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Complex of silylene with nitrogen: a combined matrix-spectroscopic and density functional theory study.

Chemistry, an Asian journal

Maier G, Reisenauer HP, Glatthaar J, Zetzmann R.
PMID: 17441055
Chem Asian J. 2006 Jul 17;1(1):195-202. doi: 10.1002/asia.200600089.

The quest for a new and productive route to matrix-isolated silylene 1 has led to the observation that the presence of nitrogen is favorable, as under such conditions 1 is stabilized by formation of a donor-acceptor complex 1 x...

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Maier G, Reisenauer HP, Glatthaar J, et al. Complex of silylene with nitrogen: a combined matrix-spectroscopic and density functional theory study. Chem Asian J. 2006;1(1):195-202doi: 10.1002/asia.200600089.
Maier, G., Reisenauer, H. P., Glatthaar, J., & Zetzmann, R. (2006). Complex of silylene with nitrogen: a combined matrix-spectroscopic and density functional theory study. Chemistry, an Asian journal, 1(1), 195-202. https://doi.org/10.1002/asia.200600089
Maier, Günther, et al. "Complex of silylene with nitrogen: a combined matrix-spectroscopic and density functional theory study." Chemistry, an Asian journal vol. 1,1 (2006): 195-202. doi: https://doi.org/10.1002/asia.200600089
Maier G, Reisenauer HP, Glatthaar J, Zetzmann R. Complex of silylene with nitrogen: a combined matrix-spectroscopic and density functional theory study. Chem Asian J. 2006 Jul 17;1(1):195-202. doi: 10.1002/asia.200600089. PMID: 17441055.
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DNase-Sensitive and -Resistant Modes of Biofilm Formation by Listeria monocytogenes.

Frontiers in microbiology

Zetzmann M, Okshevsky M, Endres J, Sedlag A, Caccia N, Auchter M, Waidmann MS, Desvaux M, Meyer RL, Riedel CU.
PMID: 26733972
Front Microbiol. 2015 Dec 22;6:1428. doi: 10.3389/fmicb.2015.01428. eCollection 2015.

Listeria monocytogenes is able to form biofilms on various surfaces and this ability is thought to contribute to persistence in the environment and on contact surfaces in the food industry. Extracellular DNA (eDNA) is a component of the biofilm...

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Zetzmann M, Okshevsky M, Endres J, et al. DNase-Sensitive and -Resistant Modes of Biofilm Formation by Listeria monocytogenes. Front Microbiol. 2015;6:1428doi: 10.3389/fmicb.2015.01428.
Zetzmann, M., Okshevsky, M., Endres, J., Sedlag, A., Caccia, N., Auchter, M., Waidmann, M. S., Desvaux, M., Meyer, R. L., & Riedel, C. U. (2015). DNase-Sensitive and -Resistant Modes of Biofilm Formation by Listeria monocytogenes. Frontiers in microbiology, 61428. https://doi.org/10.3389/fmicb.2015.01428
Zetzmann, Marion, et al. "DNase-Sensitive and -Resistant Modes of Biofilm Formation by Listeria monocytogenes." Frontiers in microbiology vol. 6 (2015): 1428. doi: https://doi.org/10.3389/fmicb.2015.01428
Zetzmann M, Okshevsky M, Endres J, Sedlag A, Caccia N, Auchter M, Waidmann MS, Desvaux M, Meyer RL, Riedel CU. DNase-Sensitive and -Resistant Modes of Biofilm Formation by Listeria monocytogenes. Front Microbiol. 2015 Dec 22;6:1428. doi: 10.3389/fmicb.2015.01428. eCollection 2015. PMID: 26733972; PMCID: PMC4686886.
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Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition.

Cancer discovery

Campbell BB, Galati MA, Stone SC, Riemenschneider AN, Edwards M, Sudhaman S, Siddaway R, Komosa M, Nunes NM, Nobre L, Morrissy AS, Zatzman M, Zapotocky M, Joksimovic L, Kalimuthu SN, Samuel D, Mason G, Bouffet E, Morgenstern DA, Aronson M, Durno C, Malkin D, Maris JM, Taylor MD, Shlien A, Pugh TJ, Ohashi PS, Hawkins CE, Tabori U.
PMID: 33563663
Cancer Discov. 2021 Jun;11(6):1454-1467. doi: 10.1158/2159-8290.CD-20-1050. Epub 2021 Feb 09.

