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Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.

Cardiovascular drugs and therapy

Tate M, Higgins GC, De Blasio MJ, Lindblom R, Prakoso D, Deo M, Kiriazis H, Park M, Baeza-Garza CD, Caldwell ST, Hartley RC, Krieg T, Murphy MP, Coughlan MT, Ritchie RH.
PMID: 32062792
Cardiovasc Drugs Ther. 2020 Apr;34(2):223. doi: 10.1007/s10557-019-06929-2.

The article "The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart".

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Tate M, Higgins GC, De Blasio MJ, et al. Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart. Cardiovasc Drugs Ther. 2020;34(2):223doi: 10.1007/s10557-019-06929-2.
Tate, M., Higgins, G. C., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garza, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. T., & Ritchie, R. H. (2020). Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart. Cardiovascular drugs and therapy, 34(2), 223. https://doi.org/10.1007/s10557-019-06929-2
Tate, Mitchel, et al. "Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart." Cardiovascular drugs and therapy vol. 34,2 (2020): 223. doi: https://doi.org/10.1007/s10557-019-06929-2
Tate M, Higgins GC, De Blasio MJ, Lindblom R, Prakoso D, Deo M, Kiriazis H, Park M, Baeza-Garza CD, Caldwell ST, Hartley RC, Krieg T, Murphy MP, Coughlan MT, Ritchie RH. Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart. Cardiovasc Drugs Ther. 2020 Apr;34(2):223. doi: 10.1007/s10557-019-06929-2. PMID: 32062792; PMCID: PMC7645541.
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Detection of changes in mitochondrial hydrogen sulfide .

Biology open

Lau GY, Barts N, Hartley RC, Tobler M, Richards JG, Murphy MP, Arndt S.
PMID: 31072908
Biol Open. 2019 May 09;8(5). doi: 10.1242/bio.041467.

In this paper, we outline the use of a mitochondria-targeted ratiometric mass spectrometry probe, MitoA, to detect

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Lau GY, Barts N, Hartley RC, et al. Detection of changes in mitochondrial hydrogen sulfide . Biol Open. 2019;8(5)doi: 10.1242/bio.041467.
Lau, G. Y., Barts, N., Hartley, R. C., Tobler, M., Richards, J. G., Murphy, M. P., & Arndt, S. (2019). Detection of changes in mitochondrial hydrogen sulfide . Biology open, 8(5), . https://doi.org/10.1242/bio.041467
Lau, Gigi Y, et al. "Detection of changes in mitochondrial hydrogen sulfide ." Biology open vol. 8,5 (2019). doi: https://doi.org/10.1242/bio.041467
Lau GY, Barts N, Hartley RC, Tobler M, Richards JG, Murphy MP, Arndt S. Detection of changes in mitochondrial hydrogen sulfide . Biol Open. 2019 May 09;8(5). doi: 10.1242/bio.041467. PMID: 31072908; PMCID: PMC6550084.
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Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation.

Frontiers in chemistry

Pala L, Senn HM, Caldwell ST, Prime TA, Warrington S, Bright TP, Prag HA, Wilson C, Murphy MP, Hartley RC.
PMID: 33033715
Front Chem. 2020 Sep 09;8:783. doi: 10.3389/fchem.2020.00783. eCollection 2020.

There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction. The large membrane potential, negative inside, across the mitochondrial inner membrane enables delivery of...

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Pala L, Senn HM, Caldwell ST, et al. Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation. Front Chem. 2020;8:783doi: 10.3389/fchem.2020.00783.
Pala, L., Senn, H. M., Caldwell, S. T., Prime, T. A., Warrington, S., Bright, T. P., Prag, H. A., Wilson, C., Murphy, M. P., & Hartley, R. C. (2020). Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation. Frontiers in chemistry, 8783. https://doi.org/10.3389/fchem.2020.00783
Pala, Laura, et al. "Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation." Frontiers in chemistry vol. 8 (2020): 783. doi: https://doi.org/10.3389/fchem.2020.00783
Pala L, Senn HM, Caldwell ST, Prime TA, Warrington S, Bright TP, Prag HA, Wilson C, Murphy MP, Hartley RC. Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation. Front Chem. 2020 Sep 09;8:783. doi: 10.3389/fchem.2020.00783. eCollection 2020. PMID: 33033715; PMCID: PMC7509049.
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Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction.

Science advances

Botting KJ, Skeffington KL, Niu Y, Allison BJ, Brain KL, Itani N, Beck C, Logan A, Murray AJ, Murphy MP, Giussani DA.
PMID: 32875110
Sci Adv. 2020 Aug 19;6(34):eabb1929. doi: 10.1126/sciadv.abb1929. eCollection 2020 Aug.

The prenatal origins of heart disease in offspring have been established. However, research in species with developmental milestones comparable to humans is lacking, preventing translation of this knowledge to clinical contexts. Using sheep and chickens, two species with similar...

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Botting KJ, Skeffington KL, Niu Y, et al. Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Sci Adv. 2020;6(34):eabb1929doi: 10.1126/sciadv.abb1929.
Botting, K. J., Skeffington, K. L., Niu, Y., Allison, B. J., Brain, K. L., Itani, N., Beck, C., Logan, A., Murray, A. J., Murphy, M. P., & Giussani, D. A. (2020). Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Science advances, 6(34), eabb1929. https://doi.org/10.1126/sciadv.abb1929
Botting, K J, et al. "Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction." Science advances vol. 6,34 (2020): eabb1929. doi: https://doi.org/10.1126/sciadv.abb1929
Botting KJ, Skeffington KL, Niu Y, Allison BJ, Brain KL, Itani N, Beck C, Logan A, Murray AJ, Murphy MP, Giussani DA. Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Sci Adv. 2020 Aug 19;6(34):eabb1929. doi: 10.1126/sciadv.abb1929. eCollection 2020 Aug. PMID: 32875110; PMCID: PMC7438086.
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Active RNA interference in mitochondria.

