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Co-Presence of Multimorbidity and Disability with Frailty: An Examination of Heterogeneity in the Frail Older Population.

The Journal of frailty & aging

Aarts S, Patel KV, Garcia ME, Van den Akker M, Verhey FR, Metsemakers JF, Van Boxtel MP, Gudnason V, Jonsdottir MK, Siggeirsdottir K, Jonsson PV, Harris TB, Launer LJ.
PMID: 27030941
J Frailty Aging. 2015;4(3):131-8. doi: 10.14283/jfa.2015.45.

BACKGROUND: Frailty is often associated with multimorbidity and disability.OBJECTIVES: We investigated heterogeneity in the frail older population by characterizing five subpopulations according to quantitative biological markers, multimorbidity and disability, and examined their association with mortality and nursing home admission.DESIGN:...

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Aarts S, Patel KV, Garcia ME, et al. Co-Presence of Multimorbidity and Disability with Frailty: An Examination of Heterogeneity in the Frail Older Population. J Frailty Aging. 2015;4(3):131-8doi: 10.14283/jfa.2015.45.
Aarts, S., Patel, K. V., Garcia, M. E., Van den Akker, M., Verhey, F. R., Metsemakers, J. F., Van Boxtel, M. P., Gudnason, V., Jonsdottir, M. K., Siggeirsdottir, K., Jonsson, P. V., Harris, T. B., & Launer, L. J. (2015). Co-Presence of Multimorbidity and Disability with Frailty: An Examination of Heterogeneity in the Frail Older Population. The Journal of frailty & aging, 4(3), 131-8. https://doi.org/10.14283/jfa.2015.45
Aarts, S, et al. "Co-Presence of Multimorbidity and Disability with Frailty: An Examination of Heterogeneity in the Frail Older Population." The Journal of frailty & aging vol. 4,3 (2015): 131-8. doi: https://doi.org/10.14283/jfa.2015.45
Aarts S, Patel KV, Garcia ME, Van den Akker M, Verhey FR, Metsemakers JF, Van Boxtel MP, Gudnason V, Jonsdottir MK, Siggeirsdottir K, Jonsson PV, Harris TB, Launer LJ. Co-Presence of Multimorbidity and Disability with Frailty: An Examination of Heterogeneity in the Frail Older Population. J Frailty Aging. 2015;4(3):131-8. doi: 10.14283/jfa.2015.45. PMID: 27030941; PMCID: PMC5367922.
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Corrigendum to "ice-templating of anisotropic structures with high permeability" [Mater. Sci. Eng. C 76 (2017) 628-636].

Materials science & engineering. C, Materials for biological applications

Pawelec KM, van Boxtel HA, Kluijtmans SGJM.
PMID: 28888017
Mater Sci Eng C Mater Biol Appl. 2017 Dec 01;81:627. doi: 10.1016/j.msec.2017.08.023. Epub 2017 Aug 12.

No abstract available.

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Pawelec KM, van Boxtel HA, Kluijtmans SGJM. Corrigendum to "ice-templating of anisotropic structures with high permeability" [Mater. Sci. Eng. C 76 (2017) 628-636]. Mater Sci Eng C Mater Biol Appl. 2017;81:627doi: 10.1016/j.msec.2017.08.023.
Pawelec, K. M., van Boxtel, H. A., & Kluijtmans, S. G. J. M. (2017). Corrigendum to "ice-templating of anisotropic structures with high permeability" [Mater. Sci. Eng. C 76 (2017) 628-636]. Materials science & engineering. C, Materials for biological applications, 81627. https://doi.org/10.1016/j.msec.2017.08.023
Pawelec, Kendell M, et al. "Corrigendum to "ice-templating of anisotropic structures with high permeability" [Mater. Sci. Eng. C 76 (2017) 628-636]." Materials science & engineering. C, Materials for biological applications vol. 81 (2017): 627. doi: https://doi.org/10.1016/j.msec.2017.08.023
Pawelec KM, van Boxtel HA, Kluijtmans SGJM. Corrigendum to "ice-templating of anisotropic structures with high permeability" [Mater. Sci. Eng. C 76 (2017) 628-636]. Mater Sci Eng C Mater Biol Appl. 2017 Dec 01;81:627. doi: 10.1016/j.msec.2017.08.023. Epub 2017 Aug 12. PMID: 28888017.
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Reevaluating excess success in psychological science.

