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Association of Pre-hospital ECG Administration With Clinical Outcomes in ST-Segment Myocardial Infarction: A Systematic Review and Meta-analysis.

The Canadian journal of cardiology

Ducas RA, Labos C, Allen D, Golian M, Jeyaraman M, Lys J, Mann A, Copstein L, Vokey S, Rabbani R, Zarychanski R, Abou-Setta AM, Menkis AH.
PMID: 27707525
Can J Cardiol. 2016 Dec;32(12):1531-1541. doi: 10.1016/j.cjca.2016.06.004. Epub 2016 Jun 14.

BACKGROUND: Delays in reperfusion for patients with myocardial ischemia leads to increased morbidity and mortality. The objective of this review was to identify, evaluate, and critically appraise the evidence on whether pre-hospital electrocardiography (ECG) reduces patient mortality and improves...

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Ducas RA, Labos C, Allen D, et al. Association of Pre-hospital ECG Administration With Clinical Outcomes in ST-Segment Myocardial Infarction: A Systematic Review and Meta-analysis. Can J Cardiol. 2016;32(12):1531-1541doi: 10.1016/j.cjca.2016.06.004.
Ducas, R. A., Labos, C., Allen, D., Golian, M., Jeyaraman, M., Lys, J., Mann, A., Copstein, L., Vokey, S., Rabbani, R., Zarychanski, R., Abou-Setta, A. M., & Menkis, A. H. (2016). Association of Pre-hospital ECG Administration With Clinical Outcomes in ST-Segment Myocardial Infarction: A Systematic Review and Meta-analysis. The Canadian journal of cardiology, 32(12), 1531-1541. https://doi.org/10.1016/j.cjca.2016.06.004
Ducas, Robin A, et al. "Association of Pre-hospital ECG Administration With Clinical Outcomes in ST-Segment Myocardial Infarction: A Systematic Review and Meta-analysis." The Canadian journal of cardiology vol. 32,12 (2016): 1531-1541. doi: https://doi.org/10.1016/j.cjca.2016.06.004
Ducas RA, Labos C, Allen D, Golian M, Jeyaraman M, Lys J, Mann A, Copstein L, Vokey S, Rabbani R, Zarychanski R, Abou-Setta AM, Menkis AH. Association of Pre-hospital ECG Administration With Clinical Outcomes in ST-Segment Myocardial Infarction: A Systematic Review and Meta-analysis. Can J Cardiol. 2016 Dec;32(12):1531-1541. doi: 10.1016/j.cjca.2016.06.004. Epub 2016 Jun 14. PMID: 27707525.
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Validity and reliability of bedside nursing assessments of pain, sedation and delirium.

Canadian journal of anaesthesia = Journal canadien d'anesthesie

Marquis F, Jamal R, Ayotte I, Ouimet S, Skrobik Y, Ryan Z.
PMID: 27518523
Can J Anaesth. 2006 Apr;53(4):A418-9. doi: 10.1007/BF03022514.

No abstract available.

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Marquis F, Jamal R, Ayotte I, et al. Validity and reliability of bedside nursing assessments of pain, sedation and delirium. Can J Anaesth. 2006;53(4):A418-9doi: 10.1007/BF03022514.
Marquis, F., Jamal, R., Ayotte, I., Ouimet, S., Skrobik, Y., & Ryan, Z. (2006). Validity and reliability of bedside nursing assessments of pain, sedation and delirium. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 53(4), A418-9. https://doi.org/10.1007/BF03022514
Marquis, François, et al. "Validity and reliability of bedside nursing assessments of pain, sedation and delirium." Canadian journal of anaesthesia = Journal canadien d'anesthesie vol. 53,4 (2006): A418-9. doi: https://doi.org/10.1007/BF03022514
Marquis F, Jamal R, Ayotte I, Ouimet S, Skrobik Y, Ryan Z. Validity and reliability of bedside nursing assessments of pain, sedation and delirium. Can J Anaesth. 2006 Apr;53(4):A418-9. doi: 10.1007/BF03022514. PMID: 27518523.
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Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study.

JMIR research protocols

Marrie RA, Graff L, Walker JR, Fisk JD, Patten SB, Hitchon CA, Lix LM, Bolton J, Sareen J, Katz A, Berrigan LI, Marriott JJ, Singer A, El-Gabalawy R, Peschken CA, Zarychanski R, Bernstein CN.
PMID: 29343461
JMIR Res Protoc. 2018 Jan 17;7(1):e15. doi: 10.2196/resprot.8794.

