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Discrepancy between Bioavailability and Hypotensive Effect of Oral and Sublingual Nifedipine.

American journal of therapeutics

Palma-Aguirre JA, Montoya-Cabrera MA, du Souich P, Hoyo-Vadillo C, Flores-Murrieta FJ, Castañeda-Hernández G.
PMID: 11850640
Am J Ther. 1995 Jan;2(1):3-9. doi: 10.1097/00045391-199501000-00002.

Nifedipine, 10-mg capsules, were given orally and sublingually to six healthy volunteers according to a randomized crossover design. Nifedipine plasma levels, blood pressure, and heart rate were determined at several times after medication. C(max) was higher (134 plus minus...

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Palma-Aguirre JA, Montoya-Cabrera MA, du Souich P, et al. Discrepancy between Bioavailability and Hypotensive Effect of Oral and Sublingual Nifedipine. Am J Ther. 1995;2(1):3-9doi: 10.1097/00045391-199501000-00002.
Palma-Aguirre, J. A., Montoya-Cabrera, M. A., du Souich, P., Hoyo-Vadillo, C., Flores-Murrieta, F. J., & Castañeda-Hernández, G. (1995). Discrepancy between Bioavailability and Hypotensive Effect of Oral and Sublingual Nifedipine. American journal of therapeutics, 2(1), 3-9. https://doi.org/10.1097/00045391-199501000-00002
Palma-Aguirre, J. A., et al. "Discrepancy between Bioavailability and Hypotensive Effect of Oral and Sublingual Nifedipine." American journal of therapeutics vol. 2,1 (1995): 3-9. doi: https://doi.org/10.1097/00045391-199501000-00002
Palma-Aguirre JA, Montoya-Cabrera MA, du Souich P, Hoyo-Vadillo C, Flores-Murrieta FJ, Castañeda-Hernández G. Discrepancy between Bioavailability and Hypotensive Effect of Oral and Sublingual Nifedipine. Am J Ther. 1995 Jan;2(1):3-9. doi: 10.1097/00045391-199501000-00002. PMID: 11850640.
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A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain.

Current oncology (Toronto, Ont.)

Hagen NA, Lapointe B, Ong-Lam M, Dubuc B, Walde D, Gagnon B, Love R, Goel R, Hawley P, Ngoc AH, du Souich P.
PMID: 21655148
Curr Oncol. 2011 Jun;18(3):e109-16. doi: 10.3747/co.v18i3.732.

BACKGROUND: Cancer pain is highly prevalent, and existing treatments are often insufficient to provide adequate relief.OBJECTIVES: We assessed the long-term safety and efficacy of subcutaneous tetrodotoxin treatment in reducing the intensity of chronic cancer-related pain.METHODS: In this multicentre open-label...

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Hagen NA, Lapointe B, Ong-Lam M, et al. A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain. Curr Oncol. 2011;18(3):e109-16doi: 10.3747/co.v18i3.732.
Hagen, N. A., Lapointe, B., Ong-Lam, M., Dubuc, B., Walde, D., Gagnon, B., Love, R., Goel, R., Hawley, P., Ngoc, A. H., & du Souich, P. (2011). A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain. Current oncology (Toronto, Ont.), 18(3), e109-16. https://doi.org/10.3747/co.v18i3.732
Hagen, N A, et al. "A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain." Current oncology (Toronto, Ont.) vol. 18,3 (2011): e109-16. doi: https://doi.org/10.3747/co.v18i3.732
Hagen NA, Lapointe B, Ong-Lam M, Dubuc B, Walde D, Gagnon B, Love R, Goel R, Hawley P, Ngoc AH, du Souich P. A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain. Curr Oncol. 2011 Jun;18(3):e109-16. doi: 10.3747/co.v18i3.732. PMID: 21655148; PMCID: PMC3108870.
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After genomic testing results: Parents' long-term views.

Journal of genetic counseling

Liang NSY, Adam S, Elliott AM, Siemens A, du Souich C, Friedman JM, Birch P.
PMID: 34165210
J Genet Couns. 2021 Jun 24; doi: 10.1002/jgc4.1454. Epub 2021 Jun 24.

Many parents are motivated to pursue genome-wide (exome or genome) sequencing to find a diagnosis for their child with a suspected but undiagnosed genetic condition. However, the impact of the genomic test extends beyond the provision of results and...