The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single, well-characterized point mutation in an oncogene. Hypermutant tumors that harbor many somatic mutations may obscure...

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Campbell BB, Galati MA, Stone SC, et al. Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer Discov. 2021;11(6):1454-1467doi: 10.1158/2159-8290.CD-20-1050.
Campbell, B. B., Galati, M. A., Stone, S. C., Riemenschneider, A. N., Edwards, M., Sudhaman, S., Siddaway, R., Komosa, M., Nunes, N. M., Nobre, L., Morrissy, A. S., Zatzman, M., Zapotocky, M., Joksimovic, L., Kalimuthu, S. N., Samuel, D., Mason, G., Bouffet, E., Morgenstern, D. A., Aronson, M., Durno, C., Malkin, D., Maris, J. M., Taylor, M. D., Shlien, A., Pugh, T. J., Ohashi, P. S., Hawkins, C. E., & Tabori, U. (2021). Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer discovery, 11(6), 1454-1467. https://doi.org/10.1158/2159-8290.CD-20-1050
Campbell, Brittany B, et al. "Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition." Cancer discovery vol. 11,6 (2021): 1454-1467. doi: https://doi.org/10.1158/2159-8290.CD-20-1050
Campbell BB, Galati MA, Stone SC, Riemenschneider AN, Edwards M, Sudhaman S, Siddaway R, Komosa M, Nunes NM, Nobre L, Morrissy AS, Zatzman M, Zapotocky M, Joksimovic L, Kalimuthu SN, Samuel D, Mason G, Bouffet E, Morgenstern DA, Aronson M, Durno C, Malkin D, Maris JM, Taylor MD, Shlien A, Pugh TJ, Ohashi PS, Hawkins CE, Tabori U. Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer Discov. 2021 Jun;11(6):1454-1467. doi: 10.1158/2159-8290.CD-20-1050. Epub 2021 Feb 09. PMID: 33563663; PMCID: PMC8406556.
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Identification of the agr Peptide of Listeria monocytogenes.

Frontiers in microbiology

Zetzmann M, Sánchez-Kopper A, Waidmann MS, Blombach B, Riedel CU.
PMID: 27446029
Front Microbiol. 2016 Jun 22;7:989. doi: 10.3389/fmicb.2016.00989. eCollection 2016.

Listeria monocytogenes (Lm) is an important food-borne human pathogen that is able to strive under a wide range of environmental conditions. Its accessory gene regulator (agr) system was shown to impact on biofilm formation and virulence and has been...

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Zetzmann M, Sánchez-Kopper A, Waidmann MS, et al. Identification of the agr Peptide of Listeria monocytogenes. Front Microbiol. 2016;7:989doi: 10.3389/fmicb.2016.00989.
Zetzmann, M., Sánchez-Kopper, A., Waidmann, M. S., Blombach, B., & Riedel, C. U. (2016). Identification of the agr Peptide of Listeria monocytogenes. Frontiers in microbiology, 7989. https://doi.org/10.3389/fmicb.2016.00989
Zetzmann, Marion, et al. "Identification of the agr Peptide of Listeria monocytogenes." Frontiers in microbiology vol. 7 (2016): 989. doi: https://doi.org/10.3389/fmicb.2016.00989
Zetzmann M, Sánchez-Kopper A, Waidmann MS, Blombach B, Riedel CU. Identification of the agr Peptide of Listeria monocytogenes. Front Microbiol. 2016 Jun 22;7:989. doi: 10.3389/fmicb.2016.00989. eCollection 2016. PMID: 27446029; PMCID: PMC4916163.
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Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency.

