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Showing 1 to 12 of 87 entries
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Systemic Inflammation in Cachexia - Is Tumor Cytokine Expression Profile the Culprit?.

Frontiers in immunology

de Matos-Neto EM, Lima JD, de Pereira WO, Figuerêdo RG, Riccardi DM, Radloff K, das Neves RX, Camargo RG, Maximiano LF, Tokeshi F, Otoch JP, Goldszmid R, Câmara NO, Trinchieri G, de Alcântara PS, Seelaender M.
PMID: 26732354
Front Immunol. 2015 Dec 24;6:629. doi: 10.3389/fimmu.2015.00629. eCollection 2015.

Cachexia affects about 80% of gastrointestinal cancer patients. This multifactorial syndrome resulting in involuntary and continuous weight loss is accompanied by systemic inflammation and immune cell infiltration in various tissues. Understanding the interactions among tumor, immune cells, and peripheral...

Towards the Development of a Low-Cost Device for the Detection of Explosives Vapors by Fluorescence Quenching of Conjugated Polymers in Solid Matrices.

Sensors (Basel, Switzerland)

Martelo LM, das Neves TFP, Figueiredo J, Marques L, Fedorov A, Charas A, Berberan-Santos MN, Burrows HD.
PMID: 29099776
Sensors (Basel). 2017 Nov 03;17(11). doi: 10.3390/s17112532.

Conjugated polymers (CPs) have proved to be promising chemosensory materials for detecting nitroaromatic explosives vapors, as they quickly convert a chemical interaction into an easily-measured high-sensitivity optical output. The nitroaromatic analytes are strongly electron-deficient, whereas the conjugated polymer sensing...

Recent developments in ultra low-level gamma-ray spectrometry at IRMM.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Hult M, Martinez Canet MJ, Kohler M, das Neves J, Johnston PN.
PMID: 10879866
Appl Radiat Isot. 2000 Jul;53(1):225-9. doi: 10.1016/s0969-8043(00)00138-x.

IRMM performs ultra low-level gamma-ray spectrometry in the underground laboratory HADES, located at the SCK-CEN site in Mol, Belgium. Recently a third low-background coaxial HPGe detector was put into operation. The detector has 60% relative efficiency and better background...

A biophysical model for transcription factories.

BMC biophysics

Canals-Hamann AZ, das Neves RP, Reittie JE, Iñiguez C, Soneji S, Enver T, Buckle VJ, Iborra FJ.
PMID: 23394119
BMC Biophys. 2013 Feb 09;6:2. doi: 10.1186/2046-1682-6-2.

SUMMARY: Transcription factories are nuclear domains where gene transcription takes place although the molecular basis for their formation and maintenance are unknown. In this study, we explored how the properties of chromatin as a polymer may contribute to the...

Bad Choices Make Good Stories: The Impaired Decision-Making Process and Skin Conductance Response in Subjects With Smartphone Addiction.

Frontiers in psychiatry

Khoury JM, Couto LFSC, Santos DA, E Silva VHO, Drumond JPS, Silva LLCE, Malloy-Diniz L, Albuquerque MR, das Neves MCL, Duarte Garcia F.
PMID: 30853918
Front Psychiatry. 2019 Feb 22;10:73. doi: 10.3389/fpsyt.2019.00073. eCollection 2019.

No abstract available.

Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems.

Pharmaceutics

Mesquita L, Galante J, Nunes R, Sarmento B, das Neves J.
PMID: 30917532
Pharmaceutics. 2019 Mar 26;11(3). doi: 10.3390/pharmaceutics11030145.

Prevention strategies play a key role in the fight against HIV/AIDS. Vaginal and rectal microbicides hold great promise in tackling sexual transmission of HIV-1, but effective and safe products are yet to be approved and made available to those...

Pawedness Trait Test (PaTRaT)-A New Paradigm to Evaluate Paw Preference and Dexterity in Rats.

