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Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity.

Physiological reports

Ali MI, Chen X, Didion SP.
PMID: 26660551
Physiol Rep. 2015 Dec;3(12). doi: 10.14814/phy2.12630.

Heterozygous endothelial nitric oxide synthase (eNOS) deficiency is associated with normal endothelium-dependent responses, however, little is known regarding the mechanisms that maintain or impair endothelial function with heterozygous eNOS deficiency. The goals of this study were to (1) determine...

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Ali MI, Chen X, Didion SP. Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity. Physiol Rep. 2015;3(12)doi: 10.14814/phy2.12630.
Ali, M. I., Chen, X., & Didion, S. P. (2015). Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity. Physiological reports, 3(12), . https://doi.org/10.14814/phy2.12630
Ali, M Irfan, et al. "Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity." Physiological reports vol. 3,12 (2015). doi: https://doi.org/10.14814/phy2.12630
Ali MI, Chen X, Didion SP. Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity. Physiol Rep. 2015 Dec;3(12). doi: 10.14814/phy2.12630. PMID: 26660551; PMCID: PMC4760452.
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Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats.

ISRN pharmacology

Onsa-Ard A, Shimbhu D, Tocharus J, Sutheerawattananonda M, Pantan R, Tocharus C.
PMID: 24312733
ISRN Pharmacol. 2013 Nov 07;2013:717529. doi: 10.1155/2013/717529. eCollection 2013.

Sericin-derived oligopeptides obtained from silk cocoons were investigated for the in vivo hypotensive effect and investigated for the underlying mechanism involved in vasodilation in isolated rat thoracic aorta. In normotensive anesthetized rats, oligopeptides induced an immediate and transient hypotensive...

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Onsa-Ard A, Shimbhu D, Tocharus J, et al. Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats. ISRN Pharmacol. 2013;2013:717529doi: 10.1155/2013/717529.
Onsa-Ard, A., Shimbhu, D., Tocharus, J., Sutheerawattananonda, M., Pantan, R., & Tocharus, C. (2013). Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats. ISRN pharmacology, 2013717529. https://doi.org/10.1155/2013/717529
Onsa-Ard, Amnart, et al. "Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats." ISRN pharmacology vol. 2013 (2013): 717529. doi: https://doi.org/10.1155/2013/717529
Onsa-Ard A, Shimbhu D, Tocharus J, Sutheerawattananonda M, Pantan R, Tocharus C. Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats. ISRN Pharmacol. 2013 Nov 07;2013:717529. doi: 10.1155/2013/717529. eCollection 2013. PMID: 24312733; PMCID: PMC3839117.
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7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice.

Drug target insights

Mutlu O, Akar F, Celikyurt IK, Tanyeri P, Ulak G, Erden F.
PMID: 25788830
Drug Target Insights. 2015 Mar 04;9:1-8. doi: 10.4137/DTI.S23378. eCollection 2015.

Nitric oxide (NO) is an atypical neurotransmitter that causes changes in cognition. Nitric oxide synthase (NOS) and guanylate cyclase (GC) inhibitors have been shown to exert some effects on cognition in previous studies; however, the findings have been controversial....

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Mutlu O, Akar F, Celikyurt IK, et al. 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice. Drug Target Insights. 2015;9:1-8doi: 10.4137/DTI.S23378.
Mutlu, O., Akar, F., Celikyurt, I. K., Tanyeri, P., Ulak, G., & Erden, F. (2015). 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice. Drug target insights, 91-8. https://doi.org/10.4137/DTI.S23378
Mutlu, Oguz, et al. "7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice." Drug target insights vol. 9 (2015): 1-8. doi: https://doi.org/10.4137/DTI.S23378
Mutlu O, Akar F, Celikyurt IK, Tanyeri P, Ulak G, Erden F. 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice. Drug Target Insights. 2015 Mar 04;9:1-8. doi: 10.4137/DTI.S23378. eCollection 2015. PMID: 25788830; PMCID: PMC4354329.
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Red ginseng saponin fraction a isolated from korean red ginseng by ultrafiltration on the porcine coronary artery.

Journal of ginseng research

Jung YH, Park KY, Jeon JH, Kwak YS, Song YB, Wee JJ, Rhee MH, Kim TW.
PMID: 23717076
J Ginseng Res. 2011 Sep;35(3):325-30. doi: 10.5142/jgr.2011.35.3.325.

Red ginseng saponin fraction-A (RGSF-A) contains a high percentage of panaxadiol saponins that were isolated from Korean red ginseng by ultrafiltration. The aim of this study was to elucidate the effects of RGSF-A on the porcine distal left anterior...