BACKGROUND: Immune-mediated inflammatory diseases (IMID), such as inflammatory bowel disease (IBD), multiple sclerosis (MS), and rheumatoid arthritis (RA), are highly prevalent in Canada and the United States and result in substantial personal and societal burden. The prevalence of psychiatric...

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Marrie RA, Graff L, Walker JR, et al. Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study. JMIR Res Protoc. 2018;7(1):e15doi: 10.2196/resprot.8794.
Marrie, R. A., Graff, L., Walker, J. R., Fisk, J. D., Patten, S. B., Hitchon, C. A., Lix, L. M., Bolton, J., Sareen, J., Katz, A., Berrigan, L. I., Marriott, J. J., Singer, A., El-Gabalawy, R., Peschken, C. A., Zarychanski, R., & Bernstein, C. N. (2018). Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study. JMIR research protocols, 7(1), e15. https://doi.org/10.2196/resprot.8794
Marrie, Ruth Ann, et al. "Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study." JMIR research protocols vol. 7,1 (2018): e15. doi: https://doi.org/10.2196/resprot.8794
Marrie RA, Graff L, Walker JR, Fisk JD, Patten SB, Hitchon CA, Lix LM, Bolton J, Sareen J, Katz A, Berrigan LI, Marriott JJ, Singer A, El-Gabalawy R, Peschken CA, Zarychanski R, Bernstein CN. Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study. JMIR Res Protoc. 2018 Jan 17;7(1):e15. doi: 10.2196/resprot.8794. PMID: 29343461; PMCID: PMC5792704.
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The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia.

Research and practice in thrombosis and haemostasis

Arnold DM, Lauzier F, Albert M, Williamson D, Li N, Zarychanski R, Doig C, McIntyre L, Freitag A, Crowther M, Saunders L, Clarke F, Bellomo R, Qushmaq I, Lopes RD, Heels-Ansdell D, Webert K, Cook D.
PMID: 30046678
Res Pract Thromb Haemost. 2017 May 31;1(1):103-111. doi: 10.1002/rth2.12004. eCollection 2017 Jul.

BACKGROUND: Platelet transfusions are commonly used to treat critically ill patients with thrombocytopenia. Whether platelet transfusions are associated with a reduction in the risk of major bleeding is unknown.PATIENTS/METHODS: Observational cohort study nested in a previous multicenter, randomized thromboprophylaxis...

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Arnold DM, Lauzier F, Albert M, et al. The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia. Res Pract Thromb Haemost. 2017;1(1):103-111doi: 10.1002/rth2.12004.
Arnold, D. M., Lauzier, F., Albert, M., Williamson, D., Li, N., Zarychanski, R., Doig, C., McIntyre, L., Freitag, A., Crowther, M., Saunders, L., Clarke, F., Bellomo, R., Qushmaq, I., Lopes, R. D., Heels-Ansdell, D., Webert, K., Cook, D. (2017). The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia. Research and practice in thrombosis and haemostasis, 1(1), 103-111. https://doi.org/10.1002/rth2.12004
Arnold, Donald M, et al. "The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia." Research and practice in thrombosis and haemostasis vol. 1,1 (2017): 103-111. doi: https://doi.org/10.1002/rth2.12004
Arnold DM, Lauzier F, Albert M, Williamson D, Li N, Zarychanski R, Doig C, McIntyre L, Freitag A, Crowther M, Saunders L, Clarke F, Bellomo R, Qushmaq I, Lopes RD, Heels-Ansdell D, Webert K, Cook D. The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia. Res Pract Thromb Haemost. 2017 May 31;1(1):103-111. doi: 10.1002/rth2.12004. eCollection 2017 Jul. PMID: 30046678; PMCID: PMC5974915.
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Transfusion in orthopaedic surgery : a retrospective multicentre cohort study.

Bone & joint open

Blankstein AR, Houston BL, Fergusson DA, Houston DS, Rimmer E, Bohm E, Aziz M, Garland A, Doucette S, Balshaw R, Turgeon A, Zarychanski R.
PMID: 34665003
Bone Jt Open. 2021 Oct;2(10):850-857. doi: 10.1302/2633-1462.210.BJO-2021-0077.R1.