Psychonomic bulletin & review

van Boxtel JJ, Koch C.
PMID: 26873831
Psychon Bull Rev. 2016 Oct;23(5):1602-1606. doi: 10.3758/s13423-016-1010-0.

Francis (Psychonomic Bulletin Review, 21, 1180-1187, 2014) recently claimed that 82 % of articles with four or more experiments published in Psychological Science between 2009 and 2012 cannot be trusted. We critique Francis' analysis and point out the dependence...

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van Boxtel JJ, Koch C. Reevaluating excess success in psychological science. Psychon Bull Rev. 2016;23(5):1602-1606doi: 10.3758/s13423-016-1010-0.
van Boxtel, J. J., & Koch, C. (2016). Reevaluating excess success in psychological science. Psychonomic bulletin & review, 23(5), 1602-1606. https://doi.org/10.3758/s13423-016-1010-0
van Boxtel, Jeroen J A, and Koch, Christof. "Reevaluating excess success in psychological science." Psychonomic bulletin & review vol. 23,5 (2016): 1602-1606. doi: https://doi.org/10.3758/s13423-016-1010-0
van Boxtel JJ, Koch C. Reevaluating excess success in psychological science. Psychon Bull Rev. 2016 Oct;23(5):1602-1606. doi: 10.3758/s13423-016-1010-0. PMID: 26873831.
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Scaffolding of small groups' metacognitive activities with an avatar.

International journal of computer-supported collaborative learning

Molenaar I, Chiu MM, Sleegers P, van Boxtel C.
PMID: 27069424
Int J Comput Support Collab Learn. 2011;6:601-624. doi: 10.1007/s11412-011-9130-z. Epub 2011 Oct 12.

Metacognitive scaffolding in a computer-supported learning environment can influence students' metacognitive activities, metacognitive knowledge and domain knowledge. In this study we analyze how metacognitive activities mediate the relationships between different avatar scaffolds on students' learning. Multivariate, multilevel analysis of...

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Molenaar I, Chiu MM, Sleegers P, et al. Scaffolding of small groups' metacognitive activities with an avatar. Int J Comput Support Collab Learn. 2011;6:601-624doi: 10.1007/s11412-011-9130-z.
Molenaar, I., Chiu, M. M., Sleegers, P., & van Boxtel, C. (2011). Scaffolding of small groups' metacognitive activities with an avatar. International journal of computer-supported collaborative learning, 6601-624. https://doi.org/10.1007/s11412-011-9130-z
Molenaar, Inge, et al. "Scaffolding of small groups' metacognitive activities with an avatar." International journal of computer-supported collaborative learning vol. 6 (2011): 601-624. doi: https://doi.org/10.1007/s11412-011-9130-z
Molenaar I, Chiu MM, Sleegers P, van Boxtel C. Scaffolding of small groups' metacognitive activities with an avatar. Int J Comput Support Collab Learn. 2011;6:601-624. doi: 10.1007/s11412-011-9130-z. Epub 2011 Oct 12. PMID: 27069424; PMCID: PMC4811593.
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Is recurrent processing necessary and/or sufficient for consciousness?.

Cognitive neuroscience

Tsuchiya N, van Boxtel JJ.
PMID: 24168345
Cogn Neurosci. 2010 Sep;1(3):230-1. doi: 10.1080/17588928.2010.497582.

Abstract Abstract While we agree with Lamme's general framework, we are not so convinced by his mapping between psychological concepts with their underlying neuronal mechanisms. Specifically, we doubt if recurrent processing is either necessary or sufficient for consciousness. A...

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Tsuchiya N, van Boxtel JJ. Is recurrent processing necessary and/or sufficient for consciousness?. Cogn Neurosci. 2010;1(3):230-1doi: 10.1080/17588928.2010.497582.
Tsuchiya, N., & van Boxtel, J. J. (2010). Is recurrent processing necessary and/or sufficient for consciousness?. Cognitive neuroscience, 1(3), 230-1. https://doi.org/10.1080/17588928.2010.497582
Tsuchiya, Naotsugu, and van Boxtel, Jeroen J A. "Is recurrent processing necessary and/or sufficient for consciousness?." Cognitive neuroscience vol. 1,3 (2010): 230-1. doi: https://doi.org/10.1080/17588928.2010.497582
Tsuchiya N, van Boxtel JJ. Is recurrent processing necessary and/or sufficient for consciousness?. Cogn Neurosci. 2010 Sep;1(3):230-1. doi: 10.1080/17588928.2010.497582. PMID: 24168345.
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The Body Action Coding System II: muscle activations during the perception and expression of emotion.

