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Showing 1 to 5 of 5 entries
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Microneedling Therapy for Atrophic Acne Scars: An Objective Evaluation.

The Journal of clinical and aesthetic dermatology

El-Domyati M, Barakat M, Awad S, Medhat W, El-Fakahany H, Farag H.
PMID: 26203319
J Clin Aesthet Dermatol. 2015 Jul;8(7):36-42.

OBJECTIVE: Treatment of acne scarring is always a challenge. Microneedling therapy or percutaneous collagen induction is a new addition to the treatment modalities for such scars and has been reported to be simple and effective in atrophic acne scar...

Allosteric Modulation of Muscarinic Acetylcholine Receptors.

Pharmaceuticals (Basel, Switzerland)

Jakubík J, El-Fakahany EE.
PMID: 27713379
Pharmaceuticals (Basel). 2010 Aug 30;3(9):2838-2860. doi: 10.3390/ph3092838.

An allosteric modulator is a ligand that binds to an allosteric site on the receptor and changes receptor conformation to produce increase (positive cooperativity) or decrease (negative cooperativity) in the binding or action of an orthosteric agonist (e.g., acetylcholine)....

Applications and limitations of fitting of the operational model to determine relative efficacies of agonists.

Scientific reports

Jakubík J, Randáková A, Rudajev V, Zimčík P, El-Fakahany EE, Doležal V.
PMID: 30874590
Sci Rep. 2019 Mar 15;9(1):4637. doi: 10.1038/s41598-019-40993-w.

Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is dependent on the system in which it is measured, especially being dependent on receptor expression...

A randomized controlled pilot study of the University of Minnesota mentoring excellence training academy: A hybrid learning approach to research mentor training.

Journal of clinical and translational science

Weber-Main AM, Shanedling J, Kaizer AM, Connett J, Lamere M, El-Fakahany EE.
PMID: 31660240
J Clin Transl Sci. 2019 Jul 18;3(4):152-164. doi: 10.1017/cts.2019.368. eCollection 2019 Aug.

INTRODUCTION: Research mentor training is a valuable professional development activity. Options for training customization (by delivery mode, dosage, content) are needed to address the many critical attributes of effective mentoring relationships and to support mentors in different institutional settings.METHODS:...

The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation.

Cell transplantation

Ibrahim MR, Medhat W, El-Fakahany H, Abdel-Raouf H, Snyder EY.
PMID: 34053245
Cell Transplant. 2021 Jan-Dec;30:9636897211014820. doi: 10.1177/09636897211014820.

When using human induced pluripotent stem cells (hiPSCs) to achieve hair follicle (HF) replacement, we found it best to emulate the earliest fundamental developmental processes of gastrulation, ectodermal lineage commitment, and dermogenesis. Viewing hiPSCs as a model of the...

Showing 1 to 5 of 5 entries