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Showing 1 to 12 of 14 entries
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Association of Genetic Variant at Chromosome 12q23.1 With Neuropathic Pain Susceptibility.

JAMA network open

Veluchamy A, Hébert HL, van Zuydam NR, Pearson ER, Campbell A, Hayward C, Meng W, McCarthy MI, Bennett DLH, Palmer CNA, Smith BH.
PMID: 34854908
JAMA Netw Open. 2021 Dec 01;4(12):e2136560. doi: 10.1001/jamanetworkopen.2021.36560.

IMPORTANCE: Neuropathic pain (NP) has important clinical and socioeconomic consequences for individuals and society. Increasing evidence indicates that genetic factors make a significant contribution to NP, but genome-wide association studies (GWASs) are scant in this field and could help...

Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat.

Molecular pharmaceutics

Berg S, Kärrberg L, Suljovic D, Seeliger F, Söderberg M, Perez-Alcazar M, Van Zuydam N, Abrahamsson B, Hugerth AM, Davies N, Bergström CAS.
PMID: 34928160
Mol Pharm. 2021 Dec 20; doi: 10.1021/acs.molpharmaceut.1c00724. Epub 2021 Dec 20.

In this work, we set out to better understand how the permeation enhancer sodium caprate (C10) influences the intestinal absorption of macromolecules. FITC-dextran 4000 (FD4) was selected as a model compound and formulated with 50-300 mM C10. Absorption was...

Association of Genetic Variant at Chromosome 12q23.1 With Neuropathic Pain Susceptibility.

JAMA network open

Veluchamy A, Hébert HL, van Zuydam NR, Pearson ER, Campbell A, Hayward C, Meng W, McCarthy MI, Bennett DLH, Palmer CNA, Smith BH.
PMID: 34854908
JAMA Netw Open. 2021 Dec 01;4(12):e2136560. doi: 10.1001/jamanetworkopen.2021.36560.

IMPORTANCE: Neuropathic pain (NP) has important clinical and socioeconomic consequences for individuals and society. Increasing evidence indicates that genetic factors make a significant contribution to NP, but genome-wide association studies (GWASs) are scant in this field and could help...

Publisher Correction: Identification of 371 genetic variants for age at first sex and birth linked to externalising behavior.

Nature human behaviour

Mills MC, Tropf FC, Brazel DM, van Zuydam N, Vaez A, Pers TH, Snieder H, Perry JRB, Ong KK, den Hoed M, Barban N, Day FR.
PMID: 34321615
Nat Hum Behav. 2021 Aug;5(8):1111. doi: 10.1038/s41562-021-01179-5.

No abstract available.

Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat.

Molecular pharmaceutics

Berg S, Kärrberg L, Suljovic D, Seeliger F, Söderberg M, Perez-Alcazar M, Van Zuydam N, Abrahamsson B, Hugerth AM, Davies N, Bergström CAS.
PMID: 34928160
Mol Pharm. 2022 Jan 03;19(1):200-212. doi: 10.1021/acs.molpharmaceut.1c00724. Epub 2021 Dec 20.

In this work, we set out to better understand how the permeation enhancer sodium caprate (C10) influences the intestinal absorption of macromolecules. FITC-dextran 4000 (FD4) was selected as a model compound and formulated with 50-300 mM C10. Absorption was...

Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.

Molecular therapy : the journal of the American Society of Gene Therapy

Zabulica M, Srinivasan RC, Akcakaya P, Allegri G, Bestas B, Firth M, Hammarstedt C, Jakobsson T, Jakobsson T, Ellis E, Jorns C, Makris G, Scherer T, Rimann N, van Zuydam NR, Gramignoli R, Forslöw A, Engberg S, Maresca M, Rooyackers O, Thöny B, Häberle J, Rosen B, Strom SC.
PMID: 33484963
Mol Ther. 2021 May 05;29(5):1903-1917. doi: 10.1016/j.ymthe.2021.01.024. Epub 2021 Jan 21.

Ornithine transcarbamylase deficiency (OTCD) is a monogenic disease of ammonia metabolism in hepatocytes. Severe disease is frequently treated by orthotopic liver transplantation. An attractive approach is the correction of a patient's own cells to regenerate the liver with gene-repaired...

Ventilation via nose cone results in similar hemodynamic parameters and blood gas levels as endotracheal intubation during open chest surgery in rats.

Laboratory animals

Krutrök N, Pehrsson S, Van Zuydam N, Jennbacken K, Wikström J.
PMID: 34407659
Lab Anim. 2021 Aug 19;236772211031039. doi: 10.1177/00236772211031039. Epub 2021 Aug 19.

Open chest surgery in rodents requires assisted breathing and the most common approach for ventilation is via an endotracheal tube. Even with well-trained operators the endotracheal intubation is technically challenging and may lead to prolonged procedures and endotracheal intubation...

Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat.

Molecular pharmaceutics

Berg S, Kärrberg L, Suljovic D, Seeliger F, Söderberg M, Perez-Alcazar M, Van Zuydam N, Abrahamsson B, Hugerth AM, Davies N, Bergström CAS.
PMID: 34928160
Mol Pharm. 2022 Jan 03;19(1):200-212. doi: 10.1021/acs.molpharmaceut.1c00724. Epub 2021 Dec 20.

In this work, we set out to better understand how the permeation enhancer sodium caprate (C10) influences the intestinal absorption of macromolecules. FITC-dextran 4000 (FD4) was selected as a model compound and formulated with 50-300 mM C10. Absorption was...

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Nature human behaviour

Mills MC, Tropf FC, Brazel DM, van Zuydam N, Vaez A, Pers TH, Snieder H, Perry JRB, Ong KK, den Hoed M, Barban N, Day FR.
PMID: 34211149
Nat Hum Behav. 2021 Dec;5(12):1717-1730. doi: 10.1038/s41562-021-01135-3. Epub 2021 Jul 01.

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify...

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Nature human behaviour

Mills MC, Tropf FC, Brazel DM, van Zuydam N, Vaez A, Pers TH, Snieder H, Perry JRB, Ong KK, den Hoed M, Barban N, Day FR.
PMID: 34211149
Nat Hum Behav. 2021 Dec;5(12):1717-1730. doi: 10.1038/s41562-021-01135-3. Epub 2021 Jul 01.

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify...

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Nature human behaviour

Mills MC, Tropf FC, Brazel DM, van Zuydam N, Vaez A, Pers TH, Snieder H, Perry JRB, Ong KK, den Hoed M, Barban N, Day FR.
PMID: 34211149
Nat Hum Behav. 2021 Dec;5(12):1717-1730. doi: 10.1038/s41562-021-01135-3. Epub 2021 Jul 01.

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify...

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Nature human behaviour

Mills MC, Tropf FC, Brazel DM, van Zuydam N, Vaez A, Pers TH, Snieder H, Perry JRB, Ong KK, den Hoed M, Barban N, Day FR.
PMID: 34211149
Nat Hum Behav. 2021 Jul 01; doi: 10.1038/s41562-021-01135-3. Epub 2021 Jul 01.

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify...

Showing 1 to 12 of 14 entries