Frontiers in behavioral neuroscience

Huis In 't Veld EM, van Boxtel GJ, de Gelder B.
PMID: 25294993
Front Behav Neurosci. 2014 Sep 23;8:330. doi: 10.3389/fnbeh.2014.00330. eCollection 2014.

Research into the expression and perception of emotions has mostly focused on facial expressions. Recently, body postures have become increasingly important in research, but knowledge on muscle activity during the perception or expression of emotion is lacking. The current...

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Huis In 't Veld EM, van Boxtel GJ, de Gelder B. The Body Action Coding System II: muscle activations during the perception and expression of emotion. Front Behav Neurosci. 2014;8:330doi: 10.3389/fnbeh.2014.00330.
Huis In 't Veld, E. M., van Boxtel, G. J., & de Gelder, B. (2014). The Body Action Coding System II: muscle activations during the perception and expression of emotion. Frontiers in behavioral neuroscience, 8330. https://doi.org/10.3389/fnbeh.2014.00330
Huis In 't Veld, Elisabeth M J, et al. "The Body Action Coding System II: muscle activations during the perception and expression of emotion." Frontiers in behavioral neuroscience vol. 8 (2014): 330. doi: https://doi.org/10.3389/fnbeh.2014.00330
Huis In 't Veld EM, van Boxtel GJ, de Gelder B. The Body Action Coding System II: muscle activations during the perception and expression of emotion. Front Behav Neurosci. 2014 Sep 23;8:330. doi: 10.3389/fnbeh.2014.00330. eCollection 2014. PMID: 25294993; PMCID: PMC4172051.
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Dependence of reproduction rate on pressure as a hallmark of deep-sea bacteria.

Applied and environmental microbiology

Yayanos AA, Dietz AS, Van Boxtel R.
PMID: 16346153
Appl Environ Microbiol. 1982 Dec;44(6):1356-61. doi: 10.1128/aem.44.6.1356-1361.1982.

Strains of bacteria in axenic culture were isolated from samples of depths between 1,957 and 10,476 m of the Pacific Ocean. All of the bacteria from this range of depths were barophilic. The pressure at which the rate of...

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Yayanos AA, Dietz AS, Van Boxtel R. Dependence of reproduction rate on pressure as a hallmark of deep-sea bacteria. Appl Environ Microbiol. 1982;44(6):1356-61doi: 10.1128/aem.44.6.1356-1361.1982.
Yayanos, A. A., Dietz, A. S., & Van Boxtel, R. (1982). Dependence of reproduction rate on pressure as a hallmark of deep-sea bacteria. Applied and environmental microbiology, 44(6), 1356-61. https://doi.org/10.1128/aem.44.6.1356-1361.1982
Yayanos, A A, et al. "Dependence of reproduction rate on pressure as a hallmark of deep-sea bacteria." Applied and environmental microbiology vol. 44,6 (1982): 1356-61. doi: https://doi.org/10.1128/aem.44.6.1356-1361.1982
Yayanos AA, Dietz AS, Van Boxtel R. Dependence of reproduction rate on pressure as a hallmark of deep-sea bacteria. Appl Environ Microbiol. 1982 Dec;44(6):1356-61. doi: 10.1128/aem.44.6.1356-1361.1982. PMID: 16346153; PMCID: PMC242196.
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Comprehensive headspace gas chromatographic analysis of denaturants in denatured ethanol.

Journal of separation science

van Boxtel N, Wolfs K, Guillén Palacín M, Van Schepdael A, Adams E.
PMID: 28792108
J Sep Sci. 2017 Oct;40(20):4004-4011. doi: 10.1002/jssc.201700468. Epub 2017 Aug 31.

To discourage consumption, ethanol is often denatured using both volatile (e.g., methyl ethyl ketone and isopropanol) and nonvolatile (e.g., denatonium benzoate) chemical substances. As a result, the analysis of denatured ethanol samples is usually performed by multiple techniques such...

