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Showing 1 to 12 of 36 entries
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The dating of shallow faults in the Earth's crust.

Nature

van der Pluijm BA, Hall CM, Vrolijk PJ, Pevear DR, Covey MC.
PMID: 11449270
Nature. 2001 Jul 12;412(6843):172-5. doi: 10.1038/35084053.

Direct dating of ductile shear zones and calculation of uplift/exhumation rates can be done using various radiometric dating techniques. But radiometric dating of shallow crustal faulting, which occurs in the crust's brittle regime, has remained difficult because the low...

CORRECTION: Innovative approaches to establish and characterize primary cultures: an .

Biology open

Liverani C, La Manna F, Groenewoud A, Mercatali L, Van Der Pluijm G, Pieri F, Cavaliere D, De Vita A, Spadazzi C, Miserocchi G, Bongiovanni A, Recine F, Riva N, Amadori D, Tasciotti E, Snaar-Jagalska E, Ibrahim T.
PMID: 28202474
Biol Open. 2017 Feb 15;6(2):309. doi: 10.1242/bio.023911.

No abstract available.

An .

Frontiers in oncology

van de Merbel AF, van der Horst G, van der Mark MH, van Uhm JIM, van Gennep EJ, Kloen P, Beimers L, Pelger RCM, van der Pluijm G.
PMID: 30333957
Front Oncol. 2018 Oct 02;8:400. doi: 10.3389/fonc.2018.00400. eCollection 2018.

Urological malignancies, including prostate and bladder carcinoma, represent a major clinical problem due to the frequent occurrence of therapy resistance and the formation of incurable distant metastases. As a result, there is an urgent need for versatile and predictive...

Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic Disease.

International journal of molecular sciences

Verhagen JMA, Burger J, Bekkers JA, den Dekker AT, von der Thüsen JH, Zajec M, Brüggenwirth HT, van der Sterre MLT, van den Born M, Luider TM, van IJcken WFJ, Wessels MW, Essers J, Roos-Hesselink JW, van der Pluijm I, van de Laar IMBH, Brosens E.
PMID: 35008861
Int J Mol Sci. 2021 Dec 31;23(1). doi: 10.3390/ijms23010438.

Thoracic aortic aneurysm is a potentially life-threatening disease with a strong genetic contribution. Despite identification of multiple genes involved in aneurysm formation, little is known about the specific underlying mechanisms that drive the pathological changes in the aortic wall....

Abnormal Aortic Wall Properties in Women with Turner Syndrome.

Aorta (Stamford, Conn.)

Bons LR, Van Den Hoven AT, Malik M, Van Den Bosch AE, McGhie JS, Duijnhouwer AL, Siebelink HJ, Hirsch A, Devos DH, Rietzschel E, von der Thüsen JH, van de Laar IMBH, Verhagen JMA, van der Pluijm I, Budde RPJ, Roos-Hesselink JW.
PMID: 33368097
Aorta (Stamford). 2020 Oct;8(5):121-131. doi: 10.1055/s-0040-1714384. Epub 2020 Dec 23.

BACKGROUND:  Turner syndrome (TS) is associated with aortic dilatation and dissection, but the underlying process is unclear. The aim of this study was to investigate the elastic properties and composition of the aortic wall in women with TS.METHODS:  In...

An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer.

Pharmacology research & perspectives

Vrouwe JPM, Kamerling IMC, van Esdonk MJ, Metselaar JM, Stuurman FE, van der Pluijm G, Burggraaf J, Osanto S.
PMID: 34414692
Pharmacol Res Perspect. 2021 Oct;9(5):e00845. doi: 10.1002/prp2.845.

Dexamethasone has antitumor activity in metastatic castration resistant prostate cancer (mCRPC). We aimed to investigate intravenous liposome-encapsulated dexamethasone disodium phosphate (liposomal dexamethasone) administration in mCRPC patients. In this exploratory first-in-man study, patients in part A received a starting dose...

In Vivo Renin Activity Imaging in the Kidney of Progeroid .