Nature medicine

Das A, Sudhaman S, Morgenstern D, Coblentz A, Chung J, Stone SC, Alsafwani N, Liu ZA, Karsaneh OAA, Soleimani S, Ladany H, Chen D, Zatzman M, Cabric V, Nobre L, Bianchi V, Edwards M, Sambira Nahum LC, Ercan AB, Nabbi A, Constantini S, Dvir R, Yalon-Oren M, Campino GA, Caspi S, Larouche V, Reddy A, Osborn M, Mason G, Lindhorst S, Bronsema A, Magimairajan V, Opocher E, De Mola RL, Sabel M, Frojd C, Sumerauer D, Samuel D, Cole K, Chiaravalli S, Massimino M, Tomboc P, Ziegler DS, George B, Van Damme A, Hijiya N, Gass D, McGee RB, Mordechai O, Bowers DC, Laetsch TW, Lossos A, Blumenthal DT, Sarosiek T, Yen LY, Knipstein J, Bendel A, Hoffman LM, Luna-Fineman S, Zimmermann S, Scheers I, Nichols KE, Zapotocky M, Hansford JR, Maris JM, Dirks P, Taylor MD, Kulkarni AV, Shroff M, Tsang DS, Villani A, Xu W, Aronson M, Durno C, Shlien A, Malkin D, Getz G, Maruvka YE, Ohashi PS, Hawkins C, Pugh TJ, Bouffet E, Tabori U.
PMID: 34992263
Nat Med. 2022 Jan 06; doi: 10.1038/s41591-021-01581-6. Epub 2022 Jan 06.

Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading deficiency (MMRD and PPD) in children harbour the highest mutational and microsatellite insertion-deletion (MS-indel) burden in humans. MMRD and PPD cancers are commonly lethal due to the inherent...

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Das A, Sudhaman S, Morgenstern D, et al. Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency. Nat Med. 2022;doi: 10.1038/s41591-021-01581-6.
Das, A., Sudhaman, S., Morgenstern, D., Coblentz, A., Chung, J., Stone, S. C., Alsafwani, N., Liu, Z. A., Karsaneh, O. A. A., Soleimani, S., Ladany, H., Chen, D., Zatzman, M., Cabric, V., Nobre, L., Bianchi, V., Edwards, M., Sambira Nahum, L. C., Ercan, A. B., Nabbi, A., Constantini, S., Dvir, R., Yalon-Oren, M., Campino, G. A., Caspi, S., Larouche, V., Reddy, A., Osborn, M., Mason, G., Lindhorst, S., Bronsema, A., Magimairajan, V., Opocher, E., De Mola, R. L., Sabel, M., Frojd, C., Sumerauer, D., Samuel, D., Cole, K., Chiaravalli, S., Massimino, M., Tomboc, P., Ziegler, D. S., George, B., Van Damme, A., Hijiya, N., Gass, D., McGee, R. B., Mordechai, O., Bowers, D. C., Laetsch, T. W., Lossos, A., Blumenthal, D. T., Sarosiek, T., Yen, L. Y., Knipstein, J., Bendel, A., Hoffman, L. M., Luna-Fineman, S., Zimmermann, S., Scheers, I., Nichols, K. E., Zapotocky, M., Hansford, J. R., Maris, J. M., Dirks, P., Taylor, M. D., Kulkarni, A. V., Shroff, M., Tsang, D. S., Villani, A., Xu, W., Aronson, M., Durno, C., Shlien, A., Malkin, D., Getz, G., Maruvka, Y. E., Ohashi, P. S., Hawkins, C., Pugh, T. J., Bouffet, E., & Tabori, U. (2022). Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency. Nature medicine, . https://doi.org/10.1038/s41591-021-01581-6
Das, Anirban, et al. "Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency." Nature medicine vol. (2022). doi: https://doi.org/10.1038/s41591-021-01581-6
Das A, Sudhaman S, Morgenstern D, Coblentz A, Chung J, Stone SC, Alsafwani N, Liu ZA, Karsaneh OAA, Soleimani S, Ladany H, Chen D, Zatzman M, Cabric V, Nobre L, Bianchi V, Edwards M, Sambira Nahum LC, Ercan AB, Nabbi A, Constantini S, Dvir R, Yalon-Oren M, Campino GA, Caspi S, Larouche V, Reddy A, Osborn M, Mason G, Lindhorst S, Bronsema A, Magimairajan V, Opocher E, De Mola RL, Sabel M, Frojd C, Sumerauer D, Samuel D, Cole K, Chiaravalli S, Massimino M, Tomboc P, Ziegler DS, George B, Van Damme A, Hijiya N, Gass D, McGee RB, Mordechai O, Bowers DC, Laetsch TW, Lossos A, Blumenthal DT, Sarosiek T, Yen LY, Knipstein J, Bendel A, Hoffman LM, Luna-Fineman S, Zimmermann S, Scheers I, Nichols KE, Zapotocky M, Hansford JR, Maris JM, Dirks P, Taylor MD, Kulkarni AV, Shroff M, Tsang DS, Villani A, Xu W, Aronson M, Durno C, Shlien A, Malkin D, Getz G, Maruvka YE, Ohashi PS, Hawkins C, Pugh TJ, Bouffet E, Tabori U. Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency. Nat Med. 2022 Jan 06; doi: 10.1038/s41591-021-01581-6. Epub 2022 Jan 06. PMID: 34992263.
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Impact of a family practice residency program on physician location in small communities.