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van Boxtel N, Wolfs K, Guillén Palacín M, et al. Comprehensive headspace gas chromatographic analysis of denaturants in denatured ethanol. J Sep Sci. 2017;40(20):4004-4011doi: 10.1002/jssc.201700468.
van Boxtel, N., Wolfs, K., Guillén Palacín, M., Van Schepdael, A., & Adams, E. (2017). Comprehensive headspace gas chromatographic analysis of denaturants in denatured ethanol. Journal of separation science, 40(20), 4004-4011. https://doi.org/10.1002/jssc.201700468
van Boxtel, Niels, et al. "Comprehensive headspace gas chromatographic analysis of denaturants in denatured ethanol." Journal of separation science vol. 40,20 (2017): 4004-4011. doi: https://doi.org/10.1002/jssc.201700468
van Boxtel N, Wolfs K, Guillén Palacín M, Van Schepdael A, Adams E. Comprehensive headspace gas chromatographic analysis of denaturants in denatured ethanol. J Sep Sci. 2017 Oct;40(20):4004-4011. doi: 10.1002/jssc.201700468. Epub 2017 Aug 31. PMID: 28792108.
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Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth.

Biotechnology for biofuels

Du W, Jongbloets JA, van Boxtel C, Pineda Hernández H, Lips D, Oliver BG, Hellingwerf KJ, Branco Dos Santos F.
PMID: 29456625
Biotechnol Biofuels. 2018 Feb 13;11:38. doi: 10.1186/s13068-018-1037-8. eCollection 2018.

BACKGROUND: Microbial bioengineering has the potential to become a key contributor to the future development of human society by providing sustainable, novel, and cost-effective production pipelines. However, the sustained productivity of genetically engineered strains is often a challenge, as...

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Du W, Jongbloets JA, van Boxtel C, et al. Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth. Biotechnol Biofuels. 2018;11:38doi: 10.1186/s13068-018-1037-8.
Du, W., Jongbloets, J. A., van Boxtel, C., Pineda Hernández, H., Lips, D., Oliver, B. G., Hellingwerf, K. J., & Branco Dos Santos, F. (2018). Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth. Biotechnology for biofuels, 1138. https://doi.org/10.1186/s13068-018-1037-8
Du, Wei, et al. "Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth." Biotechnology for biofuels vol. 11 (2018): 38. doi: https://doi.org/10.1186/s13068-018-1037-8
Du W, Jongbloets JA, van Boxtel C, Pineda Hernández H, Lips D, Oliver BG, Hellingwerf KJ, Branco Dos Santos F. Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth. Biotechnol Biofuels. 2018 Feb 13;11:38. doi: 10.1186/s13068-018-1037-8. eCollection 2018. PMID: 29456625; PMCID: PMC5809919.
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Cone-Beam CT-based position verification for oesophageal cancer: Evaluation of registration methods and anatomical changes during radiotherapy.

Technical innovations & patient support in radiation oncology

van Nunen A, van der Sangen MJC, van Boxtel M, van Haaren PMA.
PMID: 32095564
Tech Innov Patient Support Radiat Oncol. 2017 Sep 23;3:30-36. doi: 10.1016/j.tipsro.2017.07.002. eCollection 2017.

PURPOSE: To evaluate different registration methods, setup margins and number of corrections for CBCT-based position verification for oesophageal cancer and to evaluate anatomical changes during the course of radiotherapy treatment.METHODS: From 50 patients, 440 CBCT-scans were registered automatically using...

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van Nunen A, van der Sangen MJC, van Boxtel M, et al. Cone-Beam CT-based position verification for oesophageal cancer: Evaluation of registration methods and anatomical changes during radiotherapy. Tech Innov Patient Support Radiat Oncol. 2017;3:30-36doi: 10.1016/j.tipsro.2017.07.002.
van Nunen, A., van der Sangen, M. J. C., van Boxtel, M., & van Haaren, P. M. A. (2017). Cone-Beam CT-based position verification for oesophageal cancer: Evaluation of registration methods and anatomical changes during radiotherapy. Technical innovations & patient support in radiation oncology, 330-36. https://doi.org/10.1016/j.tipsro.2017.07.002
van Nunen, A, et al. "Cone-Beam CT-based position verification for oesophageal cancer: Evaluation of registration methods and anatomical changes during radiotherapy." Technical innovations & patient support in radiation oncology vol. 3 (2017): 30-36. doi: https://doi.org/10.1016/j.tipsro.2017.07.002
van Nunen A, van der Sangen MJC, van Boxtel M, van Haaren PMA. Cone-Beam CT-based position verification for oesophageal cancer: Evaluation of registration methods and anatomical changes during radiotherapy. Tech Innov Patient Support Radiat Oncol. 2017 Sep 23;3:30-36. doi: 10.1016/j.tipsro.2017.07.002. eCollection 2017. PMID: 32095564; PMCID: PMC7033772.
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Does It Matter Whether You or Your Brain Did It? An Empirical Investigation of the Influence of the Double Subject Fallacy on Moral Responsibility Judgments.