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Jung YH, Park KY, Jeon JH, et al. Red ginseng saponin fraction a isolated from korean red ginseng by ultrafiltration on the porcine coronary artery. J Ginseng Res. 2011;35(3):325-30doi: 10.5142/jgr.2011.35.3.325.
Jung, Y. H., Park, K. Y., Jeon, J. H., Kwak, Y. S., Song, Y. B., Wee, J. J., Rhee, M. H., & Kim, T. W. (2011). Red ginseng saponin fraction a isolated from korean red ginseng by ultrafiltration on the porcine coronary artery. Journal of ginseng research, 35(3), 325-30. https://doi.org/10.5142/jgr.2011.35.3.325
Jung, Young Hyun, et al. "Red ginseng saponin fraction a isolated from korean red ginseng by ultrafiltration on the porcine coronary artery." Journal of ginseng research vol. 35,3 (2011): 325-30. doi: https://doi.org/10.5142/jgr.2011.35.3.325
Jung YH, Park KY, Jeon JH, Kwak YS, Song YB, Wee JJ, Rhee MH, Kim TW. Red ginseng saponin fraction a isolated from korean red ginseng by ultrafiltration on the porcine coronary artery. J Ginseng Res. 2011 Sep;35(3):325-30. doi: 10.5142/jgr.2011.35.3.325. PMID: 23717076; PMCID: PMC3659546.
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An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts.

Regenerative therapy

Amano H, Iwaki F, Oki M, Aoki K, Ohba S.
PMID: 31667208
Regen Ther. 2019 Sep 27;11:290-296. doi: 10.1016/j.reth.2019.08.007. eCollection 2019 Dec.

OBJECTIVE: The helioxanthin derivative 4-(4-methoxyphenyl)thieno[2,3-b:5,4-c']dipyridine-2-carboxamide (TH) is a low-molecular-weight compound that was identified through screening for osteogenic compounds that enhance the activity of mouse preosteoblastic MC3T3-E1 cells. In the present study, we found that TH suppressed osteoclast differentiation.METHODS: Using...

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Amano H, Iwaki F, Oki M, et al. An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts. Regen Ther. 2019;11:290-296doi: 10.1016/j.reth.2019.08.007.
Amano, H., Iwaki, F., Oki, M., Aoki, K., & Ohba, S. (2019). An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts. Regenerative therapy, 11290-296. https://doi.org/10.1016/j.reth.2019.08.007
Amano, Hitoshi, et al. "An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts." Regenerative therapy vol. 11 (2019): 290-296. doi: https://doi.org/10.1016/j.reth.2019.08.007
Amano H, Iwaki F, Oki M, Aoki K, Ohba S. An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts. Regen Ther. 2019 Sep 27;11:290-296. doi: 10.1016/j.reth.2019.08.007. eCollection 2019 Dec. PMID: 31667208; PMCID: PMC6813560.
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Induction of Secretagogue Independent Gastric Acid Secretion .

Frontiers in physiology

Kitay AM, Ferstl FS, Link A, Geibel JP.
PMID: 31649553
Front Physiol. 2019 Oct 10;10:1264. doi: 10.3389/fphys.2019.01264. eCollection 2019.

Aspirin has been widely recommended for acute and chronic conditions for over 2,000 years. Either single or repetitive doses are commonly used for analgesic and antipyretic reasons and to prevent heart attacks, stroke, and blood clot formation. Recent studies...

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Kitay AM, Ferstl FS, Link A, et al. Induction of Secretagogue Independent Gastric Acid Secretion . Front Physiol. 2019;10:1264doi: 10.3389/fphys.2019.01264.
Kitay, A. M., Ferstl, F. S., Link, A., & Geibel, J. P. (2019). Induction of Secretagogue Independent Gastric Acid Secretion . Frontiers in physiology, 101264. https://doi.org/10.3389/fphys.2019.01264
Kitay, Alice Miriam, et al. "Induction of Secretagogue Independent Gastric Acid Secretion ." Frontiers in physiology vol. 10 (2019): 1264. doi: https://doi.org/10.3389/fphys.2019.01264
Kitay AM, Ferstl FS, Link A, Geibel JP. Induction of Secretagogue Independent Gastric Acid Secretion . Front Physiol. 2019 Oct 10;10:1264. doi: 10.3389/fphys.2019.01264. eCollection 2019. PMID: 31649553; PMCID: PMC6795678.
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Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis.

Journal of inflammation (London, England)

Shaw CA, Webb DJ, Rossi AG, Megson IL.
PMID: 19422695
J Inflamm (Lond). 2009 May 07;6:14. doi: 10.1186/1476-9255-6-14.

BACKGROUND: Nitric oxide (NO) can be both pro- and anti-apoptotic in various cell types, including macrophages. This apparent paradox may result from the actions of NO-related species generated in the microenvironment of the cell, for example the formation of...

