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Cognitive toxicity of drugs used in the elderly.

Dialogues in clinical neuroscience

von Moltke LL, Greenblatt DJ, Romach MK, Sellers EM.
PMID: 22034128
Dialogues Clin Neurosci. 2001 Sep;3(3):181-90.

The aged are an extremely heterogeneous population that is growing worldwide, included are healthy and agile individuals in their early sixties, as well as an increasing number of people over the age of 35. Pharmacotherapy is expected to continue...

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von Moltke LL, Greenblatt DJ, Romach MK, et al. Cognitive toxicity of drugs used in the elderly. Dialogues Clin Neurosci. 2001;3(3):181-90
von Moltke, L. L., Greenblatt, D. J., Romach, M. K., & Sellers, E. M. (2001). Cognitive toxicity of drugs used in the elderly. Dialogues in clinical neuroscience, 3(3), 181-90.
von Moltke, L L, et al. "Cognitive toxicity of drugs used in the elderly." Dialogues in clinical neuroscience vol. 3,3 (2001): 181-90.
von Moltke LL, Greenblatt DJ, Romach MK, Sellers EM. Cognitive toxicity of drugs used in the elderly. Dialogues Clin Neurosci. 2001 Sep;3(3):181-90. PMID: 22034128; PMCID: PMC3181655.
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Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers.

British journal of clinical pharmacology

Dijkstra FM, Zuiker RGJA, Siebenga PS, Leigh-Pemberton RA, Sun L, Manthis JD, de Kam ML, Lin R, von Moltke LL, Rezendes D, van Gerven JMA.
PMID: 35014069
Br J Clin Pharmacol. 2022 Jan 10; doi: 10.1111/bcp.15229. Epub 2022 Jan 10.

AIM: ALKS 7119 is a novel compound with in vitro affinity highest for the SERT, and for μ receptor, αMETHODS: In 10 cohorts (n=10 subjects each), PK, safety and PD (NeuroCart tests, measuring neurophysiologic effects [pupillometry, pharmaco-EEG (pEEG)], visuomotor...

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Dijkstra FM, Zuiker RGJA, Siebenga PS, et al. Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers. Br J Clin Pharmacol. 2022;doi: 10.1111/bcp.15229.
Dijkstra, F. M., Zuiker, R. G. J. A., Siebenga, P. S., Leigh-Pemberton, R. A., Sun, L., Manthis, J. D., de Kam, M. L., Lin, R., von Moltke, L. L., Rezendes, D., & van Gerven, J. M. A. (2022). Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers. British journal of clinical pharmacology, . https://doi.org/10.1111/bcp.15229
Dijkstra, Francis M, et al. "Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers." British journal of clinical pharmacology vol. (2022). doi: https://doi.org/10.1111/bcp.15229
Dijkstra FM, Zuiker RGJA, Siebenga PS, Leigh-Pemberton RA, Sun L, Manthis JD, de Kam ML, Lin R, von Moltke LL, Rezendes D, van Gerven JMA. Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers. Br J Clin Pharmacol. 2022 Jan 10; doi: 10.1111/bcp.15229. Epub 2022 Jan 10. PMID: 35014069.
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Pharmacokinetics and safety of deltoid or gluteal injection of aripiprazole lauroxil NanoCrystal.

Therapeutic advances in psychopharmacology

Hard ML, Wehr A, von Moltke L, Du Y, Farwick S, Walling DP, Sonnenberg J.
PMID: 31308935
Ther Adv Psychopharmacol. 2019 Jul 02;9:2045125319859964. doi: 10.1177/2045125319859964. eCollection 2019.

BACKGROUND: Aripiprazole lauroxil (AL), a long-acting injectable antipsychotic for the treatment of schizophrenia in adults, can be started with either 21 days of daily oral aripiprazole supplementation or a 1-day initiation regimen consisting of a single injection of a...

