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Showing 1 to 12 of 67 entries
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Progressive multifocal leukoencephalopathy in an immunocompetent patient.

Annals of clinical and translational neurology

van der Kolk NM, Arts P, van Uden IW, Hoischen A, van de Veerdonk FL, Netea MG, de Jong BA.
PMID: 27042682
Ann Clin Transl Neurol. 2016 Jan 08;3(3):226-32. doi: 10.1002/acn3.279. eCollection 2016 Mar.

Progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the brain, is typically diagnosed in immunocompromised persons. Here, we describe the diagnostic challenge of PML in an apparently immunocompetent patient. Thorough analyses, including cytokine release assays and whole exome sequencing,...

Implementation of Early Next-Generation Sequencing for Inborn Errors of Immunity: A Prospective Observational Cohort Study of Diagnostic Yield and Clinical Implications in Dutch Genome Diagnostic Centers.

Frontiers in immunology

Elsink K, Huibers MMH, Hollink IHIM, Simons A, Zonneveld-Huijssoon E, van der Veken LT, Leavis HL, Henriet SSV, van Deuren M, van de Veerdonk FL, Potjewijd J, Berghuis D, Dalm VASH, Vermont CL, van de Ven AAJM, Lambeck AJA, Abbott KM, van Hagen PM, de Bree GJ, Kuijpers TW, Frederix GWJ, van Gijn ME, van Montfrans JM.
PMID: 34992599
Front Immunol. 2021 Dec 21;12:780134. doi: 10.3389/fimmu.2021.780134. eCollection 2021.

OBJECTIVE: Inborn errors of immunity (IEI) are a heterogeneous group of disorders, affecting different components of the immune system. Over 450 IEI related genes have been identified, with new genes continually being recognized. This makes the early application of...

Natural resistance against infections: focus on COVID-19.

Trends in immunology

Netea MG, Domínguez-Andrés J, van de Veerdonk FL, van Crevel R, Pulendran B, van der Meer JWM.
PMID: 34924297
Trends Immunol. 2021 Dec 07; doi: 10.1016/j.it.2021.12.001. Epub 2021 Dec 07.

Not all individuals exposed to a pathogen develop illness: some are naturally resistant whereas others develop an asymptomatic infection. Epidemiological studies suggest that there is similar variability in susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We...

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes.

Nature immunology

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG.
PMID: 34017127
Nat Immunol. 2021 Jul;22(7):928. doi: 10.1038/s41590-021-00960-y.

No abstract available.

Covid-19-Associated Pulmonary Aspergillosis: The Other Side of the Coin.

Vaccines

Costantini C, van de Veerdonk FL, Romani L.
PMID: 33271780
Vaccines (Basel). 2020 Dec 01;8(4). doi: 10.3390/vaccines8040713.

The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a critical factor in the clinical presentation of COVID-19, which may range from asymptomatic to a fatal, multi-organ disease. A dysregulated immune response not only compromises the...

Author Correction: A guiding map for inflammation.

Nature immunology

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.
PMID: 33288963
Nat Immunol. 2021 Feb;22(2):254. doi: 10.1038/s41590-020-00846-5.

No abstract available.

An exaggerated monocyte-derived cytokine response to Candida hyphae in patients with recurrent vulvovaginal candidiasis.

The Journal of infectious diseases

Rosati D, Bruno M, Jaeger M, Kullberg BJ, van de Veerdonk F, Netea MG, Ten Oever J.
PMID: 32702099
J Infect Dis. 2020 Jul 23; doi: 10.1093/infdis/jiaa444. Epub 2020 Jul 23.

BACKGROUND: Recurrent vulvovaginal candidiasis (RVVC) affects up to 8% of women. The immunopathogenesis is still poorly known, but it has been suggested that RVVC might be due to a dysregulated innate immune response. The aim of this study was...

A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology.

Journal of fungi (Basel, Switzerland)

Janssen NAF, Brüggemann RJM, Reijers MH, Henriet SSV, Ten Oever J, de Mast Q, Berk Y, de Kort EA, Kullberg BJ, Netea MG, Buil JB, Rahamat-Langendoen JC, Bury D, Muilwijk EW, Meis JF, Verweij PE, van de Veerdonk FL.
PMID: 33182621
J Fungi (Basel). 2020 Nov 10;6(4). doi: 10.3390/jof6040274.

Invasive fungal diseases (IFDs) often represent complicated infections in complex patient populations. The Center of Expertise in Mycology Radboudumc/CWZ (EMRC) organizes a biweekly multidisciplinary mycology meeting to discuss patients with severe fungal infections and to provide comprehensive advice regarding...

Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis.

Cell reports. Medicine

Dewi IMW, Cunha C, Jaeger M, Gresnigt MS, Gkountzinopoulou ME, Garishah FM, Duarte-Oliveira C, Campos CF, Vanderbeke L, Sharpe AR, Brüggemann RJ, Verweij PE, Lagrou K, Vande Velde G, de Mast Q, Joosten LAB, Netea MG, van der Ven AJAM, Wauters J, Carvalho A, van de Veerdonk FL.
PMID: 34095887
Cell Rep Med. 2021 May 18;2(5):100289. doi: 10.1016/j.xcrm.2021.100289. eCollection 2021 May 18.

Influenza-associated pulmonary aspergillosis (IAPA) has been reported increasingly since the advent of use of neuraminidase (NA) inhibitors following the 2009 influenza pandemic. We hypothesize that blocking host NA modulates the immune response against

Diagnosing COVID-19-associated pulmonary aspergillosis.

The Lancet. Microbe

Verweij PE, Gangneux JP, Bassetti M, Brüggemann RJM, Cornely OA, Koehler P, Lass-Flörl C, van de Veerdonk FL, Chakrabarti A, Hoenigl M.
PMID: 32835328
Lancet Microbe. 2020 Jun;1(2):e53-e55. doi: 10.1016/S2666-5247(20)30027-6. Epub 2020 May 10.

No abstract available.

The Challenge of Managing COVID-19 Associated Pulmonary Aspergillosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Brüggemann RJ, van de Veerdonk FL, Verweij PE.
PMID: 32810202
Clin Infect Dis. 2021 Dec 06;73(11):e3615-e3616. doi: 10.1093/cid/ciaa1211.

No abstract available.

Pulmonary vascular remodeling and right heart failure in pulmonary hypertension: future role of positron emission tomography in decoding the enigma.

Translational respiratory medicine

Harms HJ, van de Veerdonk MC, Lammertsma AA, Vonk Noordegraaf A, Bogaard HJ.
PMID: 27234397
Transl Respir Med. 2013 Dec;1(1):16. doi: 10.1186/2213-0802-1-16. Epub 2013 Dec 11.

Whereas the insights into the cellular and molecular mechanisms of pulmonary arterial hypertension (PAH) and associated right heart failure have increased in recent years, there is a lack of clinical tools to assess the pathobiological mechanisms in patients. Positron...

Showing 1 to 12 of 67 entries