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In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma.

International journal of cancer

Hermans BCM, Derks JL, Hillen LM, van der Baan I, van den Broek EC, von der Thüsen JH, van Suylen RJ, Atmodimedjo PN, den Toom TD, Coumans-Stallinga C, Timens W, Dinjens WNM, Dubbink HJ, Speel EM, Dingemans AC.
PMID: 34674268
Int J Cancer. 2021 Oct 21; doi: 10.1002/ijc.33853. Epub 2021 Oct 21.

Up to 14% of large cell neuroendocrine carcinomas (LCNECs) are diagnosed in continuity with nonsmall cell lung carcinoma. In addition to these combined lesions, 1% to 7% of lung tumors present as co-primary tumors with multiple synchronous lesions. We...

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Hermans BCM, Derks JL, Hillen LM, et al. In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma. Int J Cancer. 2021;doi: 10.1002/ijc.33853.
Hermans, B. C. M., Derks, J. L., Hillen, L. M., van der Baan, I., van den Broek, E. C., von der Thüsen, J. H., van Suylen, R. J., Atmodimedjo, P. N., den Toom, T. D., Coumans-Stallinga, C., Timens, W., Dinjens, W. N. M., Dubbink, H. J., Speel, E. M., Dingemans, A. C. (2021). In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma. International journal of cancer, . https://doi.org/10.1002/ijc.33853
Hermans, Bregtje C M, et al. "In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma." International journal of cancer vol. (2021). doi: https://doi.org/10.1002/ijc.33853
Hermans BCM, Derks JL, Hillen LM, van der Baan I, van den Broek EC, von der Thüsen JH, van Suylen RJ, Atmodimedjo PN, den Toom TD, Coumans-Stallinga C, Timens W, Dinjens WNM, Dubbink HJ, Speel EM, Dingemans AC. In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma. Int J Cancer. 2021 Oct 21; doi: 10.1002/ijc.33853. Epub 2021 Oct 21. PMID: 34674268.
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Diagnostic accuracy of [.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

Mahieu R, den Toom IJ, van Rooij R, van Es RJJ, Hobbelink MGG, Krijger GC, Tijink BM, de Keizer B, de Bree R.
PMID: 33960126
Clin Otolaryngol. 2021 Nov;46(6):1383-1388. doi: 10.1111/coa.13798. Epub 2021 Jun 04.

No abstract available.

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Mahieu R, den Toom IJ, van Rooij R, et al. Diagnostic accuracy of [. Clin Otolaryngol. 2021;46(6):1383-1388doi: 10.1111/coa.13798.
Mahieu, R., den Toom, I. J., van Rooij, R., van Es, R. J. J., Hobbelink, M. G. G., Krijger, G. C., Tijink, B. M., de Keizer, B., & de Bree, R. (2021). Diagnostic accuracy of [. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 46(6), 1383-1388. https://doi.org/10.1111/coa.13798
Mahieu, Rutger, et al. "Diagnostic accuracy of [." Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery vol. 46,6 (2021): 1383-1388. doi: https://doi.org/10.1111/coa.13798
Mahieu R, den Toom IJ, van Rooij R, van Es RJJ, Hobbelink MGG, Krijger GC, Tijink BM, de Keizer B, de Bree R. Diagnostic accuracy of [. Clin Otolaryngol. 2021 Nov;46(6):1383-1388. doi: 10.1111/coa.13798. Epub 2021 Jun 04. PMID: 33960126.
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In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma.

International journal of cancer

Hermans BCM, Derks JL, Hillen LM, van der Baan I, van den Broek EC, von der Thüsen JH, van Suylen RJ, Atmodimedjo PN, den Toom TD, Coumans-Stallinga C, Timens W, Dinjens WNM, Dubbink HJ, Speel EM, Dingemans AC.
PMID: 34674268
Int J Cancer. 2022 Mar 01;150(5):802-815. doi: 10.1002/ijc.33853. Epub 2021 Nov 10.