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Hard ML, Wehr A, von Moltke L, et al. Pharmacokinetics and safety of deltoid or gluteal injection of aripiprazole lauroxil NanoCrystal. Ther Adv Psychopharmacol. 2019;9:2045125319859964doi: 10.1177/2045125319859964.
Hard, M. L., Wehr, A., von Moltke, L., Du, Y., Farwick, S., Walling, D. P., & Sonnenberg, J. (2019). Pharmacokinetics and safety of deltoid or gluteal injection of aripiprazole lauroxil NanoCrystal. Therapeutic advances in psychopharmacology, 92045125319859964. https://doi.org/10.1177/2045125319859964
Hard, Marjie L, et al. "Pharmacokinetics and safety of deltoid or gluteal injection of aripiprazole lauroxil NanoCrystal." Therapeutic advances in psychopharmacology vol. 9 (2019): 2045125319859964. doi: https://doi.org/10.1177/2045125319859964
Hard ML, Wehr A, von Moltke L, Du Y, Farwick S, Walling DP, Sonnenberg J. Pharmacokinetics and safety of deltoid or gluteal injection of aripiprazole lauroxil NanoCrystal. Ther Adv Psychopharmacol. 2019 Jul 02;9:2045125319859964. doi: 10.1177/2045125319859964. eCollection 2019. PMID: 31308935; PMCID: PMC6607563.
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Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet.

CPT: pharmacometrics & systems pharmacology

Sun L, Barter Z, von Moltke L, Rowland Yeo K.
PMID: 34185436
CPT Pharmacometrics Syst Pharmacol. 2021 Sep;10(9):1071-1080. doi: 10.1002/psp4.12675. Epub 2021 Jul 18.

A combination of olanzapine and samidorphan (OLZ/SAM) was recently approved by the US Food and Drug Administration for treatment of patients with schizophrenia or bipolar I disorder. The effects of moderate hepatic impairment on the pharmacokinetics (PKs) of olanzapine...

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Sun L, Barter Z, von Moltke L, et al. Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet. CPT Pharmacometrics Syst Pharmacol. 2021;10(9):1071-1080doi: 10.1002/psp4.12675.
Sun, L., Barter, Z., von Moltke, L., & Rowland Yeo, K. (2021). Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet. CPT: pharmacometrics & systems pharmacology, 10(9), 1071-1080. https://doi.org/10.1002/psp4.12675
Sun, Lei, et al. "Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet." CPT: pharmacometrics & systems pharmacology vol. 10,9 (2021): 1071-1080. doi: https://doi.org/10.1002/psp4.12675
Sun L, Barter Z, von Moltke L, Rowland Yeo K. Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet. CPT Pharmacometrics Syst Pharmacol. 2021 Sep;10(9):1071-1080. doi: 10.1002/psp4.12675. Epub 2021 Jul 18. PMID: 34185436; PMCID: PMC8452299.
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Medication dependence and anxiety.

Dialogues in clinical neuroscience

von Moltke LL, Greenblatt DJ.
PMID: 22033703
Dialogues Clin Neurosci. 2003 Sep;5(3):237-45.

Anxiety disorders are common and costly psychiatric illnesses. Pharmacological treatment was enhanced with the introduction of benzodiazepines, which proved safer and more effective than older drugs. The risk of dependence, however, has made clinicians reluctant to use these medications....

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von Moltke LL, Greenblatt DJ. Medication dependence and anxiety. Dialogues Clin Neurosci. 2003;5(3):237-45
von Moltke, L. L., & Greenblatt, D. J. (2003). Medication dependence and anxiety. Dialogues in clinical neuroscience, 5(3), 237-45.
von Moltke, Lisa L, and Greenblatt, David J. "Medication dependence and anxiety." Dialogues in clinical neuroscience vol. 5,3 (2003): 237-45.
von Moltke LL, Greenblatt DJ. Medication dependence and anxiety. Dialogues Clin Neurosci. 2003 Sep;5(3):237-45. PMID: 22033703; PMCID: PMC3181633.
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Long-acting formulations delivering aripiprazole: beyond single-value characterizations of steady-state pharmacokinetics.

Neuropsychiatric disease and treatment

McConnell SA, Desai DN, Faldu SP, Hard ML, Wehr AY, Weiden PJ, von Moltke L.
PMID: 28744131
Neuropsychiatr Dis Treat. 2017 Jul 12;13:1815-1816. doi: 10.2147/NDT.S143337. eCollection 2017.

No abstract available.

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McConnell SA, Desai DN, Faldu SP, et al. Long-acting formulations delivering aripiprazole: beyond single-value characterizations of steady-state pharmacokinetics. Neuropsychiatr Dis Treat. 2017;13:1815-1816doi: 10.2147/NDT.S143337.
McConnell, S. A., Desai, D. N., Faldu, S. P., Hard, M. L., Wehr, A. Y., Weiden, P. J., & von Moltke, L. (2017). Long-acting formulations delivering aripiprazole: beyond single-value characterizations of steady-state pharmacokinetics. Neuropsychiatric disease and treatment, 131815-1816. https://doi.org/10.2147/NDT.S143337
McConnell, Scott A, et al. "Long-acting formulations delivering aripiprazole: beyond single-value characterizations of steady-state pharmacokinetics." Neuropsychiatric disease and treatment vol. 13 (2017): 1815-1816. doi: https://doi.org/10.2147/NDT.S143337
McConnell SA, Desai DN, Faldu SP, Hard ML, Wehr AY, Weiden PJ, von Moltke L. Long-acting formulations delivering aripiprazole: beyond single-value characterizations of steady-state pharmacokinetics. Neuropsychiatr Dis Treat. 2017 Jul 12;13:1815-1816. doi: 10.2147/NDT.S143337. eCollection 2017. PMID: 28744131; PMCID: PMC5513837.
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Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types.