Frontiers in behavioral neuroscience

Cunha AM, Esteves M, das Neves SP, Borges S, Guimarães MR, Sousa N, Almeida A, Leite-Almeida H.
PMID: 29089877
Front Behav Neurosci. 2017 Oct 16;11:192. doi: 10.3389/fnbeh.2017.00192. eCollection 2017.

In rodents, dexterity is commonly analyzed in preference paradigms in which animals are given the chance to use either the left or the right front paws to manipulate food. However, paw preference and dexterity at population and individual levels...

Characterization of commercially available vaginal lubricants: a safety perspective.

Pharmaceutics

Cunha AR, Machado RM, Palmeira-de-Oliveira A, Martinez-de-Oliveira J, das Neves J, Palmeira-de-Oliveira R.
PMID: 25247884
Pharmaceutics. 2014 Sep 22;6(3):530-42. doi: 10.3390/pharmaceutics6030530.

Vaginal lubricants are widely used by women to help solve intercourse difficulties or as enhancers, but recent reports raise questions about their safety. Twelve commercially available gel products were tested for pH value, pH buffering capacity, osmolality and cytotoxicity...

Rational Development of Liposomal Hydrogels: A Strategy for Topical Vaginal Antiretroviral Drug Delivery in the Context of HIV Prevention.

Pharmaceutics

Faria MJ, Machado R, Ribeiro A, Gonçalves H, Real Oliveira MECD, Viseu T, das Neves J, Lúcio M.
PMID: 31540519
Pharmaceutics. 2019 Sep 18;11(9). doi: 10.3390/pharmaceutics11090485.

HIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising strategy for topical pre-exposure prophylaxis. Preceding the development of a microbicide containing tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC), in silico and in vitro studies were performed...

Highly divergent herpesviruses in threatened river dolphins from Brazil.

Scientific reports

Exposto Novoselecki H, Catão-Dias JL, Ewbank AC, Navas-Suárez PE, Duarte-Benvenuto A, Lial HC, Costa Silva S, Sánchez-Sarmiento AM, Gravena W, da Silva VMF, Carvalho VL, Marmontel M, Bertozzi CP, Lanes Ribeiro V, Del Rio do Valle R, Marigo J, das Neves CG, Esperón F, Sacristán C.
PMID: 34972839
Sci Rep. 2021 Dec 31;11(1):24528. doi: 10.1038/s41598-021-04059-0.

River dolphins are a highly threatened polyphyletic group comprised of four odontocete families: Iniidae, Pontoporiidae, Lipotidae, and Platanistidae, the first two endemic to South America. To address the knowledge gap regarding infectious agents in this cetacean group, we surveyed...

Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids.

Bioorganic chemistry

Felipe JL, Cassamale TB, Lourenço LD, Carvalho DB, das Neves AR, Duarte RCF, Carvalho MG, Toffoli-Kadri MC, Baroni ACM.
PMID: 34959176
Bioorg Chem. 2021 Nov 20;119:105485. doi: 10.1016/j.bioorg.2021.105485. Epub 2021 Nov 20.

This study reports the synthesis of novel neolignans-celecoxib hybrids and the evaluation of their biological activity. Analogs8-13(L13-L18) exhibited anti-inflammatory activity, inhibited glycoprotein expression (P-selectin) related to platelet activation, and were considered non- ulcerogenic in the animal model, even with...

Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids.

Bioorganic chemistry

Felipe JL, Cassamale TB, Lourenço LD, Carvalho DB, das Neves AR, Duarte RCF, Carvalho MG, Toffoli-Kadri MC, Baroni ACM.
PMID: 34959176
Bioorg Chem. 2021 Nov 20;119:105485. doi: 10.1016/j.bioorg.2021.105485. Epub 2021 Nov 20.

This study reports the synthesis of novel neolignans-celecoxib hybrids and the evaluation of their biological activity. Analogs8-13(L13-L18) exhibited anti-inflammatory activity, inhibited glycoprotein expression (P-selectin) related to platelet activation, and were considered non- ulcerogenic in the animal model, even with...

Showing 1 to 12 of 87 entries