Southern medical journal

Stefanu C, Pate ML, Zetzman MR, Goldman WW, Brandt EN.
PMID: 7434052
South Med J. 1980 Oct;73(10):1372-4. doi: 10.1097/00007611-198010000-00022.

We conducted a study to determine the practice location pattern among graduates of a family practice residency program with respect to the distribution of the physicians in nonurban areas of the country. One of the primary goals of The...

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Stefanu C, Pate ML, Zetzman MR, et al. Impact of a family practice residency program on physician location in small communities. South Med J. 1980;73(10):1372-4doi: 10.1097/00007611-198010000-00022.
Stefanu, C., Pate, M. L., Zetzman, M. R., Goldman, W. W., & Brandt, E. N. (1980). Impact of a family practice residency program on physician location in small communities. Southern medical journal, 73(10), 1372-4. https://doi.org/10.1097/00007611-198010000-00022
Stefanu, C, et al. "Impact of a family practice residency program on physician location in small communities." Southern medical journal vol. 73,10 (1980): 1372-4. doi: https://doi.org/10.1097/00007611-198010000-00022
Stefanu C, Pate ML, Zetzman MR, Goldman WW, Brandt EN. Impact of a family practice residency program on physician location in small communities. South Med J. 1980 Oct;73(10):1372-4. doi: 10.1097/00007611-198010000-00022. PMID: 7434052.
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Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition.

Cancer discovery

Campbell BB, Galati MA, Stone SC, Riemenschneider AN, Edwards M, Sudhaman S, Siddaway R, Komosa M, Nunes NM, Nobre L, Morrissy AS, Zatzman M, Zapotocky M, Joksimovic L, Kalimuthu SN, Samuel D, Mason G, Bouffet E, Morgenstern DA, Aronson M, Durno C, Malkin D, Maris JM, Taylor MD, Shlien A, Pugh TJ, Ohashi PS, Hawkins CE, Tabori U.
PMID: 33563663
Cancer Discov. 2021 Jun;11(6):1454-1467. doi: 10.1158/2159-8290.CD-20-1050. Epub 2021 Feb 09.

The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single, well-characterized point mutation in an oncogene. Hypermutant tumors that harbor many somatic mutations may obscure...

Cite
Campbell BB, Galati MA, Stone SC, et al. Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer Discov. 2021;11(6):1454-1467doi: 10.1158/2159-8290.CD-20-1050.
Campbell, B. B., Galati, M. A., Stone, S. C., Riemenschneider, A. N., Edwards, M., Sudhaman, S., Siddaway, R., Komosa, M., Nunes, N. M., Nobre, L., Morrissy, A. S., Zatzman, M., Zapotocky, M., Joksimovic, L., Kalimuthu, S. N., Samuel, D., Mason, G., Bouffet, E., Morgenstern, D. A., Aronson, M., Durno, C., Malkin, D., Maris, J. M., Taylor, M. D., Shlien, A., Pugh, T. J., Ohashi, P. S., Hawkins, C. E., & Tabori, U. (2021). Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer discovery, 11(6), 1454-1467. https://doi.org/10.1158/2159-8290.CD-20-1050
Campbell, Brittany B, et al. "Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition." Cancer discovery vol. 11,6 (2021): 1454-1467. doi: https://doi.org/10.1158/2159-8290.CD-20-1050
Campbell BB, Galati MA, Stone SC, Riemenschneider AN, Edwards M, Sudhaman S, Siddaway R, Komosa M, Nunes NM, Nobre L, Morrissy AS, Zatzman M, Zapotocky M, Joksimovic L, Kalimuthu SN, Samuel D, Mason G, Bouffet E, Morgenstern DA, Aronson M, Durno C, Malkin D, Maris JM, Taylor MD, Shlien A, Pugh TJ, Ohashi PS, Hawkins CE, Tabori U. Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer Discov. 2021 Jun;11(6):1454-1467. doi: 10.1158/2159-8290.CD-20-1050. Epub 2021 Feb 09. PMID: 33563663; PMCID: PMC8406556.
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DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.

