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Showing 1 to 12 of 34 entries
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Antithrombotic therapy in patients undergoing TAVI: an overview of Dutch hospitals.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

Nijenhuis VJ, Stella PR, Baan J, Brueren BR, de Jaegere PP, den Heijer P, Hofma SH, Kievit P, Slagboom T, van den Heuvel AF, van der Kley F, van Garsse L, van Houwelingen KG, Van't Hof AW, Ten Berg JM.
PMID: 24287807
Neth Heart J. 2014 Feb;22(2):64-9. doi: 10.1007/s12471-013-0496-6.

PURPOSE: To assess current antithrombotic treatment strategies in the Netherlands in patients undergoing transcatheter aortic valve implantation (TAVI).METHODS: For every Dutch hospital performing TAVI (n = 14) an interventional cardiologist experienced in performing TAVI was interviewed concerning heparin, aspirin,...

The impact of peroxisomes on cellular aging and death.

Frontiers in oncology

Manivannan S, Scheckhuber CQ, Veenhuis M, van der Klei IJ.
PMID: 22662318
Front Oncol. 2012 May 21;2:50. doi: 10.3389/fonc.2012.00050. eCollection 2012.

Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and β-oxidation of fatty acids. Reactive oxygen species produced by peroxisomes are a major contributing factor to cellular oxidative stress, which is supposed to...

Extra-hepatic Acromegaly.

European endocrinology

Franck SE, van der Lely AJ, Neggers S.
PMID: 30349613
Eur Endocrinol. 2013 Mar;9(1):66-70. doi: 10.17925/EE.2013.09.01.66. Epub 2013 Mar 15.

After the introduction of somatostatin analogs (LA-SMSA) and the growth hormone (GH) receptor antagonist, pegvisomant (Peg-v) normal serum insulin-like growth factor-1 (IGF-1) concentrations in virtually every patients with acromegaly is possible. The impact of these products on the GH-IGF1...

Towards an Earlier Diagnosis of Acromegaly and Gigantism.

Journal of clinical medicine

Sisco J, van der Lely AJ.
PMID: 33810319
J Clin Med. 2021 Mar 26;10(7). doi: 10.3390/jcm10071363.

Acromegaly is a rare disease and the clinical features of acromegaly develop insidiously; its diagnosis is often significantly delayed. Therefore, earlier diagnosis will improve the quality of life of the patient and reduce the need for other therapies to...

Thyroid Function in Adults with Prader-Willi Syndrome; a Cohort Study and Literature Review.

Journal of clinical medicine

Pellikaan K, Snijders F, Rosenberg AGW, Davidse K, van den Berg SAA, Visser WE, van der Lely AJ, de Graaff LCG.
PMID: 34501256
J Clin Med. 2021 Aug 25;10(17). doi: 10.3390/jcm10173804.

Prader-Willi syndrome (PWS) is a complex genetic syndrome combining hypotonia, hyperphagia, a PWS-specific neurocognitive phenotype, and pituitary hormone deficiencies, including hypothyroidism. The low muscle mass associated with PWS causes a low energy expenditure due to a low basal metabolic...

What Every Internist-Endocrinologist Should Know about Rare Genetic Syndromes in Order to Prevent Needless Diagnostics, Missed Diagnoses and Medical Complications: Five Years of 'Internal Medicine for Rare Genetic Syndromes'.

Journal of clinical medicine

Rosenberg AGW, Pater MRA, Pellikaan K, Davidse K, Kattentidt-Mouravieva AA, Kersseboom R, Bos-Roubos AG, van Eeghen A, Veen JMC, van der Meulen JJ, van Aalst-van Wieringen N, Hoekstra FME, van der Lely AJ, de Graaff LCG.
PMID: 34830739
J Clin Med. 2021 Nov 22;10(22). doi: 10.3390/jcm10225457.

Patients with complex rare genetic syndromes (CRGS) have combined medical problems affecting multiple organ systems. Pediatric multidisciplinary (MD) care has improved life expectancy, however, transfer to internal medicine is hindered by the lack of adequate MD care for adults....

Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states.

Diabetology & metabolic syndrome

Özcan B, Leenen PJM, Delhanty PJD, Baldéon-Rojas LY, Neggers SJ, van der Lely AJ.
PMID: 28572856
Diabetol Metab Syndr. 2017 May 31;9:43. doi: 10.1186/s13098-017-0239-8. eCollection 2017.

BACKGROUND: Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous studies suggest that short-term infusion of unacylated ghrelin (UAG) normalizes...

Ghrelin.

Molecular metabolism

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.
PMID: 26042199
Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun.

BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy...

Low gradient severe aortic stenosis with preserved ejection fraction: reclassification of severity by fusion of Doppler and computed tomographic data.

European heart journal

Kamperidis V, van Rosendael PJ, Katsanos S, van der Kley F, Regeer M, Al Amri I, Sianos G, Marsan NA, Delgado V, Bax JJ.
PMID: 26033985
Eur Heart J. 2015 Aug 14;36(31):2087-2096. doi: 10.1093/eurheartj/ehv188. Epub 2015 Jun 01.

AIMS: Low gradient severe aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) may be attributed to aortic valve area index (AVAi) underestimation due to the assumption of a circular shape of the left ventricular outflow tract (LVOT)...

Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins.

Frontiers in cell and developmental biology

Jansen RLM, Santana-Molina C, van den Noort M, Devos DP, van der Klei IJ.
PMID: 34095119
Front Cell Dev Biol. 2021 May 20;9:654163. doi: 10.3389/fcell.2021.654163. eCollection 2021.

PEX genes encode proteins involved in peroxisome biogenesis and proliferation. Using a comparative genomics approach, we clarify the evolutionary relationships between the 37 known PEX proteins in a representative set of eukaryotes, including all common model organisms, pathogenic unicellular...

Unacylated ghrelin binds heparan-sulfate proteoglycans which modulate its function.

Journal of molecular endocrinology

Delhanty PJD, Huisman M, Prins K, Steenbergen C, Mies R, Neggers SJCMM, van der Lely AJ, Visser JA.
PMID: 33263557
J Mol Endocrinol. 2021 Feb;66(2):83-96. doi: 10.1530/JME-20-0286.

Acylated ghrelin (AG) is a gut-derived peptide with growth hormone secretagogue (GHS), orexigenic and other physiological activities mediated by GHS receptor-1a (GHSR). Ghrelin occurs in unacylated form (UAG) with activities opposing AG, although its mechanism of action is unknown....

Risk factors and management of pasireotide-associated hyperglycemia in acromegaly.

Endocrine connections

Gadelha MR, Gu F, Bronstein MD, Brue TC, Fleseriu M, Shimon I, van der Lely AJ, Ravichandran S, Kandra A, Pedroncelli AM, Colao AAL.
PMID: 33434154
Endocr Connect. 2020 Dec;9(12):1178-1190. doi: 10.1530/EC-20-0361.

Pasireotide, a multireceptor-targeted somatostatin analog with highest affinity for somatostatin receptor subtype (SST) 5, has demonstrated superior efficacy over the SST2-preferential somatostatin analogs octreotide and lanreotide. The safety profile is similar to those of octreotide and lanreotide, except for...

Showing 1 to 12 of 34 entries