Cell research

Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X.
PMID: 32807841
Cell Res. 2021 Feb;31(2):219-228. doi: 10.1038/s41422-020-00394-5. Epub 2020 Aug 17.

RNA interference (RNAi) has been thought to be a gene-silencing pathway present in most eukaryotic cells to safeguard the genome against retrotransposition. Small interfering RNAs (siRNAs) have also become a powerful tool for studying gene functions. Given the endosymbiotic...

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Gao K, Cheng M, Zuo X, et al. Active RNA interference in mitochondria. Cell Res. 2020;31(2):219-228doi: 10.1038/s41422-020-00394-5.
Gao, K., Cheng, M., Zuo, X., Lin, J., Hoogewijs, K., Murphy, M. P., Fu, X. D., & Zhang, X. (2021). Active RNA interference in mitochondria. Cell research, 31(2), 219-228. https://doi.org/10.1038/s41422-020-00394-5
Gao, Kuanxing, et al. "Active RNA interference in mitochondria." Cell research vol. 31,2 (2021): 219-228. doi: https://doi.org/10.1038/s41422-020-00394-5
Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X. Active RNA interference in mitochondria. Cell Res. 2021 Feb;31(2):219-228. doi: 10.1038/s41422-020-00394-5. Epub 2020 Aug 17. PMID: 32807841; PMCID: PMC8027830.
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Using chemical biology to assess and modulate mitochondria: progress and challenges.

Interface focus

Logan A, Murphy MP.
PMID: 28382206
Interface Focus. 2017 Apr 06;7(2):20160151. doi: 10.1098/rsfs.2016.0151.

Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such...

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Logan A, Murphy MP. Using chemical biology to assess and modulate mitochondria: progress and challenges. Interface Focus. 2017;7(2):20160151doi: 10.1098/rsfs.2016.0151.
Logan, A., & Murphy, M. P. (2017). Using chemical biology to assess and modulate mitochondria: progress and challenges. Interface focus, 7(2), 20160151. https://doi.org/10.1098/rsfs.2016.0151
Logan, Angela, and Murphy, Michael P. "Using chemical biology to assess and modulate mitochondria: progress and challenges." Interface focus vol. 7,2 (2017): 20160151. doi: https://doi.org/10.1098/rsfs.2016.0151
Logan A, Murphy MP. Using chemical biology to assess and modulate mitochondria: progress and challenges. Interface Focus. 2017 Apr 06;7(2):20160151. doi: 10.1098/rsfs.2016.0151. PMID: 28382206; PMCID: PMC5311910.
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Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.

Cardiovascular drugs and therapy

Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T.
PMID: 32648168
Cardiovasc Drugs Ther. 2020 Jul 09; doi: 10.1007/s10557-020-07033-6. Epub 2020 Jul 09.

PURPOSE: Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack. During ischemia, succinate accumulates and its oxidation upon reperfusion by succinate dehydrogenase (SDH) drives ROS production. Inhibition of...

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Prag HA, Pala L, Kula-Alwar D, et al. Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo. Cardiovasc Drugs Ther. 2020;doi: 10.1007/s10557-020-07033-6.
Prag, H. A., Pala, L., Kula-Alwar, D., Mulvey, J. F., Luping, D., Beach, T. E., Booty, L. M., Hall, A. R., Logan, A., Sauchanka, V., Caldwell, S. T., Robb, E. L., James, A. M., Xu, Z., Saeb-Parsy, K., Hartley, R. C., Murphy, M. P., & Krieg, T. (2020). Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo. Cardiovascular drugs and therapy, . https://doi.org/10.1007/s10557-020-07033-6
Prag, Hiran A, et al. "Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo." Cardiovascular drugs and therapy vol. (2020). doi: https://doi.org/10.1007/s10557-020-07033-6
Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T. Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo. Cardiovasc Drugs Ther. 2020 Jul 09; doi: 10.1007/s10557-020-07033-6. Epub 2020 Jul 09. PMID: 32648168.
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ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives.

Interface focus

Hoogewijs K, James AM, Smith RA, Abendroth F, Gait MJ, Murphy MP, Lightowlers RN.
PMID: 28382203
Interface Focus. 2017 Apr 06;7(2):20160117. doi: 10.1098/rsfs.2016.0117.

There is an increasing interest in targeting molecules to the mitochondrial matrix. Many proteins are naturally imported through the translocase complexes found in the outer and inner mitochondrial membranes. One possible means for importing molecules is therefore to use...

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Hoogewijs K, James AM, Smith RA, et al. ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives. Interface Focus. 2017;7(2):20160117doi: 10.1098/rsfs.2016.0117.
Hoogewijs, K., James, A. M., Smith, R. A., Abendroth, F., Gait, M. J., Murphy, M. P., & Lightowlers, R. N. (2017). ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives. Interface focus, 7(2), 20160117. https://doi.org/10.1098/rsfs.2016.0117
Hoogewijs, Kurt, et al. "ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives." Interface focus vol. 7,2 (2017): 20160117. doi: https://doi.org/10.1098/rsfs.2016.0117
Hoogewijs K, James AM, Smith RA, Abendroth F, Gait MJ, Murphy MP, Lightowlers RN. ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives. Interface Focus. 2017 Apr 06;7(2):20160117. doi: 10.1098/rsfs.2016.0117. PMID: 28382203; PMCID: PMC5311907.
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Showing 1 to 8 of 8 entries