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Liang NSY, Adam S, Elliott AM, et al. After genomic testing results: Parents' long-term views. J Genet Couns. 2021;doi: 10.1002/jgc4.1454.
Liang, N. S. Y., Adam, S., Elliott, A. M., Siemens, A., du Souich, C., Friedman, J. M., & Birch, P. (2021). After genomic testing results: Parents' long-term views. Journal of genetic counseling, . https://doi.org/10.1002/jgc4.1454
Liang, Nicole Si Yan, et al. "After genomic testing results: Parents' long-term views." Journal of genetic counseling vol. (2021). doi: https://doi.org/10.1002/jgc4.1454
Liang NSY, Adam S, Elliott AM, Siemens A, du Souich C, Friedman JM, Birch P. After genomic testing results: Parents' long-term views. J Genet Couns. 2021 Jun 24; doi: 10.1002/jgc4.1454. Epub 2021 Jun 24. PMID: 34165210.
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Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications.

Cold Spring Harbor molecular case studies

Cook CB, Armstrong L, Boerkoel CF, Clarke LA, du Souich C, Demos MK, Gibson WT, Gill H, Lopez E, Patel MS, Selby K, Abu-Sharar Z, Elliott AM, Friedman JM.
PMID: 34697084
Cold Spring Harb Mol Case Stud. 2021 Dec 09;7(6). doi: 10.1101/mcs.a006125. Print 2021 Dec.

Identifying genetic mosaicism is important in establishing a diagnosis, assessing recurrence risk, and providing accurate genetic counseling. Next-generation sequencing has allowed for the identification of mosaicism at levels below those detectable by conventional Sanger sequencing or chromosomal microarray analysis....

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Cook CB, Armstrong L, Boerkoel CF, et al. Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications. Cold Spring Harb Mol Case Stud. 2021;7(6)doi: 10.1101/mcs.a006125.
Cook, C. B., Armstrong, L., Boerkoel, C. F., Clarke, L. A., du Souich, C., Demos, M. K., Gibson, W. T., Gill, H., Lopez, E., Patel, M. S., Selby, K., Abu-Sharar, Z., Elliott, A. M., & Friedman, J. M. (2021). Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications. Cold Spring Harbor molecular case studies, 7(6), . https://doi.org/10.1101/mcs.a006125
Cook, Courtney B, et al. "Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications." Cold Spring Harbor molecular case studies vol. 7,6 (2021). doi: https://doi.org/10.1101/mcs.a006125
Cook CB, Armstrong L, Boerkoel CF, Clarke LA, du Souich C, Demos MK, Gibson WT, Gill H, Lopez E, Patel MS, Selby K, Abu-Sharar Z, Elliott AM, Friedman JM. Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications. Cold Spring Harb Mol Case Stud. 2021 Dec 09;7(6). doi: 10.1101/mcs.a006125. Print 2021 Dec. PMID: 34697084.
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The Genomic Consultation Service: A clinical service designed to improve patient selection for genome-wide sequencing in British Columbia.

Molecular genetics & genomic medicine

Elliott AM, du Souich C, Adam S, Dragojlovic N, van Karnebeek C, Nelson TN, Lehman A, Lynd LD, Friedman JM.
PMID: 29851296
Mol Genet Genomic Med. 2018 May 30; doi: 10.1002/mgg3.410. Epub 2018 May 30.

BACKGROUND: Access to clinical diagnostic genome-wide sequencing (GWS; exome or whole genome sequencing) is limited in British Columbia. The establishment of a translational research initiative (CAUSES) to provide diagnostic genome-wide sequencing for 500 children necessitated the development of a...

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Elliott AM, du Souich C, Adam S, et al. The Genomic Consultation Service: A clinical service designed to improve patient selection for genome-wide sequencing in British Columbia. Mol Genet Genomic Med. 2018;doi: 10.1002/mgg3.410.
Elliott, A. M., du Souich, C., Adam, S., Dragojlovic, N., van Karnebeek, C., Nelson, T. N., Lehman, A., Lynd, L. D., & Friedman, J. M. (2018). The Genomic Consultation Service: A clinical service designed to improve patient selection for genome-wide sequencing in British Columbia. Molecular genetics & genomic medicine, . https://doi.org/10.1002/mgg3.410
Elliott, Alison M, et al. "The Genomic Consultation Service: A clinical service designed to improve patient selection for genome-wide sequencing in British Columbia." Molecular genetics & genomic medicine vol. (2018). doi: https://doi.org/10.1002/mgg3.410
Elliott AM, du Souich C, Adam S, Dragojlovic N, van Karnebeek C, Nelson TN, Lehman A, Lynd LD, Friedman JM. The Genomic Consultation Service: A clinical service designed to improve patient selection for genome-wide sequencing in British Columbia. Mol Genet Genomic Med. 2018 May 30; doi: 10.1002/mgg3.410. Epub 2018 May 30. PMID: 29851296; PMCID: PMC6081221.
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Inflammatory reactions and drug response: importance of cytochrome P450 and membrane transporters.