Cancer discovery

Chung J, Maruvka YE, Sudhaman S, Kelly J, Haradhvala NJ, Bianchi V, Edwards M, Forster VJ, Nunes NM, Galati MA, Komosa M, Deshmukh S, Cabric V, Davidson S, Zatzman M, Light N, Hayes R, Brunga L, Anderson ND, Ho B, Hodel KP, Siddaway R, Morrissy AS, Bowers DC, Larouche V, Bronsema A, Osborn M, Cole KA, Opocher E, Mason G, Thomas GA, George B, Ziegler DS, Lindhorst S, Vanan M, Yalon-Oren M, Reddy AT, Massimino M, Tomboc P, Van Damme A, Lossos A, Durno C, Aronson M, Morgenstern DA, Bouffet E, Huang A, Taylor MD, Villani A, Malkin D, Hawkins CE, Pursell ZF, Shlien A, Kunkel TA, Getz G, Tabori U.
PMID: 33355208
Cancer Discov. 2021 May;11(5):1176-1191. doi: 10.1158/2159-8290.CD-20-0790. Epub 2020 Dec 18.

Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark of MMRD alone. By genome-wide analysis of tumors with germline and...

Cite
Chung J, Maruvka YE, Sudhaman S, et al. DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells. Cancer Discov. 2020;11(5):1176-1191doi: 10.1158/2159-8290.CD-20-0790.
Chung, J., Maruvka, Y. E., Sudhaman, S., Kelly, J., Haradhvala, N. J., Bianchi, V., Edwards, M., Forster, V. J., Nunes, N. M., Galati, M. A., Komosa, M., Deshmukh, S., Cabric, V., Davidson, S., Zatzman, M., Light, N., Hayes, R., Brunga, L., Anderson, N. D., Ho, B., Hodel, K. P., Siddaway, R., Morrissy, A. S., Bowers, D. C., Larouche, V., Bronsema, A., Osborn, M., Cole, K. A., Opocher, E., Mason, G., Thomas, G. A., George, B., Ziegler, D. S., Lindhorst, S., Vanan, M., Yalon-Oren, M., Reddy, A. T., Massimino, M., Tomboc, P., Van Damme, A., Lossos, A., Durno, C., Aronson, M., Morgenstern, D. A., Bouffet, E., Huang, A., Taylor, M. D., Villani, A., Malkin, D., Hawkins, C. E., Pursell, Z. F., Shlien, A., Kunkel, T. A., Getz, G., & Tabori, U. (2021). DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells. Cancer discovery, 11(5), 1176-1191. https://doi.org/10.1158/2159-8290.CD-20-0790
Chung, Jiil, et al. "DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells." Cancer discovery vol. 11,5 (2021): 1176-1191. doi: https://doi.org/10.1158/2159-8290.CD-20-0790
Chung J, Maruvka YE, Sudhaman S, Kelly J, Haradhvala NJ, Bianchi V, Edwards M, Forster VJ, Nunes NM, Galati MA, Komosa M, Deshmukh S, Cabric V, Davidson S, Zatzman M, Light N, Hayes R, Brunga L, Anderson ND, Ho B, Hodel KP, Siddaway R, Morrissy AS, Bowers DC, Larouche V, Bronsema A, Osborn M, Cole KA, Opocher E, Mason G, Thomas GA, George B, Ziegler DS, Lindhorst S, Vanan M, Yalon-Oren M, Reddy AT, Massimino M, Tomboc P, Van Damme A, Lossos A, Durno C, Aronson M, Morgenstern DA, Bouffet E, Huang A, Taylor MD, Villani A, Malkin D, Hawkins CE, Pursell ZF, Shlien A, Kunkel TA, Getz G, Tabori U. DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells. Cancer Discov. 2021 May;11(5):1176-1191. doi: 10.1158/2159-8290.CD-20-0790. Epub 2020 Dec 18. PMID: 33355208; PMCID: PMC8223607.
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