Frontiers in psychology

Maoz U, Sita KR, van Boxtel JJA, Mudrik L.
PMID: 31114527
Front Psychol. 2019 Apr 30;10:950. doi: 10.3389/fpsyg.2019.00950. eCollection 2019.

Despite progress in cognitive neuroscience, we are still far from understanding the relations between the brain and the conscious self. We previously suggested that some neuroscientific texts that attempt to clarify these relations may in fact make them more...

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Maoz U, Sita KR, van Boxtel JJA, et al. Does It Matter Whether You or Your Brain Did It? An Empirical Investigation of the Influence of the Double Subject Fallacy on Moral Responsibility Judgments. Front Psychol. 2019;10:950doi: 10.3389/fpsyg.2019.00950.
Maoz, U., Sita, K. R., van Boxtel, J. J. A., & Mudrik, L. (2019). Does It Matter Whether You or Your Brain Did It? An Empirical Investigation of the Influence of the Double Subject Fallacy on Moral Responsibility Judgments. Frontiers in psychology, 10950. https://doi.org/10.3389/fpsyg.2019.00950
Maoz, Uri, et al. "Does It Matter Whether You or Your Brain Did It? An Empirical Investigation of the Influence of the Double Subject Fallacy on Moral Responsibility Judgments." Frontiers in psychology vol. 10 (2019): 950. doi: https://doi.org/10.3389/fpsyg.2019.00950
Maoz U, Sita KR, van Boxtel JJA, Mudrik L. Does It Matter Whether You or Your Brain Did It? An Empirical Investigation of the Influence of the Double Subject Fallacy on Moral Responsibility Judgments. Front Psychol. 2019 Apr 30;10:950. doi: 10.3389/fpsyg.2019.00950. eCollection 2019. PMID: 31114527; PMCID: PMC6502898.
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Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.

Communications biology

Nguyen L, Jager M, Lieshout R, de Ruiter PE, Locati MD, Besselink N, van der Roest B, Janssen R, Boymans S, de Jonge J, IJzermans JNM, Doukas M, Verstegen MMA, van Boxtel R, van der Laan LJW, Cuppen E, Kuijk E.
PMID: 34795391
Commun Biol. 2021 Nov 18;4(1):1301. doi: 10.1038/s42003-021-02839-y.

Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here, we performed whole-genome sequencing on clonally expanded single liver...

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Nguyen L, Jager M, Lieshout R, et al. Precancerous liver diseases do not cause increased mutagenesis in liver stem cells. Commun Biol. 2021;4(1):1301doi: 10.1038/s42003-021-02839-y.
Nguyen, L., Jager, M., Lieshout, R., de Ruiter, P. E., Locati, M. D., Besselink, N., van der Roest, B., Janssen, R., Boymans, S., de Jonge, J., IJzermans, J. N. M., Doukas, M., Verstegen, M. M. A., van Boxtel, R., van der Laan, L. J. W., Cuppen, E., & Kuijk, E. (2021). Precancerous liver diseases do not cause increased mutagenesis in liver stem cells. Communications biology, 4(1), 1301. https://doi.org/10.1038/s42003-021-02839-y
Nguyen, Luan, et al. "Precancerous liver diseases do not cause increased mutagenesis in liver stem cells." Communications biology vol. 4,1 (2021): 1301. doi: https://doi.org/10.1038/s42003-021-02839-y
Nguyen L, Jager M, Lieshout R, de Ruiter PE, Locati MD, Besselink N, van der Roest B, Janssen R, Boymans S, de Jonge J, IJzermans JNM, Doukas M, Verstegen MMA, van Boxtel R, van der Laan LJW, Cuppen E, Kuijk E. Precancerous liver diseases do not cause increased mutagenesis in liver stem cells. Commun Biol. 2021 Nov 18;4(1):1301. doi: 10.1038/s42003-021-02839-y. PMID: 34795391; PMCID: PMC8602268.
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