International journal of molecular sciences

van Thiel BS, van der Linden J, Ridwan Y, Garrelds IM, Vermeij M, Clahsen-van Groningen MC, Qadri F, Alenina N, Bader M, Roks AJM, Danser AHJ, Essers J, van der Pluijm I.
PMID: 34830315
Int J Mol Sci. 2021 Nov 18;22(22). doi: 10.3390/ijms222212433.

Changes in the renin-angiotensin system, known for its critical role in the regulation of blood pressure and sodium homeostasis, may contribute to aging and age-related diseases. While the renin-angiotensin system is suppressed during aging, little is known about its...

First in human evaluation of [.

EJNMMI research

van der Aart J, Golla SSV, van der Pluijm M, Schwarte LA, Schuit RC, Klein PJ, Metaxas A, Windhorst AD, Boellaard R, Lammertsma AA, van Berckel BNM.
PMID: 30054846
EJNMMI Res. 2018 Jul 27;8(1):69. doi: 10.1186/s13550-018-0424-2.

BACKGROUND: Efforts to develop suitable positron emission tomography (PET) tracers for the ion channel site of human N-methyl-D-aspartate (NMDA) receptors have had limited success. [RESULTS: Best fits of the brain time-activity curves were obtained using an irreversible two-tissue compartment...

Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by .

ACS pharmacology & translational science

Ansbro MR, Itkin Z, Chen L, Zahoranszky-Kohalmi G, Amaratunga C, Miotto O, Peryea T, Hobbs CV, Suon S, Sá JM, Dondorp AM, van der Pluijm RW, Wellems TE, Simeonov A, Eastman RT.
PMID: 33344893
ACS Pharmacol Transl Sci. 2020 Nov 02;3(6):1144-1157. doi: 10.1021/acsptsci.0c00110. eCollection 2020 Dec 11.

The first-line treatments for uncomplicated

Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell.

Oxidative medicine and cellular longevity

Ataei Ataabadi E, Golshiri K, van der Linden J, de Boer M, Duncker DJ, Jüttner A, de Vries R, Van Veghel R, van der Pluijm I, Dutheil S, Chalgeri S, Zhang L, Lin A, Davis RE, Snyder GL, Danser AHJ, Roks AJM.
PMID: 34504640
Oxid Med Cell Longev. 2021 Aug 31;2021:2308317. doi: 10.1155/2021/2308317. eCollection 2021.

Persistently unrepaired DNA damage has been identified as a causative factor for vascular ageing. We have previously shown that a defect in the function or expression of the DNA repair endonuclease ERCC1 (excision repair cross complement 1) in mice...

Innovative approaches to establish and characterize primary cultures: an .

Biology open

Liverani C, La Manna F, Groenewoud A, Mercatali L, Van Der Pluijm G, Pieri F, Cavaliere D, De Vita A, Spadazzi C, Miserocchi G, Bongiovanni A, Recine F, Riva N, Amadori D, Tasciotti E, Snaar-Jagalska E, Ibrahim T.
PMID: 27895047
Biol Open. 2017 Feb 15;6(2):133-140. doi: 10.1242/bio.022483.

Patient-derived specimens are an invaluable resource to investigate tumor biology. However,

Molecular phenotyping and functional assessment of smooth muscle-like cells with pathogenic variants in aneurysm genes ACTA2, MYH11, SMAD3 and FBN1.

Human molecular genetics

Burger J, Bogunovic N, de Wagenaar NP, Liu H, van Vliet N, IJpma A, Maugeri A, Micha D, Verhagen HJM, Ten Hagen TLM, Majoor-Krakauer D, van der Pluijm I, Essers J, Yeung KK.
PMID: 34244757
Hum Mol Genet. 2021 Nov 16;30(23):2286-2299. doi: 10.1093/hmg/ddab190.

Aortic aneurysms (AAs) are pathological dilatations of the aorta. Pathogenic variants in genes encoding for proteins of the contractile machinery of vascular smooth muscle cells (VSMCs), genes encoding proteins of the transforming growth factor beta signaling pathway and extracellular...

Showing 1 to 12 of 36 entries