American journal of physiology. Gastrointestinal and liver physiology

Shanahan MT, Kanke M, Oyesola OO, Hung YH, Koch-Laskowski K, Singh AP, Peck BCE, Biraud M, Sheahan B, Cortes JE, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait-Wojno ED, Sethupathy P.
PMID: 34643097
Am J Physiol Gastrointest Liver Physiol. 2021 Dec 01;321(6):G668-G681. doi: 10.1152/ajpgi.00222.2021. Epub 2021 Oct 13.

MicroRNA-mediated regulation is critical for the proper development and function of the small intestinal (SI) epithelium. However, it is not known which microRNAs are expressed in each of the cell types of the SI epithelium. To bridge this important...

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Shanahan MT, Kanke M, Oyesola OO, et al. Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. Am J Physiol Gastrointest Liver Physiol. 2021;321(6):G668-G681doi: 10.1152/ajpgi.00222.2021.
Shanahan, M. T., Kanke, M., Oyesola, O. O., Hung, Y. H., Koch-Laskowski, K., Singh, A. P., Peck, B. C. E., Biraud, M., Sheahan, B., Cortes, J. E., Gong, H., Sahoo, D. K., Cubitt, R., Kurpios, N. A., Mochel, J. P., Allenspach, K., McElroy, S. J., Ding, S., von Moltke, J., Dekaney, C. M., Tait-Wojno, E. D., & Sethupathy, P. (2021). Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. American journal of physiology. Gastrointestinal and liver physiology, 321(6), G668-G681. https://doi.org/10.1152/ajpgi.00222.2021
Shanahan, Michael T, et al. "Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types." American journal of physiology. Gastrointestinal and liver physiology vol. 321,6 (2021): G668-G681. doi: https://doi.org/10.1152/ajpgi.00222.2021
Shanahan MT, Kanke M, Oyesola OO, Hung YH, Koch-Laskowski K, Singh AP, Peck BCE, Biraud M, Sheahan B, Cortes JE, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait-Wojno ED, Sethupathy P. Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 01;321(6):G668-G681. doi: 10.1152/ajpgi.00222.2021. Epub 2021 Oct 13. PMID: 34643097.
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Tuning tuft cells: new ligands and effector functions reveal tissue-specific function.

Current opinion in immunology

Billipp TE, Nadjsombati MS, von Moltke J.
PMID: 33166855
Curr Opin Immunol. 2021 Feb;68:98-106. doi: 10.1016/j.coi.2020.09.006. Epub 2020 Nov 06.

Tuft cells are rare chemosensory epithelial cells that monitor their environment and relay messages to the surrounding tissue via secretion of neuromodulatory and immunomodulatory molecules. In the small intestine tuft cells detect helminth infection, protist colonization, and bacterial dysbiosis,...

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Billipp TE, Nadjsombati MS, von Moltke J. Tuning tuft cells: new ligands and effector functions reveal tissue-specific function. Curr Opin Immunol. 2020;68:98-106doi: 10.1016/j.coi.2020.09.006.
Billipp, T. E., Nadjsombati, M. S., & von Moltke, J. (2021). Tuning tuft cells: new ligands and effector functions reveal tissue-specific function. Current opinion in immunology, 6898-106. https://doi.org/10.1016/j.coi.2020.09.006
Billipp, Tyler E, et al. "Tuning tuft cells: new ligands and effector functions reveal tissue-specific function." Current opinion in immunology vol. 68 (2021): 98-106. doi: https://doi.org/10.1016/j.coi.2020.09.006
Billipp TE, Nadjsombati MS, von Moltke J. Tuning tuft cells: new ligands and effector functions reveal tissue-specific function. Curr Opin Immunol. 2021 Feb;68:98-106. doi: 10.1016/j.coi.2020.09.006. Epub 2020 Nov 06. PMID: 33166855; PMCID: PMC7925335.
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Showing 1 to 8 of 8 entries