AIMS: Orthopaedic surgeries are complex, frequently performed procedures associated with significant haemorrhage and perioperative blood transfusion. Given refinements in surgical techniques and changes to transfusion practices, we aim to describe contemporary transfusion practices in orthopaedic surgery in order to...

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Blankstein AR, Houston BL, Fergusson DA, et al. Transfusion in orthopaedic surgery : a retrospective multicentre cohort study. Bone Jt Open. 2021;2(10):850-857doi: 10.1302/2633-1462.210.BJO-2021-0077.R1.
Blankstein, A. R., Houston, B. L., Fergusson, D. A., Houston, D. S., Rimmer, E., Bohm, E., Aziz, M., Garland, A., Doucette, S., Balshaw, R., Turgeon, A., & Zarychanski, R. (2021). Transfusion in orthopaedic surgery : a retrospective multicentre cohort study. Bone & joint open, 2(10), 850-857. https://doi.org/10.1302/2633-1462.210.BJO-2021-0077.R1
Blankstein, Anna R, et al. "Transfusion in orthopaedic surgery : a retrospective multicentre cohort study." Bone & joint open vol. 2,10 (2021): 850-857. doi: https://doi.org/10.1302/2633-1462.210.BJO-2021-0077.R1
Blankstein AR, Houston BL, Fergusson DA, Houston DS, Rimmer E, Bohm E, Aziz M, Garland A, Doucette S, Balshaw R, Turgeon A, Zarychanski R. Transfusion in orthopaedic surgery : a retrospective multicentre cohort study. Bone Jt Open. 2021 Oct;2(10):850-857. doi: 10.1302/2633-1462.210.BJO-2021-0077.R1. PMID: 34665003; PMCID: PMC8558454.
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Correction to: Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians.

Canadian journal of anaesthesia = Journal canadien d'anesthesie

Leeies M, Gershengorn HB, Charbonney E, Kumar A, Fergusson D, Turgeon AF, Cowan J, Paunovic B, Embil J, Houston DS, Houston B, Rimmer E, Siddiqui F, Cameron B, Murthy S, Marshall JC, Fowler R, Zarychanski R.
PMID: 33694127
Can J Anaesth. 2021 Aug;68(8):1310-1311. doi: 10.1007/s12630-021-01964-w.

No abstract available.

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Leeies M, Gershengorn HB, Charbonney E, et al. Les immunoglobulines intraveineuses pour le choc septique : une enquête nationale canadienne auprès des médecins intensivistes et spécialistes des maladies infectieuses. Correction to: Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. Can J Anaesth. 2021;68(8):1310-1311doi: 10.1007/s12630-021-01964-w.
Leeies, M., Gershengorn, H. B., Charbonney, E., Kumar, A., Fergusson, D., Turgeon, A. F., Cowan, J., Paunovic, B., Embil, J., Houston, D. S., Houston, B., Rimmer, E., Siddiqui, F., Cameron, B., Murthy, S., Marshall, J. C., Fowler, R., & Zarychanski, R. (2021). Les immunoglobulines intraveineuses pour le choc septique : une enquête nationale canadienne auprès des médecins intensivistes et spécialistes des maladies infectieuses. Correction to: Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 68(8), 1310-1311. https://doi.org/10.1007/s12630-021-01964-w
Leeies, Murdoch, et al. "Les immunoglobulines intraveineuses pour le choc septique : une enquête nationale canadienne auprès des médecins intensivistes et spécialistes des maladies infectieuses." Correction to: Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. Canadian journal of anaesthesia = Journal canadien d'anesthesie vol. 68,8 (2021): 1310-1311. doi: https://doi.org/10.1007/s12630-021-01964-w
Leeies M, Gershengorn HB, Charbonney E, Kumar A, Fergusson D, Turgeon AF, Cowan J, Paunovic B, Embil J, Houston DS, Houston B, Rimmer E, Siddiqui F, Cameron B, Murthy S, Marshall JC, Fowler R, Zarychanski R. Les immunoglobulines intraveineuses pour le choc septique : une enquête nationale canadienne auprès des médecins intensivistes et spécialistes des maladies infectieuses. Correction to: Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. Can J Anaesth. 2021 Aug;68(8):1310-1311. doi: 10.1007/s12630-021-01964-w. PMID: 33694127.
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Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19.

medRxiv : the preprint server for health sciences

Lofgren SM, Nicol MR, Bangdiwala AS, Pastick KA, Okafor EC, Skipper CP, Pullen MF, Engen NW, Abassi M, Williams DA, Nascene AA, Axelrod ML, Lother SA, MacKenzie LJ, Drobot G, Marten N, Cheng MP, Zarychanshi R, Schwartz IS, Silverman M, Chagla Z, Kelly LE, McDonald EG, Lee TC, Hullsiek KH, Boulware DR, Rajasingham R.
PMID: 32743591
medRxiv. 2020 Sep 21; doi: 10.1101/2020.07.16.20155531.