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Shaw CA, Webb DJ, Rossi AG, et al. Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis. J Inflamm (Lond). 2009;6:14doi: 10.1186/1476-9255-6-14.
Shaw, C. A., Webb, D. J., Rossi, A. G., & Megson, I. L. (2009). Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis. Journal of inflammation (London, England), 614. https://doi.org/10.1186/1476-9255-6-14
Shaw, Catherine A, et al. "Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis." Journal of inflammation (London, England) vol. 6 (2009): 14. doi: https://doi.org/10.1186/1476-9255-6-14
Shaw CA, Webb DJ, Rossi AG, Megson IL. Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis. J Inflamm (Lond). 2009 May 07;6:14. doi: 10.1186/1476-9255-6-14. PMID: 19422695; PMCID: PMC2689212.
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Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor.

Laboratory animal research

Endale M, Song JC, Rhee MH, Liu KH, Kim TK, Kwon JG, Park KS, Chung KM, Kim TW.
PMID: 22232640
Lab Anim Res. 2011 Dec;27(4):317-25. doi: 10.5625/lar.2011.27.4.317. Epub 2011 Dec 19.

Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scarce. The present study investigated the effects of Suaeda...

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Endale M, Song JC, Rhee MH, et al. Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor. Lab Anim Res. 2011;27(4):317-25doi: 10.5625/lar.2011.27.4.317.
Endale, M., Song, J. C., Rhee, M. H., Liu, K. H., Kim, T. K., Kwon, J. G., Park, K. S., Chung, K. M., & Kim, T. W. (2011). Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor. Laboratory animal research, 27(4), 317-25. https://doi.org/10.5625/lar.2011.27.4.317
Endale, Mehari, et al. "Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor." Laboratory animal research vol. 27,4 (2011): 317-25. doi: https://doi.org/10.5625/lar.2011.27.4.317
Endale M, Song JC, Rhee MH, Liu KH, Kim TK, Kwon JG, Park KS, Chung KM, Kim TW. Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by β-adrenoceptor. Lab Anim Res. 2011 Dec;27(4):317-25. doi: 10.5625/lar.2011.27.4.317. Epub 2011 Dec 19. PMID: 22232640; PMCID: PMC3251762.
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Different effects of different phosphodiesterase type-5 inhibitors in pre-eclampsia.

Pregnancy hypertension

Karasu E, Kayacan N, Sadan G, Dinc B.
PMID: 26009031
Pregnancy Hypertens. 2011 Jul-Oct;1(3):231-7. doi: 10.1016/j.preghy.2011.04.002. Epub 2011 May 06.

OBJECTIVES: We aimed to determine the effects of sildenafil and vardenafil in human umbilical artery preparation taken from pre-eclamptic or normal pregnant women, and also to investigate the underlying mechanisms in these effects.STUDY DESIGN: Fifteen pregnant women with pre-eclampsia...

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Karasu E, Kayacan N, Sadan G, et al. Different effects of different phosphodiesterase type-5 inhibitors in pre-eclampsia. Pregnancy Hypertens. 2011;1(3):231-7doi: 10.1016/j.preghy.2011.04.002.
Karasu, E., Kayacan, N., Sadan, G., & Dinc, B. (2011). Different effects of different phosphodiesterase type-5 inhibitors in pre-eclampsia. Pregnancy hypertension, 1(3), 231-7. https://doi.org/10.1016/j.preghy.2011.04.002
Karasu, Edibe, et al. "Different effects of different phosphodiesterase type-5 inhibitors in pre-eclampsia." Pregnancy hypertension vol. 1,3 (2011): 231-7. doi: https://doi.org/10.1016/j.preghy.2011.04.002
Karasu E, Kayacan N, Sadan G, Dinc B. Different effects of different phosphodiesterase type-5 inhibitors in pre-eclampsia. Pregnancy Hypertens. 2011 Jul-Oct;1(3):231-7. doi: 10.1016/j.preghy.2011.04.002. Epub 2011 May 06. PMID: 26009031.
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Vasorelaxant effect of water fraction of .

International Journal of Cardiology. Hypertension

Manshor NM, Razali N, Jusoh RR, Asmawi MZ, Mohamed N, Zainol S, Altaf R, Dewa A.
PMID: 33447753
Int J Cardiol Hypertens. 2020 Jan 11;4:100024. doi: 10.1016/j.ijchy.2020.100024. eCollection 2020 Mar.

OBJECTIVE: This study aims to fractionate water extract of METHODS: Water extract of RESULTS: WF-LPWE produced dose-dependent vasorelaxant effect in endothelium-denuded aortic ring and showed non-competitive inhibition of dose-response curves of PE-induced contraction, and at its higher concentrations reduced...