Up to 14% of large cell neuroendocrine carcinomas (LCNECs) are diagnosed in continuity with nonsmall cell lung carcinoma. In addition to these combined lesions, 1% to 7% of lung tumors present as co-primary tumors with multiple synchronous lesions. We...

Cite
Hermans BCM, Derks JL, Hillen LM, et al. In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma. Int J Cancer. 2021;150(5):802-815doi: 10.1002/ijc.33853.
Hermans, B. C. M., Derks, J. L., Hillen, L. M., van der Baan, I., van den Broek, E. C., von der Thüsen, J. H., van Suylen, R. J., Atmodimedjo, P. N., den Toom, T. D., Coumans-Stallinga, C., Timens, W., Dinjens, W. N. M., Dubbink, H. J., Speel, E. M., Dingemans, A. C. (2022). In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma. International journal of cancer, 150(5), 802-815. https://doi.org/10.1002/ijc.33853
Hermans, Bregtje C M, et al. "In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma." International journal of cancer vol. 150,5 (2022): 802-815. doi: https://doi.org/10.1002/ijc.33853
Hermans BCM, Derks JL, Hillen LM, van der Baan I, van den Broek EC, von der Thüsen JH, van Suylen RJ, Atmodimedjo PN, den Toom TD, Coumans-Stallinga C, Timens W, Dinjens WNM, Dubbink HJ, Speel EM, Dingemans AC. In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma. Int J Cancer. 2022 Mar 01;150(5):802-815. doi: 10.1002/ijc.33853. Epub 2021 Nov 10. PMID: 34674268.
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Functional .

Clinical cancer research : an official journal of the American Association for Cancer Research

Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, Kanaar R, Martens JWM, Jager A, van Gent DC.
PMID: 30139880
Clin Cancer Res. 2018 Dec 15;24(24):6277-6287. doi: 10.1158/1078-0432.CCR-18-0063. Epub 2018 Aug 23.

PURPOSE: Tumors of germline EXPERIMENTAL DESIGN: Fresh samples of 170 primary breast cancer were analyzed using the RECAP test. The molecular explanation for the HRD phenotype was investigated by exploring RESULTS: RECAP was completed successfully in 148 of 170...

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Meijer TG, Verkaik NS, Sieuwerts AM, et al. Functional . Clin Cancer Res. 2018;24(24):6277-6287doi: 10.1158/1078-0432.CCR-18-0063.
Meijer, T. G., Verkaik, N. S., Sieuwerts, A. M., van Riet, J., Naipal, K. A. T., van Deurzen, C. H. M., den Bakker, M. A., Sleddens, H. F. B. M., Dubbink, H. J., den Toom, T. D., Dinjens, W. N. M., Lips, E., Nederlof, P. M., Smid, M., van de Werken, H. J. G., Kanaar, R., Martens, J. W. M., Jager, A., & van Gent, D. C. (2018). Functional . Clinical cancer research : an official journal of the American Association for Cancer Research, 24(24), 6277-6287. https://doi.org/10.1158/1078-0432.CCR-18-0063
Meijer, Titia G, et al. "Functional ." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 24,24 (2018): 6277-6287. doi: https://doi.org/10.1158/1078-0432.CCR-18-0063
Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, Kanaar R, Martens JWM, Jager A, van Gent DC. Functional . Clin Cancer Res. 2018 Dec 15;24(24):6277-6287. doi: 10.1158/1078-0432.CCR-18-0063. Epub 2018 Aug 23. PMID: 30139880.
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Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience.

Cancers

den Toom IJ, Boeve K, Lobeek D, Bloemena E, Donswijk ML, de Keizer B, Klop WMC, Leemans CR, Willems SM, Takes RP, Witjes MJH, de Bree R.
PMID: 32635357
Cancers (Basel). 2020 Jul 03;12(7). doi: 10.3390/cancers12071783.

BACKGROUND: Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking...