INTRODUCTION: Use of hydroxychloroquine in hospitalized patients with COVID-19, especially in combination with azithromycin, has raised safety concerns. Here, we report safety data from three outpatient randomized clinical trials.METHODS: We conducted three randomized, double-blind, placebo-controlled trials investigating hydroxychloroquine as...

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Lofgren SM, Nicol MR, Bangdiwala AS, et al. Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19. medRxiv. 2020;doi: 10.1101/2020.07.16.20155531.
Lofgren, S. M., Nicol, M. R., Bangdiwala, A. S., Pastick, K. A., Okafor, E. C., Skipper, C. P., Pullen, M. F., Engen, N. W., Abassi, M., Williams, D. A., Nascene, A. A., Axelrod, M. L., Lother, S. A., MacKenzie, L. J., Drobot, G., Marten, N., Cheng, M. P., Zarychanshi, R., Schwartz, I. S., Silverman, M., Chagla, Z., Kelly, L. E., McDonald, E. G., Lee, T. C., Hullsiek, K. H., Boulware, D. R., & Rajasingham, R. (2020). Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.07.16.20155531
Lofgren, Sarah M, et al. "Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.07.16.20155531
Lofgren SM, Nicol MR, Bangdiwala AS, Pastick KA, Okafor EC, Skipper CP, Pullen MF, Engen NW, Abassi M, Williams DA, Nascene AA, Axelrod ML, Lother SA, MacKenzie LJ, Drobot G, Marten N, Cheng MP, Zarychanshi R, Schwartz IS, Silverman M, Chagla Z, Kelly LE, McDonald EG, Lee TC, Hullsiek KH, Boulware DR, Rajasingham R. Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19. medRxiv. 2020 Sep 21; doi: 10.1101/2020.07.16.20155531. PMID: 32743591; PMCID: PMC7386515.
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National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research.

Intensive care medicine experimental

Mendelson AA, Lansdell C, Fox-Robichaud AE, Liaw P, Arora J, Cailhier JF, Cepinskas G, Charbonney E, Dos Santos C, Dwivedi D, Ellis CG, Fergusson D, Fiest K, Gill SE, Hendrick K, Hunniford VT, Kowalewska PM, Krewulak K, Lehmann C, Macala K, Marshall JC, Mawdsley L, McDonald B, McDonald E, Medeiros SK, Muniz VS, Osuchowski M, Presseau J, Sharma N, Sohrabipour S, Sunohara-Neilson J, Vázquez-Grande G, Veldhuizen RAW, Welsh D, Winston BW, Zarychanski R, Zhang H, Zhou J, Lalu MM.
PMID: 33738642
Intensive Care Med Exp. 2021 Mar 19;9(1):14. doi: 10.1186/s40635-020-00366-4.

Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical models of the complex human condition of...

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Mendelson AA, Lansdell C, Fox-Robichaud AE, et al. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp. 2021;9(1):14doi: 10.1186/s40635-020-00366-4.
Mendelson, A. A., Lansdell, C., Fox-Robichaud, A. E., Liaw, P., Arora, J., Cailhier, J. F., Cepinskas, G., Charbonney, E., Dos Santos, C., Dwivedi, D., Ellis, C. G., Fergusson, D., Fiest, K., Gill, S. E., Hendrick, K., Hunniford, V. T., Kowalewska, P. M., Krewulak, K., Lehmann, C., Macala, K., Marshall, J. C., Mawdsley, L., McDonald, B., McDonald, E., Medeiros, S. K., Muniz, V. S., Osuchowski, M., Presseau, J., Sharma, N., Sohrabipour, S., Sunohara-Neilson, J., Vázquez-Grande, G., Veldhuizen, R. A. W., Welsh, D., Winston, B. W., Zarychanski, R., Zhang, H., Zhou, J., Lalu, M. M. (2021). National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive care medicine experimental, 9(1), 14. https://doi.org/10.1186/s40635-020-00366-4
Mendelson, Asher A, et al. "National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research." Intensive care medicine experimental vol. 9,1 (2021): 14. doi: https://doi.org/10.1186/s40635-020-00366-4
Mendelson AA, Lansdell C, Fox-Robichaud AE, Liaw P, Arora J, Cailhier JF, Cepinskas G, Charbonney E, Dos Santos C, Dwivedi D, Ellis CG, Fergusson D, Fiest K, Gill SE, Hendrick K, Hunniford VT, Kowalewska PM, Krewulak K, Lehmann C, Macala K, Marshall JC, Mawdsley L, McDonald B, McDonald E, Medeiros SK, Muniz VS, Osuchowski M, Presseau J, Sharma N, Sohrabipour S, Sunohara-Neilson J, Vázquez-Grande G, Veldhuizen RAW, Welsh D, Winston BW, Zarychanski R, Zhang H, Zhou J, Lalu MM. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp. 2021 Mar 19;9(1):14. doi: 10.1186/s40635-020-00366-4. PMID: 33738642; PMCID: PMC7973346.
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Screening Tools for Anxiety in People with Multiple Sclerosis: A Systematic Review.