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Manshor NM, Razali N, Jusoh RR, et al. Vasorelaxant effect of water fraction of . Int J Cardiol Hypertens. 2020;4:100024doi: 10.1016/j.ijchy.2020.100024.
Manshor, N. M., Razali, N., Jusoh, R. R., Asmawi, M. Z., Mohamed, N., Zainol, S., Altaf, R., & Dewa, A. (2020). Vasorelaxant effect of water fraction of . International Journal of Cardiology. Hypertension, 4100024. https://doi.org/10.1016/j.ijchy.2020.100024
Manshor, Nurul Maizan, et al. "Vasorelaxant effect of water fraction of ." International Journal of Cardiology. Hypertension vol. 4 (2020): 100024. doi: https://doi.org/10.1016/j.ijchy.2020.100024
Manshor NM, Razali N, Jusoh RR, Asmawi MZ, Mohamed N, Zainol S, Altaf R, Dewa A. Vasorelaxant effect of water fraction of . Int J Cardiol Hypertens. 2020 Jan 11;4:100024. doi: 10.1016/j.ijchy.2020.100024. eCollection 2020 Mar. PMID: 33447753; PMCID: PMC7803023.
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Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery.

Frontiers in pharmacology

Moreira LN, Silva JF, Silva GC, Lemos VS, Cortes SF.
PMID: 29872397
Front Pharmacol. 2018 May 22;9:528. doi: 10.3389/fphar.2018.00528. eCollection 2018.

D-pinitol is a cyclitol present in several edible plant species and extensively investigated for the treatment of metabolic diseases in humans, as food supplement, and demonstrated protective effects in the cardiovascular system. For these reasons, the present work aimed...

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Moreira LN, Silva JF, Silva GC, et al. Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery. Front Pharmacol. 2018;9:528doi: 10.3389/fphar.2018.00528.
Moreira, L. N., Silva, J. F., Silva, G. C., Lemos, V. S., & Cortes, S. F. (2018). Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery. Frontiers in pharmacology, 9528. https://doi.org/10.3389/fphar.2018.00528
Moreira, Luciana N, et al. "Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery." Frontiers in pharmacology vol. 9 (2018): 528. doi: https://doi.org/10.3389/fphar.2018.00528
Moreira LN, Silva JF, Silva GC, Lemos VS, Cortes SF. Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery. Front Pharmacol. 2018 May 22;9:528. doi: 10.3389/fphar.2018.00528. eCollection 2018. PMID: 29872397; PMCID: PMC5972298.
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Vasodilatory action of trans-4-methoxy-β-nitrostyrene in rat isolated pulmonary artery.

Clinical and experimental pharmacology & physiology

Arruda-Barbosa L, Vasconcelos-Silva AA, Borges RS, Duarte GP, Magalhães PJC, Lahlou S.
PMID: 33506524
Clin Exp Pharmacol Physiol. 2021 May;48(5):717-725. doi: 10.1111/1440-1681.13467. Epub 2021 Jan 27.

Trans-4-methoxy-β-nitrostyrene (T4MN) induced more potent vasorelaxant effects in resistance arteries from hypertensive rats than its parent drug, β-nitrostyrene 1-nitro-2-phenylethene (NPe). To better understand the influence of insertion of the electron-releasing methoxy group in the aromatic ring of NPe, we...

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Arruda-Barbosa L, Vasconcelos-Silva AA, Borges RS, et al. Vasodilatory action of trans-4-methoxy-β-nitrostyrene in rat isolated pulmonary artery. Clin Exp Pharmacol Physiol. 2021;48(5):717-725doi: 10.1111/1440-1681.13467.
Arruda-Barbosa, L., Vasconcelos-Silva, A. A., Borges, R. S., Duarte, G. P., Magalhães, P. J. C., & Lahlou, S. (2021). Vasodilatory action of trans-4-methoxy-β-nitrostyrene in rat isolated pulmonary artery. Clinical and experimental pharmacology & physiology, 48(5), 717-725. https://doi.org/10.1111/1440-1681.13467
Arruda-Barbosa, Loeste, et al. "Vasodilatory action of trans-4-methoxy-β-nitrostyrene in rat isolated pulmonary artery." Clinical and experimental pharmacology & physiology vol. 48,5 (2021): 717-725. doi: https://doi.org/10.1111/1440-1681.13467
Arruda-Barbosa L, Vasconcelos-Silva AA, Borges RS, Duarte GP, Magalhães PJC, Lahlou S. Vasodilatory action of trans-4-methoxy-β-nitrostyrene in rat isolated pulmonary artery. Clin Exp Pharmacol Physiol. 2021 May;48(5):717-725. doi: 10.1111/1440-1681.13467. Epub 2021 Jan 27. PMID: 33506524.
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Showing 1 to 12 of 28 entries