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den Toom IJ, Boeve K, Lobeek D, et al. Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience. Cancers (Basel). 2020;12(7)doi: 10.3390/cancers12071783.
den Toom, I. J., Boeve, K., Lobeek, D., Bloemena, E., Donswijk, M. L., de Keizer, B., Klop, W. M. C., Leemans, C. R., Willems, S. M., Takes, R. P., Witjes, M. J. H., & de Bree, R. (2020). Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience. Cancers, 12(7), . https://doi.org/10.3390/cancers12071783
den Toom, Inne J, et al. "Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience." Cancers vol. 12,7 (2020). doi: https://doi.org/10.3390/cancers12071783
den Toom IJ, Boeve K, Lobeek D, Bloemena E, Donswijk ML, de Keizer B, Klop WMC, Leemans CR, Willems SM, Takes RP, Witjes MJH, de Bree R. Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience. Cancers (Basel). 2020 Jul 03;12(7). doi: 10.3390/cancers12071783. PMID: 32635357; PMCID: PMC7407164.
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Correction: Functional .

Clinical cancer research : an official journal of the American Association for Cancer Research

Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, Kanaar R, Martens JWM, Jager A, van Gent DC.
PMID: 31043383
Clin Cancer Res. 2019 May 01;25(9):2935. doi: 10.1158/1078-0432.CCR-19-0936.

No abstract available.

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Meijer TG, Verkaik NS, Sieuwerts AM, et al. Correction: Functional . Clin Cancer Res. 2019;25(9):2935doi: 10.1158/1078-0432.CCR-19-0936.
Meijer, T. G., Verkaik, N. S., Sieuwerts, A. M., van Riet, J., Naipal, K. A. T., van Deurzen, C. H. M., den Bakker, M. A., Sleddens, H. F. B. M., Dubbink, H. J., den Toom, T. D., Dinjens, W. N. M., Lips, E., Nederlof, P. M., Smid, M., van de Werken, H. J. G., Kanaar, R., Martens, J. W. M., Jager, A., & van Gent, D. C. (2019). Correction: Functional . Clinical cancer research : an official journal of the American Association for Cancer Research, 25(9), 2935. https://doi.org/10.1158/1078-0432.CCR-19-0936
Meijer, Titia G, et al. "Correction: Functional ." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 25,9 (2019): 2935. doi: https://doi.org/10.1158/1078-0432.CCR-19-0936
Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, Kanaar R, Martens JWM, Jager A, van Gent DC. Correction: Functional . Clin Cancer Res. 2019 May 01;25(9):2935. doi: 10.1158/1078-0432.CCR-19-0936. PMID: 31043383.
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Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development.

NPJ microgravity

Manzano A, Herranz R, den Toom LA, Te Slaa S, Borst G, Visser M, Medina FJ, van Loon JJWA.
PMID: 29644337
NPJ Microgravity. 2018 Apr 04;4:9. doi: 10.1038/s41526-018-0041-4. eCollection 2018.

Clinostats and Random Positioning Machine (RPM) are used to simulate microgravity, but, for space exploration, we need to know the response of living systems to fractional levels of gravity (partial gravity) as they exist on Moon and Mars. We...

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Manzano A, Herranz R, den Toom LA, et al. Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development. NPJ Microgravity. 2018;4:9doi: 10.1038/s41526-018-0041-4.
Manzano, A., Herranz, R., den Toom, L. A., Te Slaa, S., Borst, G., Visser, M., Medina, F. J., & van Loon, J. J. W. A. (2018). Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development. NPJ microgravity, 49. https://doi.org/10.1038/s41526-018-0041-4
Manzano, Aránzazu, et al. "Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development." NPJ microgravity vol. 4 (2018): 9. doi: https://doi.org/10.1038/s41526-018-0041-4
Manzano A, Herranz R, den Toom LA, Te Slaa S, Borst G, Visser M, Medina FJ, van Loon JJWA. Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development. NPJ Microgravity. 2018 Apr 04;4:9. doi: 10.1038/s41526-018-0041-4. eCollection 2018. PMID: 29644337; PMCID: PMC5884789.
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The professionalization of chaplaincy .

Journal of health care chaplaincy

Den Toom N, Kruizinga R, Liefbroer AI, Körver J.
PMID: 34715766
J Health Care Chaplain. 2021 Oct 29;1-16. doi: 10.1080/08854726.2021.1996810. Epub 2021 Oct 29.