International journal of MS care

Litster B, Fiest KM, Patten SB, Fisk JD, Walker JR, Graff LA, Bolton JM, Sareen J, Marriott JJ, Berrigan LI, Bernstein CN, Zarychanski R, Singer A, Hitchon CA, Peschken CA, Marrie RA.
PMID: 27999521
Int J MS Care. 2016 Nov-Dec;18(6):273-281. doi: 10.7224/1537-2073.2016-004.

No abstract available.

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Litster B, Fiest KM, Patten SB, et al. Screening Tools for Anxiety in People with Multiple Sclerosis: A Systematic Review. Int J MS Care. 2016;18(6):273-281doi: 10.7224/1537-2073.2016-004.
Litster, B., Fiest, K. M., Patten, S. B., Fisk, J. D., Walker, J. R., Graff, L. A., Bolton, J. M., Sareen, J., Marriott, J. J., Berrigan, L. I., Bernstein, C. N., Zarychanski, R., Singer, A., Hitchon, C. A., Peschken, C. A., Marrie, R. A. (2016). Screening Tools for Anxiety in People with Multiple Sclerosis: A Systematic Review. International journal of MS care, 18(6), 273-281. https://doi.org/10.7224/1537-2073.2016-004
Litster, Brittany, et al. "Screening Tools for Anxiety in People with Multiple Sclerosis: A Systematic Review." International journal of MS care vol. 18,6 (2016): 273-281. doi: https://doi.org/10.7224/1537-2073.2016-004
Litster B, Fiest KM, Patten SB, Fisk JD, Walker JR, Graff LA, Bolton JM, Sareen J, Marriott JJ, Berrigan LI, Bernstein CN, Zarychanski R, Singer A, Hitchon CA, Peschken CA, Marrie RA. Screening Tools for Anxiety in People with Multiple Sclerosis: A Systematic Review. Int J MS Care. 2016 Nov-Dec;18(6):273-281. doi: 10.7224/1537-2073.2016-004. PMID: 27999521; PMCID: PMC5166593.
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Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysis.

CMAJ open

Mercier E, Boutin A, Shemilt M, Lauzier F, Zarychanski R, Fergusson DA, Moore L, McIntyre LA, Archambault P, Légaré F, Rousseau F, Lamontagne F, Nadeau L, Turgeon AF.
PMID: 27975043
CMAJ Open. 2016 Jul 22;4(3):E371-E382. doi: 10.9778/cmajo.20150061. eCollection 2016.

BACKGROUND: Prognosis is difficult to establish early after moderate or severe traumatic brain injury despite representing an important concern for patients, families and medical teams. Biomarkers, such as neuron-specific enolase, have been proposed as potential early prognostic indicators. Our...

