/s12178-017-9384-9. PMID: 28185125; PMCID: PMC5344855.
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Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.

ACS medicinal chemistry letters

Zhou Y, Manka JT, Rodriguez AL, Weaver CD, Days EL, Vinson PN, Jadhav S, Hermann EJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.
PMID: 23308336
ACS Med Chem Lett. 2010 Nov 11;1(8):433-438. doi: 10.1021/ml100181a. Epub 2010 Aug 13.

This Letter describes the discovery, SAR and in vitro and in vivo pharmacological profile of a novel non-MPEP derived mGlu(5) positive allosteric modulator (PAM) based upon an N-aryl piperazine chemotype. This mGlu(5) chemotype exhibits the ability to act as...

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Zhou Y, Manka JT, Rodriguez AL, et al. Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS Med Chem Lett. 2010;1(8):433-438doi: 10.1021/ml100181a.
Zhou, Y., Manka, J. T., Rodriguez, A. L., Weaver, C. D., Days, E. L., Vinson, P. N., Jadhav, S., Hermann, E. J., Jones, C. K., Conn, P. J., Lindsley, C. W., & Stauffer, S. R. (2010). Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS medicinal chemistry letters, 1(8), 433-438. https://doi.org/10.1021/ml100181a
Zhou, Ya, et al. "Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity." ACS medicinal chemistry letters vol. 1,8 (2010): 433-438. doi: https://doi.org/10.1021/ml100181a
Zhou Y, Manka JT, Rodriguez AL, Weaver CD, Days EL, Vinson PN, Jadhav S, Hermann EJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR. Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS Med Chem Lett. 2010 Nov 11;1(8):433-438. doi: 10.1021/ml100181a. Epub 2010 Aug 13. PMID: 23308336; PMCID: PMC3539763.
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