Chaplaincy has become increasingly professionalized in response to both the standardization in healthcare and the changing religious landscape. Whereas several studies have paid attention to the professionalization of chaplaincy as a whole, no research has been found that describes...

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Den Toom N, Kruizinga R, Liefbroer AI, et al. The professionalization of chaplaincy . J Health Care Chaplain. 2021;1-16doi: 10.1080/08854726.2021.1996810.
Den Toom, N., Kruizinga, R., Liefbroer, A. I., & Körver, J. (2021). The professionalization of chaplaincy . Journal of health care chaplaincy, 1-16. https://doi.org/10.1080/08854726.2021.1996810
Den Toom, Niels, et al. "The professionalization of chaplaincy ." Journal of health care chaplaincy vol. (2021): 1-16. doi: https://doi.org/10.1080/08854726.2021.1996810
Den Toom N, Kruizinga R, Liefbroer AI, Körver J. The professionalization of chaplaincy . J Health Care Chaplain. 2021 Oct 29;1-16. doi: 10.1080/08854726.2021.1996810. Epub 2021 Oct 29. PMID: 34715766.
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Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy-Comparison to a Historic Elective Neck Dissection Cohort.

Frontiers in oncology

Mahieu R, den Toom IJ, Boeve K, Lobeek D, Bloemena E, Donswijk ML, de Keizer B, Klop WMC, Leemans CR, Willems SM, Takes RP, Witjes MJH, de Bree R.
PMID: 33968742
Front Oncol. 2021 Apr 23;11:644306. doi: 10.3389/fonc.2021.644306. eCollection 2021.

No abstract available.

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Mahieu R, den Toom IJ, Boeve K, et al. Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy-Comparison to a Historic Elective Neck Dissection Cohort. Front Oncol. 2021;11:644306doi: 10.3389/fonc.2021.644306.
Mahieu, R., den Toom, I. J., Boeve, K., Lobeek, D., Bloemena, E., Donswijk, M. L., de Keizer, B., Klop, W. M. C., Leemans, C. R., Willems, S. M., Takes, R. P., Witjes, M. J. H., & de Bree, R. (2021). Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy-Comparison to a Historic Elective Neck Dissection Cohort. Frontiers in oncology, 11644306. https://doi.org/10.3389/fonc.2021.644306
Mahieu, Rutger, et al. "Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy-Comparison to a Historic Elective Neck Dissection Cohort." Frontiers in oncology vol. 11 (2021): 644306. doi: https://doi.org/10.3389/fonc.2021.644306
Mahieu R, den Toom IJ, Boeve K, Lobeek D, Bloemena E, Donswijk ML, de Keizer B, Klop WMC, Leemans CR, Willems SM, Takes RP, Witjes MJH, de Bree R. Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy-Comparison to a Historic Elective Neck Dissection Cohort. Front Oncol. 2021 Apr 23;11:644306. doi: 10.3389/fonc.2021.644306. eCollection 2021. PMID: 33968742; PMCID: PMC8103896.
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Blood clot removal by cryoextraction in critically ill patients with pulmonary hemorrhage.

Journal of thoracic disease

Schmidt LH, Schulze AB, Goerlich D, Schliemann C, Kessler T, Rottmann V, den Toom D, Rosenow F, Sackarnd J, Evers G, Mohr M.
PMID: 31737317
J Thorac Dis. 2019 Oct;11(10):4319-4327. doi: 10.21037/jtd.2019.09.46.

BACKGROUND: Severe pulmonary hemorrhage is a life-threatening complication in critically ill patients. Due to tracheobronchial obstruction, ventilation is often impaired. Traditionally, rigid bronchoscopy is an option for recanalization. However, in comparison to flexible bronchoscopy, the application of rigid bronchoscopy...