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Mercier E, Boutin A, Shemilt M, et al. Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysis. CMAJ Open. 2016;4(3):E371-E382doi: 10.9778/cmajo.20150061.
Mercier, E., Boutin, A., Shemilt, M., Lauzier, F., Zarychanski, R., Fergusson, D. A., Moore, L., McIntyre, L. A., Archambault, P., Légaré, F., Rousseau, F., Lamontagne, F., Nadeau, L., & Turgeon, A. F. (2016). Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysis. CMAJ open, 4(3), E371-E382. https://doi.org/10.9778/cmajo.20150061
Mercier, Eric, et al. "Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysis." CMAJ open vol. 4,3 (2016): E371-E382. doi: https://doi.org/10.9778/cmajo.20150061
Mercier E, Boutin A, Shemilt M, Lauzier F, Zarychanski R, Fergusson DA, Moore L, McIntyre LA, Archambault P, Légaré F, Rousseau F, Lamontagne F, Nadeau L, Turgeon AF. Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysis. CMAJ Open. 2016 Jul 22;4(3):E371-E382. doi: 10.9778/cmajo.20150061. eCollection 2016. PMID: 27975043; PMCID: PMC5143026.
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Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials.

CNS drugs

Meskill GJ, Davis CW, Zarycranski D, Doliba M, Schwartz JC, Dayno JM.
PMID: 34935103
CNS Drugs. 2021 Dec 21; doi: 10.1007/s40263-021-00886-x. Epub 2021 Dec 21.

BACKGROUND: Pitolisant, a selective histamine 3 receptor antagonist/inverse agonist, is indicated for the treatment of excessive daytime sleepiness or cataplexy in adults with narcolepsy. The efficacy and safety of pitolisant have been demonstrated in randomized placebo-controlled trials. When evaluating...

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Meskill GJ, Davis CW, Zarycranski D, et al. Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials. CNS Drugs. 2021;doi: 10.1007/s40263-021-00886-x.
Meskill, G. J., Davis, C. W., Zarycranski, D., Doliba, M., Schwartz, J. C., & Dayno, J. M. (2021). Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials. CNS drugs, . https://doi.org/10.1007/s40263-021-00886-x
Meskill, Gerard J, et al. "Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials." CNS drugs vol. (2021). doi: https://doi.org/10.1007/s40263-021-00886-x
Meskill GJ, Davis CW, Zarycranski D, Doliba M, Schwartz JC, Dayno JM. Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials. CNS Drugs. 2021 Dec 21; doi: 10.1007/s40263-021-00886-x. Epub 2021 Dec 21. PMID: 34935103.
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Prophylactic tranexamic acid use in non-cardiac surgeries at high risk for transfusion.

Transfusion medicine (Oxford, England)

Houston BL, Fergusson DA, Falk J, Krupka E, Perelman I, Breau RH, McIsaac DI, Rimmer E, Houston DS, Garland A, Ariano RE, Tinmouth A, Balshaw R, Turgeon AF, Jacobsohn E, Zarychanski R.
PMID: 33938051
Transfus Med. 2021 Aug;31(4):236-242. doi: 10.1111/tme.12780. Epub 2021 May 02.

BACKGROUND: Tranexamic acid (TXA) reduces transfusion in a wide range of surgical populations, although its real-world use in non-cardiac surgeries has not been well described. The objective of this study was to describe prophylactic TXA use in non-cardiac surgeries...

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Houston BL, Fergusson DA, Falk J, et al. Prophylactic tranexamic acid use in non-cardiac surgeries at high risk for transfusion. Transfus Med. 2021;31(4):236-242doi: 10.1111/tme.12780.
Houston, B. L., Fergusson, D. A., Falk, J., Krupka, E., Perelman, I., Breau, R. H., McIsaac, D. I., Rimmer, E., Houston, D. S., Garland, A., Ariano, R. E., Tinmouth, A., Balshaw, R., Turgeon, A. F., Jacobsohn, E., & Zarychanski, R. (2021). Prophylactic tranexamic acid use in non-cardiac surgeries at high risk for transfusion. Transfusion medicine (Oxford, England), 31(4), 236-242. https://doi.org/10.1111/tme.12780
Houston, Brett L, et al. "Prophylactic tranexamic acid use in non-cardiac surgeries at high risk for transfusion." Transfusion medicine (Oxford, England) vol. 31,4 (2021): 236-242. doi: https://doi.org/10.1111/tme.12780
Houston BL, Fergusson DA, Falk J, Krupka E, Perelman I, Breau RH, McIsaac DI, Rimmer E, Houston DS, Garland A, Ariano RE, Tinmouth A, Balshaw R, Turgeon AF, Jacobsohn E, Zarychanski R. Prophylactic tranexamic acid use in non-cardiac surgeries at high risk for transfusion. Transfus Med. 2021 Aug;31(4):236-242. doi: 10.1111/tme.12780. Epub 2021 May 02. PMID: 33938051.
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