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Showing 1 to 12 of 48 entries
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Future science OA

Meijer TG, Naipal KA, Jager A, van Gent DC.
PMID: 28670477
Future Sci OA. 2017 Mar 27;3(2):FSO190. doi: 10.4155/fsoa-2017-0003. eCollection 2017 Jun.

Optimal patient stratification is of utmost importance in the era of personalized medicine. Prediction of individual treatment responses by functional

Complete Genome Sequences of 11 Bordetella pertussis Strains Representing the Pandemic ptxP3 Lineage.

Genome announcements

Bart MJ, van der Heide HG, Zeddeman A, Heuvelman K, van Gent M, Mooi FR.
PMID: 26607899
Genome Announc. 2015 Nov 25;3(6). doi: 10.1128/genomeA.01394-15.

Pathogen adaptation has contributed to the resurgence of pertussis. To facilitate our understanding of this adaptation we report here 11 completely closed and annotated Bordetella pertussis genomes representing the pandemic ptxP3 lineage. Our analyses included six strains which do...

Exclusion as urban policy: The Dutch 'Act on Extraordinary Measures for Urban Problems'.

Urban studies (Edinburgh, Scotland)

van Gent W, Hochstenbach C, Uitermark J.
PMID: 30443086
Urban Stud. 2018 Aug;55(11):2337-2353. doi: 10.1177/0042098017717214. Epub 2017 Jul 27.

The Dutch government introduced the Act on Extraordinary Measures for Urban Problems in 2006 to bolster local regeneration efforts. The act enables local governments to stop specific groups of deprived households from moving into designated neighbourhoods. More specifically, the...

Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study.

Diagnostics (Basel, Switzerland)

van der Werf NR, van Gent M, Booij R, Bos D, van der Lugt A, Budde RPJ, Greuter MJW, van Straten M.
PMID: 34943428
Diagnostics (Basel). 2021 Nov 25;11(12). doi: 10.3390/diagnostics11122192.

In order to assess coronary artery calcium (CAC) quantification reproducibility for photon-counting computed tomography (PCCT) at reduced tube potential, an anthropomorphic thorax phantom with low-, medium-, and high-density CAC inserts was scanned with PCCT (NAEOTOM Alpha, Siemens Healthineers) at...

Mental health and well-being of university staff during the coronavirus disease 2019 levels 4 and 5 lockdown in an Eastern Cape university, South Africa.

The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa

van Niekerk RL, van Gent MM.
PMID: 33824757
S Afr J Psychiatr. 2021 Mar 08;27:1589. doi: 10.4102/sajpsychiatry.v27i0.1589. eCollection 2021.

BACKGROUND: The mental health of university staff members is often neglected and might have been exacerbated during the coronavirus disease 2019 (COVID-19) pandemic.AIM: The aim of this study was to determine the mental health and well-being of staff members...

Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: the effect of electrosurgery on tissue discrimination using ex vivo animal tissue models.

Biomedical optics express

Amiri SA, Van Gent CM, Dankelman J, Hendriks BHW.
PMID: 32499933
Biomed Opt Express. 2020 Apr 07;11(5):2402-2415. doi: 10.1364/BOE.385621. eCollection 2020 May 01.

Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance...

The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.

Cancers

van Wijk LM, Vermeulen S, Meijers M, van Diest MF, Ter Haar NT, de Jonge MM, Solleveld-Westerink N, van Wezel T, van Gent DC, Kroep JR, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG.
PMID: 33003546
Cancers (Basel). 2020 Sep 29;12(10). doi: 10.3390/cancers12102805.

Recent studies have shown that the efficacy of PARP inhibitors in epithelial ovarian carcinoma (EOC) is related to tumor-specific defects in homologous recombination (HR) and extends beyond

The US3 kinase of Herpes Simplex virus phosphorylates the RNA sensor RIG-I to suppress innate immunity.

Journal of virology

van Gent M, Chiang JJ, Muppala S, Chiang C, Azab W, Kattenhorn L, Knipe DM, Osterrieder N, Gack MU.
PMID: 34935440
J Virol. 2021 Dec 22;JVI0151021. doi: 10.1128/JVI.01510-21. Epub 2021 Dec 22.

Recent studies demonstrated that the signaling activity of the cytosolic pathogen sensor retinoic acid-inducible gene-I (RIG-I) is modulated by a variety of post-translational modifications (PTMs) to fine-tune the antiviral type I interferon (IFN) response. Whereas K63-linked ubiquitination of the...

A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.

Cancer research

Pulver EM, Mukherjee C, van de Kamp G, Roobol SJ, Rother MB, van der Gulden H, de Bruijn R, Lattanzio MV, van der Burg E, Drenth AP, Verkaik NS, Hahn K, Klarenbeek S, de Korte-Grimmerink R, van de Ven M, Pritchard CEJ, Huijbers IJ, Xia B, van Gent DC, Essers J, van Attikum H, Ray Chaudhuri A, Bouwman P, Jonkers J.
PMID: 34548335
Cancer Res. 2021 Dec 15;81(24):6171-6182. doi: 10.1158/0008-5472.CAN-21-1415. Epub 2021 Sep 21.

The

Guide-free Cas9 from pathogenic .

Science advances

Saha C, Mohanraju P, Stubbs A, Dugar G, Hoogstrate Y, Kremers GJ, van Cappellen WA, Horst-Kreft D, Laffeber C, Lebbink JHG, Bruens S, Gaskin D, Beerens D, Klunder M, Joosten R, Demmers JAA, van Gent D, Mouton JW, van der Spek PJ, van der Oost J, van Baarlen P, Louwen R.
PMID: 32596446
Sci Adv. 2020 Jun 17;6(25):eaaz4849. doi: 10.1126/sciadv.aaz4849. eCollection 2020 Jun.

CRISPR-Cas9 systems are enriched in human pathogenic bacteria and have been linked to cytotoxicity by an unknown mechanism. Here, we show that upon infection of human cells,

Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair.

Cancers

Zhang W, Liao CY, Chtatou H, Incrocci L, van Gent DC, van Weerden WM, Nonnekens J.
PMID: 31635359
Cancers (Basel). 2019 Oct 18;11(10). doi: 10.3390/cancers11101593.

Androgen-deprivation therapy was shown to improve treatment outcome of external beam radiation therapy (EBRT) for locally advanced prostate cancer (PCa). DNA damage response (DDR) was suggested to play a role in the underlying mechanism, but conflicting results were reported....

Fertility-sparing treatment in early endometrial cancer: current state and future strategies.

Obstetrics & gynecology science

Obermair A, Baxter E, Brennan DJ, McAlpine JN, Muellerer JJ, Amant F, van Gent MDJM, Coleman RL, Westin SN, Yates MS, Krakstad C, Janda M.
PMID: 32689770
Obstet Gynecol Sci. 2020 Jul;63(4):417-431. doi: 10.5468/ogs.19169. Epub 2020 Jul 08.

Endometrial cancer (EC) is the fifth most common cancer in women worldwide. Global estimates show rising incidence rates in both developed and developing countries. Most women are diagnosed postmenopausal, but 14-25% of patients are premenopausal and 5% are under...

Showing 1 to 12 of 48 entries