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Schmidt LH, Schulze AB, Goerlich D, et al. Blood clot removal by cryoextraction in critically ill patients with pulmonary hemorrhage. J Thorac Dis. 2019;11(10):4319-4327doi: 10.21037/jtd.2019.09.46.
Schmidt, L. H., Schulze, A. B., Goerlich, D., Schliemann, C., Kessler, T., Rottmann, V., den Toom, D., Rosenow, F., Sackarnd, J., Evers, G., & Mohr, M. (2019). Blood clot removal by cryoextraction in critically ill patients with pulmonary hemorrhage. Journal of thoracic disease, 11(10), 4319-4327. https://doi.org/10.21037/jtd.2019.09.46
Schmidt, Lars Henning, et al. "Blood clot removal by cryoextraction in critically ill patients with pulmonary hemorrhage." Journal of thoracic disease vol. 11,10 (2019): 4319-4327. doi: https://doi.org/10.21037/jtd.2019.09.46
Schmidt LH, Schulze AB, Goerlich D, Schliemann C, Kessler T, Rottmann V, den Toom D, Rosenow F, Sackarnd J, Evers G, Mohr M. Blood clot removal by cryoextraction in critically ill patients with pulmonary hemorrhage. J Thorac Dis. 2019 Oct;11(10):4319-4327. doi: 10.21037/jtd.2019.09.46. PMID: 31737317; PMCID: PMC6837984.
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Stereotactic Body Radiation Therapy after Chemotherapy for Unresectable Perihilar Cholangiocarcinoma: The STRONG Trial, a Phase I Safety and Feasibility Study.

Cancers

Baak R, Willemssen FEJA, van Norden Y, Eskens FALM, Milder MTW, Heijmen BJM, Koerkamp BG, Sprengers D, van Driel LMJW, Klümpen HJ, den Toom W, Koedijk MS, IJzermans JNM, Méndez Romero A.
PMID: 34439146
Cancers (Basel). 2021 Aug 07;13(16). doi: 10.3390/cancers13163991.

BACKGROUND: In unresectable pCCA, the standard of care is palliative chemotherapy. We investigated the feasibility and safety of adding stereotactic body radiation therapy (SBRT) after chemotherapy.METHODS: Patients with unresectable pCCA, stage T1-T4N0-N1M0, ECOG 0-1, having finished 6-8 cycles of...

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Baak R, Willemssen FEJA, van Norden Y, et al. Stereotactic Body Radiation Therapy after Chemotherapy for Unresectable Perihilar Cholangiocarcinoma: The STRONG Trial, a Phase I Safety and Feasibility Study. Cancers (Basel). 2021;13(16)doi: 10.3390/cancers13163991.
Baak, R., Willemssen, F. E. J. A., van Norden, Y., Eskens, F. A. L. M., Milder, M. T. W., Heijmen, B. J. M., Koerkamp, B. G., Sprengers, D., van Driel, L. M. J. W., Klümpen, H. J., den Toom, W., Koedijk, M. S., IJzermans, J. N. M., & Méndez Romero, A. (2021). Stereotactic Body Radiation Therapy after Chemotherapy for Unresectable Perihilar Cholangiocarcinoma: The STRONG Trial, a Phase I Safety and Feasibility Study. Cancers, 13(16), . https://doi.org/10.3390/cancers13163991
Baak, Rogier, et al. "Stereotactic Body Radiation Therapy after Chemotherapy for Unresectable Perihilar Cholangiocarcinoma: The STRONG Trial, a Phase I Safety and Feasibility Study." Cancers vol. 13,16 (2021). doi: https://doi.org/10.3390/cancers13163991
Baak R, Willemssen FEJA, van Norden Y, Eskens FALM, Milder MTW, Heijmen BJM, Koerkamp BG, Sprengers D, van Driel LMJW, Klümpen HJ, den Toom W, Koedijk MS, IJzermans JNM, Méndez Romero A. Stereotactic Body Radiation Therapy after Chemotherapy for Unresectable Perihilar Cholangiocarcinoma: The STRONG Trial, a Phase I Safety and Feasibility Study. Cancers (Basel). 2021 Aug 07;13(16). doi: 10.3390/cancers13163991. PMID: 34439146; PMCID: PMC8394718.
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