Expert review of clinical pharmacology

Dumais G, Iovu M, du Souich P.
PMID: 24422735
Expert Rev Clin Pharmacol. 2008 Sep;1(5):627-47. doi: 10.1586/17512433.1.5.627.

Inflammatory reactions (IRs), both infectious and aseptic, downregulate numerous enzymes of cytochrome P450 (CYP) and ATP-binding cassette transporters. The mechanism involves proinflammatory cytokines and activation of transcription factors, nuclear factor-κB, CCAAT-enhancer-binding protein-β and c-myc, which bind to negative regulatory...

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Dumais G, Iovu M, du Souich P. Inflammatory reactions and drug response: importance of cytochrome P450 and membrane transporters. Expert Rev Clin Pharmacol. 2008;1(5):627-47doi: 10.1586/17512433.1.5.627.
Dumais, G., Iovu, M., & du Souich, P. (2008). Inflammatory reactions and drug response: importance of cytochrome P450 and membrane transporters. Expert review of clinical pharmacology, 1(5), 627-47. https://doi.org/10.1586/17512433.1.5.627
Dumais, Guillaume, et al. "Inflammatory reactions and drug response: importance of cytochrome P450 and membrane transporters." Expert review of clinical pharmacology vol. 1,5 (2008): 627-47. doi: https://doi.org/10.1586/17512433.1.5.627
Dumais G, Iovu M, du Souich P. Inflammatory reactions and drug response: importance of cytochrome P450 and membrane transporters. Expert Rev Clin Pharmacol. 2008 Sep;1(5):627-47. doi: 10.1586/17512433.1.5.627. PMID: 24422735.
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Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications.

Cold Spring Harbor molecular case studies

Cook CB, Armstrong L, Boerkoel CF, Clarke LA, du Souich C, Demos MK, Gibson WT, Gill H, Lopez E, Patel MS, Selby K, Abu-Sharar Z, Elliott AM, Friedman JM.
PMID: 34697084
Cold Spring Harb Mol Case Stud. 2021 Dec 09;7(6). doi: 10.1101/mcs.a006125. Print 2021 Dec.

Identifying genetic mosaicism is important in establishing a diagnosis, assessing recurrence risk, and providing accurate genetic counseling. Next-generation sequencing has allowed for the identification of mosaicism at levels below those detectable by conventional Sanger sequencing or chromosomal microarray analysis....

Cite
Cook CB, Armstrong L, Boerkoel CF, et al. Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications. Cold Spring Harb Mol Case Stud. 2021;7(6)doi: 10.1101/mcs.a006125.
Cook, C. B., Armstrong, L., Boerkoel, C. F., Clarke, L. A., du Souich, C., Demos, M. K., Gibson, W. T., Gill, H., Lopez, E., Patel, M. S., Selby, K., Abu-Sharar, Z., Elliott, A. M., & Friedman, J. M. (2021). Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications. Cold Spring Harbor molecular case studies, 7(6), . https://doi.org/10.1101/mcs.a006125
Cook, Courtney B, et al. "Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications." Cold Spring Harbor molecular case studies vol. 7,6 (2021). doi: https://doi.org/10.1101/mcs.a006125
Cook CB, Armstrong L, Boerkoel CF, Clarke LA, du Souich C, Demos MK, Gibson WT, Gill H, Lopez E, Patel MS, Selby K, Abu-Sharar Z, Elliott AM, Friedman JM. Somatic mosaicism detected by genome-wide sequencing in 500 parent-child trios with suspected genetic disease: clinical and genetic counseling implications. Cold Spring Harb Mol Case Stud. 2021 Dec 09;7(6). doi: 10.1101/mcs.a006125. Print 2021 Dec. PMID: 34697084.
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Showing 1 to 7 of 7 entries